Journal of the Turkish Chemical Society, Section A: Chemistry最新文献_第3页

A Novel Method Development and Validation by Ultra-Performance Liquid Chromatography for Assay of Asciminib in Dosage Form 超高效液相色谱法测定阿西米尼剂型的方法建立及验证

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2023-05-31 DOI: 10.18596/jotcsa.1228364

Pridhvi Krishna GADDEY, Raja SUNDARARAJAN

{"title":"A Novel Method Development and Validation by Ultra-Performance Liquid Chromatography for Assay of Asciminib in Dosage Form","authors":"Pridhvi Krishna GADDEY, Raja SUNDARARAJAN","doi":"10.18596/jotcsa.1228364","DOIUrl":"https://doi.org/10.18596/jotcsa.1228364","url":null,"abstract":"The main objective of the present study was to develop and validate simple, precise, sensitive and accurate UPLC method for the estimation of asciminib in pure and dosage form. The UPLC method was developed by using Waters Acquity liquid chromatographic system and Zorbax Phenyl (100x1.0mm,1.7µm) column. The developed method was validated according to the international conference on harmonization (ICH) guidelines. The chromatographic separation of asciminib with good resolutions has been achieved by using the mobile phase acetonitrile: ammonium dihydrogen phosphate buffer (20:80 v/v) at a flow rate of 0.5 mL/min, injection volume of 5 µL, and at 242 nm wavelength. The validated method was found to be linear in the range of 4 - 60 µg/mL. The limit of detection (LOD) and limit of quantification (LOQ) for asciminib were found to be 0.4 and 0.12 µg/mL respectively. The % RSD was found to be less than 2 % revealing the precision of the developed method. Besides, the recovery rate was observed close to 100 % confirming the accuracy of the method. Minor alterations in the chromatographic conditions have revealed robustness and ruggedness of the developed method. The developed analytical method is simple, precise, sensitive, and reproducible which can be used for the estimation of asciminib.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytarabine determination from urine for Toxicokinetic and Excretion studies by High- Performance Liquid Chromatography-Tandem Mass Spectrometry 高效液相色谱-串联质谱法测定尿中阿糖胞苷的毒性动力学和排泄研究

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2023-05-31 DOI: 10.18596/jotcsa.1190202

İbrahim DANİŞ, Ayşegül GÖLCÜ, Durişehvar ÜNAL

{"title":"Cytarabine determination from urine for Toxicokinetic and Excretion studies by High- Performance Liquid Chromatography-Tandem Mass Spectrometry","authors":"İbrahim DANİŞ, Ayşegül GÖLCÜ, Durişehvar ÜNAL","doi":"10.18596/jotcsa.1190202","DOIUrl":"https://doi.org/10.18596/jotcsa.1190202","url":null,"abstract":"Cytarabine (Cyt) (also known as cytosine arabinoside (ara-C)) used in the treatment of acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL). CYT applied in high doses for treatment can cause renal failure. Monitoring excreted urine drug levels can help kidney failure. For this reason, a method was developed and validated by HPLC-MSMS for urine CYT analysis, which is not included in the literature. In this study, a liquid chromatography (HPLC) with triple quadrupole Mass Spectrometric (MS/MS) method developed for the determination of Cyt from urine for toxicokinetic evaluation. Positive MRM mode selected for the quantification of Cyt. The product and major fragment ion for Cyt 244.0 &gt; 112.0 m/z, for IS 198.0 &gt; 152.0 m/z. The optimal MS parameters for Cyt and IS are as follows Fragmentor 80 V, 70 V, Collision energy, 6, 9 respectively. A novel simple, high-throughput and highly sensitive HPLC-MS/MS method was successfully developed and validated for the determination of Cyt from urine. The developed method has a simple one-step extraction method and a short run time (2.0 minutes) for analysis. The proposed method could be practical and reliable for excretion and toxicokinetic studies and as well as the Therapeutic Drug Monitoring study in humans without an invasive route for Cyt.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135250420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical and Spectroscopic Characterization of the Microcrystalline Cellulose Derivatives from Corn Cob and Daniella Oliveri Wastes 玉米芯和牛尾草废料微晶纤维素衍生物的物理和光谱表征

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2023-02-28 DOI: 10.18596/jotcsa.1107627

Mariam Temitope BAKER, Olubunmi Stephen OGUNTOYE

{"title":"Physical and Spectroscopic Characterization of the Microcrystalline Cellulose Derivatives from Corn Cob and Daniella Oliveri Wastes","authors":"Mariam Temitope BAKER, Olubunmi Stephen OGUNTOYE","doi":"10.18596/jotcsa.1107627","DOIUrl":"https://doi.org/10.18596/jotcsa.1107627","url":null,"abstract":"Cellulose was extracted from wood dust waste samples of Daniella oliveri and corn cobs by acetic acid and alkaline pretreatment methods, while microcrystalline cellulose (MCC) derivative was produced by acid hydrolysis in 2 M HCl. The samples were tested for pH, moisture content, swelling capacities and ash contents. The data obtained were compared with those of commercial MCCs found in the literature. The functional groups in the microcrystalline cellulose derivatives was confirmed by the Fourier transform infrared (FTIR) spectroscopic method with characteristic absorption bands of;–OH stretching at 3416 cm-1; C-H stretching at 2918 cm-1; -OH bending at 1377 cm-1; 1159 cm-1; and C-O-C pyranose ring skeletal vibrations at 1026-1033 cm-1. The crystallinity absorption bands appeared at 1436 and 850 cm-1. The characteristic morphological features were established by scanning electron microscopy (SEM). Furthermore, the crystallinity of the microcrystalline cellulose was further confirmed using the X-ray powder diffraction (X-RD) technique, which showed three main reflections at 2θ=14.70°, 22.09°, and 34.24°.These results supported that microcrystalline cellulose derivative as cellulose I type and the acid pretreatment did not affect the structure of the MCC. The crystallinity indices were 69.3 and 73.2%, respectively. Daniella Oliveri and corn cob microcrystalline cellulose are, therefore, potential materials for further processing.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135583725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sorption of Cobalt and Nickel on Narcissus Tazetta L. Leaf Powder 水仙叶粉对钴和镍的吸附

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2021-05-29 DOI: 10.18596/JOTCSA.881291

Süleyman İnan, Bekir Özkan

引用次数: 2

Functionalized Sepiolitic Clay Nanofibers as a Natural Ingredient in Medical Cosmetics 功能化海泡石粘土纳米纤维作为医用化妆品的天然成分

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2021-03-06 DOI: 10.18596/JOTCSA.847163

B. Benli, Ecehan Gönül

引用次数: 0

Monoamine Oxidase Inhibitory Effects of Medicinal Plants in Management of Alzheimer's Disease 药用植物对阿尔茨海默病的抑制作用

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2021-02-28 DOI: 10.18596/JOTCSA.823874

Tuba Ege, Hayriye Deniz Şelimen

{"title":"Monoamine Oxidase Inhibitory Effects of Medicinal Plants in Management of Alzheimer's Disease","authors":"Tuba Ege, Hayriye Deniz Şelimen","doi":"10.18596/JOTCSA.823874","DOIUrl":"https://doi.org/10.18596/JOTCSA.823874","url":null,"abstract":"Alzheimer's disease is the most common progressive neurodegenerative disorder that effects large population of society especially elderly people. Environmental and/or genetic factors contribute Alzheimer's disease to become a pivotal health problem but this relationship remains ambiguous. Globally growing prevalence of Alzheimer’s disease requires to understand cellular pathways that lead to Alzheimer’s disease and to develop new strategies for prevention and treatment. Elevated monoamine oxidase (MAO) enzymes activity with ages is associated with etiology of Alzheimer's disease. Inhibition of monoamine oxidase enzyme can protect from neuronal damage, thus it become one of the key pathway for management of Alzheimer’s disease. Using bioactive compounds from medicinal plants as potential monoamine oxidase inhibitors might be a better solution considering undesired side effects of synthetic drugs on human body. The purpose of this review is to implicate the importance of pharmacophore analysis which explains pharmacological properties of medicinal plants and interaction of bioactive compound from plants with MAO enzyme.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48185288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species 部分Achillea属植物的微量元素、抗胆碱酯酶活性及ADME/Tox图谱分析

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2021-02-28 DOI: 10.18596/JOTCSA.849654

D. Taşkın, T. Şahin, Mücahit Özdemir, B. Yalçın

{"title":"Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species","authors":"D. Taşkın, T. Şahin, Mücahit Özdemir, B. Yalçın","doi":"10.18596/JOTCSA.849654","DOIUrl":"https://doi.org/10.18596/JOTCSA.849654","url":null,"abstract":"In this study, the anti-cholinesterase activities of different extracts of Achillea lycaonica, A. vermicularis and A. nobilis L. subsp. neilreichii (Kerner) Formanek species were examined and then trace elements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, and Pb) of the plants were analysed by ICP-MS. The pharmacokinetic properties of the phenolic compounds of these plants previously analyzed by us and the ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) profiles of the trace elements we identified in this study were estimated. According to the data obtained, it was determined that all three plants showed high acetyl-cholinesterase inhibition activity. The concentration of trace elements was lower than that declared by WHO, except for the A. lycaonica. It was determined that V, Cr, Fe, Co, and As metals in A. lycaonica exceeded the limit values determined by WHO. According to ADMET estimates, it is thought that the toxic values of all three plants are not high, and therefore the use of A. nobilis and A. vermicularis plants does not pose any health risk but A lycaonica should be used carefully due to the heavy metals.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41493716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Screening and Antibacterial Activity of Pistacia atlantica and Pinus canariensis Extracts 黄连木和金丝雀松提取物的植物化学筛选及其抗菌活性

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2021-02-17 DOI: 10.18596/JOTCSA.836074

Obaida Alhajali, Adnan Ali-Nizam

引用次数: 2

Corrosion Inhibitive Potentials Of (E)-5-((4-Benzoylphenyl)Diazenyl)-2-Hydroxybenzoic Acid On Mild Steel Surface In 0.5 M HCl- Experimental And DFT Calculations （E）-5-（（4-苯甲酰基苯基）二氮基）-2-羟基苯甲酸在0.5M盐酸中对软钢表面的缓蚀电位-实验和DFT计算

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2021-01-30 DOI: 10.18596/JOTCSA.821488

J. Amoko, O. Akinyele, O. Oyeneyin, Dare Olayanju

{"title":"Corrosion Inhibitive Potentials Of (E)-5-((4-Benzoylphenyl)Diazenyl)-2-Hydroxybenzoic Acid On Mild Steel Surface In 0.5 M HCl- Experimental And DFT Calculations","authors":"J. Amoko, O. Akinyele, O. Oyeneyin, Dare Olayanju","doi":"10.18596/JOTCSA.821488","DOIUrl":"https://doi.org/10.18596/JOTCSA.821488","url":null,"abstract":"One of the ways of reducing metal corrosion and its devastating effects is by using organic corrosion inhibitors. This is because of the π-conjugation in their moieties, their ability to donate electrons to the metal’s vacant d-orbitals, and their low lying LUMO orbitals for accepting electrons as well from the metal, all these improve their adsorption on the metal surface. (E)-5-((4-benzoylphenyl)diazenyl)-2-hydroxybenzoic acid (AD4) was synthesized via the coupling reaction of p-aminobenzonephenone and Salicylic acid, characterized via FTIR, UV/Vis, 1H-NMR, and 13C-NMR spectroscopy. The melting point of AD4 is 103oC–106oC indicating that it is thermally stable and pure. Gravimetric and potentiodynamic polarization techniques were employed to obtain the corrosion rates (Cr) and percentage inhibition efficiency (%IE) at different concentrations of the inhibitor and at different temperatures. The thermodynamic parameters like Enthalpy, ∆Hoads, Entropy, ∆Soads and free energy of adsorption (∆Gads) of Adsorption were calculated. The Langmuir adsorption isotherm was used to describe the adsorption of AD4 molecules on mild steel. Quantum mechanical calculations were employed to calculate the electronic properties and global reactivity descriptors of AD4. The theoretical results are broadly consistent with experimental results. From the results obtained AD4 could be used as a corrosion inhibition agent in the oil and gas industries.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47746203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Calcined Eggshell for Removal of Victoria Blue R Dye from Wastewater Medium by Adsorption 煅烧蛋壳吸附法去除废水介质中维多利亚蓝R染料

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2020-11-11 DOI: 10.18596/jotcsa.760083

İ̇lknur Tosun Satir, Kadir Erol

引用次数: 8