Journal of Thyroid Research最新文献_第8页

Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases 216例胫骨前黏液性水肿的形态学多样性及其机制演变过程和结果的回顾性研究

IF 2.1

Journal of Thyroid Research Pub Date : 2016-08-25 DOI: 10.1155/2016/2652174

C. Lan, Yi Wang, Xia Zeng, J. Zhao, Xiaoxi Zou

{"title":"Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases","authors":"C. Lan, Yi Wang, Xia Zeng, J. Zhao, Xiaoxi Zou","doi":"10.1155/2016/2652174","DOIUrl":"https://doi.org/10.1155/2016/2652174","url":null,"abstract":"Background. Pretibial myxedema (PTM) is a rare dermopathy. The morphologic features and mechanism of its evolving process are not reported in large case series. Methods. 216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome. Results. First appearing lesions evolved into 6 variants that were correlated with serum TRAb levels. Subvariants were caused by different kinds and frequencies of local trauma. The evolving process could be classified into 4 stages that were correlated with serum TRAb levels and perivascular infiltration of CD8+ and CD4+ lymphocytes. Serum TRAb levels at remission and in nonrecurred cases became lower than those before therapy and in recurred cases, respectively, but increased when PTM relapsed. TRAb level in nodule variant went down invariably with the extension of course and its autoimmune activity had a trend to stop but in other 5 variants TRAb levels fluctuated. Their autoimmune activities had no trends to stop and clinically worsen through intermittent repeats of active and stable stages. Conclusions. In the chronic course of PTM, nodule variant is self-limited and other 5 variants are not self-limited. PTM needed early treatment to avoid severe variants.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"51 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78018076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Significance of Interleukin-6 in Papillary Thyroid Carcinoma 白细胞介素-6在甲状腺乳头状癌中的意义

IF 2.1

Journal of Thyroid Research Pub Date : 2016-03-13 DOI: 10.1155/2016/6178921

T. Kobawala, T. Trivedi, K. Gajjar, Darshita H. Patel, G. Patel, N. Ghosh

{"title":"Significance of Interleukin-6 in Papillary Thyroid Carcinoma","authors":"T. Kobawala, T. Trivedi, K. Gajjar, Darshita H. Patel, G. Patel, N. Ghosh","doi":"10.1155/2016/6178921","DOIUrl":"https://doi.org/10.1155/2016/6178921","url":null,"abstract":"This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions. As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC. Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases. ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign thyroid diseases and PTC. The circulating IL-6 was significantly associated with poor overall survival in PTC patients. IL-6 immunoreactivity was significantly high in PTC patients as compared to the benign thyroid disease patients. Significantly higher IL-6 mRNA expression was also observed in the primary tumour tissues of PTC patients than the adjacent normal tissues. The protein expression of IL-6 at both the circulating and tissue level correlated with disease aggressiveness in PTC patients. Moreover, a significant positive correlation was observed between the IL-6 protein and mRNA expression in the primary tumours of PTC patients. Finally in conclusion, IL-6 has an important role in thyroid cancer progression. Thus targeting IL-6 signalling can help in clinical management of thyroid carcinoma patients.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74814752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Effect of Preoperative Nerve Block on Postthyroidectomy Headache and Cervical Pain: A Randomized Prospective Study 术前神经阻滞对甲状腺切除术后头痛和颈椎疼痛的影响:一项随机前瞻性研究

IF 2.1

Journal of Thyroid Research Pub Date : 2016-03-13 DOI: 10.1155/2016/9785849

Sunil Malla Bujar Barua, A. Mishra, K. Kishore, S. Mishra, G. Chand, G. Agarwal, A. Agarwal, A. Verma

{"title":"Effect of Preoperative Nerve Block on Postthyroidectomy Headache and Cervical Pain: A Randomized Prospective Study","authors":"Sunil Malla Bujar Barua, A. Mishra, K. Kishore, S. Mishra, G. Chand, G. Agarwal, A. Agarwal, A. Verma","doi":"10.1155/2016/9785849","DOIUrl":"https://doi.org/10.1155/2016/9785849","url":null,"abstract":"The aim of the current study was to investigate the efficacy of greater occipital nerve (GON) block and bilateral superficial cervical plexuses (BSCP) blocks in alleviating postoperative occipital headache and posterior neck pain after thyroidectomy. This randomized prospective study consisted of 75 women undergoing total thyroidectomy. Patients were randomized into three groups: Group I (n = 25): patients receiving GON, Group II (n = 25): patients receiving bilateral (BSCP) blocks, and Group III (n = 25): patients receiving no block. Assessment of occipital headache, posterior neck, and incision site pains was made at 12 hours and 24 hours after extubation by Visual Analogue Scale (VAS). In comparison to Group III significantly fewer patients in Groups I and II experienced occipital headache at 12 (p = 0.006) and 24 hours (p = 0.005) and also posterior neck pain at 24 hours (p = 0.003). Mean VAS scores at 12 and 24 hours for occipital headache (p = 0.003 and p = 0.041) and posterior neck pain (p = 0.015 and p = 0.008) were significantly lower in Group I. The differences between Groups II and III were not significant except for the occipital headache at 12 hours. The efficacy of GON block is superior to BSCP blocks in alleviating postthyroidectomy occipital headache and posterior cervical pain.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"4 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90475579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review 全甲状腺切除术的安全性和有效性及其与甲状腺次全切除术和其他甲状腺手术的比较:系统综述

IF 2.1

Journal of Thyroid Research Pub Date : 2016-02-24 DOI: 10.1155/2016/7594615

Ashwini Aithal Padur, Naveen Kumar, A. Guru, Satheesha Nayak Badagabettu, Swamy Ravindra Shanthakumar, M. Virupakshamurthy, J. Patil

{"title":"Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review","authors":"Ashwini Aithal Padur, Naveen Kumar, A. Guru, Satheesha Nayak Badagabettu, Swamy Ravindra Shanthakumar, M. Virupakshamurthy, J. Patil","doi":"10.1155/2016/7594615","DOIUrl":"https://doi.org/10.1155/2016/7594615","url":null,"abstract":"Diseases associated with the thyroid gland are one of the most frequently seen endocrine disorders across the globe. Total thyroidectomy is currently the preferred treatment for many thyroid diseases. Controversies exist among surgeons regarding safety of total thyroidectomy due to the risk associated with it like postoperative hypoparathyroidism or recurrent laryngeal nerve damage. Since, in the recent years, the incidence of thyroidectomy is in increasing trend in south Indian population, this review aims to study the available data regarding the appropriateness and safety of total thyroidectomy and compares it with subtotal thyroidectomy and other thyroid surgeries. This is a retrospective comprehensive review of various articles and publications regarding total and partial thyroidectomy performed across the world. Many retrospective studies and few prospective studies suggest that the incidence of transient hypocalcemia is higher after total thyroidectomy than after subtotal thyroidectomy, but the incidence of other complications including recurrent laryngeal nerve palsy and postoperative hematoma is not significantly different between the two procedures. Hence in our review we found that total thyroidectomy is safe and cost effective with low complication rates and provides little significant advantage of being safer procedure compared to subtotal thyroidectomy.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"360 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76432393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism 产前暴露于多种甲状腺激素干扰物:对葡萄糖和脂质代谢的影响

IF 2.1

Journal of Thyroid Research Pub Date : 2016-02-17 DOI: 10.1155/2016/8765049

Deborah Molehin, M. Dekker Nitert, K. Richard

{"title":"Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism","authors":"Deborah Molehin, M. Dekker Nitert, K. Richard","doi":"10.1155/2016/8765049","DOIUrl":"https://doi.org/10.1155/2016/8765049","url":null,"abstract":"Background. Thyroid hormones (THs) are essential for normal human fetal development and play a major role in the regulation of glucose and lipid metabolism. Delivery of TH to target tissues is dependent on processes including TH synthesis, transport, and metabolism. Thyroid hormone endocrine disruptors (TH-EDCs) are chemical substances that interfere with these processes, potentially leading to adverse pregnancy outcomes. Objectives. This review focuses on the effects of prenatal exposures to combinations of TH-EDCs on fetal and neonatal glucose and lipid metabolism and also discusses the various mechanisms by which TH-EDCs interfere with other hormonal pathways. Methods. We conducted a comprehensive narrative review on the effects of TH-EDCs with particular emphasis on exposure during pregnancy. Discussion. TH imbalance has been linked to many metabolic processes and the effects of TH imbalance are particularly pronounced in early fetal development due to fetal dependence on maternal TH for proper growth and development. The pervasive presence of EDCs in the environment results in ubiquitous exposure to either single or mixtures of EDCs with deleterious effects on metabolism. Conclusions. Further evaluation of combined effects of TH-EDCs on fetal metabolic endpoints could improve advice provided to expectant mothers.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"69 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77351135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area 地方性甲状腺肿区偶发的甲状腺乳头状小癌

IF 2.1

Journal of Thyroid Research Pub Date : 2016-02-02 DOI: 10.1155/2016/1784397

E. Gürleyik, G. Gurleyik, B. Karapolat, U. Onsal

{"title":"Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area","authors":"E. Gürleyik, G. Gurleyik, B. Karapolat, U. Onsal","doi":"10.1155/2016/1784397","DOIUrl":"https://doi.org/10.1155/2016/1784397","url":null,"abstract":"Clinical and pathological characteristics of incidental papillary thyroid microcancer cases, surgical, medical, and nuclear treatment methods, and patients' outcome were studied during follow-up period of 102 months. We studied 37 patients with incidental papillary thyroid microcancer (I-PTM). The surgical procedure was total thyroidectomy in 29 and hemithyroidectomy in 8 patients. Size, multifocality, and bilateralism of PTM foci, thyroid capsule invasion, and presence of lymphovascular invasion were histopathological parameters. We analysed adjuvant medical and nuclear treatment and patients' outcome during follow-up period of 102 (61–144) months. The prevalence rates of I-PTM were 9.4% in 395 thyroidectomy cases. Histopathological examination reported unifocal disease in 30 and multifocal disease in 7 (18%) patients. Multifocal disease was bilateral in 6 (20.1%) patients. The mean size of the PTM foci was 4.88 mm. The rate of thyroid capsule invasion was 5.4%. All patients received a suppressive dose of LT4 to achieve a low serum TSH level. Adjuvant surgical and nuclear treatment was not performed in our cases. We did not find any negative changes in blood chemistry and ultrasound imaging, and any unfavourable events as locoregional and systemic recurrence. In conclusion, diagnosis of I-PTM is common that multifocality and bilateralism appear as pathologic features. The prognosis is excellent after surgical treatment and TSH suppression. Routine adjuvant nuclear treatment is unnecessary in majority of patients.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"11 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87552195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells 槲皮素诱导人甲状腺乳头状癌细胞死亡

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-20 DOI: 10.1155/2016/9843675

E. M. Altundag, Tolga Kasacı, A. Yılmaz, B. Karademir, S. Koçtürk, S. Koçtürk, Y. Taga, A. Yalçın

{"title":"Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells","authors":"E. M. Altundag, Tolga Kasacı, A. Yılmaz, B. Karademir, S. Koçtürk, S. Koçtürk, Y. Taga, A. Yalçın","doi":"10.1155/2016/9843675","DOIUrl":"https://doi.org/10.1155/2016/9843675","url":null,"abstract":"In this study, we have investigated the antiproliferative effect of quercetin on human papillary thyroid cancer cells and determined the apoptotic mechanisms underlying its actions. We have used different concentrations of quercetin to induce apoptosis and measured cell viability. Apoptosis and cell cycle analysis was determined by flow cytometry using Annexin V and propidium iodide. Finally, we have measured changes in caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) protein expression levels as hallmarks of apoptosis and Hsp90 protein expression level as a marker of proteasome activity in treated and control cells. Quercetin treatment of human papillary thyroid cancer cells resulted in decreased cell proliferation and increased rate of apoptosis by caspase activation. Furthermore, it was demonstrated that quercetin induces cancer cell apoptosis by downregulating the levels of Hsp90. In conclusion, we have shown that quercetin induces downregulation of Hsp90 expression that may be involved in the decrease of chymotrypsin-like proteasome activity which, in order, induces inhibition of growth and causes cell death in thyroid cancer cells. Thus, quercetin appears to be a promising candidate drug for Hsp90 downregulation and apoptosis of thyroid cancer cells.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"5 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90144785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma TNF-α与粘附分子l -选择素、VCAM-1在甲状腺乳头状癌中的意义

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-11 DOI: 10.1155/2016/8143695

T. Kobawala, T. Trivedi, K. Gajjar, Darshita H. Patel, G. Patel, N. Ghosh

{"title":"Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma","authors":"T. Kobawala, T. Trivedi, K. Gajjar, Darshita H. Patel, G. Patel, N. Ghosh","doi":"10.1155/2016/8143695","DOIUrl":"https://doi.org/10.1155/2016/8143695","url":null,"abstract":"Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study. The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals. However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases. Further the expression of TNF-α and L-Selectin was also significantly higher in the primary tumors of PTC patients, relative to the benign thyroid diseases. The expression of L-Selectin and VCAM-1 significantly correlated with aggressive tumor behavior. In PTC patients, the circulating TNF-α levels significantly positively correlated with the levels of L-Selectin, while TNF-α immunoreactivity was significantly associated with VCAM-1 expression. Serum TNF-α was found to be a significant prognosticator for OS in PTC patients. Overall the results signify that the interaction between TNF-α and the adhesion molecules may have a role in thyroid carcinogenesis and understanding this complexity may offer potential therapeutic targets for better management of thyroid cancer.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"16 4 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80090214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Corrigendum to "How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer". “如何处理信号?”以ret基因型为导向选择治疗甲状腺髓样癌的激酶抑制剂的当前基础”。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-06-28 DOI: 10.1155/2016/2168046

Hugo Prazeres, Joana Torres, Fernando Rodrigues, Joana P Couto, João Vinagre, Manuel Sobrinho-Simões, Paula Soares

引用次数: 0

The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology. 人群T4/TSH设定点数据与T4/TSH生理的关系

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-03-31 DOI: 10.1155/2016/6351473

Stephen Paul Fitzgerald, Nigel Geoffrey Bean

{"title":"The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology.","authors":"Stephen Paul Fitzgerald, Nigel Geoffrey Bean","doi":"10.1155/2016/6351473","DOIUrl":"https://doi.org/10.1155/2016/6351473","url":null,"abstract":"<p><p>Context. Population studies of the distribution of T4/TSH set points suggest a more complex inverse relationship between T4 and TSH than that suggested by physiological studies. The reasons for the similarities and differences between the curves describing these relationships are unresolved. Methods. We subjected the curve, derived from empiric data, describing the TSH suppression response to T4, and the more mathematically derived curve describing the T4 response to TSH, to the different possible models of population variation. The implied consequences of these in terms of generating a population distribution of T4/TSH equilibrium points (a \"population curve\") were generated and compared to the empiric population curve. The physiological responses to primary hypothyroidism and hyperthyroidism were incorporated into the analysis. Conclusions. Though the population curve shows a similarly inverse relationship, it is describing a different relationship than the curve describing the suppression of TSH by T4. The population curve is consistent with the physiological studies of the TSH response to T4 and implies a greater interindividual variation in the positive thyroid T4 response to TSH than in the central inhibitory TSH response to T4. The population curve in the dysthyroid states is consistent with known physiological responses to these states. </p>","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"6351473"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6351473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34439052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25