Journal of Thyroid Research最新文献_第8页

Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism 产前暴露于多种甲状腺激素干扰物:对葡萄糖和脂质代谢的影响

IF 2.1

Journal of Thyroid Research Pub Date : 2016-02-17 DOI: 10.1155/2016/8765049

Deborah Molehin, M. Dekker Nitert, K. Richard

{"title":"Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism","authors":"Deborah Molehin, M. Dekker Nitert, K. Richard","doi":"10.1155/2016/8765049","DOIUrl":"https://doi.org/10.1155/2016/8765049","url":null,"abstract":"Background. Thyroid hormones (THs) are essential for normal human fetal development and play a major role in the regulation of glucose and lipid metabolism. Delivery of TH to target tissues is dependent on processes including TH synthesis, transport, and metabolism. Thyroid hormone endocrine disruptors (TH-EDCs) are chemical substances that interfere with these processes, potentially leading to adverse pregnancy outcomes. Objectives. This review focuses on the effects of prenatal exposures to combinations of TH-EDCs on fetal and neonatal glucose and lipid metabolism and also discusses the various mechanisms by which TH-EDCs interfere with other hormonal pathways. Methods. We conducted a comprehensive narrative review on the effects of TH-EDCs with particular emphasis on exposure during pregnancy. Discussion. TH imbalance has been linked to many metabolic processes and the effects of TH imbalance are particularly pronounced in early fetal development due to fetal dependence on maternal TH for proper growth and development. The pervasive presence of EDCs in the environment results in ubiquitous exposure to either single or mixtures of EDCs with deleterious effects on metabolism. Conclusions. Further evaluation of combined effects of TH-EDCs on fetal metabolic endpoints could improve advice provided to expectant mothers.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"69 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77351135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area 地方性甲状腺肿区偶发的甲状腺乳头状小癌

IF 2.1

Journal of Thyroid Research Pub Date : 2016-02-02 DOI: 10.1155/2016/1784397

E. Gürleyik, G. Gurleyik, B. Karapolat, U. Onsal

{"title":"Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area","authors":"E. Gürleyik, G. Gurleyik, B. Karapolat, U. Onsal","doi":"10.1155/2016/1784397","DOIUrl":"https://doi.org/10.1155/2016/1784397","url":null,"abstract":"Clinical and pathological characteristics of incidental papillary thyroid microcancer cases, surgical, medical, and nuclear treatment methods, and patients' outcome were studied during follow-up period of 102 months. We studied 37 patients with incidental papillary thyroid microcancer (I-PTM). The surgical procedure was total thyroidectomy in 29 and hemithyroidectomy in 8 patients. Size, multifocality, and bilateralism of PTM foci, thyroid capsule invasion, and presence of lymphovascular invasion were histopathological parameters. We analysed adjuvant medical and nuclear treatment and patients' outcome during follow-up period of 102 (61–144) months. The prevalence rates of I-PTM were 9.4% in 395 thyroidectomy cases. Histopathological examination reported unifocal disease in 30 and multifocal disease in 7 (18%) patients. Multifocal disease was bilateral in 6 (20.1%) patients. The mean size of the PTM foci was 4.88 mm. The rate of thyroid capsule invasion was 5.4%. All patients received a suppressive dose of LT4 to achieve a low serum TSH level. Adjuvant surgical and nuclear treatment was not performed in our cases. We did not find any negative changes in blood chemistry and ultrasound imaging, and any unfavourable events as locoregional and systemic recurrence. In conclusion, diagnosis of I-PTM is common that multifocality and bilateralism appear as pathologic features. The prognosis is excellent after surgical treatment and TSH suppression. Routine adjuvant nuclear treatment is unnecessary in majority of patients.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"11 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87552195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells 槲皮素诱导人甲状腺乳头状癌细胞死亡

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-20 DOI: 10.1155/2016/9843675

E. M. Altundag, Tolga Kasacı, A. Yılmaz, B. Karademir, S. Koçtürk, S. Koçtürk, Y. Taga, A. Yalçın

{"title":"Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells","authors":"E. M. Altundag, Tolga Kasacı, A. Yılmaz, B. Karademir, S. Koçtürk, S. Koçtürk, Y. Taga, A. Yalçın","doi":"10.1155/2016/9843675","DOIUrl":"https://doi.org/10.1155/2016/9843675","url":null,"abstract":"In this study, we have investigated the antiproliferative effect of quercetin on human papillary thyroid cancer cells and determined the apoptotic mechanisms underlying its actions. We have used different concentrations of quercetin to induce apoptosis and measured cell viability. Apoptosis and cell cycle analysis was determined by flow cytometry using Annexin V and propidium iodide. Finally, we have measured changes in caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) protein expression levels as hallmarks of apoptosis and Hsp90 protein expression level as a marker of proteasome activity in treated and control cells. Quercetin treatment of human papillary thyroid cancer cells resulted in decreased cell proliferation and increased rate of apoptosis by caspase activation. Furthermore, it was demonstrated that quercetin induces cancer cell apoptosis by downregulating the levels of Hsp90. In conclusion, we have shown that quercetin induces downregulation of Hsp90 expression that may be involved in the decrease of chymotrypsin-like proteasome activity which, in order, induces inhibition of growth and causes cell death in thyroid cancer cells. Thus, quercetin appears to be a promising candidate drug for Hsp90 downregulation and apoptosis of thyroid cancer cells.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"5 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90144785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma TNF-α与粘附分子l -选择素、VCAM-1在甲状腺乳头状癌中的意义

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-11 DOI: 10.1155/2016/8143695

T. Kobawala, T. Trivedi, K. Gajjar, Darshita H. Patel, G. Patel, N. Ghosh

{"title":"Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma","authors":"T. Kobawala, T. Trivedi, K. Gajjar, Darshita H. Patel, G. Patel, N. Ghosh","doi":"10.1155/2016/8143695","DOIUrl":"https://doi.org/10.1155/2016/8143695","url":null,"abstract":"Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study. The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals. However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases. Further the expression of TNF-α and L-Selectin was also significantly higher in the primary tumors of PTC patients, relative to the benign thyroid diseases. The expression of L-Selectin and VCAM-1 significantly correlated with aggressive tumor behavior. In PTC patients, the circulating TNF-α levels significantly positively correlated with the levels of L-Selectin, while TNF-α immunoreactivity was significantly associated with VCAM-1 expression. Serum TNF-α was found to be a significant prognosticator for OS in PTC patients. Overall the results signify that the interaction between TNF-α and the adhesion molecules may have a role in thyroid carcinogenesis and understanding this complexity may offer potential therapeutic targets for better management of thyroid cancer.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"16 4 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80090214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Corrigendum to "How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer". “如何处理信号?”以ret基因型为导向选择治疗甲状腺髓样癌的激酶抑制剂的当前基础”。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-06-28 DOI: 10.1155/2016/2168046

Hugo Prazeres, Joana Torres, Fernando Rodrigues, Joana P Couto, João Vinagre, Manuel Sobrinho-Simões, Paula Soares

引用次数: 0

The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology. 人群T4/TSH设定点数据与T4/TSH生理的关系

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-03-31 DOI: 10.1155/2016/6351473

Stephen Paul Fitzgerald, Nigel Geoffrey Bean

{"title":"The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology.","authors":"Stephen Paul Fitzgerald, Nigel Geoffrey Bean","doi":"10.1155/2016/6351473","DOIUrl":"https://doi.org/10.1155/2016/6351473","url":null,"abstract":"Context. Population studies of the distribution of T4/TSH set points suggest a more complex inverse relationship between T4 and TSH than that suggested by physiological studies. The reasons for the similarities and differences between the curves describing these relationships are unresolved. Methods. We subjected the curve, derived from empiric data, describing the TSH suppression response to T4, and the more mathematically derived curve describing the T4 response to TSH, to the different possible models of population variation. The implied consequences of these in terms of generating a population distribution of T4/TSH equilibrium points (a \"population curve\") were generated and compared to the empiric population curve. The physiological responses to primary hypothyroidism and hyperthyroidism were incorporated into the analysis. Conclusions. Though the population curve shows a similarly inverse relationship, it is describing a different relationship than the curve describing the suppression of TSH by T4. The population curve is consistent with the physiological studies of the TSH response to T4 and implies a greater interindividual variation in the positive thyroid T4 response to TSH than in the central inhibitory TSH response to T4. The population curve in the dysthyroid states is consistent with known physiological responses to these states. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"6351473"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6351473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34439052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

FRTL-5 Rat Thyroid Cells Release Thyroglobulin Sequestered in Exosomes: A Possible Novel Mechanism for Thyroglobulin Processing in the Thyroid. FRTL-5大鼠甲状腺细胞释放外泌体中隔离的甲状腺球蛋白:甲状腺中甲状腺球蛋白加工的可能新机制

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-06-09 DOI: 10.1155/2016/9276402

Pavel Vlasov, Sonia Q Doi, Donald F Sellitti

引用次数: 8

Predictors of Regional Lymph Node Recurrence after Initial Thyroidectomy in Patients with Thyroid Cancer. 甲状腺癌患者甲状腺切除术后局部淋巴结复发的预测因素。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-06-14 DOI: 10.1155/2016/4127278

Amirsina Sharifi, Abolfazl Shojaeifard, Ahmadreza Soroush, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmoudzade

{"title":"Predictors of Regional Lymph Node Recurrence after Initial Thyroidectomy in Patients with Thyroid Cancer.","authors":"Amirsina Sharifi, Abolfazl Shojaeifard, Ahmadreza Soroush, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmoudzade","doi":"10.1155/2016/4127278","DOIUrl":"https://doi.org/10.1155/2016/4127278","url":null,"abstract":"Background. Regional lymph node recurrence (RLNR) is common in patients with thyroid cancer but clinicopathological predictors are unclear. We aimed to clarify these predictors and identify patients who would benefit from prophylactic lymph node dissection the most. Method. 343 patients with different types of thyroid cancer were analyzed retrospectively. All patients underwent total thyroidectomy between 2007 and 2013. Results. The median ± interquartile range of patients' age was 40 ± 25 years. 245 (71.4%) patients were female. Regarding the risk of regional lymph node recurrence, we found that male gender, age ≥45 years, non-PTC (i.e., medullary, follicular, and anaplastic types) histopathology, T3 (i.e., tumor size >4 cm in the greatest dimension limited to the thyroid or any tumor with minimal extrathyroid extension), stage IVa, and isolated cervical lymphadenopathy as initial manifestation (ICL) are significant risk factors. T3 (p < 0.001; odds ratio = 156.41, 95% CI [55.72-439.1]) and ICL (p < 0.001; odds ratio = 77.79, 95% CI [31.55-191.81]) were the strongest predictors of regional lymph node recurrence. Conclusion. We found easily achievable risk factors for RLNR in thyroid cancers patients. We suggested that patients with specific clinicopathological features like male gender, age ≥45 years, larger tumor size, and extrathyroidal extension be considered as prophylactic lymphadenectomy candidates. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"4127278"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4127278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34724094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Change in Practice over Four Decades in the Management of Graves' Disease in Scotland. 苏格兰四十年来Graves病管理实践的变化

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-05-30 DOI: 10.1155/2016/9697849

D M Smith, S Dutta, F Ahmed, M A Thaha

{"title":"Change in Practice over Four Decades in the Management of Graves' Disease in Scotland.","authors":"D M Smith, S Dutta, F Ahmed, M A Thaha","doi":"10.1155/2016/9697849","DOIUrl":"https://doi.org/10.1155/2016/9697849","url":null,"abstract":"There is continuing debate on the optimal treatment for Grave's thyrotoxicosis with a resultant variation in clinical practice. The present study aimed to ascertain changes in practice in the treatment of Grave's thyrotoxicosis in Tayside, Scotland, over the past four decades. Methods. The “Scottish automated follow-up register” (SAFUR) was queried to identify all patients treated for Grave's thyrotoxicosis from 1968 to 2007 inclusive. Patients were divided into 4 groups (Groups A to D) according to the decades. Demographic profile, treatment modalities, radioactive iodine (RAI) dose, and recurrence rates were studied and outcomes were compared by χ 2 test and ANOVA using SPSS v15.0. A p value of < 0.05 was considered significant. Results. Altogether, 3737 patients were diagnosed with Grave's thyrotoxicosis over the 4 decades. Use of RAI has increased from 43.1% in Group A to 68% in Group D (p < 0.001). The dose of RAI has increased (p < 0.001) and there has been a reduction in recurrence rate with higher dose of RAI. Surgical intervention rates decreased from 55.3% to 12.3% (p < 0.001) over time. Conclusions. Analysis of a large dataset of patients with Grave's thyrotoxicosis suggests increasing use of RAI as the preferred first line of treatment. Furthermore, using a single higher dose of RAI and adoption of total thyroidectomy have decreased recurrence rates.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"9697849"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9697849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34650745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations. 胰腺癌甲状腺功能减退:外源性甲状腺激素在肿瘤侵袭中的作用——初步观察。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-03-31 DOI: 10.1155/2016/2454989

Konrad Sarosiek, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Galina I Chipitsyna, Charles J Yeo, Hwyda A Arafat

{"title":"Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations.","authors":"Konrad Sarosiek, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Galina I Chipitsyna, Charles J Yeo, Hwyda A Arafat","doi":"10.1155/2016/2454989","DOIUrl":"https://doi.org/10.1155/2016/2454989","url":null,"abstract":"According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012. The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival. To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1. We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage (P < 0.05). Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion (P < 0.05). We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"2454989"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2454989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34439051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19