Journal of Thyroid Research最新文献_第9页

FRTL-5 Rat Thyroid Cells Release Thyroglobulin Sequestered in Exosomes: A Possible Novel Mechanism for Thyroglobulin Processing in the Thyroid. FRTL-5大鼠甲状腺细胞释放外泌体中隔离的甲状腺球蛋白:甲状腺中甲状腺球蛋白加工的可能新机制

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-06-09 DOI: 10.1155/2016/9276402

Pavel Vlasov, Sonia Q Doi, Donald F Sellitti

引用次数: 8

Predictors of Regional Lymph Node Recurrence after Initial Thyroidectomy in Patients with Thyroid Cancer. 甲状腺癌患者甲状腺切除术后局部淋巴结复发的预测因素。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-06-14 DOI: 10.1155/2016/4127278

Amirsina Sharifi, Abolfazl Shojaeifard, Ahmadreza Soroush, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmoudzade

{"title":"Predictors of Regional Lymph Node Recurrence after Initial Thyroidectomy in Patients with Thyroid Cancer.","authors":"Amirsina Sharifi, Abolfazl Shojaeifard, Ahmadreza Soroush, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmoudzade","doi":"10.1155/2016/4127278","DOIUrl":"https://doi.org/10.1155/2016/4127278","url":null,"abstract":"Background. Regional lymph node recurrence (RLNR) is common in patients with thyroid cancer but clinicopathological predictors are unclear. We aimed to clarify these predictors and identify patients who would benefit from prophylactic lymph node dissection the most. Method. 343 patients with different types of thyroid cancer were analyzed retrospectively. All patients underwent total thyroidectomy between 2007 and 2013. Results. The median ± interquartile range of patients' age was 40 ± 25 years. 245 (71.4%) patients were female. Regarding the risk of regional lymph node recurrence, we found that male gender, age ≥45 years, non-PTC (i.e., medullary, follicular, and anaplastic types) histopathology, T3 (i.e., tumor size >4 cm in the greatest dimension limited to the thyroid or any tumor with minimal extrathyroid extension), stage IVa, and isolated cervical lymphadenopathy as initial manifestation (ICL) are significant risk factors. T3 (p < 0.001; odds ratio = 156.41, 95% CI [55.72-439.1]) and ICL (p < 0.001; odds ratio = 77.79, 95% CI [31.55-191.81]) were the strongest predictors of regional lymph node recurrence. Conclusion. We found easily achievable risk factors for RLNR in thyroid cancers patients. We suggested that patients with specific clinicopathological features like male gender, age ≥45 years, larger tumor size, and extrathyroidal extension be considered as prophylactic lymphadenectomy candidates. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"4127278"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4127278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34724094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Change in Practice over Four Decades in the Management of Graves' Disease in Scotland. 苏格兰四十年来Graves病管理实践的变化

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-05-30 DOI: 10.1155/2016/9697849

D M Smith, S Dutta, F Ahmed, M A Thaha

{"title":"Change in Practice over Four Decades in the Management of Graves' Disease in Scotland.","authors":"D M Smith, S Dutta, F Ahmed, M A Thaha","doi":"10.1155/2016/9697849","DOIUrl":"https://doi.org/10.1155/2016/9697849","url":null,"abstract":"There is continuing debate on the optimal treatment for Grave's thyrotoxicosis with a resultant variation in clinical practice. The present study aimed to ascertain changes in practice in the treatment of Grave's thyrotoxicosis in Tayside, Scotland, over the past four decades. Methods. The “Scottish automated follow-up register” (SAFUR) was queried to identify all patients treated for Grave's thyrotoxicosis from 1968 to 2007 inclusive. Patients were divided into 4 groups (Groups A to D) according to the decades. Demographic profile, treatment modalities, radioactive iodine (RAI) dose, and recurrence rates were studied and outcomes were compared by χ 2 test and ANOVA using SPSS v15.0. A p value of < 0.05 was considered significant. Results. Altogether, 3737 patients were diagnosed with Grave's thyrotoxicosis over the 4 decades. Use of RAI has increased from 43.1% in Group A to 68% in Group D (p < 0.001). The dose of RAI has increased (p < 0.001) and there has been a reduction in recurrence rate with higher dose of RAI. Surgical intervention rates decreased from 55.3% to 12.3% (p < 0.001) over time. Conclusions. Analysis of a large dataset of patients with Grave's thyrotoxicosis suggests increasing use of RAI as the preferred first line of treatment. Furthermore, using a single higher dose of RAI and adoption of total thyroidectomy have decreased recurrence rates.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"9697849"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9697849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34650745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations. 胰腺癌甲状腺功能减退:外源性甲状腺激素在肿瘤侵袭中的作用——初步观察。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-03-31 DOI: 10.1155/2016/2454989

Konrad Sarosiek, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Galina I Chipitsyna, Charles J Yeo, Hwyda A Arafat

{"title":"Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations.","authors":"Konrad Sarosiek, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Galina I Chipitsyna, Charles J Yeo, Hwyda A Arafat","doi":"10.1155/2016/2454989","DOIUrl":"https://doi.org/10.1155/2016/2454989","url":null,"abstract":"According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012. The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival. To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1. We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage (P < 0.05). Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion (P < 0.05). We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"2454989"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2454989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34439051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Association between Tumor Size and Bilateral Involvement in Papillary Thyroid Carcinoma. 甲状腺乳头状癌肿瘤大小与双侧受累的关系。

IF 2.1

Journal of Thyroid Research Pub Date : 2016-01-01 Epub Date: 2016-04-24 DOI: 10.1155/2016/8470252

Suna Erkilic, Fatih Celenk, Zehra Bozdag

{"title":"Association between Tumor Size and Bilateral Involvement in Papillary Thyroid Carcinoma.","authors":"Suna Erkilic, Fatih Celenk, Zehra Bozdag","doi":"10.1155/2016/8470252","DOIUrl":"https://doi.org/10.1155/2016/8470252","url":null,"abstract":"Background. Tumor multifocality and bilaterality of papillary thyroid carcinoma (PTC) are important factors when selecting the most appropriate surgical procedure. The aim of this study was to assess the bilaterality rate in PTC and the relationship between the tumor size and bilaterality. Materials and Methods. Thyroidectomy specimens with a diagnosis of PTC were retrospectively reviewed in the Pathology Department of a tertiary care medical center. Specimens were divided into three groups according to the size of the primary and contralateral tumor foci. Tumors less than or equal to 1 cm in each lobe were included in group 1. Group 2 consisted of tumors greater than 1 cm in one lobe and less than 1 cm in the other lobe. Tumors greater than 1 cm in each lobe were included in group 3. Results. We identified 868 total thyroidectomy specimens with a diagnosis of PTC between 2001 and 2011. Of these cases, both thyroid lobes were involved in 262 cases (32%). There were 109 (42%), 121 (46%), and 32 cases (12%) in group 1, group 2, and group 3, respectively. Conclusion. Bilaterality is frequent in PTC and is not related to tumor size. Accordingly, the high frequency of bilateral disease in PTC should be kept in mind when determining the extent of the surgical procedure. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2016 ","pages":"8470252"},"PeriodicalIF":2.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8470252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34572373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective 艾滋病毒感染和获得性免疫缺陷综合征患者甲状腺功能障碍的患病率和预测因素:印度视角

IF 2.1

Journal of Thyroid Research Pub Date : 2015-12-22 DOI: 10.1155/2015/517173

N. Sharma, Lokesh Sharma, D. Dutta, A. K. Gadpayle, A. Anand, K. Gaurav, S. Mukherjee, R. Bansal

{"title":"Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective","authors":"N. Sharma, Lokesh Sharma, D. Dutta, A. K. Gadpayle, A. Anand, K. Gaurav, S. Mukherjee, R. Bansal","doi":"10.1155/2015/517173","DOIUrl":"https://doi.org/10.1155/2015/517173","url":null,"abstract":"Background. Predictors of thyroid dysfunction in HIV are not well determined. This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians. Methods. Consecutive HIV patients, 18–70 years of age, without any severe comorbid state, having at least 1-year follow-up at the antiretroviral therapy clinic, underwent clinical assessment and hormone assays. Results. From initially screened 527 patients, 359 patients (61.44 ± 39.42 months' disease duration), having good immune function [CD4 count >200 cell/mm3: 90.25%; highly active antiretroviral therapy (HAART): 88.58%], were analyzed. Subclinical hypothyroidism (ScH) was the commonest thyroid dysfunction (14.76%) followed by sick euthyroid syndrome (SES) (5.29%) and isolated low TSH (3.1%). Anti-TPO antibody (TPOAb) was positive in 3.90%. Baseline CD4 count had inverse correlation with TPOAb after adjusting for age and body mass index. Stepwise linear regression revealed baseline CD4 count, TPOAb, and tuberculosis to be best predictors of ScH after adjusting for age, weight, duration of HIV, and history of opportunistic fungal and viral infections. Conclusion. Burden of thyroid dysfunction in chronic HIV infection with stable immune function is lower compared to pre-HAART era. Thyroid dysfunction is primarily of nonautoimmune origin, predominantly ScH. Severe immunodeficiency at disease onset, TPOAb positivity, and tuberculosis were best predictors of ScH.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"27 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2015-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79100781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto's Encephalopathy 有和没有甲状腺疾病的受试者脑脊液中的甲状腺自身抗体:对桥本脑病的影响

IF 2.1

Journal of Thyroid Research Pub Date : 2015-12-21 DOI: 10.1155/2015/819072

I. Ilias, V. Karagiorga, G. Paraskevas, A. Bougea, Maria Bourbouli, A. Pappa, S. Nikopoulou, E. Kapaki

{"title":"Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto's Encephalopathy","authors":"I. Ilias, V. Karagiorga, G. Paraskevas, A. Bougea, Maria Bourbouli, A. Pappa, S. Nikopoulou, E. Kapaki","doi":"10.1155/2015/819072","DOIUrl":"https://doi.org/10.1155/2015/819072","url":null,"abstract":"Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease. Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease. Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P = 0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P = 0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P = 0.063). Conclusions. Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF. Therefore, regarding Hashimoto's encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"134 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2015-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88893319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments 放射性碘难治性分化甲状腺癌治疗的患者获益与风险权衡

IF 2.1

Journal of Thyroid Research Pub Date : 2015-11-30 DOI: 10.1155/2015/438235

A. Mohamed, J. González, Angelyn O. Fairchild

{"title":"Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments","authors":"A. Mohamed, J. González, Angelyn O. Fairchild","doi":"10.1155/2015/438235","DOIUrl":"https://doi.org/10.1155/2015/438235","url":null,"abstract":"Background. The aims of this study were to assess patients' preferences to wait or start systemic treatment and understand how patients would make tradeoffs between certain severe adverse events (AEs) and additional months of progression-free survival (PFS). Materials and Methods. Adults in France, Germany, and Spain with a diagnosis of DTC and who have had at least one RAI treatment completed a direct-elicitation question and a discrete-choice experiment (DCE) online. The direct-elicitation question asked respondents whether they would opt out of treatment when their tumor is RAI-R. In the DCE, respondents chose between 12 pairs of hypothetical RAI-R DTC treatment profiles. Profiles were defined by magnitudes of efficacy (PFS) and safety (severe hand-foot skin reaction [HFSR], severe proteinuria, and severe hypertension). A main-effects random-parameters logit model was estimated. Results. 134 patients completed the survey. Most patients (86.6%) opted for treatment rather than “wait and see” decision. Patients placed a greater weight on the risk of severe hypertension than the risk of proteinuria and HFSR. Conclusions. DTC patients showed preference toward treatment for RAI-R DTC over watchful waiting. Patients' concerns about the risk of severe hypertension appeared to have had a greater effect on patients' choice than severe proteinuria or HFSR.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"18 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2015-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73097797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population 亚临床甲状腺功能减退的心血管危险因素:尼泊尔人群的病例对照研究

IF 2.1

Journal of Thyroid Research Pub Date : 2015-10-07 DOI: 10.1155/2015/305241

Rajendra Kc, S. Khatiwada, Kishun Deo Mehta, P. Pandey, M. Lamsal, S. Majhi

{"title":"Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population","authors":"Rajendra Kc, S. Khatiwada, Kishun Deo Mehta, P. Pandey, M. Lamsal, S. Majhi","doi":"10.1155/2015/305241","DOIUrl":"https://doi.org/10.1155/2015/305241","url":null,"abstract":"Objectives. To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP). Results. Subclinical hypothyroid patients had significantly higher diastolic BP, total cholesterol, LDL cholesterol, and hs-CRP than controls. The odds ratio of having hypercholesterolemia (>200 mg/dL), low HDL cholesterol (<40 mg/dL), undesirable LDL-cholesterol (>100 mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI ≥ 23 Kg/m2) in subclinical hypothyroidism was 2.29 (95% CI; 1.2–4.38, p = 0.011), 1.73 (95% CI; 0.82–3.62, p = 0.141), 3.04 (95% CI; 1.66–5.56, p < 0.001), 2.02 (95% CI; 1.12–3.64, p = 0.018), 3.35 (95% CI; 1.72–6.55, p < 0.001), and 0.9 (95% CI; 0.48–1.67, p = 0.753), respectively, as compared to controls. Conclusion. Subclinical hypothyroid patients are associated with higher risk for cardiovascular disease than euthyroid subjects.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"23 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2015-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91077188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT. DXA和HR-pQCT评估长期左甲状腺素替代治疗甲状腺切除术患者的骨指数。

IF 2.1

Journal of Thyroid Research Pub Date : 2015-01-01 Epub Date: 2015-07-13 DOI: 10.1155/2015/796871

Emil Moser, Tanja Sikjaer, Leif Mosekilde, Lars Rejnmark

{"title":"Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT.","authors":"Emil Moser, Tanja Sikjaer, Leif Mosekilde, Lars Rejnmark","doi":"10.1155/2015/796871","DOIUrl":"https://doi.org/10.1155/2015/796871","url":null,"abstract":"Background. Studies on bone effects of long-term substitution therapy with levothyroxine (LT4) have shown discrepant results. Previous studies have, however, not evaluated volumetric bone mineral densities (vBMD), bone structure, and strength using high resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA). Using a cross-sectional design, we aimed to determine whether BMD, structure, and strength are affected in hypothyroid patients on LT4 substitution therapy. Methods. We compared 49 patients with well-substituted hypothyroidism with 49 age- and gender-matched population based controls. Areal BMD was assessed by DXA, vBMD and bone geometry by HR-pQCT, and bone strength by FEA. Results. Patients had been thyroidectomized due to thyroid cancer (10%) and nontoxic (33%) or toxic goiter (57%). 82% were women. TSH levels did not differ between groups, but patients had significantly higher levels of T4 (p < 0.001) and lower levels of T3 (p < 0.01). Compared to controls, patients had higher levels of magnesium (p < 0.05), whereas ionized calcium and PTH were lower (p < 0.05). Bone scans did not reveal any differences in BMD, bone geometry, or strength. Conclusion. If patients with hypothyroidism are well-substituted with LT4, the disease does not affect bone indices to any major degree. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2015 ","pages":"796871"},"PeriodicalIF":2.1,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/796871","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33967126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14