Journal of Thyroid Research最新文献_第10页

Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population. 老年女性混合甲状腺结节和实性甲状腺结节的超声表现与恶性肿瘤的差异分析。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-06-23 DOI: 10.1155/2014/761653

María Inés Vera, Tomás Meroño, María Agustina Urrutia, Carina Parisi, Yanina Morosan, Melanie Rosmarin, Marta Schnitman, Fernando Brites, Silvio Grisendi, María Sol Serrano, Wilfredo Luciani, Leonardo Serrano, Carlos Zuk, Guillermo De Barrio, Claudia Cejas, María Cristina Faingold, Gabriela Brenta

{"title":"Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population.","authors":"María Inés Vera, Tomás Meroño, María Agustina Urrutia, Carina Parisi, Yanina Morosan, Melanie Rosmarin, Marta Schnitman, Fernando Brites, Silvio Grisendi, María Sol Serrano, Wilfredo Luciani, Leonardo Serrano, Carlos Zuk, Guillermo De Barrio, Claudia Cejas, María Cristina Faingold, Gabriela Brenta","doi":"10.1155/2014/761653","DOIUrl":"https://doi.org/10.1155/2014/761653","url":null,"abstract":"Objective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age = 69 ± 8 years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, P: 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all P < 0.05). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25-6.10), P: 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"761653"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/761653","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32524326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves' Disease Study. 巴塞杜氏病缓解诱导和维持研究》中208名患者的TSH受体自身免疫、甲状腺功能亢进、甲状腺肿和眼眶病之间的关系

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-02-18 DOI: 10.1155/2014/165487

Peter Laurberg, Birte Nygaard, Stig Andersen, Allan Carlé, Jesper Karmisholt, Anne Krejbjerg, Inge Bülow Pedersen, Stine Linding Andersen

{"title":"Association between TSH-Receptor Autoimmunity, Hyperthyroidism, Goitre, and Orbitopathy in 208 Patients Included in the Remission Induction and Sustenance in Graves' Disease Study.","authors":"Peter Laurberg, Birte Nygaard, Stig Andersen, Allan Carlé, Jesper Karmisholt, Anne Krejbjerg, Inge Bülow Pedersen, Stine Linding Andersen","doi":"10.1155/2014/165487","DOIUrl":"10.1155/2014/165487","url":null,"abstract":"Background. Graves' disease may have a number of clinical manifestations with varying degrees of activity that may not always run in parallel. Objectives. To study associations between serum levels of TSH-receptor autoantibodies and the three main manifestations of Graves' disease (hyperthyroidism, goiter, and presence of orbitopathy) at the time of diagnosis of hyperthyroidism. Methods. We describe a cohort of 208 patients with newly diagnosed Graves' hyperthyroidism. Patients were enrolled in a multiphase study of antithyroid drug therapy of Graves' hyperthyroidism, entitled \"Remission Induction and Sustenance in Graves' Disease (RISG).\" Patients were systematically tested for degree of biochemical hyperthyroidism, enlarged thyroid volume by ultrasonography, and the presence of orbitopathy. Results. Positive correlations were found between the levels of TSH-receptor autoantibodies in serum and the three manifestations of Graves' disease: severeness of hyperthyroidism, presence of enlarged thyroid, and presence of orbitopathy, as well as between the different types of manifestations. Only around half of patients had enlarged thyroid gland at the time of diagnosis of hyperthyroidism, whereas 25-30% had orbitopathy. Conclusions. A positive but rather weak correlation was found between TSH-receptor antibodies in serum and the major clinical manifestation of Graves' disease. Only half of the patients had an enlarged thyroid gland at the time of diagnosis. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"165487"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32232657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

There is no elevation of immunoglobulin e levels in Albanian patients with autoimmune thyroid diseases. 阿尔巴尼亚自身免疫性甲状腺疾病患者的免疫球蛋白e水平没有升高。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-05-14 DOI: 10.1155/2014/283709

Hatixhe Latifi-Pupovci, Besa Gacaferri-Lumezi, Violeta Lokaj-Berisha

{"title":"There is no elevation of immunoglobulin e levels in Albanian patients with autoimmune thyroid diseases.","authors":"Hatixhe Latifi-Pupovci, Besa Gacaferri-Lumezi, Violeta Lokaj-Berisha","doi":"10.1155/2014/283709","DOIUrl":"10.1155/2014/283709","url":null,"abstract":"Background. Studies in several ethnic groups reported high incidence of elevated levels of immunoglobulin E (IgE) in patients with autoimmune thyroid diseases (ATD), especially in patients with Graves' disease. Objective. To study association between serum levels of IgE and thyroid stimulating hormone receptor antibodies (TRAb) in Albanian patients with ATD. Material and Methods. Study was performed in 40 patients with Graves' disease, 15 patients with Hashimoto's thyroiditis, and 14 subjects in the control group. The IgE levels were measured by immunoradiometric assay, whereas the TRAb levels were measured by radioreceptor assay. Results. In all groups of subjects the IgE levels were within reference values (<200 kIU/L). Significant difference in mean concentration of IgE was found between two groups of Graves' disease patients, and those with normal and elevated TRAb levels (22.57 versus 45.03, P < 0.05). Positive correlation was found between TRAb and IgE only in Graves' disease patients (r = 0.43, P = 0.006). Conclusion. In Albanian patients with ATD there is no elevation of IgE levels. This could be the result of low prevalence of allergic diseases in Albanian population determined by genetic and environmental factors. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"283709"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32451427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Beneficial Effects of Valproic Acid in Thyroid Cancer Are Mediated through Promoting Redifferentiation and Reducing Stemness Level: An In Vitro Study. 丙戊酸对甲状腺癌的有益作用是通过促进再分化和降低干细胞水平介导的:一项体外研究

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-05-15 DOI: 10.1155/2014/218763

Vahid Haghpanah, Mohsen Malehmir, Bagher Larijani, Shahin Ahmadian, Kamran Alimoghaddam, Ramin Heshmat, Ardeshir Ghavamzadeh, Khadijeh Adabi, Seyed H Ghaffari

{"title":"The Beneficial Effects of Valproic Acid in Thyroid Cancer Are Mediated through Promoting Redifferentiation and Reducing Stemness Level: An In Vitro Study.","authors":"Vahid Haghpanah, Mohsen Malehmir, Bagher Larijani, Shahin Ahmadian, Kamran Alimoghaddam, Ramin Heshmat, Ardeshir Ghavamzadeh, Khadijeh Adabi, Seyed H Ghaffari","doi":"10.1155/2014/218763","DOIUrl":"https://doi.org/10.1155/2014/218763","url":null,"abstract":"Valproic acid (VPA) has been identified as a histone deacetylase inhibitor, inducing differentiation in transformed cells. However, no study has shown the effect of VPA in the redifferentiation induction and stemness of anaplastic thyroid. The main objective of this study was to evaluate the efficacy of VPA as a differentiation therapy agent in human thyroid cancer based on its effect on stemness and differentiation process. Indications for differentiation of 8305C and B-CPAP cell lines following VPA treatment were obtained by analyzing cell proliferation rate, morphological changes, adherent-dependent colony formation, and Hoechst 33342 staining. The expressions of stemness, differentiation, and aggressiveness specific marker genes were measured by quantitative RT-PCR. VPA treatment effectively showed growth inhibition in both cell lines. The high nuclear-cytoplasmic (N : C) ratio of 8305C cells markedly decreased and treated cells became more epithelial-like. Treated cells showed stronger Hoechst 33342 fluorescence compared with control cells. The hTERT and OCT-4 reduction was paralleled with adherent-dependent colony formation decrement in both cell lines. VPA effectively induced NIS and TTF-1 in anaplastic cells, it whereas showed no clear pattern in papillary cell line. VPA treatment also resulted in the reduction of MMP-2 and MMP-9. These finding suggest that VPA could redifferentiate the anaplastic thyroid cancer cells. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"218763"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/218763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32454765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Symptoms and signs associated with postpartum thyroiditis. 产后甲状腺炎的相关症状和体征。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-10-27 DOI: 10.1155/2014/531969

Maureen Groer, Cecilia Jevitt

{"title":"Symptoms and signs associated with postpartum thyroiditis.","authors":"Maureen Groer, Cecilia Jevitt","doi":"10.1155/2014/531969","DOIUrl":"https://doi.org/10.1155/2014/531969","url":null,"abstract":"Background. Postpartum thyroiditis (PPT) is a common triphasic autoimmune disease in women with thyroid peroxidase (TPO) autoantibodies. This study evaluated women's thyroid disease symptoms, physical findings, stress levels, and thyroid stimulating hormone (TSH) levels across six postpartum months in three groups, TPO negative, TPO positive, and PPT positive women. Methods. Women were recruited in midpregnancy (n = 631) and TPO status was determined which then was used to form the three postpartum groups. The three groups were compared on TSH levels, thyroid symptoms, weight, blood pressure, heart rate, a thyroid exam, and stress scores. Results. Fifty-six percent of the TPO positive women developed PPT. Hypothyroid group (F (2, 742) = 5.8, P = .003) and hyperthyroid group (F (2, 747) = 6.6, P = .001) subscale scores differed by group. Several symptoms and stress scores were highest in the PPT group. Conclusions. The normal postpartum is associated with many symptoms that mimic thyroid disease symptoms, but severity is greater in women with either TPO or PPT positivity. While the most severe symptoms were generally seen in PPT positive women, even TPO positive women seem to have higher risk for these signs and symptoms.","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"531969"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/531969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32821758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Urinary Iodine Clearance following Iodinated Contrast Administration: A Comparison of Euthyroid and Postthyroidectomy Subjects. 碘造影剂给药后尿碘清除率:甲状腺功能正常和甲状腺切除术后受试者的比较。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-11-12 DOI: 10.1155/2014/580569

Janice D Ho, James F Tsang, Kylie A Scoggan, William D Leslie

{"title":"Urinary Iodine Clearance following Iodinated Contrast Administration: A Comparison of Euthyroid and Postthyroidectomy Subjects.","authors":"Janice D Ho, James F Tsang, Kylie A Scoggan, William D Leslie","doi":"10.1155/2014/580569","DOIUrl":"https://doi.org/10.1155/2014/580569","url":null,"abstract":"Purpose. To compare iodine clearance following iodinated contrast administration in thyroidectomised thyroid cancer patients and euthyroid individuals. Methods. A convenience population (6 thyroidectomised thyroid cancer patients and 7 euthyroid controls) was drawn from patients referred for iodinated contrast-enhanced computed tomography (CT) studies. Subjects had sequential urine samples collected up to 6 months (50 samples from the thyroidectomised and 63 samples from the euthyroid groups). t-tests and generalised estimating equations (GEE) were used to test for group differences in urinary iodine creatinine ratios. Results. Groups had similar urinary iodine creatinine ratios at baseline, with a large increase 2 weeks following iodinated contrast (P = 0.005). Both groups had a return of urinary iodine creatinine ratios to baseline by 4 weeks, with no significant group differences overall or at any time point. Conclusions. Thyroidectomised patients did not have a significantly different urinary iodine clearance than euthyroid individuals following administration of iodinated contrast. Both had a return of urinary iodine creatinine ratios to baseline within 4 weeks. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"580569"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/580569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32882674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Histopathological Changes of the Thyroid and Parathyroid Glands in HIV-Infected Patients. hiv感染患者甲状腺和甲状旁腺的组织病理学变化。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-01-22 DOI: 10.1155/2014/364146

Rabia Cherqaoui, K M Mohamed Shakir, Babak Shokrani, Sujay Madduri, Faria Farhat, Vinod Mody

{"title":"Histopathological Changes of the Thyroid and Parathyroid Glands in HIV-Infected Patients.","authors":"Rabia Cherqaoui, K M Mohamed Shakir, Babak Shokrani, Sujay Madduri, Faria Farhat, Vinod Mody","doi":"10.1155/2014/364146","DOIUrl":"https://doi.org/10.1155/2014/364146","url":null,"abstract":"Objective. To study histopathology of the thyroid and parathyroid glands in HIV-infected African Americans in the United States. Methods. A retrospective review of 102 autopsy cases done by the Department of Pathology at Howard University Hospital from 1980 through 2007 was conducted. The histopathological findings of the thyroid and parathyroid glands were reviewed, both macroscopically and microscopically. A control group of autopsy patients with chronic non-HIV diseases was examined. Results. There were 71 males (70%) and 31 females (30%) with an average age of 38 years (range: 20-71 y). Thirteen patients with abnormal thyroid findings were identified. Interstitial fibrosis was the most common histological finding (4.9%), followed by thyroid hyperplasia (1.9%). Infectious disease affecting the thyroid gland was limited to 2.9% and consisted of mycobacterium tuberculosis, Cryptococcus neoformans, and cytomegalovirus. Kaposi sarcoma of the thyroid gland was present in only one case (0.9%). Parathyroid hyperplasia was the most common histological change noted in the parathyroid glands. Comparing the histological findings of cases and controls, we found a similar involvement of the thyroid, with a greater prevalence of parathyroid hyperplasia in HIV patients. Conclusion. Thyroid and parathyroid abnormalities are uncommon findings in the HIV-infected African American population. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"364146"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/364146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32169138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Parathyroid gland involvement by thyroid cancer: results from a large series of thyroidectomies performed in two italian university hospitals and review of the literature. 甲状腺癌累及甲状旁腺:意大利两所大学医院进行的大量甲状腺切除术的结果和文献回顾。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-11-11 DOI: 10.1155/2014/685425

Giampaolo Papi, Stefania Corrado, Guido Fadda, Antonino Maiorana, Livia Maccio, Salvatore Maria Corsello, Alfredo Pontecorvi

{"title":"Parathyroid gland involvement by thyroid cancer: results from a large series of thyroidectomies performed in two italian university hospitals and review of the literature.","authors":"Giampaolo Papi, Stefania Corrado, Guido Fadda, Antonino Maiorana, Livia Maccio, Salvatore Maria Corsello, Alfredo Pontecorvi","doi":"10.1155/2014/685425","DOIUrl":"https://doi.org/10.1155/2014/685425","url":null,"abstract":"Objectives.Parathyroid involvement by thyroid cancer (TC) has not been frequently investigated in thyroidectomy-based studies. We aimed to detect cases of parathyroid invasion by TC in a large series of thyroidectomies and to review the literature on this topic. Study Design. A 10-yr period database research was made from the files of the Section of Pathology of two Italian University Hospitals. Out of 22,310 thyroidectomies, 10 patients with parathyroid involvement by TC were found. Results. The 10 patients, 7 females and 3 males, aged 55 ± 14 years (range 34-76, median 56) had papillary thyroid carcinoma and accounted for 0.4% of subjects affected by all TCs and submitted to thyroidectomy. The tumor invaded perithyroid soft tissues in 6 patients and central neck (level VI) lymph nodes in 3. Parathyroid involvement by TC occurred by infiltration in 6 cases, extension through an intervening pseudocapsule in 1, and both patterns in 3. All patients are alive and disease free at 5.6 ± 3-yr follow-up. Conclusion. Limited to thyroidectomy series, our results and literature data suggest that parathyroid involvement by TC has a 0.4-3.9% incidence rate; mainly affects women in their sixth-seventh decade of life; is associated to a good prognosis, unless massive extrathyroid extension of TC occurs. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"685425"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/685425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32849633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models. lenvatinib (e7080)的抗肿瘤活性:一种在临床前人甲状腺癌模型中靶向多种受体酪氨酸激酶的血管生成抑制剂。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-09-10 DOI: 10.1155/2014/638747

Osamu Tohyama, Junji Matsui, Kotaro Kodama, Naoko Hata-Sugi, Takayuki Kimura, Kiyoshi Okamoto, Yukinori Minoshima, Masao Iwata, Yasuhiro Funahashi

{"title":"Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models.","authors":"Osamu Tohyama, Junji Matsui, Kotaro Kodama, Naoko Hata-Sugi, Takayuki Kimura, Kiyoshi Okamoto, Yukinori Minoshima, Masao Iwata, Yasuhiro Funahashi","doi":"10.1155/2014/638747","DOIUrl":"https://doi.org/10.1155/2014/638747","url":null,"abstract":"Inhibition of tumor angiogenesis by blockading the vascular endothelial growth factor (VEGF) signaling pathway is a promising therapeutic strategy for thyroid cancer. Lenvatinib mesilate (lenvatinib) is a potent inhibitor of VEGF receptors (VEGFR1-3) and other prooncogenic and prooncogenic receptor tyrosine kinases, including fibroblast growth factor receptors (FGFR1-4), platelet derived growth factor receptor α (PDGFRα), KIT, and RET. We examined the antitumor activity of lenvatinib against human thyroid cancer xenograft models in nude mice. Orally administered lenvatinib showed significant antitumor activity in 5 differentiated thyroid cancer (DTC), 5 anaplastic thyroid cancer (ATC), and 1 medullary thyroid cancer (MTC) xenograft models. Lenvatinib also showed antiangiogenesis activity against 5 DTC and 5 ATC xenografts, while lenvatinib showed in vitro antiproliferative activity against only 2 of 11 thyroid cancer cell lines: that is, RO82-W-1 and TT cells. Western blot analysis showed that cultured RO82-W-1 cells overexpressed FGFR1 and that lenvatinib inhibited the phosphorylation of FGFR1 and its downstream effector FRS2. Lenvatinib also inhibited the phosphorylation of RET with the activated mutation C634W in TT cells. These data demonstrate that lenvatinib provides antitumor activity mainly via angiogenesis inhibition but also inhibits FGFR and RET signaling pathway in preclinical human thyroid cancer models. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"638747"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/638747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32730250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 348

Frequency of Adverse Events of Antithyroid Drugs Administered during Pregnancy. 妊娠期间使用抗甲状腺药物不良事件的频率。

IF 2.1

Journal of Thyroid Research Pub Date : 2014-01-01 Epub Date: 2014-01-09 DOI: 10.1155/2014/952352

Ai Yoshihara, Jaeduk Yoshimura Noh, Natsuko Watanabe, Kenji Iwaku, Sakiko Kobayashi, Miho Suzuki, Hidemi Ohye, Masako Matsumoto, Yo Kunii, Koji Mukasa, Kiminori Sugino, Koichi Ito

{"title":"Frequency of Adverse Events of Antithyroid Drugs Administered during Pregnancy.","authors":"Ai Yoshihara, Jaeduk Yoshimura Noh, Natsuko Watanabe, Kenji Iwaku, Sakiko Kobayashi, Miho Suzuki, Hidemi Ohye, Masako Matsumoto, Yo Kunii, Koji Mukasa, Kiminori Sugino, Koichi Ito","doi":"10.1155/2014/952352","DOIUrl":"https://doi.org/10.1155/2014/952352","url":null,"abstract":"The frequency and types of adverse events after initial antithyroid drug (ATD) therapy during pregnancy have never been reported, nor has whether the frequency of adverse events is the same as among nonpregnant subjects ever been investigated. We investigated retrospectively the frequency of adverse events after initial ATD administration to previously untreated Graves' disease (GD) patients during pregnancy. We reviewed the charts of cases of 91 untreated pregnant women who came to our hospital for the first time and were newly diagnosed with GD during the period between January 1, 1999, and December 31, 2011. Thiamazole (MMI) was used to treat 40 patients and 51 patients were treated with propylthiouracil (PTU). Adverse events occurred in 5 patients (5/40; 12.5%) treated with MMI, and they consisted of cutaneous reactions in 5 patients. Adverse events occurred in five patients (5/51; 9.8%) treated with PTU, and they consisted of hepatotoxicity in two patients and cutaneous reactions in three patients. No patients experienced agranulocytosis or ANCA-related vasculitis. Comparison with the expected rate of adverse events in nonpregnant individuals showed that the frequency of adverse events in pregnant individuals was low. ","PeriodicalId":17394,"journal":{"name":"Journal of Thyroid Research","volume":"2014 ","pages":"952352"},"PeriodicalIF":2.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/952352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32112459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13