Journal of The Electrochemical Society最新文献_第2页

Enhanced Thermal Stability and Electrochemical Performance of Positive Electrolytes in Vanadium Flow Batteries via a Bifunctional Additive System 双功能添加剂体系增强钒液流电池正极电解质的热稳定性和电化学性能

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-11-01 DOI: 10.1149/1945-7111/ae1e37

Ze Lei, Yongqi Guo, Fancheng Meng, Yongchao Wang, Xiaoxia Li, Desheng Chen, Lina Wang

{"title":"Enhanced Thermal Stability and Electrochemical Performance of Positive Electrolytes in Vanadium Flow Batteries via a Bifunctional Additive System","authors":"Ze Lei, Yongqi Guo, Fancheng Meng, Yongchao Wang, Xiaoxia Li, Desheng Chen, Lina Wang","doi":"10.1149/1945-7111/ae1e37","DOIUrl":"https://doi.org/10.1149/1945-7111/ae1e37","url":null,"abstract":"As a promising large-scale electrochemical energy storage system, vanadium flow batteries suffer from the inadequate thermal stability of positive electrolytes at elevated temperatures. Conventional additives, while improving thermal stability, often compromise electrochemical properties. Herein, a novel dual-additive strategy that synergistically enhances both thermal stability and electrochemical activity was proposed. The bifunctional additive system—comprising methanesulfonic acid (MSA) and ammonium dihydrogen phosphate (ADP)—extends the onset time for V(V) electrolyte precipitation at 45 °C from 1 day to 10 days, through phosphate-mediated complexation and the strongly protonating environment provided by methanesulfonic acid. In terms of electrochemical performance, the bifunctional additive demonstrates the optimal redox reversibility, reduced charge transfer resistance, decreased polarization resistance, and increased diffusion coefficient, which may be attributed to the nitrogen/sulfur bifunctional modification on the working electrode induced by the additives. In single-cell tests at 100 mA·cm −2 , the electrolyte with the addition of 0.1 mol·l −1 MSA and 0.1 mol·l −1 ADP achieves the highest capacity retention of 73.9% after 50 cycles and an energy efficiency of 83.1%. This study paves a new paradigm for for simultaneously enhancing the stability and electrochemical performances of positive vanadium electrolytes.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 11","pages":"110528-110528"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced Graphene Oxide/ZnO Composites Based Solid Polymer Electrolyte for High-Performance All-Solid-State Lithium Metal Batteries 基于还原氧化石墨烯/ZnO复合材料的高性能全固态锂金属电池固体聚合物电解质

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-11-01 DOI: 10.1149/1945-7111/ae1daf

Qi Qin, Yang Sun, Changze Wu, Meng Song, Fengyi Cao, Zhaotuo Wang, Yunan Li

{"title":"Reduced Graphene Oxide/ZnO Composites Based Solid Polymer Electrolyte for High-Performance All-Solid-State Lithium Metal Batteries","authors":"Qi Qin, Yang Sun, Changze Wu, Meng Song, Fengyi Cao, Zhaotuo Wang, Yunan Li","doi":"10.1149/1945-7111/ae1daf","DOIUrl":"https://doi.org/10.1149/1945-7111/ae1daf","url":null,"abstract":"The solid fillers incorporated into poly(ethylene oxide) (PEO) matrix are prone to agglomeration due to their high surface energy or strong van der Waals forces, consequently resulting in a deterioration of the ionic conductivity in PEO-based solid polymer electrolytes (SPEs). Herein, reduced graphene oxide (RGO)/ZnO composites as solid fillers were fabricated via simply annealing method. In RGO/ZnO composites, ZnO nanoparticles featuring abundant oxygen vacancies are homogeneously dispersed and firmly anchored onto both sides of the RGO sheets, constructing a 3D continuous channel for Li + ions transport. Due to the synergistic interplay of hydrogen bonding interactions and Lewis acid-base interactions between RGO/ZnO and TFSI − ions, the fabricated PEO/RGO/ZnO (PRZ) SPE exhibits an excellent ionic conductivity of 5.3 × 10 −4 S cm −1 , a high t Li+ of 0.48, and an electrochemical stability window of 5.4 V at 60 °C. Moreover, the Li|PRZ|Li symmetric cell delivers a long-term stable cycling over 800 h under a current density of 0.1 mA cm −2 at 60 °C. As a result, the assembled all-solid-state LFP|PRZ|Li cell provides an initial specific discharge capacity of 154.7 mA h g −1 and an impressive capacity retention of 92.2% after 100 cycles at a current density 0.2 C under 60 °C.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 11","pages":"110527-110527"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxylated Multi-Walled Carbon Nanotubes and Spherical Zn-MOF Nanoparticles Enable Electrochemical Detection of Trans-Resveratrol 羟基化多壁碳纳米管和球形Zn-MOF纳米颗粒实现了反式白藜芦醇的电化学检测

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-10-01 DOI: 10.1149/1945-7111/ae125c

Nai-Cui Liu, Yuzhu Zhao, Tao Zhan, Moldir Rustem, Zhencheng Chen, Guo‐Cheng Han, Xiao‐Zhen Feng, Heinz‐Bernhard Kraatz

{"title":"Hydroxylated Multi-Walled Carbon Nanotubes and Spherical Zn-MOF Nanoparticles Enable Electrochemical Detection of Trans-Resveratrol","authors":"Nai-Cui Liu, Yuzhu Zhao, Tao Zhan, Moldir Rustem, Zhencheng Chen, Guo‐Cheng Han, Xiao‐Zhen Feng, Heinz‐Bernhard Kraatz","doi":"10.1149/1945-7111/ae125c","DOIUrl":"https://doi.org/10.1149/1945-7111/ae125c","url":null,"abstract":"Trans-resveratrol (TRA) has garnered significant attention due to its multiple pharmacological activities. This study fabricated a Zn-MOF/MWNTs-OH/GCE electrochemical detection platform for TRA detection by modifying a glassy carbon electrode (GCE) with a composite of hydroxyl-functionalized multi-walled carbon nanotubes (MWNTs-OH) and zinc-based metal-organic framework (Zn-MOF). The structure and composition of the materials were characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. The results indicate that the Zn-MOF/MWNTs-OH/GCE has an excellent electrochemical response to TRA, featuring a linear detection range of 1.00–600.00 μM and a detection limit of 0.32 μM. Additionally, the detection platform exhibits good reproducibility, stability, and selectivity. In the grape skin sample detection, the recovery rate ranges from 98.48% to 105.19%, the RSD is less than 4.62%, and the accuracy of the results is verified by fluorometry.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 10","pages":"107505-107505"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Electrocatalytic Activity of ZIF-67C/CuO-NiO Composite for the Sensoring of Nitrite in Food ZIF-67C/CuO-NiO复合材料对食品中亚硝酸盐传感的电催化活性增强

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-10-01 DOI: 10.1149/1945-7111/ae13c4

Xiaoyun Lin, S. Srinivasa Rao, Zhuo You, Miaomiao Zou

{"title":"Enhanced Electrocatalytic Activity of ZIF-67C/CuO-NiO Composite for the Sensoring of Nitrite in Food","authors":"Xiaoyun Lin, S. Srinivasa Rao, Zhuo You, Miaomiao Zou","doi":"10.1149/1945-7111/ae13c4","DOIUrl":"https://doi.org/10.1149/1945-7111/ae13c4","url":null,"abstract":"An enhanced electrocatalytic composite-ZIF-67C/CuO-NiO was prepared via hydrothermal and calcination method, and the ZIF-67C/CuO-NiO/GCE was constructed for the identification of nitrite in foods. The morphology and structure of ZIF-67C/CuO-NiO composite was characterized by X-ray diffraction and scanning electron microscopy. The construction process of the modified electrode was characterized by electrochemical impedance spectroscopy and cyclic voltammetry techniques. The electrocatalytic performance of different modified electrodes for nitrite were investigated through i - t curve. The experimental results indicated that the ZIF-67C/CuO-NiO/GCE showed a good electrocatalytic ability for nitrite, and the current change was proportional to the concentration of nitrite. The linear range (LR) was 0.2∼125 μM ( R 1 = 0.9981) and 125∼455 μM ( R 2 = 0.996), and the detection limit was 0.073 μM. The proposed method was successfully applied to determinate nitrite content in ham sausage and small dried fish, and the recovery rate was between 96.17% and 105.43%, indicating satisfactory method performance.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 10","pages":"107509-107509"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Cycling Stability of Composite Polymer Electrolyte-Based Solid-State Lithium Batteries Enabled by Single-Crystal NCM811 Cathodes 单晶NCM811阴极增强复合聚合物电解质固态锂电池的循环稳定性

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-10-01 DOI: 10.1149/1945-7111/ae0fe7

Ди Шао, Chong Xu, Yu He, Lei Xu, Bing Ding, Xiaogang Zhang

{"title":"Enhanced Cycling Stability of Composite Polymer Electrolyte-Based Solid-State Lithium Batteries Enabled by Single-Crystal NCM811 Cathodes","authors":"Ди Шао, Chong Xu, Yu He, Lei Xu, Bing Ding, Xiaogang Zhang","doi":"10.1149/1945-7111/ae0fe7","DOIUrl":"https://doi.org/10.1149/1945-7111/ae0fe7","url":null,"abstract":"Polyethylene oxide (PEO)-based composite polymer electrolytes have attracted considerable research attention for application in solid-state lithium batteries owing to their excellent mechanical flexibility and facile processability. Nevertheless, the narrow electrochemical stability window of these polymer electrolytes severely restricts their operational compatibility with high-voltage cathodes. This work investigates the failure mechanism of solid-state lithium batteries employing PEO-based composite polymer electrolytes paired with the Ni-rich cathode LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811). Electrochemical analysis reveals that while PEO-based composite polymer electrolytes decomposition initiates above 4.0 V (vs Li + /Li), the resulting degradation products retain sufficient ionic conduction capability. However, when cycled to higher cutoff potentials of 4.3 V, systematic characterization identifies structural decay and microcrack generation within the polycrystalline NCM811 cathode particles as the predominant failure mode. The incorporation of LiNbO 3 coated single-crystal NCM811 cathodes into PEO-based solid-state battery systems effectively suppresses cathode-electrolyte interfacial reactions and enhance the structural stability of NCM811 during prolonged cycling. Electrochemical measurements revealed that LiNbO 3 -coated single-crystal NCM811 battery delivered an initial capacity of 171.3 mAh g −1 , with capacity retention of 80% after 100 cycles and 62.3% after 200 cycles. The elucidated degradation mechanisms in this work provide fundamental guidelines for cathode material design and electrolyte formulation optimization for PEO-based solid-state batteries.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 10","pages":"100526-100526"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synergistic Chloride-Choline Bitartrate Strategy for Ultralight Copper Powders with Enhanced Mechanical Stability and Ultralow Apparent Density 增强机械稳定性和超低表观密度的超轻铜粉氯化物-胆碱双酒石酸盐协同策略

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-10-01 DOI: 10.1149/1945-7111/ae0eb5

Youpo Mise, Shaohua Wang, Wenzhong Shi, Yakun Yin, Zejia Wang, Juan An, Xuejiao Zhou, Wentang Xia, Wenqiang Yang

{"title":"Synergistic Chloride-Choline Bitartrate Strategy for Ultralight Copper Powders with Enhanced Mechanical Stability and Ultralow Apparent Density","authors":"Youpo Mise, Shaohua Wang, Wenzhong Shi, Yakun Yin, Zejia Wang, Juan An, Xuejiao Zhou, Wentang Xia, Wenqiang Yang","doi":"10.1149/1945-7111/ae0eb5","DOIUrl":"https://doi.org/10.1149/1945-7111/ae0eb5","url":null,"abstract":"This study developed a synergistic strategy using chloride ions (Cl − ) and choline bitartrate (CBT) as binary additives to address the longstanding trade-off between high specific surface area and structural stability in ultralight copper powders (UCPs). Multiscale electrochemical analyses and morphological characterization revealed that the Cl − -CBT pair modulated copper electrodeposition kinetics via dynamic coordination and interfacial adsorption, enabling control of dendritic growth. At a Cl − :CBT molar ratio of 1:1, the system promoted three-dimensional instantaneous nucleation, reduced charge transfer resistance by 27.3%, and constructed a fractal dendritic architecture with balanced branch density and structural integrity. This strategy mitigated excessive dendrite thinning and structural collapse and improved mechanical robustness. Under a benchmark factory process conditions, the synthesized UCP (P-Cl-CBT) exhibited ultralow apparent density (0.41 g cm −3 ), refined median particle size (D 50 , 44.25 μm), and enhanced process efficiency (3.3% higher current efficiency, 5.9% lower energy consumption). In vibration testing (24 h, 2.5 Hz, 20 mm amplitude), the fractal framework retained >95% structural integrity, with negligible changes in D 50 (Δ = −2.69%) and apparent density (Δ = +2.4%). Elemental and crystallographic analyses indicated negligible additive incorporation and preservation of the face-centered cubic (FCC) structure, consistent with high purity.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 10","pages":"103502-103502"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deconvoluting Sources of Overpotential of Oxide Ion Conducting Membrane Assisted Inert Anode 氧化离子导电膜辅助惰性阳极过电位的反卷积源

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-09-29 DOI: 10.1149/1945-7111/ae0d02

Song Mao, Xiao Yang, Qiyang Lu

{"title":"Deconvoluting Sources of Overpotential of Oxide Ion Conducting Membrane Assisted Inert Anode","authors":"Song Mao, Xiao Yang, Qiyang Lu","doi":"10.1149/1945-7111/ae0d02","DOIUrl":"https://doi.org/10.1149/1945-7111/ae0d02","url":null,"abstract":"Inert anode assisted by using oxide ion conducting membranes, such as yttria-stabilized zirconia (YSZ), offers a sustainable alternative to traditional graphite anodes for molten salt electrolysis by enabling oxygen evolution instead of CO 2 emission. However, the polarization behavior as well as the different sources of overpotential of such anode has not been thoroughly investigated. This work systematically deconvolutes the overpotential of an oxide ion conducting membrane assisted inert anode into three components, i.e., ohmic overpotential ( η ohmic ), anodic catalytic overpotential ( η catalyst ), and mass transport overpotential ( η mt ), by combining insights from multiple electrochemical techniques. Quantitative analysis provides strong evidence for the existence of the diffusion boundary layer near the molten salt/YSZ interface. We demonstrate that forced convection can significantly reduce η mt by thinning the diffusion boundary layer near the molten salt/YSZ interface. Conversely, η catalyst remains independent of the concentration of oxide ions, governed instead by oxygen exchange kinetics at the catalyst. These findings highlight strategies to optimize electrolysis efficiency, including enhancing oxide ion supply by forced convection, employing optimized catalysts and reducing ohmic losses from the oxide ion conducting membrane.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 10","pages":"104503-104503"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile Synthesis of Bagasse-Based Hierarchical Porous Carbon for High-Efficiency Supercapacitors 高效超级电容器用甘蔗渣基分层多孔碳的简易合成

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-09-01 DOI: 10.1149/1945-7111/ae0883

Baoning Zhu, Wenjun Zhu, Zijun Sun, Qijun Zhong, Jiale Chen, Zehong Tang, Xiaohui Ren, Xiong He, Jinghua Liu

引用次数: 1

Electrochemical Behavior of Cr²⁺ in NaCl-CaCl₂ Molten Salt and Electrodeposition of Chromium Coatings Cr2+在NaCl-CaCl2熔盐中的电化学行为及铬镀层的电沉积

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-08-29 DOI: 10.1149/1945-7111/ae00fb

Chuntao Ge, Qian Kou, Rong Li, Wenjuan Qi, Junjie Xu, Jun Zhang, Saijun Xiao

{"title":"Electrochemical Behavior of Cr<sup>2+</sup> in NaCl-CaCl<sub>2</sub> Molten Salt and Electrodeposition of Chromium Coatings","authors":"Chuntao Ge, Qian Kou, Rong Li, Wenjuan Qi, Junjie Xu, Jun Zhang, Saijun Xiao","doi":"10.1149/1945-7111/ae00fb","DOIUrl":"https://doi.org/10.1149/1945-7111/ae00fb","url":null,"abstract":"The NaCl-CaCl 2 molten salt system presents a cost-effective and stable medium for the electrodeposition of metallic chromium. However, the electrochemical behavior of Cr 2+ and the deposition process for dense chromium coatings within this system remain unexplored. Using CrCl 2 as a precursor, this study investigated the electrochemical behavior of Cr 2+ in NaCl-CaCl 2 molten salt at 620 °C through cyclic voltammetry and square wave voltammetry. The results revealed that the reduction of Cr 2+ involved a one-step, two-electron exchanged reaction (Cr 2+ + 2e − →Cr), exhibiting quasi-reversible behavior controlled by diffusion, with a diffusion coefficient of 0.5 × 10 –5 cm 2 s −1 . Electrodeposition on a molybdenum substrate demonstrated that current density significantly influenced coating morphology. An optimal condition of 30 mA cm −2 yielded a dense and uniform chromium coating, whereas current densities of 50–70 mA cm −2 resulted in significant degradation in coating planarity due to concentration polarization. Deposition time exhibited a linear positive correlation with coating thickness. Extending deposition time eliminated initial island growth and enhanced coating continuity. X-ray diffraction confirmed the coating consisted of pure chromium phase with a strong (200) preferred orientation. This research provided a theoretical and experimental foundation for electrodepositing chromium metal coatings in the NaCl-CaCl 2 molten salt system.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 9","pages":"092505-092505"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Circulating Tumor DNA Methylation with Photoelectrochemical Sensor Signatures Decoded by Attention Mechanisms 循环肿瘤DNA甲基化与光电化学传感器信号解码的注意机制

4区工程技术

Journal of The Electrochemical Society Pub Date : 2025-07-01 DOI: 10.1149/1945-7111/adf806

Ping Sun, Guoliang Wang, Jianjun Xu, Wenqiang Wang, Shaobo Hu, Chen Zhang

{"title":"Circulating Tumor DNA Methylation with Photoelectrochemical Sensor Signatures Decoded by Attention Mechanisms","authors":"Ping Sun, Guoliang Wang, Jianjun Xu, Wenqiang Wang, Shaobo Hu, Chen Zhang","doi":"10.1149/1945-7111/adf806","DOIUrl":"https://doi.org/10.1149/1945-7111/adf806","url":null,"abstract":"Integration of ultrasensitive photoelectrochemical (PEC) sensing with advanced computational analysis presents a novel approach for early cancer detection through circulating tumor DNA (ctDNA) methylation profiling. We report a synergistic platform combining BiOBr/WS 2 heterojunction–based PEC sensor with attention–driven deep learning to decode cancer–specific methylation signatures. The BiOBr/WS 2 composite, synthesized via a two–step hydrothermal process, demonstrated enhanced visible–light absorption and charge separation efficiency, achieving a 2.3–fold higher photocurrent response than pristine BiOBr. This sensor enabled ultrasensitive ctDNA detection with a linear range spanning six orders of magnitude (0.5 fM to 500 pM) and an ultralow detection limit of 0.05 fM. Deep learning revealed that attention mechanisms prioritized methylation loci in promoter regions and gene bodies, achieving 75% classification accuracy and a ROC AUC of 0.889. The model identified bidirectional methylation patterns, with 73% of high–weight CpG sites showing cancer–specific hypomethylation, challenging traditional hypermethylation–centric paradigms. The sensor exhibited exceptional selectivity against mismatched sequences, 95% signal stability over 7 days, and 97%–103% recovery in human serum. By bridging nanomaterial–enhanced PEC transduction with context–aware methylation analysis, this work establishes robust framework for non–invasive cancer screening, emphasizing the critical role of epigenetic heterogeneity in early intervention strategies.","PeriodicalId":17364,"journal":{"name":"Journal of The Electrochemical Society","volume":"172 8","pages":"087509-087509"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0