Journal of the International Association of Providers of AIDS Care最新文献

{"title":"Determinants of Appointment Spacing Model Acceptance Among People Living With HIV in Dessie City, Northeast Ethiopia: Case-Control Study.","authors":"Ehetenesh Berihun, Hawa Wolie, Missale Kasahun, Silewondim Mekonen, Meron Birhanu, Mulugeta Ashagrie, Sisay Gedamu, Abebe Dires","doi":"10.1177/23259582261433148","DOIUrl":"10.1177/23259582261433148","url":null,"abstract":"<p><p>IntroductionIn Ethiopia, the appointment spacing model (ASM) has been adopted since 2017. However, a significant proportion of eligible people living with HIV (PLHIV) are not enrolling in this model. Hence, the aim of the study was to assess the determinants of ASM acceptance among PLHIV in Northeast Ethiopia.MethodsAn institution-based case-control study was conducted. Cases were PLHIV who were enrolled in ASM. Multivariable logistic regression analysis was used to identify the determinants of ASM acceptance at a <i>p</i>-value of <.05.ResultsA total of 305 PLHIV were participated in the study. Being female (Adjusted Odds Ratio (AOR) = 1.90; 95% CI: 1.07-3.35), rural residence (AOR = 3.27; 95% CI: 1.61-6.63), receiving ART over 5 years (AOR = 2.64; 95% CI: 1.32-5.25), HIV disclosure (AOR = 3.64; 95% CI: 1.57-8.41), and PLHIV who required 1 to 3 hours to reach the ART clinic (AOR = 0.33; 95% CI: 0.15-0.73) were associated with the ASM acceptance.ConclusionsSex, residence, duration on ART, HIV disclosure status, and time required to reach the ART clinic were found to be associated with the ASM acceptance.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261433148"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of Adolescents Living With HIV During the COVID-19 Pandemic in Dar es Salaam, Tanzania: A Qualitative Study.","authors":"Tumaini Nyamhanga, David Gitagno, Rachel Mtei, Matthew Caputo, Sylvia Kaaya, Claudia Hawkins, Lisa R Hirschhorn","doi":"10.1177/23259582261446450","DOIUrl":"10.1177/23259582261446450","url":null,"abstract":"<p><p>BackgroundLimited research evidence exists on the experiences of adolescents living with HIV about their access to antiretroviral therapy during the COVID-19 pandemic in Tanzania.ObjectiveTo explore the lived experiences of adolescents living with HIV during the COVID-19 pandemic, including COVID-19-related anxiety, facilitators and barriers to accessing HIV care and treatment, and the coping strategies employed to remain healthy and resilient and if differences existed based on levels of anxiety.MethodsWe adopted a case study design to understand both normative and individual lived experiences of purposefully sampled adolescents receiving HIV care during the COVID-19 pandemic with higher and lower anxiety levels. A total of 32 participants took part in the study, including 24 in focus group discussions and 8 in in-depth interviews. Data were analyzed using thematic analysis.ResultsAdolescents living with HIV faced heightened anxiety and notable barriers to accessing HIV services during the COVID-19 pandemic. Their anxiety was driven by fear of infection, uncertainty about prevention measures, concerns about receiving care outside HIV clinics, and a perceived increased vulnerability. Many reported difficulty attending clinic appointments, largely due to government- and parent-imposed restrictions such as stay-at-home directives, mandatory mask use, and limited public transport capacity, but no difference based on anxiety level.To cope, adolescents relied on treatment adherence knowledge, self-efficacy, and family support. Both low- and high-anxiety groups encountered similar barriers to care and treatment adherence; however, those with higher anxiety reported greater fear of infection, less confidence in coping, and less helpful coping skills. No differences were observed by sex or age.ConclusionThe findings highlight that self-efficacy, risk-reduction knowledge, problem-solving skills, and family support helped reduce anxiety and support treatment adherence among adolescents living with HIV, underscoring the need for targeted support programs during public health crises.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261446450"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Culturally Informed Peer Support Model for Men Who Have Sex With Men Living With HIV: A Qualitative Study in Indonesia.","authors":"Endah Sri Wahyuni, Eti Poncorini Pamungkasari, Vitri Widyaningsih","doi":"10.1177/23259582261469771","DOIUrl":"10.1177/23259582261469771","url":null,"abstract":"<p><p>BackgroundMen who have sex with men (MSM) living with HIV in Indonesia experience intersecting stigma affecting psychosocial wellbeing and healthcare engagement. Existing peer support models often lack cultural and spiritual relevance.AimThis study aimed to develop a culturally informed peer support model based on the experiences of MSM living with HIV and key stakeholders.MethodsA qualitative study was conducted in Central Java, Indonesia, using in-depth interviews, a focus group discussion, and field observations. Data were analysed using reflexive thematic analysis.ResultsThree themes emerged: stigma and internalised stigma, barriers to healthcare access, and the need for holistic peer support integrating psychosocial, spiritual, and cultural aspects. These informed a culturally grounded peer support model integrating the Information-Motivation-Behavioural Skills framework with the Javanese philosophy of <i>Sangkan Paraning Dumadi</i>.ConclusionThis model may support HIV care engagement and improve the relevance of peer support interventions among MSM living with HIV.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261469771"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MASLD in PLWH on ART: Predominance of Metabolic Risk Factors and Insights From Novel Biomarkers-A Cross-Sectional Study in Wrocław, Poland.","authors":"Michał Biały, Małgorzata Inglot","doi":"10.1177/23259582261436955","DOIUrl":"10.1177/23259582261436955","url":null,"abstract":"<p><p>BackgroundMASLD (NAFLD) is the most common chronic hepatopathy and has a rising prevalence in PLWH, with etiological factors being interplay of HIV-specific with general ones.MethodsWe conducted a cross-sectional study (<i>n</i> = 93). Patients were assessed in an outpatient clinic in Poland (April-October 2021) using clinical, metabolic data, irisin, CK-18, adiponectin, and leptin. Noninvasive formulas were used to assess the MASLD risk biochemically.ResultsNo statistically relevant differences in MASLD-related scores among different ART regimens were found, with weak correlations were found between CD4 count and NAFLD-LFS (<i>R</i> < .3), and ART duration with non-HDL-C (<i>R</i> = -.22) and NFS (<i>R</i> = .23). Lifetime weight amplitude showed relationship with biochemical MASLD-related formulas and hepatitis (<i>P</i> = .037); among the biomarkers, leptin exhibited several correlations, strongest with HSI (<i>R</i> = .56) and BMI (<i>R</i> = .53).ConclusionsMASLD corresponded more with general than with ART-related factors. Leptin may value when evaluating MASLD risk.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261436955"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth and Access to HIV Care for Youth: A National Mixed-Methods Study of U.S. HIV Healthcare Provider Practices and Perspectives.","authors":"E A Barr, R P Momin, Q Qian, Robin Beach, Mary Catherine Lingwall, M E Paul, Hannah Armitage, H Wu, Thomas P Giordano","doi":"10.1177/23259582261467830","DOIUrl":"10.1177/23259582261467830","url":null,"abstract":"<p><p>BackgroundYouth living with HIV (YWH) face persistent barriers to care engagement and viral suppression. Telehealth expanded post-COVID-19 emergence, offering new possibilities for access, but provider perspectives on its use with YWH are underexplored.MethodsA national mixed-methods survey captured experiences of 156 HIV care providers. Quantitative data were analyzed using descriptive and inferential statistics; qualitative data were analyzed using reflexive thematic analysis.ResultsMost providers (88.5%) believed telehealth would continue to play a role in HIV care. Reported benefits included improved access (80.7%) and workflow efficiency (64.7%). However, providers were significantly less likely to discuss sensitive topics \"often\" via telehealth compared to in-person care, including mental health (81.4% vs. 92.9%, p = 0.0008) and sexual health (77.9% vs. 93.6%, p < 0.0001).ConclusionsWhile telehealth improves access for YWH, hybrid care models and targeted provider training are needed to address privacy, communication, and trust when discussing sensitive health concerns.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261467830"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Function Screening in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy.","authors":"Ana Filipa Bolas, Umbelina Caixas, Paula Bogalho, José Silva-Nunes","doi":"10.1177/23259582261439968","DOIUrl":"10.1177/23259582261439968","url":null,"abstract":"<p><p>BackgroundPeople living with human immunodeficiency virus (HIV) may develop endocrine dysfunction, particularly involving the thyroid gland. Although overt thyroid dysfunction in patients living with HIV is similar to that of the general population, subclinical thyroid dysfunction is significantly more prevalent. This study aims to evaluate the prevalence of changes in thyroid function in patients living with HIV on antiretroviral therapy and to determine whether routine thyroid function testing is warranted.MethodsRetrospective observational study including 249 people living with HIV on antiretroviral therapy and followed in an Internal Medicine outpatient clinic between 2018 and 2023. Patients with a history of thyroid disease before 2018, those receiving treatment with amiodarone, lithium, interferon, and/or tyrosine kinase inhibitors, and those lacking thyroid function assessment or medical records before 2023 were excluded.ResultsOf the 249 patients, 96.4% showed no abnormalities in thyroid function. Thyroid dysfunction was identified in nine patients (3.6%): four (1.6%) had subclinical hypothyroidism, one (0.4%) Hashimoto's thyroiditis, two (0.8%) antibody-negative hypothyroidism, and two (0.8%) subclinical hyperthyroidism.ConclusionThe overall prevalence of thyroid dysfunction was low, suggesting no benefit in systematic screening of thyroid function among patients living with HIV on antiretroviral therapy.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261439968"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression, Medication Adherence, and Beliefs as Determinants of Health-Related Quality of Life among People Living with HIV: A Cross-Sectional Pharmacoepidemiologic Study in Indonesia.","authors":"Muh Akbar Bahar, Hardiyanti Syarif, Neily Zakiyah, Najmiatul Fitria","doi":"10.1177/23259582261452316","DOIUrl":"10.1177/23259582261452316","url":null,"abstract":"<p><p>ObjectiveTo examine the associations of depression, medication adherence, and medication beliefs with HRQoL among people living with HIV (PLWH) in primary healthcare (PHC) settings in Indonesia.MethodsThis cross-sectional study included PLWH attending 6 PHCs in Makassar (July-September 2025). HRQoL was assessed using the EuroQol 5-Dimension 5-Level (EQ-5D-5L); depression using the Patient Health Questionnaire-9 (PHQ-9); adherence using the Medication Adherence Report Scale (MARS); and beliefs using the Beliefs about Medicines Questionnaire (BMQ). Multivariable linear regression examined associations with HRQoL.ResultsAmong 400 participants (median age 30 years, interquartile range: 11), mean EQ-5D-5L utility was 0.94 ± 0.10. Higher depression severity was associated with lower HRQoL (β=-0.006; <i>P</i> < .001), while adherence and beliefs were not significant after adjustment.ConclusionDepression was the only independent psychosocial predictor of HRQoL, highlighting the need for integrated mental health support in HIV care within PHC settings.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261452316"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13187373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Social Vulnerability on Exercise Outcomes: A Longitudinal Study of Physical Function in Older People With HIV.","authors":"Evelyn Iriarte, Kellie L Hawkins, Melissa P Wilson, Allison R Webel, Vitor Hf Oliveira, Vincent Khuu, Grace L Kulik, Paul Cook, Debashis Ghosh, Catherine Jankowski, Kristine M Erlandson","doi":"10.1177/23259582261448699","DOIUrl":"10.1177/23259582261448699","url":null,"abstract":"<p><p>ObjectivesTo examine whether the Social Vulnerability Index (SVI) moderated changes in physical function during supervised and unsupervised phases of an exercise intervention in older adults with HIV.MethodsThis exploratory analysis used data from the High Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults with HIV. Participants completed 16 weeks of supervised high- or moderate-intensity exercise, followed by 12 weeks of unsupervised support (personalized coaching or educational text messages). Linear mixed-effects models assessed SVI moderation effects on 400-meter walk time (400-MWT) and Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF).ResultsAmong 117 participants, SVI did not moderate 400-MWT in either phase or PROMIS-PF during supervised exercise; however, higher SVI was associated with declines in self-reported physical function during the unsupervised phase (<i>P</i> = .03), robust to adjustment and sensitivity analyses.ConclusionsFindings suggest supervised exercise benefits participants across vulnerability levels, but sustained support may be needed to prevent disparities.Parent Trial InformationThe High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults with HIV trial, ClinicalTrials.gov: NCT04550676.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261448699"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Chronic Comorbidities in People Living With HIV in Peru.","authors":"Marleny Nolasco, Evelyn Hsieh, Patricia J Garcia, Monica M Diaz","doi":"10.1177/23259582261470497","DOIUrl":"10.1177/23259582261470497","url":null,"abstract":"<p><p>BackgroundAdvances in antiretroviral therapy (ART) have extended the life expectancy of people living with HIV (PWH) in Peru, shifting the healthcare focus toward managing chronic non-communicable comorbidities (NCDs). Yet data on NCD burden among aging PWH in Peru are sparse.MethodsWe conducted a scoping review of peer-reviewed studies from PubMed and LILACS, in English or Spanish, that assessed non-AIDS comorbidities in Peruvian adults with HIV.ResultsWe identified 23 studies, all from Lima, mostly cross-sectional or retrospective, involving predominantly male ART patients. Commonly investigated comorbidities included neurocognitive impairment, mental health disorders (especially depression), cardiovascular disease, and metabolic syndrome; bone disease and non-AIDS malignancies were less studied.ConclusionsFindings suggest frequent cognitive, metabolic, and cardiovascular issues among PWH. Yet critical gaps remain: little is known about frailty, disability, or long-term outcomes. Expanded screening, longitudinal studies, and integrated care models are needed to improve long-term health in aging PWH in Peru.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261470497"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B and C Virus Among Prisoners in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.","authors":"Tsegaamlak Kumelachew Derse, Desalegn Mitiku Kidie, Addisu Simachew Asgai, Tadios Lidetu, Yideg Abinew, Asaye Worku Agegn, Misganaw Alelign, Moges Tadesse Abebe","doi":"10.1177/23259582261494741","DOIUrl":"https://doi.org/10.1177/23259582261494741","url":null,"abstract":"<p><p>ObjectiveTo estimate the pooled prevalence and identify transmission drivers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among incarcerated populations in sub-Saharan Africa.MethodsA systematic review and meta-analysis was conducted following a search encompassing Medical Subject Headings (MeSH) and free-text terms from database inception through February 2025. Data were synthesized from 26 studies involving 77,760 prisoners across sub-Saharan Africa. A random-effects model was used to calculate pooled prevalence estimates, assess regional variation, and evaluate odds ratios (OR) for potential transmission risk factors.ResultsThe overall pooled prevalence was 13.0% for HBV and 8.0% for HCV among prisoners. Significant regional disparities were observed, with West Africa presenting the highest HBV burden (16.3%) and East Africa showing the highest HCV burden (8.8%). Key independent predictors of infection included sharing sharp objects (OR, 1.98), tattooing (OR, 1.92), and intravenous drug use (OR, 1.38).ConclusionIncarcerated populations in sub-Saharan Africa experience a high burden of viral hepatitis driven by parenteral exposure and high-risk sexual interactions. Addressing these gaps requires targeted screening, comprehensive harm reduction, condom provision, and integrating prison health services into national elimination strategies.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261494741"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}