Journal of the International Association of Providers of AIDS Care最新文献

{"title":"U = U: A Catalyst for Ending AIDS as a Public Health Threat.","authors":"José M Zuniga","doi":"10.1177/23259582241282561","DOIUrl":"10.1177/23259582241282561","url":null,"abstract":"","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"23 ","pages":"23259582241282561"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome Complicated by Large Bilateral Psoas Abscess: A Case Report.","authors":"Adriam M Castilla-Encinas, Valeria Rocio Soto Salas, Hugo Alvarez-Delgado, Jhon E Bocanegra-Becerra, Paola L Rondan","doi":"10.1177/23259582241293302","DOIUrl":"10.1177/23259582241293302","url":null,"abstract":"<p><p>Immune reconstitution inflammatory syndrome is a common manifestation in human immunodeficiency virus (HIV)-positive patients infected with tuberculosis (TB). One of the unusual complications of this condition is the development of psoas abscess. We describe a case of immune reconstitution inflammatory syndrome (IRIS) in a patient with disseminated TB under treatment, HIV-positive with a low CD4 cell count, complicated by bilateral psoas abscess. Our patient presented with fever, abdominal pain, and lymphadenopathy, typical symptoms of TB-IRIS. Diagnosis was confirmed by surgical drainage of the abscess of the right iliac psoas muscle with detection of acid-fast bacteria on Ziehl-Neelsen staining and negative culture of purulent discharge. Treatment with prednisone was started in addition to continuation of antituberculosis therapy and antiretroviral therapy.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"23 ","pages":"23259582241293302"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilevel Factors Impacting PrEP Engagement Among Young Gay Men and Young Transgender Women in Thailand: A Qualitative Analysis.","authors":"Peter A Newman,&nbsp;Suchon Tepjan,&nbsp;Kangwan Fongkaew,&nbsp;Pakorn Akkakanjanasupar,&nbsp;Jan Willem de Lind van Wijngaarden,&nbsp;Nuttapon Chonwanarat","doi":"10.1177/23259582231188221","DOIUrl":"https://doi.org/10.1177/23259582231188221","url":null,"abstract":"<p><p>Half of new HIV infections in Thailand are among young people, the majority of whom are young gay and other men who have sex with men (YMSM) and young transgender women (YTGW). Amid low pre-exposure prophylaxis (PrEP) coverage, we explored practice-based factors that impact PrEP engagement among YMSM and YTGW. In 2018, we conducted 4 focus group discussions with 20 YMSM and 5 YTGW, and 22 in-depth interviews (5 in 2022) with healthcare providers (HCPs), community-based organization (CBO)/nongovernmental organization (NGO) staff, and peer educators. The inclusion of PrEP in universal healthcare coverage, including YMSM and YTGW, is a substantial facilitator of PrEP use; however, systemic barriers at microsocial (lack of communication about PrEP from HCPs, teachers, parents), mesosocial (healthcare-service fragmentation, lack of PrEP-competent HCPs), and macrosocial levels (annual quotas on free HIV-testing, HIV- and sexual-stigma) constrain and disincentivize adolescents' engagement with PrEP. National scale-up of youth-friendly and LGBT-affirmative CBO/NGO clinics, HCP training, and tailored programs to support adolescents' adherence may promote PrEP engagement among YMSM and YTGW in Thailand.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231188221"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Cognitive Performance of a South African Cohort of People With HIV and Comorbid Major Depressive Disorder.","authors":"Anna J Dreyer, Sam Nightingale, Lena S Andersen, Jasper S Lee, Hetta Gouse, Steven A Safren, Conall O'Cleirigh, Kevin G F Thomas, John A Joska","doi":"10.1177/23259582231203192","DOIUrl":"10.1177/23259582231203192","url":null,"abstract":"<p><p>Women with HIV (WWH) may be more vulnerable to cognitive impairment than men with HIV (MWH), which may be explained by the direct effects of HIV or by sociodemographic and psychiatric characteristics. We recruited 105 people with HIV (PWH; 76 women) with incomplete antiretroviral therapy adherence, comorbid major depressive disorder, and socioeconomically disadvantaged backgrounds. Participants completed neuropsychological testing and measures gathering sociodemographic, medical, and psychiatric information. We compared WWH and MWH cognitive performance using unadjusted and adjusted regressions, and within each respective group, we explored predictors of cognitive performance. Results showed no significant between-sex differences in cognitive performance, both globally and within domains. Fewer years of education (<i>β</i> = 0.94), illiteracy (<i>β</i> = 4.55), and greater food insecurity (<i>β </i>= -0.28) predicted lower cognitive performance in WWH but not MWH. We conclude that sex differences in PWH are likely due to sample characteristics representing broader inequalities, rather than true biological differences.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231203192"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/7a/10.1177_23259582231203192.PMC10548808.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41134915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Model for Accelerating Access to Care and Treatment for Children and Adolescents Living with HIV in Nigeria, Tanzania, Uganda, and Zambia: The Faith-Based Action for Scaling-Up Testing and Treatment for the Epidemic Response (FASTER) Initiative.","authors":"Daniel Oliver, David Mabirizi, Marisa Hast, Mary Grace Alwano, Chalilwe Chungu, Alphonce Kelemani, Chizoba Mbanefo, Jessica Gross, KaeAnne Parris, Stephanie Dowling, Adele Clark, Amanda Williams, Lauren Simao, Carolyn Amole, Kanchana Suggu, Jibrin Kama, Felton Mpasela, Leah Mtui, Vennie Nabitaka, Renée Saunders, Dhelia Williamson, Emilia D Rivadeneira, Susan Hrapcak, Sophie Nantume, Esther Nazziwa, Megumi Itoh, Edward Machage, Chibuzor Onyenuobi, Gloria Munthali, Anath Rwebembera, Mwiya Mwiya, Cordelia Katureebe, Akudo Ikpeazu, Thomas Fenn","doi":"10.1177/23259582231186701","DOIUrl":"10.1177/23259582231186701","url":null,"abstract":"<p><p>The number of children newly infected with HIV dropped by 50%, from 320 000 in 2010 to 160 000 in 2021. Despite progress, ongoing gaps persist in diagnosis, continuity of care, and treatment optimization. In response, the United States President's Emergency Plan for AIDS Relief created the Faith-based Action for Scaling-Up Testing and Treatment for Epidemic Response (FASTER). Faith-based Action for Scaling-Up Testing and Treatment for Epidemic Response addressed gaps in countries with the highest unmet need by working with government to operationalize innovative interventions and ensure alignment with national priorities and with communities living with HIV to ensure the change was community-led. Between 2019 and 2021, FASTER's interventions were incorporated into national policies, absorbed by Ministries of Health, and taken up in subsequent awards and country operating plans. Continued effort is needed to sustain gains made during the FASTER initiative and to continue scaling evidence-based interventions to ensure that children and adolescents are not left behind in the global HIV response.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231186701"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/02/10.1177_23259582231186701.PMC10388624.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9909796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Changes in Alcohol Use During Pregnancy and the Postpartum Transition Among People With HIV in South Africa and Uganda.","authors":"Amelia M Stanton,&nbsp;Benjamin D Hornstein,&nbsp;Nicholas Musinguzi,&nbsp;Brett Dolotina,&nbsp;Catherine Orrell,&nbsp;Gideon Amanyire,&nbsp;Stephen Asiimwe,&nbsp;Anna Cross,&nbsp;Christina Psaros,&nbsp;David Bangsberg,&nbsp;Judith A Hahn,&nbsp;Jessica E Haberer,&nbsp;Lynn T Matthews","doi":"10.1177/23259582231161029","DOIUrl":"https://doi.org/10.1177/23259582231161029","url":null,"abstract":"<p><p>Identifying factors associated with alcohol use changes during pregnancy is important for developing interventions for people with HIV (PWH). Pregnant PWH (n = 202) initiating antiretroviral therapy in Uganda and South Africa completed two assessments, 6 months apart (T1, T2). Categories were derived based on AUDIT-C scores: \"no use\" (AUDIT-C = 0 at T1 and T2), \"new use\" (AUDIT-C = 0 at T1, >0 at T2), \"quit\" (AUDIT-C > 0 at T1, =0 at T2), and \"continued use\" (AUDIT-C > 0, T1 and T2). Factors associated with these categories were assessed. Most participants had \"no use\" (68%), followed by \"continued use\" (12%), \"quit\" (11%), and \"new use\" (9%). Cohabitating with a partner was associated with lower relative risk of \"continued use.\" Borderline significant associations between food insecurity and higher risk of \"new use\" and between stigma and reduced likelihood of \"quitting\" also emerged. Alcohol use interventions that address partnership, food security, and stigma could benefit pregnant and postpartum PWH.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231161029"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9587331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-Related Stigma Shapes Research Participation for Youth Living With HIV in Kenya.","authors":"Emma Gillette,&nbsp;Violet Naanyu,&nbsp;Winstone Nyandiko,&nbsp;Ashley Chory,&nbsp;Michael Scanlon,&nbsp;Josephine Aluoch,&nbsp;Hillary Koros,&nbsp;Celestine Ashimosi,&nbsp;Whitney Beigon,&nbsp;Dennis Munyoro,&nbsp;Janet Lidweye,&nbsp;Jack Nyagaya,&nbsp;Allison DeLong,&nbsp;Rami Kantor,&nbsp;Rachel Vreeman","doi":"10.1177/23259582231170732","DOIUrl":"https://doi.org/10.1177/23259582231170732","url":null,"abstract":"<p><p><b>Introduction:</b> HIV stigma affects medication adherence, psychosocial outcomes, and clinical management for youth living with HIV (YLWH). We explored the impact of HIV stigma on research participation, to inform the ethical engagement of this vulnerable group. <b>Methods:</b> We interviewed 40 YLWH, 20 caregivers, and 39 subject matter experts (SMEs); transcripts were analyzed by HK and EG, with emerging themes confirmed by JA and AC. <b>Results:</b> All categories of participants identified the impacts of stigma on YLWH research participation, suggesting implementing privacy protections, considering recruitment locations carefully, and developing supportive relationships with YLWH. SMEs suggested that YLWH experience uniquely high risks from stigma due to the compounding effects of developmental challenges and transitionary life period. Accidental HIV disclosure and subsequent stigma were identified as a risk of research participation; some viewed the creation of community through research as a benefit. <b>Conclusion:</b> Participants provided insights into stigma-related considerations for research with YLWH, which may guide engagement protocols.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231170732"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/4c/10.1177_23259582231170732.PMC10141251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10061692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcomes After Switching to Second-Line Anti-Retroviral Therapy: Results From the Thai National Treatment Program.","authors":"Pupe Sudsila, Sirinya Teeraananchai, Sasisopin Kiertiburanakul, Cheewanan Lertpiriyasuwat, Rattaphon Triamwichanon, Sivaporn Gatechompol, Opass Putcharoen, Ploenchan Chetchotisakd, Anchalee Avihingsanon, Stephen J Kerr, Kiat Ruxrungtham","doi":"10.1177/23259582231220513","DOIUrl":"10.1177/23259582231220513","url":null,"abstract":"<p><p>This study aimed to assess second-line antiretroviral therapy (ART) outcomes in a National HIV Treatment program. People living with HIV aged ≥18 years initiating first-line ART who switched to second-line protease inhibitor-based regimens from January 2008 to May 2019, with a minimum of 1-year follow-up were studied. The primary outcome was second-line treatment failure (two consecutive virological failure episodes (viral load ≥1000 copies/mL)). Of 318,506 PLH initiating ART, 29,015 (9.1%) switched to second-line regimens after a median (IQR) ART duration of 1.63 (0.60-3.59) years. Lost to follow-up (LTFU) occurred in 5316 (18.3%) of whom 1376 (5%) remained LTFU and alive; 4606 (15.9%) died. Cumulative second-line failure incidence was 9.8% at 6 years, more common in females, younger PLH those with lower switch CD4 cell counts. Multidisciplinary, innovative support systems are needed to improve second-line treatment outcomes, particularly those relating to modifiable risk factors.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231220513"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>\"Pharmacies are Everywhere, and You can get it at any Time\"</i>: Experiences With Pharmacy-Based PrEP Delivery Among Adolescent Girls and Young Women in Kisumu, Kenya.","authors":"Melissa Vera, Elizabeth Bukusi, Pauline Achieng, Helen Aketch, Evelyne Araka, Jared M Baeten, Kristin Beima-Sofie, Grace John-Stewart, Pamela K Kohler, Melissa L Mugambi, Bernard Nyerere, Josephine Odoyo, Caroline Omom, Christine Omondi, Katrina F Ortblad, Jillian Pintye","doi":"10.1177/23259582231215882","DOIUrl":"10.1177/23259582231215882","url":null,"abstract":"<p><strong>Introduction: </strong>Many Kenyan adolescent girls and young women (AGYW) with behaviors associated with HIV acquisition access contraception at retail pharmacies. Offering oral pre-exposure prophylaxis (PrEP) in pharmacies could help reach AGYW with PrEP services.</p><p><strong>Methods: </strong>We piloted PrEP delivery at 3 retail pharmacies in Kisumu, Kenya. AGYW purchasing contraception were offered PrEP by nurses with remote prescriber oversight. AGYW who accepted were provided with a free 1-month supply. We conducted in-depth interviews with AGYW 30 days postobtaining PrEP. Transcripts were analyzed to explore experiences of AGYW accessing PrEP at pharmacies.</p><p><strong>Results: </strong>We conducted 41 interviews. AGYW preferred pharmacies for accessing PrEP and they were willing to pay for PrEP even if available for free at clinics. Reasons for this preference included accessibility, lack of queues, and medication stockouts, privacy, anonymity, autonomy, and high-quality counseling from our study nurses.</p><p><strong>Conclusions: </strong>Pharmacies may be an important PrEP access option for this population.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231215882"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and Willingness to use Condoms and Preexposure Prophylaxis among Gay, Bisexual, and Other Cisgendered Men who Have sex with men in Slum Communities in Ghana. BSGH-004.","authors":"Gamji Rabiu Abu-Ba'are, Osman Wumpini Shamrock, Amos Apreku, George Rudolph Kofi Agbemedu, Edem Yaw Zigah, Oliver C Ezechi, LaRon E Nelson, Kwasi Torpey","doi":"10.1177/23259582231209649","DOIUrl":"10.1177/23259582231209649","url":null,"abstract":"<p><p><b>Introduction:</b> Research has begun to examine human immunodeficiency virus (HIV) prevention strategies within the Ghanaian context. Still, little is known about specific populations such as gay, bisexual, and other cisgender men who have sex with men (GBMSM) living in slum communities. We studied HIV prevention strategies such as condoms and preexposure prophylaxis (PrEP) in slum communities and the awareness and willingness to use these choices among GBMSM. This qualitative study examines HIV prevention strategies, specifically examining PrEP and condom use behaviors among GBMSM in Ghana. <b>Methods:</b> We conducted in-depth face-to-face interviews among 12 GBMSM from slums in Accra and Kumasi cities in Ghana. Data were analyzed through a summative content analysis with multiple reviewers to develop codes. Data were collected from participants in January 2022. <b>Results:</b> We found the fear and perceived risk of infection were motivators for consistent condom use, especially during anal sex. GBMSM living with HIV receiving antiretroviral therapy were more inclined to use condoms. We found motivations for using PrEP were influenced by the type of sexual activity and a history of negative HIV status. Also, the barriers to PrEP for GBMSM included limited access to healthcare facilities and the distance to these facilities. <b>Conclusions:</b> To improve condom and PrEP access and uptake, we recommend addressing structural barriers by increasing the number of health facilities and implementing targeted interventions to address the lack of information on HIV awareness and prevention. Involving peer educators may also effectively promote HIV prevention strategies, especially in communities with limited access to healthcare such as slums. Overcoming these access constraints could significantly enhance awareness and prevention of HIV, leading to improved health outcomes for GBMSM living in slum communities.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"22 ","pages":"23259582231209649"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71482954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}