Journal of the International Association of Providers of AIDS Care最新文献

{"title":"Utilization and Associated Factors of the Community-Based Differentiated Service Delivery Model Among ART Users in Dessie Public Health Facilities, Northeast Ethiopia: A Mixed Method Study.","authors":"Endalkachew Mesfin Gebeyehu, Eyob Tilahun Abeje, Lakew Asmare","doi":"10.1177/23259582261423607","DOIUrl":"10.1177/23259582261423607","url":null,"abstract":"<p><p>BackgroundDifferentiated service delivery models (DSDMs) are client-centered approaches to HIV care that improve efficiency through simplification, task shifting, and decentralization. However, utilization of Ethiopia's community-based DSDM remains low, and its determinants are not well understood.ObjectiveTo assess the utilization of and factors associated with community-based DSDM among ART users in Dessie public health facilities, Northeast Ethiopia, 2025.MethodsA convergent mixed-methods cross-sectional study was conducted among 635 randomly selected ART users. Quantitative data were collected using interviewer-administered questionnaires and analyzed using multivariable logistic regression in STATA 16. In-depth interviews with purposively selected ART users were analyzed thematically to explore contextual barriers and facilitators.ResultsOverall, 17.1% (95% CI: 14.3-20.3%) utilized community-based DSDM. Utilization was positively associated with primary education, HIV status disclosure, and ART regimen change, but negatively associated with prior loss to follow-up and baseline CD4 ≥ 500 cells/mm³. Qualitative findings highlighted information gaps, stigma, and misconceptions as barriers, while peer support facilitated uptake.ConclusionCommunity-based DSDM utilization remains suboptimal, underscoring the need for strengthened counseling, stigma reduction, and targeted patient education to enhance uptake.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261423607"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12926529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Worker Experiences and Perspectives on the Integration of Long-Acting Injectable Antiretroviral Therapy into a Safety-Net HIV Clinic in the Southeastern United States.","authors":"Hanna E Huffstetler, Christopher Lopez, Harsh Agarwal, Odai A Mansour, Vivian F Go, Claire E Farel, Sonia Napravnik, Sarah E Rutstein","doi":"10.1177/23259582261426448","DOIUrl":"10.1177/23259582261426448","url":null,"abstract":"<p><p>BackgroundFollowing its approval by the US Food and Drug Administration in January 2021, clinics have moved to implement the first long-acting antiretroviral regimen (cabotegravir [CAB] and rilpivirine [RPV]) into routine care.MethodsIn this qualitative implementation study, we characterize health worker experiences with the introduction of CAB/RPV into a safety net HIV clinic in the Southeastern US during the first 10 months of service integration. Interviews were analyzed using directed content analysis and results were synthesized using the updated Consolidated Framework for Implementation Research.ResultsHealth workers described both successes and challenges. Successes included strong awareness of and enthusiasm for CAB/RPV and the integration of supportive resources over time. Challenges included inconsistent communication about logistics, perceived pressures on human resources, and concerns about structural barriers affecting patient access to care.ConclusionsFindings highlight the resource demands of implementing CAB/RPV, and the complex array of factors that shape successful implementation.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261426448"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12932877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis Treatment Uptake and Outcomes Among HIV-Positive Patients on Antiretroviral Therapy at a Tertiary Health Facility in South-South, Nigeria.","authors":"Adesuwa Queen Aigbokhaode, Ayodapo Oluwadare Jegede, Nosa Lancy Orhue, Omo Ekeneam, Oluwaseun Opeyemi Adesoye, Noruwa Patience Ekhator, Silvia Isioma Ezemenahi, Emmanuel Okechukwu Ezunu, Raymond Aghimien, Uchenna Enwereuzo, Ibukun Jacob Akinkunmi","doi":"10.1177/23259582261470686","DOIUrl":"10.1177/23259582261470686","url":null,"abstract":"<p><p>BackgroundThere is a significant intersection between Tuberculosis (TB) and HIV, which has contributed greatly to the disease burden, especially in Nigeria. Among approximately 1.9 million people living with HIV (PLHIV), an estimated 46,000 also had TB in 2019 alone. HIV-associated TB incidence has continuously increased nationally. It is important to understand how PLHIV with TB undergo treatment because this is essential for improving outcomes. This study assessed the uptake of TB treatment and evaluated outcomes among PLHIV receiving antiretroviral therapy at a tertiary healthcare facility in South-South Nigeria.MethodsThe study was a hospital-based retrospective cohort study, that reviewed the records of 213 PLHIV treated for TB between January 2015 and December 2019. Patient records were examined and data extracted using a structured pro forma. Analysis was done with IBM SPSS version 26 using descriptive statistics (frequencies and Percentages) and inferential statistics (chi-square test) with statistical significance set at p < 0.05.ResultsAll participants were enrolled in the National Tuberculosis, Leprosy and Buruli Ulcer Control Programme (NTBLCP). Of these, 182 individuals (85.5%) successfully completed the full 24-week course of anti-tuberculosis therapy. Treatment outcomes were classified separately, with 99 (46.5%) patients cured and 74 (34.7%) completing treatment without bacteriological confirmation, 28 (13.1%) discontinued treatment prematurely, and 12 (5.6%) were referred to other healthcare facilities for continued care.ConclusionTB treatment outcomes among PLHIV were suboptimal, with notable levels of default and transfer-out. Outcomes were significantly associated with socio-demographic factors and treatment duration. Strengthening adherence, support mechanisms and improving access to affordable diagnostic monitoring services may enhance TB treatment outcomes among PLHIV.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261470686"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Enablers and Barriers to HIV Testing Service Uptake Among Adolescent Girls and Young Women in Kilimanjaro, Tanzania: A Contextual Analysis.","authors":"Bernard Njau, Nasrath Fadhili, Editruda Gamassa, Damian Jeremia","doi":"10.1177/23259582261470679","DOIUrl":"10.1177/23259582261470679","url":null,"abstract":"<p><p>Adolescent girls and young women (AGYW) are among the high-risk groups for new HIV infection, particularly in Sub-Saharan Africa (SSA). HIV testing is an entry path to HIV care and treatment and is crucial in ending the HIV epidemic by 2023. Despite the availability of HIV Testing Services (HTS) in most SSA countries, including Tanzania, most AGYW are undiagnosed HIV or have ongoing HIV exposure. This study explored the enablers for and barriers to the uptake of HTS among AGYW aged 15-24 in northern Tanzania. This qualitative study was conducted between 4^th October and 30^th November 2024 in the Kilimanjaro Region, northern Tanzania. We included AGYW attending four purposively selected Care and Treatment (CTC) sites. Four Focused Group Discussions (FGDs) (two for 15-19 years and 20-24 years, respectively) were conducted using a semi-structured interview guide to explore perceived enablers for and barriers to the uptake of HTS among AGYW. Data were analyzed using thematic content analysis, and findings were presented narratively, using verbatim quotes. A total of 32 AGYW participated in the FGDs, more than half (53%) were aged 20- 24 years old and had primary education, and 63% (n = 20/32) were still in school. Perceived enablers that may facilitate the uptake of HTS include small blood samples collected, trust of a sexual partner, confidentiality of HIV test results, and existing social support. Other perceived enablers were the provider-centred HIV approach, comprehensive HIV education, health benefits of ARV use, and antenatal care as an entry point to HTS. Perceived barriers to HTS uptake include lack of HTS knowledge, being asymptomatic, fear of HIV test results, spiritual healing beliefs, being visible at the health facility, and anticipated stigma. Other perceived barriers were the provider's negative attitudes, long waiting times, lack of confidentiality of HIV test results, and transport costs. This calls for a multifaceted, client-centred intervention that strengthens the perceived enablers and simultaneously addresses the perceived barriers to create an enabling environment for uptake of HTS among AGYW.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261470679"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Distress and Associated Factors Among Women Who Experienced Gender Based Violence in Ethiopia: A Systematic Review and Meta-Analysis.","authors":"Agerie Mengistie Zeleke, Yared Mulu Gelaw, Tadesse Getu, Abrham Degu Melesse, Wenpeng You","doi":"10.1177/23259582261473483","DOIUrl":"10.1177/23259582261473483","url":null,"abstract":"<p><p>IntroductionOngoing internal conflicts in Ethiopia have increased women's exposure to gender-based violence (GBV), placing them at greater risk of mental distress. Although the Ethiopian Ministry of Health, in collaboration with multiple stakeholders, has implemented interventions to address the mental health needs of GBV survivors, synthesized evidence on the prevalence of mental distress and its associated factors remains limited. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of mental distress and identify factors associated with mental distress among women who have experienced GBV in Ethiopia.MethodWe conducted a systematic review and meta-analysis by searching major databases, including PubMed, Scopus, Wiley Online Library, African Journals Online, Web of Science, and ScienceDirect, from January 1, 2026, to February 1, 2026. Google Scholar was also searched. Data were extracted using a standardised Excel form and analysed using STATA version 11. Forest plots, Cochran's Q test, and subgroup analyses were used to assess heterogeneity. Publication bias was evaluated using funnel plots and Egger's regression test. A random-effects model was applied to estimate the pooled prevalence of mental distress.ResultThe pooled prevalence of mental distress among women who experienced gender-based violence in Ethiopia was 62.38% (95% CI: 54.18, 70.57) among 5510 study participants. Lack of formal education(AOR:2.43,95%CI:1.79,3.31),being widowed or separated, rural residence(AOR: 2.10, 95% CI: 1.59,2.76), low monthly income (AOR:2.44,95%CI: 1.49,4.00), exposure to stressful life events(AOR:2.15, 95% CI: 1.03, 23.38), and a family history of mental illness (AOR: 4.56, 95% CI: 2.54,8.21), husbanded substance abused(AOR:2.64,95%CI:1.86,3.75), strong social support (AOR: 0.37, 95% CI: 0.22, 0.61) were identified factors for mental distress.ConclusionMental distress is highly prevalent among women who experience gender-based violence in Ethiopia. Lack of formal education, rural residence, low income, husband's substance abuse, having social support, and a family history of mental illness were identified as factors for mental distress. There is an urgent need to strengthen integrated and targeted interventions to address this substantial psychological burden. Strengthening community and family-based social support systems should be prioritised given their strong protective effect.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261473483"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and Contextual Determinants of HIV Testing Practices Among Adolescent Girls and Young Women in Sub-Saharan Africa: A Multi-Level Mixed-Effects Analysis.","authors":"Tsegaamlak Kumelachew Derse, Desalegn Mitiku Kide, Addisu Simachew Asgai, Tadios Lidetu, Jenberu Mekurianew Kelkay, Zemenu Addis, Asaye Worku Agegn","doi":"10.1177/23259582261494706","DOIUrl":"https://doi.org/10.1177/23259582261494706","url":null,"abstract":"<p><p>BackgroundAdolescent girls and young women (AGYW) in Sub-Saharan Africa (SSA) face a disproportionate HIV risk. Achieving UNAIDS 95-95-95 targets requires high diagnostic coverage, yet critical gaps persist. This multi-country study evaluated individual- and community-level factors associated with HIV testing across 21 SSA nations.MethodsSecondary data analysis was performed on a pooled sample of 92,935 young women (ages 15-24) from recent Demographic and Health Surveys (DHS) across 1,678 primary sampling units (clusters). Multi-level mixed-effects logistic regression was utilized to assess individual (Level-1) and contextual community-level (Level-2) factors associated with lifetime HIV testing practices.ResultsLifetime HIV testing prevalence was 44.74% (n = 41,576), exposing a 55.26% testing gap. In the fully adjusted model (Model III), age (20-24 vs. 15-19 years: Adjusted Odds Ratio (AOR) = 2.342, 95% Confidence Interval (CI: 2.262, 2.424) and higher formal education (AOR) = 4.975, 95% (CI: 4.548, 5.443) were strongly associated with testing. Marital status showed significant associations, peaking among widowed, divorced, or separated women (AOR) = 5.160, 95% (CI: 4.665, 5.706). Comprehensive HIV knowledge doubled the odds of testing (AOR) = 2.024, 95% (CI: 1.958, 2.093). Contextually, high community media saturation was positively associated with testing (AOR) = 2.803, 95% (CI: 2.295, 3.422), whereas high community-level education demonstrated an inverse association (AOR) = 0.314, 95% (CI: 0.261, 0.378). The residual Median Odds Ratio (MOR = 1.30) indicated moderate cluster-level variation.ConclusionHIV testing practices among SSA young women are associated with nested sociodemographic, cognitive, and community-level factors. Strategies targeting expanded community media engagement, youth-friendly out-of-clinic screening, and discreet HIV self-testing options may help improve diagnostic coverage.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261494706"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incident Hypertension with Antiretroviral Therapy in the OPERA Cohort.","authors":"Gerald Pierone, Laurence Brunet, Jennifer S Fusco, Philip C Lackey, Michael B Wohlfeiler, Douglas T Dieterich, Cassidy Henegar, Vani Vannappagari, Bryn Jones, Annemiek de Ruiter, Gregory P Fusco","doi":"10.1177/23259582261445148","DOIUrl":"10.1177/23259582261445148","url":null,"abstract":"<p><p>Purpose of the researchTo compare incident hypertension rates across antiretroviral therapy regimens among adults with HIV in routine clinical care in the US-based OPERA cohort.Major findingsThe hypertension incidence rate was 4.16 per 100 person-years (95% CI: 3.75, 4.61) among 3220 ART-naïve individuals, and 4.60 (95% CI: 3.99, 5.30) among 1442 ART-experienced individuals. There was no statistically significant difference in incident hypertension between regimens at the class-level (integrase inhibitor with/without tenofovir alafenamide (TAF), boosted protease inhibitor, and non-nucleoside reverse transcriptase inhibitor) nor the drug-level (dolutegravir three-drug regimen with/without TAF, dolutegravir/lamivudine, bictegravir/emtricitabine/TAF, and boosted darunavir with TAF three-drug regimen).ConclusionsIn this large cohort representing routine clinical care in the USA, classes of antiretrovirals and specific agent combinations with or without TAF were not statistically significantly associated with incident hypertension. Other factors are likely to be more important drivers of hypertension than antiretroviral therapy selection in people with HIV.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261445148"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of Small-Group Education and Community Partner Networking for Reengagement and Retention in Clinical Services Among People With HIV in the United States.","authors":"Gena Dolson, Amanda Glazar, Kellie L Hawkins, Stacey B Trooskin, Aima A Ahonkhai, Becky Carney","doi":"10.1177/23259582261457314","DOIUrl":"10.1177/23259582261457314","url":null,"abstract":"<p><p>ObjectiveThe <i>Building HIV Pathways</i> initiative was developed to address gaps in retention in HIV care.MethodsThe initiative consisted of small-group didactic sessions and faculty/participant discussions with HIV providers and external partners.ResultsWe delivered small-group educational sessions to 219 participants at 9 HIV clinics. The average relative gain in confidence at posttraining in regard to implementing measures to identify and reengage patients with care was 27% (<i>P</i> < .01) and at 30-day follow-up was 22% (<i>P</i> < .01). Intent-to-change practices at posttraining around identifying patients no longer attending clinic were observed, including intent to improve use of resources and increase collaboration with external organizations. There was a 58% increase (<i>P</i> < .01) in collaboration with external partners at follow-up.ConclusionThe <i>Building HIV Pathways</i> initiative demonstrated that in-person, small-group education and strengthening linkages with external partners can improve HIV clinic staff awareness and help build relationships with community partners to reengage patients in HIV clinical services.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261457314"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Antiretroviral Therapy and Its Predictors Among Clients Enrolled to Community Differentiated ART Service Delivery Model in Amhara Region, Ethiopia, 2024; Multi-Centered Retrospective Follow up Study.","authors":"Tadewos Kassaw Tarekegn, Hailemarriam Mekonnen, Birhanu Melaku, Addisu Simachew Asgai, Tadios Lidetu","doi":"10.1177/23259582261475556","DOIUrl":"10.1177/23259582261475556","url":null,"abstract":"<p><p>BackgroundCommunity-based ART service delivery brings HIV care closer to clinically stable clients and may improve outcomes while reducing burdens on patients and health facilities. However, evidence from low income setting remains limited.MethodsInstitution based retrospective follow-up study was conducted from 422 adult ART users selected by simple random sampling. Data were analyzed using STATA 15. Multivariable Cox proportional hazards regression identified predictors of treatment outcomes.ResultsThe cumulative incidence of good ART treatment outcome was 81.99% (95% CI: 77.98-85.54%). Median survival time was 11 months (IQR: 5-12). Missing ART doses reduced survival by 54% (AHR=0.46; 95% CI: 0.22-0.95). Good retention in care (AHR=1.58), tuberculosis prophylaxis (AHR=1.38), and adequate drug supply (AHR=1.39) significantly improved survival.ConclusionTreatment outcomes were suboptimal. Strengthening retention, tuberculosis prophylaxis, drug supply, and adherence support could improve survival.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582261475556"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Daily Oral PrEP at HIV/AIDS Service Organizations in Lima, Peru: Early Findings From the PrEP PERU Demonstration Study.","authors":"Pamela Ramírez, Alexander J Lankowski, Jorge A Gallardo-Cartagena, Pedro Gonzales, Javier Valencia, Javier R Lama, Mey León, Javier Salvatierra, Hugo Sanchez, Robinson Cabello, Kelika A Konda, Jorge L Sanchez","doi":"10.1177/23259582251411793","DOIUrl":"10.1177/23259582251411793","url":null,"abstract":"<p><p>BackgroundDespite global declines in HIV incidence, new infections continue to rise in Latin America. Oral tenofovir-based HIV pre-exposure prophylaxis (PrEP) is effective and can reduce incidence where implemented. PrEP PERU is a prospective cohort study evaluating daily oral PrEP delivery at HIV/AIDS service organizations (ASOs) in Peru.MethodsWe assessed 12-month PrEP retention and adherence among men who have sex with men (MSM) enrolled at 4 ASOs in Lima before the COVID-19 pandemic. The analysis included participants with ≥12 months of follow-up before the March 2020 lockdown. Follow-up visits occurred at weeks 4, 12, and quarterly thereafter. We used robust Poisson regression to evaluate associations between baseline characteristics and 2 outcomes: retention (attending ≥3 follow-up visits within 12 months) and optimal adherence (proportion of days covered ≥80%).ResultsAmong 264 MSM who initiated PrEP, median age was 31 years (IQR: 27-37). Retention at 12 months was 71%, and 55% achieved optimal adherence. Retention was associated with age ≥30 and bisexual identity in adjusted models. Optimal adherence was associated with being employed at baseline.ConclusionsPrEP delivery through ASOs in Lima is feasible and supports sustained engagement among MSM. Targeted strategies are needed to improve outcomes among younger individuals.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"25 ","pages":"23259582251411793"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}