Journal of the Egyptian National Cancer Institute最新文献_第5页

Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature 特鲁索综合征胰腺癌患者的预后：日本文献中病例报告的系统回顾

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-12-14 DOI: 10.1186/s43046-023-00202-2

Munehiro Wakabayashi, Yoshinori Kikuchi, Kazuhisa Yamaguchi, Takahisa Matsuda

引用次数: 0

Impact of family history of cancer on colorectal cancer screening: a propensity score-matched analysis from the Health Information National Trends Survey (HINTS) 癌症家族史对大肠癌筛查的影响：全国健康信息趋势调查（HINTS）的倾向得分匹配分析

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-12-11 DOI: 10.1186/s43046-023-00201-3

Maxwell Akonde, Eric Mishio Bawa, Ottovon Bismark Dakurah, Rajat Das Gupta

{"title":"Impact of family history of cancer on colorectal cancer screening: a propensity score-matched analysis from the Health Information National Trends Survey (HINTS)","authors":"Maxwell Akonde, Eric Mishio Bawa, Ottovon Bismark Dakurah, Rajat Das Gupta","doi":"10.1186/s43046-023-00201-3","DOIUrl":"https://doi.org/10.1186/s43046-023-00201-3","url":null,"abstract":"Early detection of colon cancer leads to better survival outcomes. This can be achieved through colorectal cancer (CRC) screening. People with a family history of cancer (FHC) have increased risk of developing CRC. Increasing screening in this group will reduce CRC mortality. This study evaluated CRC screening in people with FHC. The study used data from the Health Information National Trends Survey (HINTS) 5, cycle 3. This is an annual cross-sectional survey with a nationally representative sample of American adults. The objective was to study the association between FHC and performing CRC screening. Propensity score matching was used to create a matched population with variables that constituted beliefs in cancer from the survey. Replication procedure, which is based on repeated sampling and allows for accurate computation of standard errors, was used for calculating statistical tests. Multivariable models were fitted in the matched population to assess the association between FHC and performing CRC screening. People with FHC were 14% (OR = 1.14; 95% CI: 0.81–1.60) more likely to perform CRC screening than those without FHC, even though not statistically significant. Age in years (OR = 1.14; 95% CI: 1.12–5.27) had increased likelihood of performing CRC screening, while other races such as American Indians/Alaskan Natives (except African Americans) compared to Caucasians (OR = 0.49; 95% CI: 0.29–0.84) had significantly decreased likelihood of performing CRC screening. FHC was not significantly associated with having a colorectal cancer screening test. Public health advocacy should be directed towards increasing awareness of CRC screening among people with FHC.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"4 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of high- and low-risk human papillomavirus genotypes and their prophylactic vaccination coverage among West African women: systematic review. 高危和低危人乳头瘤病毒基因型分布及其在西非妇女中的预防性疫苗接种覆盖率:系统评价

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-12-07 DOI: 10.1186/s43046-023-00196-x

Rogomenoma Alice Ouedraogo, Ali Kande, Wendyam Marie Christelle Nadembega, Djeneba Ouermi, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Charlemagne Marie Ragnag-Newende Ouedraogo, Olga Mélanie Lompo, Jacques Simpore

{"title":"Distribution of high- and low-risk human papillomavirus genotypes and their prophylactic vaccination coverage among West African women: systematic review.","authors":"Rogomenoma Alice Ouedraogo, Ali Kande, Wendyam Marie Christelle Nadembega, Djeneba Ouermi, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Charlemagne Marie Ragnag-Newende Ouedraogo, Olga Mélanie Lompo, Jacques Simpore","doi":"10.1186/s43046-023-00196-x","DOIUrl":"10.1186/s43046-023-00196-x","url":null,"abstract":"Introduction: The second most deadly gynecological cancer worldwide, cervical cancer is steadily on the rise in sub-Saharan Africa, while vaccination programs are struggling to get off the ground. This systematic review's aim was to assess the prevalence and distribution of high- and low-risk HPV genotypes in West African women.Methods: Original studies were retrieved from PubMed/Medline, Embase, Scopus, Google Scholar, and Science Direct. In these studies, Human papillomavirus (HPV) DNA was assessed in cervical samples by polymerase chain reaction (PCR), Hybrid capture, and sequencing. The quality of the articles was assessed and the results were extracted and reviewed.Results: Thirty-nine studies from 10 West African countries were included for the systematic review including 30 for the pooled analysis. From an overall of 17358 participants, 5126 of whom were infected with at least one HPV genotype, the systematic review showed a prevalence varying from 8.9% to 81.8% in the general population. In contrast, the pooled prevalence of infection was 28.6% (n = 3890; 95% CI 27.85-29.38), and HPV-52 (13.3%), HPV-56 (9.3%), and HPV-35 (8.2) were the most frequent. Quadrivalent and nonavalent vaccines covered 18.2% and 55.8% of identified genotypes respectively.Conclusion: Faced with this growing public health challenge in West Africa, it would be necessary for all its countries to have reliable data on HPV infection and to introduce the nonavalent vaccine. A study of the genotypic distribution of HPV in high-grade precancerous lesions and cervical cancer would be very useful in West Africa.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"39"},"PeriodicalIF":1.8,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of current literature on gestational trophoblastic neoplasia. 妊娠滋养细胞瘤的文献综述。

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-11-27 DOI: 10.1186/s43046-023-00195-y

Mehwish Shahzadi, Saqib Raza Khan, Muhammad Tariq, Sehrish Sarwar Baloch, Aisha Shahid, Munira Moosajee, Zarka Samon

{"title":"Review of current literature on gestational trophoblastic neoplasia.","authors":"Mehwish Shahzadi, Saqib Raza Khan, Muhammad Tariq, Sehrish Sarwar Baloch, Aisha Shahid, Munira Moosajee, Zarka Samon","doi":"10.1186/s43046-023-00195-y","DOIUrl":"10.1186/s43046-023-00195-y","url":null,"abstract":"Background: Gestational Trophoblastic Neoplasia (GTN) is a disease of the reproductive age group with an incidence rate of <1% among all tumors involving the female reproductive tract. It occurs because of aberrant fertilization. Patients are diagnosed early because of aggravated symptoms during pregnancy. Moreover, patients also bleed from the tumor sites, which leads to early presentation. A cure rate of 100% can be achieved with adequate treatment.Main body: In this literature review, the authors have brought to attention the risk factors, classification, and various treatment options in GTN patients according to their stratification as per the WHO scoring system. Patients are categorized into low and high risk based on the FIGO scoring system. Patients with low risk are treated with single-agent methotrexate or actinomycin-D. Despite the superiority of actinomycin-D in terms of efficacy, methotrexate remains the first choice of therapy in low-risk patients due to its better toxicity profile. Multi-agent chemotherapy with etoposide, methotrexate, actinomycin-D, cyclophosphamide and vincristine (EMA-CO) leads to complete remission in 93% of high-risk GTN patients. Around 40% of patients with incomplete responses are salvaged with platinum-based multi-agent chemotherapy. Isolated chemo-resistant clones can be salvaged with surgical interventions.Conclusion: The mortality in patients with GTN has significantly reduced over time. With adequate multi-disciplinary support, patients with GTN can ultimately be cured and can spend every day healthy reproductive life.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"37"},"PeriodicalIF":1.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting average length of hospital stay as a control measure to decrease COVID-19 hospital-acquired infection in surgical cancer patients. 以平均住院时间为控制指标降低外科肿瘤患者COVID-19医院获得性感染

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-11-20 DOI: 10.1186/s43046-023-00199-8

Sarah S Nasr, Ghada M Sherif, Maha Abdel Wahab, Hatem Aboelkasem

{"title":"Targeting average length of hospital stay as a control measure to decrease COVID-19 hospital-acquired infection in surgical cancer patients.","authors":"Sarah S Nasr, Ghada M Sherif, Maha Abdel Wahab, Hatem Aboelkasem","doi":"10.1186/s43046-023-00199-8","DOIUrl":"10.1186/s43046-023-00199-8","url":null,"abstract":"Background: The global spread of coronaviruses had a great impact on the economic and social situation of most countries. As the backbone of any society, the health sector made a significant contribution through applying emergency risk management plans in order to control the pandemic. Monitoring the average length of hospital stay (ALOS) was an effective way to release the capacity of the health system during this time. The aim was to evaluate the effect of applying risk assessment/management strategies on ALOS and the impact of this ALOS on COVID-19 infection rates among cancer patients.Methods: This is a prospective cohort study. All admitted cancer patients in 6 surgical departments from January to June 2021 were included.Results: A total of 1287 patients were admitted to 6 surgical departments during the selected period. About 46% of them had surgery (n = 578), while 54% did not have surgery (n = 700). Among surgical patients, admission rates were highest in February and head and neck department (24% and 22.1%, respectively), and lowest in April and chest department (12.4% and 8%, respectively). ALOS was significantly different across the 6 months (p value < 0.001) with lower ALOS in (April, May, and June) than in (January-February, and March). No significant difference was found across the 6 surgical departments (p value = 0.423). Twenty-eight patients became COVID-19 positive after admission, 25 of them (89%) were infected from March to June-during the time of the third wave-and a significant decreasing linear trend (p value = 0.009) was found.Conclusion: ALOS had significantly reduced with commitment to infection control (IC) interventions and recommendations. The significant decreasing trend of COVID-19 infection from March to June (unlike the rising curve of the 3rd COVID-19 wave by that time) could be explained by improvement in ALOS.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"36"},"PeriodicalIF":1.8,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cell therapy for hepatocellular carcinoma and end-stage liver disease. 肝细胞癌和终末期肝病的干细胞治疗。

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-11-06 DOI: 10.1186/s43046-023-00194-z

Mona S Abdellateif, Abdel-Rahman N Zekri

{"title":"Stem cell therapy for hepatocellular carcinoma and end-stage liver disease.","authors":"Mona S Abdellateif, Abdel-Rahman N Zekri","doi":"10.1186/s43046-023-00194-z","DOIUrl":"https://doi.org/10.1186/s43046-023-00194-z","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a major health problem worldwide, especially for patients who are suffering from end-stage liver disease (ESLD). The ESLD is considered a great challenge for clinicians due to the limited chance for liver transplantation, which is the only curative treatment for those patients. Stem cell-based therapy as a part of regenerative medicine represents a promising application for ESLD patients. Many clinical trials were performed to assess the utility of bone marrow-derived stem cells as a potential therapy for patients with liver diseases. The aim of the present study is to present and review the various types of stem cell-based therapy, including the mesenchymal stem cells (MSCs), BM-derived mononuclear cells (BM-MNCs), CD34 + hematopoietic stem cells (HSCs), induced pluripotent stem cells (iPSCs), and cancer stem cells.Though this type of therapy achieved promising results for the treatment of ESLD, however still there is a confounding data regarding its clinical application. A large body of evidence is highly required to evaluate the stem cell-based therapy after long-term follow-up, with respect to the incidence of toxicity, immunogenicity, and tumorigenesis that developed in many patients.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"35"},"PeriodicalIF":1.8,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71482949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameloblastic fibro-dentinoma: a rare mixed odontogenic tumor case report with review of literature. 成釉纤维牙本质瘤：一例罕见的牙源性混合肿瘤病例报告及文献复习。

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-10-30 DOI: 10.1186/s43046-023-00193-0

Nihal Mohamed Ahmed Darwish, Hatem Wael Abdel-Fattah Amer, Nesma Nabil Mohamed Mahrous

{"title":"Ameloblastic fibro-dentinoma: a rare mixed odontogenic tumor case report with review of literature.","authors":"Nihal Mohamed Ahmed Darwish, Hatem Wael Abdel-Fattah Amer, Nesma Nabil Mohamed Mahrous","doi":"10.1186/s43046-023-00193-0","DOIUrl":"https://doi.org/10.1186/s43046-023-00193-0","url":null,"abstract":"Background: Ameloblastic fibro-dentinoma is considered a rare, benign, mixed odontogenic tumor that occurs mainly in the posterior mandible in the 1st-2nd decade of life. Although the clinical behavior of Ameloblastic fibro-dentinoma is similar to that of ameloblastic fibroma, there is a debate about whether Ameloblastic fibro-dentinoma is a developing hamartomatous odontoma or a separate neoplastic odontogenic tumor like ameloblastic fibroma. However, it is important to understand the histopathogenesis of this rare tumor.Case presentation: A case report presenting an 11-year-old male child with a swelling in the posterior mandible. Radiographic examination revealed a multilocular lesion with mixed radiodensity related to the impacted lower left second premolar tooth. Incisional biopsy was done, and microscopic examination revealed cords and nests of odontogenic follicles lined by ameloblast-like cells and central stellate reticulum-like cells in the primitive ecto-mesenchymal stroma with areas of dentinoid material and osteodentin. The diagnosis was ameloblastic fibro-dentinoma. Surgical excision of the lesion was done, and the patient was followed up for 1 year without evidence of recurrence.Conclusion: Reporting such a rare entity clarifies the debate about its nature and the importance of early diagnosis of lesions that are associated with unerupted teeth showing how it is effective in early management and prognosis.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"34"},"PeriodicalIF":1.8,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiological modulation of hepatoma cell lines and hepatitis B subviral particles secretion in response to 650 nm low level laser treatment. 650nm低水平激光治疗对肝癌细胞系和乙型肝炎亚病毒颗粒分泌的光生物学调节。

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-10-23 DOI: 10.1186/s43046-023-00190-3

Ghada M Al-Toukhy, Reda A Suef, Sarah Hassan, Mohamed M S Farag, Tarek A El-Tayeb, Mohamed T M Mansour

{"title":"Photobiological modulation of hepatoma cell lines and hepatitis B subviral particles secretion in response to 650 nm low level laser treatment.","authors":"Ghada M Al-Toukhy, Reda A Suef, Sarah Hassan, Mohamed M S Farag, Tarek A El-Tayeb, Mohamed T M Mansour","doi":"10.1186/s43046-023-00190-3","DOIUrl":"10.1186/s43046-023-00190-3","url":null,"abstract":"Background: Chronic hepatitis B virus (HBV) infection is a serious global health concern, with an increased incidence and risk of developing cirrhosis and hepatocellular carcinoma (HCC). Patients chronically infected with HBV are likely to experience chronic oxidative stress, leading to mitochondrial dysfunction. Photobiomodulation is induced by the absorption of low-level laser therapy (LLLT) with a red or infrared laser by cytochrome C oxidase enzyme, resulting in mitochondrial photoactivation. Although it is widely used in clinical practice, the use of LLL as adjuvant therapy for persistent HBV infection is uncommon. This study aimed to investigate the effect of LLLT dosage from 2 J/cm2 to 10 J/cm2 of red diode laser (650 nm) on both hepatoma cell lines (HepG2.2.15 [integrated HBV genome stable cell model] and non-integrated HepG2), with a subsequent impact on HBVsvp production.Methods: The present study evaluated the effects of different fluences of low-level laser therapy (LLLT) irradiation on various aspects of hepatoma cell behavior, including morphology, viability, ultrastructure, and its impact on HBVsvp synthesis.Results: In response to LLLT irradiation, we observed a considerable reduction in viability, proliferation, and HBVsvp production in both hepatoma cell lines HepG2.2.15 and HepG2. Ultrastructural modification of mitochondria and nuclear membranes: This effect was dose, cell type, and time-dependent.Conclusions: The use of LLLT may be a promising therapy for HCC and HBV patients by reducing cell proliferation, HBVsvp production, and altering mitochondrial and nuclear structure involved in cellular death inducers. Further research is required to explore its clinical application.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"33"},"PeriodicalIF":1.8,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapeutic strategy in the management of gastric cancer: molecular profiles, current practice, and ongoing trials. 癌症治疗中的免疫治疗策略：分子概况、当前实践和正在进行的试验。

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-10-02 DOI: 10.1186/s43046-023-00192-1

Mengxiao Lu, Yingjie Wu, Yixin Zhang, Yu Yu, ShengJie Wang, Xiaobao Su

引用次数: 0

Micronuclei detection in oral cytologic smear: does it add diagnostic value? 口腔细胞学涂片微核检测：是否增加诊断价值？

IF 1.8

Journal of the Egyptian National Cancer Institute Pub Date : 2023-09-25 DOI: 10.1186/s43046-023-00188-x

Alaa Elnaggar, Gihane Madkour, Neveen Tahoun, Ayman Amin, Fat'heya M Zahran

{"title":"Micronuclei detection in oral cytologic smear: does it add diagnostic value?","authors":"Alaa Elnaggar, Gihane Madkour, Neveen Tahoun, Ayman Amin, Fat'heya M Zahran","doi":"10.1186/s43046-023-00188-x","DOIUrl":"10.1186/s43046-023-00188-x","url":null,"abstract":"Background: Screening and early diagnosis of oral squamous cell carcinoma (OSCC) are directly associated with increased survival rate and improved prognosis. Noninvasive diagnostic tools have been implemented in the early detection as toluidine blue staining, optical imaging, and oral cytology. This study aimed to assess and compare the presence of micronuclei (MN) in oral exfoliative cytology of healthy controls, subjects exposed to high-risk factors for oral cancer, subjects with oral potentially malignant lesions (OPMLs), and those with malignant oral lesions.Subjects and methods: A total number of 92 subjects were divided into 46 healthy controls with no oral mucosal lesions (23 with no evidence of cancer risk factors and 23 with cancer risk factors), 23 with OPMLs and 23 with oral malignant lesions. All the 92 participants were subjected to cytological sampling for detection of MN. The final diagnosis of the oral lesions was confirmed by the histopathological picture and compared to the cytological results.Results: The results showed that the diagnostic accuracy of MN was higher in OPMLs group (95.2%). The sensitivity of MN test in malignant group was much lower (52.2%); however, all the cytological criteria of malignancy were markedly detected as compared to the OPMLs group.Conclusions: Conventional oral cytology supported by MN is highly beneficial as adjunctive tool in the screening for early detection of dysplastic oral lesions.","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"35 1","pages":"31"},"PeriodicalIF":1.8,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0