Journal of the Brazilian Chemical Society最新文献_第4页

FeCl3-Catalyzed Cross-Coupling for Improving the Synthesis of Upadacitinib fecl3催化交叉偶联改进Upadacitinib的合成

4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-16 DOI: 10.21577/0103-5053.20230165

Ziling Li, Chundiao Shi, Shengchang Xiang, Chulong Liu, Ximing Zheng

引用次数: 0

Design and Evaluation of Systemic Administration of Nano Silica MCM48:Eu3+ in Mouse Brain 纳米二氧化硅MCM48:Eu3+在小鼠脑内系统给药的设计与评价

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230056

L. Azevedo, B. Andrade-da-Costa, R. Augusto, L. Luz, I. de Souza, Licarion Pinto, I. Alves, S. Alves Júnior

{"title":"Design and Evaluation of Systemic Administration of Nano Silica MCM48:Eu3+ in Mouse Brain","authors":"L. Azevedo, B. Andrade-da-Costa, R. Augusto, L. Luz, I. de Souza, Licarion Pinto, I. Alves, S. Alves Júnior","doi":"10.21577/0103-5053.20230056","DOIUrl":"https://doi.org/10.21577/0103-5053.20230056","url":null,"abstract":"In the present study, we tested the proof of concept that mobil mesoporous silica nanoparticle composition of matter (MCM) No. 48 doped with trivalent europium (nanoMCM48:Eu3+) administered systemically intravenously can act as a suitable vehicle to deliver neural cells to the brain of healthy adult Swiss mice without causing tissue damage. Moreover, we also tested the ability of this nanoparticle to release molecules in vitro, using as drug models caffeine or nicotine in phosphate buffer solution with pH 7.4 adequate to intra and extra-celular medium of the brain. The caffeine and nicotine adsorbed nanoparticles (CAF@MCM48:Eu3+ and NIC@MCM48:Eu3+) were observed in the parenchyma of the cerebral cortex and diffusely dispersed in the cellular cytoplasm. Statistical analysis using multivariate partner recognition methods indicated that there was no sign of cell damage, as it was characterized by chromatin condensation, nuclear condensation, or fragmentation. The characterization of nanoMCM48:Eu3+ as particle size, luminescent properties and release of active components were analyzed. The CAF@MCM48:Eu3+ and NIC@MCM48:Eu3+ nanoparticles were observed in the cerebral cortex parenchyma and diffusely dispersed in the cell cytoplasm, and the release of active components was analyzed. Therefore, the studies showed that mesoporous silica nanoparticles administered systemically via intravenous tissue can act as a suitable vehicle for neural cells in the brain of healthy mice without causing damage.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68336194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wavepress is a User-Friendly Toolkit for Computational Chemistry, Drug Design and Material Science Wavepress是一个用户友好的计算化学，药物设计和材料科学工具包

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230057

M. Gonçalves, Cleiton Nunes, T. Sáfadi, Teodorico C. Ramalho

引用次数: 1

Synthesis of Fentanyl Triazole Derivatives and their Affinity for Mu-Opioid and Sigma-1 Receptors 芬太尼三唑衍生物的合成及其对mu -阿片和Sigma-1受体的亲和力

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230059

Ruth Paulino, R. Alves, Joanna Matalińska, Piotr F. J. Lipiński, R. Freitas

引用次数: 0

Preparation of Composite Films of Sodium Alginate-Based Extracted from Seaweeds Macrocystis pyrifera and Lessonia trabeculata Loaded with Aminoethoxyvinylglycine 氨基乙氧基乙烯基甘氨酸海藻酸钠复合膜的制备

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230064

N. A. Villacrés, É. Cavalheiro, Carla C Schmitt, T. Venâncio, H. Alarcón, A. Valderrama

{"title":"Preparation of Composite Films of Sodium Alginate-Based Extracted from Seaweeds Macrocystis pyrifera and Lessonia trabeculata Loaded with Aminoethoxyvinylglycine","authors":"N. A. Villacrés, É. Cavalheiro, Carla C Schmitt, T. Venâncio, H. Alarcón, A. Valderrama","doi":"10.21577/0103-5053.20230064","DOIUrl":"https://doi.org/10.21577/0103-5053.20230064","url":null,"abstract":"Composite films are an alternative in the replacement of synthetic polymers. These films can be prepared from polysaccharides and used to store various drugs to be applied in different areas. In addition, aminoethoxyvinylglycine (AVG) is an ethylene inhibitor that prolongs shelf life of food. For this reason, this research aimed to take advantage of the brown algae Macrocystis pyrifera and Lessonia trabeculata to extract sodium alginate and produce films composed of sodium alginate/ kappa-carrageenan/iota-carrageenan, which were plasticized with glycerol and polyethylene glycol 400 and loaded with aminoethoxyvinylglycine. The extracted sodium alginate was characterized by 1 H and 13C nuclear magnetic resonance (NMR), size exclusion chromatography coupled with multi-angle light scattering (SEC-MALS), thermogravimetry (TG/DTG), Fourier transform infrared (FTIR), and X-ray diffraction (XRD); and the composite films were characterized by FTIR, XRD, TG/DTG, and scanning electron microscopy (SEM). Then, the drug release kinetics were investigated using Higuchi and Korsmeyer-Peppas kinetic models. The extracted alginates obtained were of low molecular weight, and the films showed desirable properties for AVG release. Furthermore, drug release profiles revealed that AVG release is governed by Fick’s Law, and this is favored at low temperatures. In summary, sodium alginate allows the preparation of composite films, which can replace synthetic polymers to be used in the loading and releasing of drugs.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosa 鼻杆菌颗粒状副腺分泌的代谢组学特征和生物活性研究

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230052

E. D. Barros, Evaldo dos Santos Monção Filho, Mariluce Fonseca, P. Alves, A. L. Santos, C. Feitosa, Dulce Helena Silva, Pedro M S Costa, C. Pessoa, Carmem D L Campos, C. Monteiro, M. Chaves, G. V. Vieira Júnior

{"title":"Unraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosa","authors":"E. D. Barros, Evaldo dos Santos Monção Filho, Mariluce Fonseca, P. Alves, A. L. Santos, C. Feitosa, Dulce Helena Silva, Pedro M S Costa, C. Pessoa, Carmem D L Campos, C. Monteiro, M. Chaves, G. V. Vieira Júnior","doi":"10.21577/0103-5053.20230052","DOIUrl":"https://doi.org/10.21577/0103-5053.20230052","url":null,"abstract":"Toads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piauí state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 µg mL-1) and prostate (IC50 = 1.6 µg mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 µg mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68335116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Phytotoxic Evaluation of 3-Indolylglycine Derivatives as New Natural-Like Herbicides 新型天然除草剂3-吲哚甘氨酸衍生物的合成及植物毒性评价

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230058

A. Amaral, Julia Willig, C. Olguin, I. Oliveira, H. Stefani, G. Botteselle, F. Manarin

引用次数: 0

Mitochondria-Targeted Ergosterol Peroxide Derivatives: Synthesis, Anticancer Properties and Their Preliminary Mechanism of Inhibiting MCF-7 Cell Proliferation 线粒体靶向过氧化麦角甾醇衍生物的合成、抗癌特性及其抑制MCF-7细胞增殖的初步机制

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230054

Wenkang Ren, Jiale Wu, Jiafeng Wang, Haijun Wang, Ying Han, Yu Lin, M. Bu

{"title":"Mitochondria-Targeted Ergosterol Peroxide Derivatives: Synthesis, Anticancer Properties and Their Preliminary Mechanism of Inhibiting MCF-7 Cell Proliferation","authors":"Wenkang Ren, Jiale Wu, Jiafeng Wang, Haijun Wang, Ying Han, Yu Lin, M. Bu","doi":"10.21577/0103-5053.20230054","DOIUrl":"https://doi.org/10.21577/0103-5053.20230054","url":null,"abstract":"Ergosterol peroxide (EP) has been extensively studied for its antitumor activities. However, its further development has been restricted due to its limited intracellular accumulation and poor aqueous solubility. In this study, a novel triphenylphosphonium cation (TPP+) moiety was coupled to ergosterol peroxide to precisely target it at tumor cell mitochondria. The synthesized Mito-EP derivatives Mito-EP-3a-3d displayed stronger cytotoxicity than the EP parent and exhibited selectively cytotoxic effects between cancer cells and normal gastric epithelial (GES-1) cells. The most potent compound, Mito-EP-3b, was 9.7-fold more efficacious than ergosterol peroxide in the MCF-7 (breast cancer) cell line and showed good selectivity (SI = IC50GES-1/IC50MCF-7 = 4.04, IC50: concentrations to inhibit 50% of cell growth). Furthermore, Mito-EP-3b was able to decrease the mitochondrial membrane potential and induced reactive oxygen species production, accompanied by activating the expression of cytochrome c and Bax, while Bcl-2 expression was suppressed. The molecular mechanism may refer to the mitochondrial apoptotic pathway. Overall, the above results incentivize the further study of Mito-EP-3b derivatives as potent anticancer agents.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"184 21 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68336374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Potential Application of Membrane Obtained from Sisal Bagasse in the Removal of Inhibitors from the Fermentation Process 剑麻甘蔗渣膜在去除发酵过程中抑制剂方面的潜在应用

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230066

F. Xavier, A. Silva, M. Lima, M. D. da Fonseca, M. da Conceição

引用次数: 0

Evaluation of Wettability Alteration by Oil Doped with Organic Acid and Low-High Brine Solutions in Sandstone and Carbonate Rocks 砂岩和碳酸盐岩中有机酸掺杂油和低-高盐水对润湿性蚀变的评价

IF 1.4 4区化学

Journal of the Brazilian Chemical Society Pub Date : 2023-10-06 DOI: 10.21577/0103-5053.20230055

Veronica Santos, T. Felix, I. Mantovani, Rodrigo Balen, José da Cunha Neto, C. Fernandes, N. Debacher

{"title":"Evaluation of Wettability Alteration by Oil Doped with Organic Acid and Low-High Brine Solutions in Sandstone and Carbonate Rocks","authors":"Veronica Santos, T. Felix, I. Mantovani, Rodrigo Balen, José da Cunha Neto, C. Fernandes, N. Debacher","doi":"10.21577/0103-5053.20230055","DOIUrl":"https://doi.org/10.21577/0103-5053.20230055","url":null,"abstract":"Petroleum reserves available worldwide are geologically based mainly on sedimentary and carbonate rocks, and the reservoir performance depends on the intrinsic properties of each rock and their response to changes in wettability. Recently, the change in wettability with low-salinity brine has been used to improve the oil recovery, which is an environmentally friendly and low investment, but there is no unanimity about the mechanisms of oil recovery process. Therefore, the aim of this study is to investigate the process involved in the wettability associated with interactions between the surface of powdered reservoir rock samples and the surrounding fluids. The reservoir rock surface (sandstone, calcite and dolomite) was evaluated under three different conditions. The total amount of adsorbed oil on aged samples was twice as high in carbonate rocks as in sandstone. The thermal gravimetric analysis (TGA) for the desorption steps of the organic fraction on dolomite and calcite indicates that the treatment under high brine concentration favored the oil desorption and the opposite result was observed for sandstone. This behavior suggests that carbonate rocks adsorb more strongly the organic phase compared to sandstone.","PeriodicalId":17257,"journal":{"name":"Journal of the Brazilian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68336587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0