ACTA Medical Health Sciences最新文献_第3页

The learning impact of the Online Formative Assessment system (OFAs) for undergraduate medical students 在线形成性评估系统(OFAs)对医学本科学生学习的影响

ACTA Medical Health Sciences Pub Date : 2022-10-30 DOI: 10.35990/amhs.v1n2.p71-78

S. M. Sari, Hindun Saadah

{"title":"The learning impact of the Online Formative Assessment system (OFAs) for undergraduate medical students","authors":"S. M. Sari, Hindun Saadah","doi":"10.35990/amhs.v1n2.p71-78","DOIUrl":"https://doi.org/10.35990/amhs.v1n2.p71-78","url":null,"abstract":"Formative assessment is a continuum process of evaluating students’ performance to enhance\u0000\u0000students’ learning quality. The shift to full-online learning in pandemics reduces student-\u0000lecturer attachments during formative assessment. Therefore, we developed the Online\u0000\u0000Formative Assessment system (OFAs) based on a self-regulatory learning framework. This\u0000study aimed to explore the learning impact of OFAs, such as learning preparation, feedback\u0000perception, and self-reflection. We used the mixed method with an exploratory approach. We\u0000collected quantitative data from 150 students who experienced OFAs, using 26 questions\u0000adapted from AEQ (Assessment Experience Questionnaire) and analyzed by pre-post design\u0000(paired-T test). To explore a deeper understanding, we conducted 6 FGDs (N=28). Finally, we\u0000analyzed the quantitative and qualitative data sequentially. We found the difference in students’\u0000preparation (p<0.5), feedback perception (p<0.5), and no difference in self-reflection (p>0.5).\u0000In Qualitative data, we found three themes as follows: (1) OFAs improve student preparation\u0000in learning; 2) Students are aware of being assessed during tutorials; 3) Require more specific\u0000and individual written feedback; 4) Lack of self-reflection due to unspecific feedback. These\u0000findings represent that learning impact is a complex pathway that online assessment systems\u0000\u0000can drive. It needs externally driven feedback quality and internally driven factors such as self-\u0000reflection skills. However, we found the challenges to improving students' quality feedback and\u0000\u0000self-reflection skills. This study brings further research on student-lecturer engagement in\u0000online formative assessment.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116977010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Health Protocols and Incidence of COVID-19 in Young Doctors Complete Vaccinated 完成疫苗接种的年轻医生COVID-19健康方案特点及发病率

ACTA Medical Health Sciences Pub Date : 2022-10-30 DOI: 10.35990/amhs.v1n2_p79-87

Asti Kristianti, S. Q. Indriyana, Ilma Fiddiyanti

{"title":"Characteristics of Health Protocols and Incidence of COVID-19 in Young Doctors Complete Vaccinated","authors":"Asti Kristianti, S. Q. Indriyana, Ilma Fiddiyanti","doi":"10.35990/amhs.v1n2_p79-87","DOIUrl":"https://doi.org/10.35990/amhs.v1n2_p79-87","url":null,"abstract":"COVID-19 is a respiratory disease that has currently become a pandemic in the world. West\u0000Java is one of the provinces with the most cases of COVID-19 in Indonesia. Health workers\u0000\u0000including young doctors are a group that has a very high risk of getting infected with COVID-\u000019. The purpose of this study was to determine the characteristics of health protocols and\u0000\u0000COVID-19 cases in young doctors at Faculty of Medicine, General Achmad Yani University\u0000(FK UNJANI) who were fully vaccinated against COVID-19. This study was designed as a\u0000descriptive study with a cross-sectional approach. The characteristics assesses in this study\u0000were: age, gender, and a confirmed history of COVID-19. Data was collected in June 2021-\u0000September 2022 using google form to fill out a questionnaire. The questionnaire was filled out\u0000by 105 eligible respondents. Respondents have received at least 2 doses of the COVID-19\u0000vaccine and are aged between 22-23 years. The characteristics of respondents were 71 females\u0000(68.57%) and 33 males (31.43%). A total of 78.1% had confirmed COVID-19 and 21.9% had\u0000never been infected. A total of 52,4% respondents had good health protocols and 47.6% had\u0000poor health protocols.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126808565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac damage in an adolescent patient with COVID-19: a case report 青少年新冠肺炎患者心脏损伤1例报告

ACTA Medical Health Sciences Pub Date : 2022-10-30 DOI: 10.35990/amhs.v1n2.p88-96

P. Pujowaskito, T. S. Tartila, N. Tafriend, F. D. K. Jannah, Elsy Mayasari

{"title":"Cardiac damage in an adolescent patient with COVID-19: a case report","authors":"P. Pujowaskito, T. S. Tartila, N. Tafriend, F. D. K. Jannah, Elsy Mayasari","doi":"10.35990/amhs.v1n2.p88-96","DOIUrl":"https://doi.org/10.35990/amhs.v1n2.p88-96","url":null,"abstract":"COVID-19 has been found to affect the cardiovascular system leading to myocardial damage.\u0000A study of 41 patients in Wuhan, China, found that 12% of COVID-19 patients experienced\u0000virus-related acute cardiac damage.Subsequent bigger Chinese studies also found acute cardiac\u0000damage in 7.2% to 27.8% of hospitalized patients. As a chronicsequela, this condition may\u0000result in cardiomyopathy. We report acase of an adolescent COVID-19 survivor with dilated\u0000cardiomyopathy with no underlying heart disease. A male patient aged 16 years old was\u0000admitted to our outpatient clinic with the primary symptom of exhaustion and had recovered\u0000frommild to moderate COVID-19 one month prior to the visit. No previous history of heart\u0000disease was documented. Physical examination showed no abnormalities. Laboratory results\u0000revealed substantially elevated NT-proBNP (7705 pg/mL) and D-dimer (1850 ng/mL). ECG\u0000presented normal sinus rhythm with poorR wave progression. Echocardiography revealed all\u0000chamber dilatation, eccentric left ventricular hypertrophy, globalhypokinetic, moderate mitral\u0000regurgitation, and reduced ejection fraction (22%). We diagnosed the patient with new-onset\u0000dilated cardiomyopathy and began treatment with candesartan, bisoprolol, furosemide,\u0000spironolactone, rivaroxaban, and trimetazidine. The recovery was steady at three-month\u0000follow-up visit. The emergence of new-onset cardiomyopathy in this previously healthy\u0000adolescent raisesthepossibility of COVID-19 acting asthe sole cause of myocardial injuryin the\u0000absence of underlying heart disease. To avoid further complications, comprehensive evaluation\u0000and effective therapy should be implemented during hospitalization and post-discharge.\u0000Additional tests such as cardiac magnetic resonance imaging and endomyocardial biopsies\u0000shouldbe performed to support final proof.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124147968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between presbycusis with quality of life based on hearing handicap inventory for the elderly screening version (HHIE-S) 基于老年人听力障碍量表筛查版(HHIE-S)的老年性耳聋与生活质量的相关性研究

ACTA Medical Health Sciences Pub Date : 2022-10-30 DOI: 10.35990/amhs.v1n2_p54-63

Nurbaiti Nazarudin, Vania Nanda Priasty, Iwan Darmawan Ma’mur

{"title":"Correlation between presbycusis with quality of life based on hearing handicap inventory for the elderly screening version (HHIE-S)","authors":"Nurbaiti Nazarudin, Vania Nanda Priasty, Iwan Darmawan Ma’mur","doi":"10.35990/amhs.v1n2_p54-63","DOIUrl":"https://doi.org/10.35990/amhs.v1n2_p54-63","url":null,"abstract":"Presbycusis is an age-related hearing loss caused by a degeneration process which is a\u0000cumulative effect of various risk factors. Hearing Handicap Inventory for the Elderly-Screening\u0000version (HHIE-S) questionnaire is a questionnaire that can be used to measure the quality of\u0000life in patients with hearing loss. This study aimed to determine the relationship between\u0000presbycusis with the quality of life. The research uses cross sectional analytical research\u0000methods. The data used in form of primary data is the result of filling in the guided questionnaire\u0000and the results of the audiogram, while secondary data is in the form of medical records of\u0000presbycusis patients at Dustira Hospital in the period January 2017-December 2018. Data were\u0000analyzed by Chi-Square and Spearman Correlation Test. The incidence of presbycusis in the\u0000period January 2017-December 2018 at Dustira Hospital was 2,6%. The result showed most of\u0000the patients were 65-74 years old (61,8%), male (52,7%), married (58,2%), economic were\u0000similar between moderate and low economic status (49.1%), had a history of chronic diseases\u0000(76, 4%), had a moderate degree of hearing loss (61,8%) and had a mild-moderate degree of\u0000quality of life (52,7%). Based on HHIE-S questionnaire the results showed that there was a\u0000significant and strong relationship between presbycusis and patients’ quality of life (p <0.001)\u0000and r=0,509. In conclusion, degrees of hearing loss in presbycusis patients will correspond to\u0000degrees of decrease in quality of life.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116596186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in Mediterranean diet adherence on lipid profile and plasma atherogenic index in dyslipidemia patients 地中海饮食依从性对血脂异常患者血脂和血浆动脉粥样硬化指数的影响

ACTA Medical Health Sciences Pub Date : 2022-06-30 DOI: 10.35990/amhs.v1n1.p1-9

Dewi R Handayani, Khomaini Hasan, Iis Inayati Rakhmat, Endry Septiadi, Yudith Y Kusmala

{"title":"Differences in Mediterranean diet adherence on lipid profile and plasma atherogenic index in dyslipidemia patients","authors":"Dewi R Handayani, Khomaini Hasan, Iis Inayati Rakhmat, Endry Septiadi, Yudith Y Kusmala","doi":"10.35990/amhs.v1n1.p1-9","DOIUrl":"https://doi.org/10.35990/amhs.v1n1.p1-9","url":null,"abstract":"Dyslipidemia is lipid metabolism disorder as indicated by increase in total cholesterol,\u0000triglycerides, Low Density Lipoprotein (LDL) and decrease in High Density Lipoprotein\u0000(HDL). Riset Kesehatan Dasar (RISKESDAS) Database in 2018 showed 12.6% Indonesian\u0000population aged 55-64 years had high cholesterol and very high LDL and triglycerides. The\u0000Mediterranean diet is non-pharmacotherapeutic treatments in the form of nutrition therapy for\u0000dyslipidemic patients. This study aimed to determine differences of adherence to the\u0000Mediterranean diet on lipid profile and Plasma Atherogenic Index (PAI) in dyslipidemic\u0000patients at a private clinic in Bandung. It used an observational analytic method with a\u0000prospective cohort of 30 dyslipidemia patients. Sampling was done by systematic random\u0000sampling technique. The subjects were divided into 3 categories based on adherence, namely\u0000low, medium and high, then lipid profile examination and PAI were assessed at the end of the\u0000month. Total cholesterol, LDL, HDL data were analyzed using Anova and Post Hoc Tukey\u0000while triglycerides and PAI were analyzed using Kruskal Wallis and Mann Whitney. Adherence\u0000to the Mediterranean diet showed significant results on total cholesterol (p=0.007), LDL level\u0000(p=0.019), HDL level (p=0.006), triglycerides (p=0.005) and PAI (p=0.036). The result was\u0000associated due to the influence of food content rich in monounsaturated fatty acids (MUFA),\u0000polyunsaturated fatty acids (PUFA), phytosterols and polyphenols that affect the levels of lipid\u0000profiles and PAI.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117059971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of red guava fruitghurt in lowering blood glucose levels in streptozotocin induced rats 红番石榴果提取物降低链脲佐菌素诱导大鼠血糖水平的潜力

ACTA Medical Health Sciences Pub Date : 2022-06-30 DOI: 10.35990/amhs.v1n1.p19-27

Ania K. P. Dewi, Rona J H Dewi, Endry Septiadi

{"title":"Potential of red guava fruitghurt in lowering blood glucose levels in streptozotocin induced rats","authors":"Ania K. P. Dewi, Rona J H Dewi, Endry Septiadi","doi":"10.35990/amhs.v1n1.p19-27","DOIUrl":"https://doi.org/10.35990/amhs.v1n1.p19-27","url":null,"abstract":"Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose\u0000levels due to decreased insulin production, insulin action or both. Red guava fruitghurt contains\u0000flavonoid phytochemical compound. This research aims to determine the effect of red guava\u0000fruitghurt on reducing blood glucose levels in rats. The study was laboratory experiment. The\u0000subjects of this study were white rats (Rattus norvegicus) with wistar lines, where each group\u0000needed 5 rats, therefore the total was 25 rats. The sampling technique used is simple random\u0000sampling, The experimental animals are grouped into 5 groups, negative control, positive\u0000control, treatment 1 (administration of fruitghurt), treatment 2 (administration of\u0000glibenclamide), and treatment 3 (combination of fruitghurt and glibenclamide). The data\u0000analysis was performed with paired t test, one way anova, pairwise comparison test and post\u0000hoc duncan. The study found that red guava fruitghurt can reduce blood glucose levels in rats\u0000induced by streptozotocin and show a probability value or p value of 0.000 (p value < 0.05),\u0000meaning that there is a significant difference between Treatment 1, 2, and 3. The blood glucose\u0000level of rats after administration of fruitghurt was 75.4mg/dl, after administration of\u0000glibenclamide was 48.4mg/dl and the combination of fruitghurt and glibenclamide was\u000044.0mg/dl. From these data, it can be seen that the most influential treatment in reducing blood\u0000glucose levels is the combination of fruitghurt and glibenclamide. The significant effect in\u0000lowering blood glucose levels is the combination of fruitghurt and glibenclamide.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115315157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing self-aware mindfulness to manage mood disorder in the adolescent - A Case Report 发展自我意识正念以管理青少年的情绪障碍-个案报告

ACTA Medical Health Sciences Pub Date : 2022-06-30 DOI: 10.35990/amhs.v1n1.p45-53

K. Puspitasari

{"title":"Developing self-aware mindfulness to manage mood disorder in the adolescent - A Case Report","authors":"K. Puspitasari","doi":"10.35990/amhs.v1n1.p45-53","DOIUrl":"https://doi.org/10.35990/amhs.v1n1.p45-53","url":null,"abstract":"Major depressive disorder (MDD) with psychotic is a complicated affective disease\u0000characterized by abnormal clinical sympotms, including neurovegetative disfunction (appetite\u0000or sleep disturbances), cognitive dissonance (inappropriate guilt, feelings of worthlessness),\u0000aberrant psychomotor activities (agitation or retardation), and elevated suicide risk with\u0000psychotic features such as delusions or nihilistic, non-bizarre delusions, somatic, poverty,\u0000worthlessness, or delusional beliefs about guilt and being punished, and sometimes appear\u0000hallucination. The prevalence of MDD with psychotic features increases with age. In general\u0000population, the point prevalence of MDD is about 2% to 4% and it is increasing about 20%\u0000lifetime risk. Depression is a leading cause of burden of disease among young people. Current\u0000treatments are not uniformly effective, in part due to the heterogeneous nature of MDD. MDD\u0000is caused by many factors. A 22-year-old male presented to the inpatient psychiatric unit with\u0000suicide attempt. The patient reported experiencing a lack of energy, difficulty falling asleep,\u0000lack of motivation, and feeling overwhelmed about his work and experiencing auditoric\u0000hallucination. The insight level was 5. Multiaxial diagnosis are axis I: major depressive episode\u0000with psychotic symptoms; axis II and III: currently not found; axis IV: problems with\u0000workplace; axis V: GAF 20-11. Patient treated with pharmacotherapy group Selective\u0000Serotonin Reuptake Inhibitor (SSRI) and second-generation antipsychotics which combined\u0000with supportive psychotherapy such as mindfullness.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132647853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noise induced hearing loss among furniture factory workers PT Chitose Cimahi 家具厂工人噪音引起的听力损失

ACTA Medical Health Sciences Pub Date : 2022-06-30 DOI: 10.35990/amhs.v1n1.p10-18

Yanti Nurrokhmawati1, Desire M Nataliningrum, Dian Anggraeny

{"title":"Noise induced hearing loss among furniture factory workers PT Chitose Cimahi","authors":"Yanti Nurrokhmawati1, Desire M Nataliningrum, Dian Anggraeny","doi":"10.35990/amhs.v1n1.p10-18","DOIUrl":"https://doi.org/10.35990/amhs.v1n1.p10-18","url":null,"abstract":"Noise Induced Hearing Loss (NIHL) is a quite common health problem among factory workers,\u0000including furniture manufacturing factories. Noises above the threshold intensity for a long time\u0000can conduct to hearing loss, either temporary or permanent. If this is not taken seriously, it\u0000conducts to auditory and non-auditory impacts. The purpose of the study was to determine the\u0000prevalence of noise-induced hearing loss, worker characteristics, length of work, PPE use\u0000habits and auditory/non-auditory symptoms among workers at PT Chitose in Cimahi, West\u0000Java. Subjects were 66 workers consisting of 62 men and 4 women who were selected by total\u0000sampling, with a cross-sectional descriptive research method. Anamnesis was performed by\u0000filling out a questionnaire, physical examination of the ear, and pure tone audiometry. The\u0000results showed that the prevalence of NIHL was found in 37 people (56%). Out of patients with\u0000NIHL the average age was 37.8 years, male gender 95%, the workplace was from production\u0000department 73%, the average length of work was 16.6 years, never used PPE 54%. The most\u0000perceived auditory symptoms were tinnitus 54%, and the most non-auditory symptoms were\u0000difficulty sleeping 19%. The prevalence of NIHL among PT Chitose Cimahi workers is quite\u0000high. This is due to exposure to noise and is influenced by various risk factors. Occupational\u0000preventive program is needed from the company and rehabilitation for workers to overcome\u0000this. In conclusion, hearing loss found in PT Chitose Cimahi furniture factory workers is hearing\u0000loss caused by noise.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124162084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in mediterranean diet adherence on bmi, waist circumference, fat percentage, muscle mass in obesity 地中海饮食对体重指数、腰围、脂肪百分比、肥胖肌肉质量的影响

ACTA Medical Health Sciences Pub Date : 2022-06-30 DOI: 10.35990/amhs.v1n1.p28-37

Endry Septiadi, Dinar Mutiara, Henny Juliastuti, Iis I Rakhmat, Dewi R Handayani

引用次数: 0

The black rice ethanol extract effect on polymorphonuclear cells proliferation of rats induced by lipopolysaccharide 黑米乙醇提取物对脂多糖诱导大鼠多形核细胞增殖的影响

ACTA Medical Health Sciences Pub Date : 2022-06-30 DOI: 10.35990/amhs.v1n1.p38-44

Henny Juliastuti, Maman Djamaludin, Hadi Alwani

{"title":"The black rice ethanol extract effect on polymorphonuclear cells proliferation of rats induced by lipopolysaccharide","authors":"Henny Juliastuti, Maman Djamaludin, Hadi Alwani","doi":"10.35990/amhs.v1n1.p38-44","DOIUrl":"https://doi.org/10.35990/amhs.v1n1.p38-44","url":null,"abstract":"Inflammation is a defense that exists in the body when an infection occurs. Excessive\u0000inflammatory reactions can be induced by lipopolysaccharides (LPS) which are the most\u0000immunogenic components of a bacterial capsule or cell wall, which will result in damaging\u0000effects on the body. Black rice (Oryza sativa L.indica) is one of the natural ingredients\u0000that contains phenols, flavonoids, and antioxidant anthocyanin as immunomodulator. This\u0000study aims to find out the effect of giving black rice ethanol extract as an antiinflammatory to the proliferation of polymorphonuclear cells (PMN) in the spleen of rats\u0000induced on lipopolysaccharides. This study was conducted using 27 mice who were given\u0000black rice ethanol extract as much as 400 mg/kg BW in 14 days and then rats induced by LPS\u00000.3 mg/kg BW at 24 hours intraperitoneally before being CO2 euthanized and taken the spleen\u0000to be checked for measuring the size of the germinal center diameter. The observations showed\u0000the results of the germinal center diameter size in the treatment group with a value of\u00001,311 ± 0.226 μm (p<0.05 compared to positive control group which showed that LPS\u0000administration led to the disorganization of the white pulp and the reduction of lymphocyte\u0000cells and PMN in the germinal center. In conclusion, black rice ethanol extract at a dose\u0000of 400 mg/kgBB can affect the proliferation of PMN indicated by changes in the\u0000morphology of the white pulp in the germinal center in the spleen of rats.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"760 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116126977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0