Astri Pradini, Dian Anggraeny, T. Bisri, Diana Akmalia
{"title":"Effect of antioxidants on kidney damage repair in - diabetes-induced animal: a literature study","authors":"Astri Pradini, Dian Anggraeny, T. Bisri, Diana Akmalia","doi":"10.35990/amhs.v2n1.p46-53","DOIUrl":"https://doi.org/10.35990/amhs.v2n1.p46-53","url":null,"abstract":"Diabetes mellitus is a disease characterized by hyperglycemia. Chronic hyperglycemia indiabetes mellitus can cause various complications, one of which is diabetic nephropathy,which affects the kidney. Chronic hyperglycemia causes an increase in free radicals and adecrease in antioxidant activity resulting in oxidative stress conditions. This study aims to determine kidney damage caused by oxidative stress and the role of antioxidants in reducingthis damage through literature studies. The literature used comes from Google search results such as PubMed, Google Scholar, ResearchGate, and ScienceDirect. From the search results, ten journals meeting the inclusion and exclusion criteria were selected for review and comparison so that a conclusion could be drawn. The results of this literature study have demonstrated that biochemical parameters, such as increased levels of creatinine, urea, malondialdehyde (MDA), and decreased antioxidant enzymes, as well as kidney histological\u0000parameters, such as changes in the shape of tubules, glomeruli, and increased kidney expression, are indicators of kidney damage caused by oxidative stress. The mechanism of antioxidants in reducing kidney damage is through DNA cutting, binding to phenolic OH groups, down-regulation of the oxidase expression of nitrogen oxides 4 nicotinamide adenine dinucleotide phosphate (Nox4 NADPH), antioxidant enzyme systems, activation of the activated protein kinase pathway - silent mating type information regulation 2 homolog 1- peroxisome proliferator-activated receptor-γ coactivator 1α (AMPK-SirT1- PGC-1 α), protein glycation reactions, and inhibition of protein 53 (P53) so that erythroid nuclear factor 2-related factor 2 (Nrf2) can activate antioxidant gene transcription.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131857959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DESCRIPTION OF MAMMAE CARCINOMA PATIENTS BASED ON AGE AND STADIUM AT HASAN SADIKIN HOSPITAL BANDUN","authors":"Lukmana Lokarjana, Endah Hamidah Abbas, Nurul Aida Fathya, Ajeng Wahyuni Kartika","doi":"10.35990/amhs.v2n1.p1-8","DOIUrl":"https://doi.org/10.35990/amhs.v2n1.p1-8","url":null,"abstract":"Mammary carcinoma is a disease when normal cells are genetically mutated and become abnormal. Cells can divide and proliferate abnormally and invade breast tissue originating from the ductal epithelium or its lobules. Malignant disease caused by mammary carcinoma is a significant problem faced by women in the world. In 2017 mammary carcinoma experienced by women ranked first in new cases, namely 252,710 cases. Every increase in age is thought to be one factor influencing the mammary carcinoma incidence due to hormonal exposure for a long time. This study aimed to describe the age and stage level experienced by patients with mammary carcinoma at Hasan Sadikin Hospital, Bandung. This study used the descriptive method. The data collected was obtained from the medical records of mammary carcinoma patients recorded at the Surgical Oncology Unit of Hasan Sadikin Hospital in Bandung from January to December 2018. Sampling carried out using a total sampling technique. The results showed there were 414 breast carcinoma patients. Mammary carcinoma was primarily found at the age of 36-50 years by 52.7%. The most common stage of mammary carcinoma is stage III B by 41.1%. The breast cancer incidence increases with age, and the high proportion in stage III is due to lack of information and awareness to early detection and delay in seeking treatment. It is recommended that the related regional health installations further increase education about the dangers of mammary carcinoma to women. It is hoped that there will be no increase in mammary carcinoma cases.","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133891384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Bisri, Elly Noer Rochmah, Arief Kurniawan, Angela Stella
{"title":"The Comparison between Spinal Anesthesia Bupivacaine and Sevoflurane \u0000Anesthesia for Cesarean Section on Apgar Score","authors":"T. Bisri, Elly Noer Rochmah, Arief Kurniawan, Angela Stella","doi":"10.35990/amhs.v1n3.p128-136","DOIUrl":"https://doi.org/10.35990/amhs.v1n3.p128-136","url":null,"abstract":"The use of the anesthetic technique for cesarean section is still debatable because of the side \u0000effects caused by anesthesia for mothers and neonates. The succeed to determine anesthetic \u0000technique can be seen from the outcome of the final condition of the mother and the neonates. \u0000The assessment of the succeed to determine anesthetic technique in neonates has been using the \u0000Apgar score by assessing the clinical status of the newborn in the first and fifth minutes. This \u0000research is aimed to understand the comparison between Apgar scores in cesarean section using \u0000general anesthesia sevoflurane and spinal anesthesia bupivacaine. This research is analytical \u0000retrospective with a cross-sectional study approach, using a total sample of 40 patients who \u0000performed cesarean section from August to November 2021, the samples were taken by \u0000consecutive sampling. The data was taken from the medical records of the Melinda Mother and \u0000Child Hospital, Bandung. The results of this research showed that there was no significant \u0000difference in the APGAR Score first minute between general anesthesia and spinal anesthesia \u0000(p=0,054) in the fifth minute (p=0,708). There was no effect on APGAR scores in the general \u0000anesthesia sevoflurane group and spinal anesthesia bupivacaine group, and both anesthetic \u0000groups had a good effect on neonates","PeriodicalId":171840,"journal":{"name":"ACTA Medical Health Sciences","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123090702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}