Journal of Solid Tumors最新文献_第6页

Durable response in a thymic neuroendocrine tumor: A case report and review of the literature 胸腺神经内分泌肿瘤的持久反应:1例报告及文献回顾

Journal of Solid Tumors Pub Date : 2017-04-19 DOI: 10.5430/JST.V7N2P23

Y. Syed, Daniel H Miller, Liuyan Jiang, Arya N. Bagherpour, S. Ko

引用次数: 0

Can detection of Braf p.V600E mutation be improved? Comparison of allele specific multiplex sequencing to present tests Braf p.V600E突变的检测是否可以提高?等位基因特异性多重序列与现有测试的比较

Journal of Solid Tumors Pub Date : 2017-04-12 DOI: 10.5430/JST.V7N2P14

T. Vinayagamoorthy, David Y. Zhang, F. Ye, Dilanthi Vinayagamoorthy, R. Hodkinson

{"title":"Can detection of Braf p.V600E mutation be improved? Comparison of allele specific multiplex sequencing to present tests","authors":"T. Vinayagamoorthy, David Y. Zhang, F. Ye, Dilanthi Vinayagamoorthy, R. Hodkinson","doi":"10.5430/JST.V7N2P14","DOIUrl":"https://doi.org/10.5430/JST.V7N2P14","url":null,"abstract":"Objective: This is an investigative study to evaluate a new companion diagnostic platform, allele specific multiplex sequencing (ASMS). Detection of Braf p.V600E from solid tumors is used as the test model with the following objectives: 1) whether ASMS can detect Braf p.V600E/K mutations from a variety of solid tumors, 2) whether ASMS can detect all Braf p.V600E from samples that were positive for Braf V600E by SNaPshot or Ion Torrent, and 3) whether ASMS can detect Braf p.V600E among samples that were reported negative by SNaPshot or Ion Torrent. Methods: ASMS is a novel modification (US Patent 6197510) of traditional Sanger sequencing, with Lower Limit of Detection (LLOD) of 20 GE (Genome Equivalent) and 0.001% sensitivity. We compared ASMS to clinical samples previously tested either by SNaPshot or Ion Torrent methods. Results: We analyzed 83 DNA extracts from FFPE samples (41 tested by SNaPshot and 42 tested by Ion Torrent). There was a total of thirty-seven samples positive for Braf p.V600E (16 by Ion Torrent; 21 by SNaPshot), and all of these samples tested positive by ASMS for Braf p.V600E. Out of the 46 negatives for Braf p.V600E (20 by SNaPshot; 26 by Ion Torrent samples), ASMS detected Braf p.V600E positive results in 10 of the SNaPshot and in 18 of the Ion Torrent negative samples. ASMS could detect both Braf p.V600E and the wild-type Braf p.V600 simultaneously with 40 pg of FFPE DNA extracts. Conclusions: ASMS assay detected all Braf p.V600E positives from different types of solid tumors that previously tested positive by SNaPshot or Ion Torrent. Further, ASMS was able to detect Braf p.V600E among samples that were reported negative by SNaPshot or Ion Torrent.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"74 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2017-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72678099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Unusual behaviour of a retroperitoneal sarcoma: A case report and review of the literature 腹膜后肉瘤的异常行为:一例报告和文献复习

Journal of Solid Tumors Pub Date : 2017-01-18 DOI: 10.5430/JST.V7N1P57

A. Azzam, A. Elkak

引用次数: 0

Intravascular disseminated coagulopathy as a debut of metastatic prostate cancer: A case report 血管内弥散性凝血功能障碍是转移性前列腺癌的首次表现:1例报告

Journal of Solid Tumors Pub Date : 2017-01-17 DOI: 10.5430/JST.V7N1P52

P. E. Olarte, Nerea Inés Muñoz Unceta, R. M. Kopp, J. Olmedo, D. C. Gauna, L. Paz-Ares

引用次数: 0

Correlation between Campanacci’s radiological classification of giant cell tumor of bone and expression of Cyclin D1 and PCNA 骨巨细胞瘤Campanacci放射学分型与Cyclin D1和PCNA表达的关系

Journal of Solid Tumors Pub Date : 2017-01-10 DOI: 10.5430/JST.V7N1P47

E. Estrada-Villaseñor, Hidalgo Bravo Alberto, C. Bandala, P. D. L. Garza-Montano, Reyes Medina Naxieli, Pichardo Bahena Raúl, E. Delgado-Cedillo, L. Linares-González, G. Rico-Martínez

引用次数: 2

Prophylactic anticoagulant therapy decreases the incidence of deep vein thrombosis in patients with solid tumors: A systematic review and meta-analysis 预防性抗凝治疗降低实体肿瘤患者深静脉血栓的发生率:一项系统回顾和荟萃分析

Journal of Solid Tumors Pub Date : 2017-01-03 DOI: 10.5430/JST.V7N1P35

Yunjiao Zhou, Gong Yang, Chenglei Huang

{"title":"Prophylactic anticoagulant therapy decreases the incidence of deep vein thrombosis in patients with solid tumors: A systematic review and meta-analysis","authors":"Yunjiao Zhou, Gong Yang, Chenglei Huang","doi":"10.5430/JST.V7N1P35","DOIUrl":"https://doi.org/10.5430/JST.V7N1P35","url":null,"abstract":"It is not well understood the efficacy and safety of primary deep vein thrombosis (DVT) prophylaxis of anticoagulants in patients with solid tumors. This systematic review and meta-analysis of randomized controlled trials (RCT) determines the relative ratio of primary DVT, survival rate and bleeding events among patients with solid tumors treated with anticoagulants or placebo. Comprehensive literature searches were conducted through the Pubmed, Ovid MEDLINE and EMBASE databases published from January 1st, 1993 to December 31st, 2015. Statistical analysis was performed by RevMan 5.0 software. For DVT events, the risk ratio in 16 trials between the prophylactic and control patients was statistically significant at 0.45 [0.36-0.58]; for major bleeding events, the risk ratio in 18 trials between the prophylactic and control patients was not statistically significant at 1.33 [0.99-1.79], while that in 15 trials with clinically relevant non-major bleeding was statistically significant at 1.83 [1.46-2.30]; the risk ratio for the mortality rate of patients with solid tumors in 16 trials was not statistically significant at 0.97 [0.93-1.02]. In conclusion, the risk ratio in this meta-analysis showed a significantly reduced incidence of DVT with anticoagulant use. Treatment to patients who had solid tumors with prophylactic anticoagulants enhanced the incidence rate of non-major bleeding but has no significant impact on the incidence rate of major bleeding. No significant differences were found in the mortality outcomes between anticoagulant and non-anticoagulant groups.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"6 1","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2017-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82825365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¹⁸F-PET/CT imaging of metastasis to the thyroid gland: Imaging findings and effect on patient management. 甲状腺转移的18F-PET/CT成像:影像学表现及其对患者治疗的影响。

Journal of Solid Tumors Pub Date : 2017-01-01 DOI: 10.5430/jst.v7n2p7

Giovanni G Millare, Michael Kwon, Beth S Edeiken-Monroe, J Matthew Debnam

{"title":"18F-PET/CT imaging of metastasis to the thyroid gland: Imaging findings and effect on patient management.","authors":"Giovanni G Millare, Michael Kwon, Beth S Edeiken-Monroe, J Matthew Debnam","doi":"10.5430/jst.v7n2p7","DOIUrl":"https://doi.org/10.5430/jst.v7n2p7","url":null,"abstract":"Purpose: While metastasis to the thyroid from a primary cancer remote to the thyroid is uncommon, current imaging techniques have improved detection of these intrathyroid metastases. The purpose of this study was to evaluate the 18F-PET/CT appearance of intrathyroid metastases and assess the impact of detection on patient management.Methods: The 18F-PET/CT appearance of intrathyroid metastasis, including standardized uptake value (SUV), disease extent, and the effect on patient management following diagnosis were retrospectively reviewed. Inclusion criteria included 18F-PET/CT imaging and diagnosis of the intrathyroid metastasis matching the remote primary tumor.Results: Intrathyroid metastasis were detected in 24 patients. The intrathyroid metastases presented on 18F-PET/CT as focal nodular uptake (n = 21), multiple nodular uptake (n = 2), or diffuse uptake/infiltration of the thyroid gland (n = 1). The SUV ranged between 3.9 and 42 (median 12.5 ± 7.5); in 2 patients, the FDG-avidity was minimal. On 18F-PET/CT, distant metastases were present outside the neck (n = 18), or limited to the neck (n = 6). In 2 of these 6 patients, the thyroid was the only site of metastatic disease. Due to the metastatic disease, the therapy was changed in 23 of 24 patients; 1 patient was lost to follow-up.Conclusion: In any patient with a previous or current history of an extrathyroid malignancy, an 18FDG-avid thyroid mass or diffuse infiltration of the thyroid on 18F-PET/CT should be considered a potential intrathyoid metastasis until proven otherwise. Knowledge of an intrathyroid metastasis may impact patient management, especially if the thyroid or neck are the only sites of metastatic disease.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"7 2","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/jst.v7n2p7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36645889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

ARMS-PCR based diagnosis of APCB and KRAS genes in colorectal cancer patients in Iraqi Sulaimania province 基于ARMS-PCR的伊拉克苏莱曼尼亚省结直肠癌患者APCB和KRAS基因诊断

Journal of Solid Tumors Pub Date : 2016-12-30 DOI: 10.5430/jst.v7n1p27

G. Salih, Shad Sudad

引用次数: 0

Effects of whole brain radiation on blood counts 全脑辐射对血液计数的影响

Journal of Solid Tumors Pub Date : 2016-12-12 DOI: 10.5430/JST.V7N1P23

K. Foo, A. Patel, Gregory M. Richards, B. Goldsmith, A. Turtz, Piya V. Saraiya, R. Somer, N. Lerman, H. Goldman, G. Kubicek

引用次数: 2

Papillary mesothelioma of peritoneum involving fallopian tube: A challenging case 累及输卵管的腹膜乳头状间皮瘤:一个具有挑战性的病例

Journal of Solid Tumors Pub Date : 2016-12-05 DOI: 10.5430/JST.V7N1P20

Asim Quershi, V. Gowri, I. Burney, M. A. Kalbani

引用次数: 1