Journal of Solid Tumors最新文献_第5页

Comparative sonographic review of benign and malignant breast masses 乳腺良恶性肿块的超声对比分析

Journal of Solid Tumors Pub Date : 2018-01-23 DOI: 10.5430/JST.V8N1P42

M. AfodunA, D. EzeE, K. QuadriK, O. MuhammedA, A. MasudM., K. LawalS, O. BuhariM, O. AyindeT

引用次数: 1

Isolated pituitary metastasis from renal cell carcinoma in a horseshoe kidney 马蹄肾肾细胞癌的分离性垂体转移

Journal of Solid Tumors Pub Date : 2018-01-11 DOI: 10.5430/JST.V8N1P37

K. Win, N. Blocher, W. Tester, Serge Ginzburg, L. Pomo

{"title":"Isolated pituitary metastasis from renal cell carcinoma in a horseshoe kidney","authors":"K. Win, N. Blocher, W. Tester, Serge Ginzburg, L. Pomo","doi":"10.5430/JST.V8N1P37","DOIUrl":"https://doi.org/10.5430/JST.V8N1P37","url":null,"abstract":"Objective: To describe a patient with isolated symptomatic pituitary metastasis from Renal Cell Carcinoma (RCC) in a horseshoe kidney. Case report: We report a case of 56-year-old man with RCC of a horseshoe kidney with symptomatic isolated pituitary gland metastasis. He initially presented to us for evaluation of a sellar mass. He complained of fatigue, 50-pound weight loss, anorexia, constipation and nonspecific abdominal pain for 4 months. CT head showed 2.6 cm × 1.8 cm × 2.5 cm sellar mass likely with bilateral cavernous sinus extension. Pituitary function evaluation revealed panhypopituitarism. CT abdomen/pelvis for the evaluation of abdominal pain showed 12.1 cm solid mass in the right renal moiety of a horseshoe kidney. Hydrocortisone and levothyroxine therapy led to cessation of weight loss, but unmasked diabetes insipidus requiring desmopressin therapy. Right heminephrectomy confirmed RCC. Soon after he complained of progressively worsening headache and visual disturbance. Histopathology from urgent trans-sphenoidal hypophysectomy revealed RCC. The patient began post-surgical radiotherapy, but eventually he declined further treatments. In the end, he was placed on hospice where he passed away. Conclusion: Symptomatic pituitary metastasis from RCC are rare and most of those occur in the setting of diffuse metastatic disease. They typically mimic signs and symptoms of non-functioning macroadenomas. They can be synchronous, metachronous or even the presenting lesion of the primary tumor. A pituitary mass in the setting of malignancy should raise suspicion for metastatic disease even though it is extremely rare.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"51 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2018-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85165025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Primary breast carcinoma with features of the follicular variant of papillary thyroid carcinoma 具有滤泡型甲状腺乳头状癌特征的原发性乳腺癌

Journal of Solid Tumors Pub Date : 2018-01-11 DOI: 10.5430/JST.V8N1P32

Nektarios Koufopoulos, K. Kapatou, F. Antoniadou, D. Nasikas, I. Karaitianos, S. Kokkali, D. Nasi, L. Khaldi

引用次数: 0

N-cadherin and hyaluronan expression in head and neck squamous cell carcinoma, relation to patient outcomes n -钙粘蛋白和透明质酸在头颈部鳞状细胞癌中的表达与患者预后的关系

Journal of Solid Tumors Pub Date : 2017-12-05 DOI: 10.5430/JST.V8N1P19

H. Hendawy, Afaf T. Ibrahiem, El-Nagdy Sy, W. Zedan

{"title":"N-cadherin and hyaluronan expression in head and neck squamous cell carcinoma, relation to patient outcomes","authors":"H. Hendawy, Afaf T. Ibrahiem, El-Nagdy Sy, W. Zedan","doi":"10.5430/JST.V8N1P19","DOIUrl":"https://doi.org/10.5430/JST.V8N1P19","url":null,"abstract":"Background: Epithelial-mesenchymal transition (EMT) is regarded as an essential step for tumor invasion and metastasis. In squamous cell carcinoma of head and neck (HNSCC), N-Cadherin expression and its involvement in tumor progression remains a controversial topic. Aim of the study: The present study aimed to assess the expression of N-cadherin and HA in HNSCC and further study their relation to patients survival and outcomes. Material and methods: Fifty-eight retrospective selected cases of head and neck squamous carcinomas (HNSCCs) with available paraffin blocks. Complete clinico-pathological and follow-up data were recorded. Immune staining for N-cadherin and hyaluronan were done, also, we study the correlation of the results with patients survival data. Results: Squamous cell carcinoma islands demonstrated high N-cadherin expression in 55.2% and low expression in 44.8%. N-cadherin high expression was significantly ( p < .05) associated with large tumor sizes, advanced TNM clinical stage, increased incidence of recurrence and patient’s death. A significant correlation was recorded between the presence of neural invasion and N-cadherin expression ( p = .004). Strong intensity of stromal HA was significantly ( p < .05) associated with an oral site, nodal metastasis, and higher TNM stage. Patients with high N-cadherin expression, diffuse hyaluronan, and strong stromal hyaluronan reaction had significantly lower DFS rates ( p < .05). High N-cadherin expression, diffuse hyaluronan immunoreactivity, and strong stromal hyaluronan reaction intensity had significantly lower OS rates ( p < .05). Conclusion: N-cadherin and hyaluronan could be important and promising biomarkers during surveillance of patients with HNSCC.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"42 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2017-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79425412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases 上颌骨成釉细胞癌:一例罕见病例报告及新病例回顾

Journal of Solid Tumors Pub Date : 2017-10-15 DOI: 10.5430/JST.V8N1P15

S. Sargolzaei, Arash Khaleghjoo, N. Taghavi

引用次数: 1

Chondroblastoma-like chondroma of soft tissue: A report of two cases 软组织成软骨细胞瘤样软骨瘤2例报告

Journal of Solid Tumors Pub Date : 2017-09-26 DOI: 10.5430/JST.V8N1P10

D. Zaccarini, Z. Badar, A. Valente, G. D. Roza

引用次数: 0

Relationship between salivary adiponectin, IGF-1, obesity and breast cancer 唾液脂联素、IGF-1、肥胖与乳腺癌的关系

Journal of Solid Tumors Pub Date : 2017-09-22 DOI: 10.5430/JST.V8N1P1

C. Streckfus

{"title":"Relationship between salivary adiponectin, IGF-1, obesity and breast cancer","authors":"C. Streckfus","doi":"10.5430/JST.V8N1P1","DOIUrl":"https://doi.org/10.5430/JST.V8N1P1","url":null,"abstract":"Objective: The objective of this study was to determine if adiponectin and IGF-1 salivary concentrations are altered in combination with the presence of obesity and breast cancer. The null hypothesis is that there are no significant adiponectin and IGF-1 concentration alterations secondary to the presence of obesity and/or carcinoma of the breast. Methods: There were two groups of test subjects: healthy controls (n = 20) and individuals diagnosed with breast cancer (n = 20). The two cohorts were further stratified into four groups. These included subjects who are healthy and of normal BMI (n = 10); are healthy but have an elevated BMI (n = 10); have breast cancer and a normal BMI (n = 10); and have cancer and an elevated BMI (n = 10). The presence and concentration of adiponectin and IGF-1 was determined using the ELISA methodology. Results: The investigation revealed a significant increase in mean adiponectin levels in subjects with cancer compared to the controls (t = -2.57; p < .01). Individuals that were diagnosed with breast cancer and were obese exhibited the highest concentrations (F = 5.13; p < .005) of adiponectin. Adiponectin concentrations were also found to be correlated to IGF-I levels (r = 0.05; p < .001). Conclusion: Salivary adiponectin levels were significantly higher among cancer group. There were no significant differences between the cancer and control groups for IGF-I levels.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"85 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76806272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Salivary proline rich peptide decreases cell growth in HCC38 triple negative breast cancer cell line 唾液富含脯氨酸肽抑制HCC38三阴性乳腺癌细胞系细胞生长

Journal of Solid Tumors Pub Date : 2017-06-27 DOI: 10.5430/JST.V7N2P38

C. Streckfus, Daniel Arreola, C. Streckfus, L. Bigler

引用次数: 2

Benign meningioma with complete erosion of the skull in a 38-year-old Ghanaian woman 良性脑膜瘤伴头颅完全糜烂一例38岁的加纳妇女

Journal of Solid Tumors Pub Date : 2017-06-02 DOI: 10.5430/JST.V7N2P34

E. Der, R. Mikdad, B. J. Leuri, A. Adam

引用次数: 1

A phase II trial of neoadjuvant doxorubicin plus cyclophosphamide followed by lapatinib plus docetaxel sequential with adjuvant trastuzumab for treatment of early HER2 positive breast cancers 新辅助阿霉素+环磷酰胺，拉帕替尼+多西他赛序贯与辅助曲妥珠单抗治疗早期HER2阳性乳腺癌的II期试验

Journal of Solid Tumors Pub Date : 2017-05-05 DOI: 10.5430/JST.V7N2P28

G. Vidal, N. Vontela, Mary M Chen, J. Ryder, Shruti N Sheth, E. Guardino

{"title":"A phase II trial of neoadjuvant doxorubicin plus cyclophosphamide followed by lapatinib plus docetaxel sequential with adjuvant trastuzumab for treatment of early HER2 positive breast cancers","authors":"G. Vidal, N. Vontela, Mary M Chen, J. Ryder, Shruti N Sheth, E. Guardino","doi":"10.5430/JST.V7N2P28","DOIUrl":"https://doi.org/10.5430/JST.V7N2P28","url":null,"abstract":"Background: The use of HER2 targeting therapy has revolutionized the treatment of HER2 positive breast cancers. Here, we investigate whether a sequential approach to dual HER2 blockade of lapatinib followed by trastuzumab will result in improved clinical outcomes. Methods: This was a single institution, open label, single arm, phase II trial in women with HER2 positive breast cancer. Volunteers were treated with sequential neoadjuvant doxorubicin (60 mg/m2) and cyclophosphamide (600 mg/m2) (AC) for 4 cycles followed by docetaxel (100 mg/m2) concurrent with lapatinib (1,250 mg) (TL) daily for 21 days for four cycles before definitive surgery. The primary end point was pathologic complete response (pCR). Results: The study accrued only 21 of the 71 planned patients from 2/28/2007 to 5/25/2010. All patients (100%) experienced down staging. The pCR rate was 41% (7/18). 11 patients had tumor size of T3 or greater, 3 of which experienced pCR and only 1 underwent breast conservation (lumpectomy). The most common hematologic AE (all grades) was anemia 17/21 (81%). There were no incidences of grade 3 or 4 anemia. 10 of 21 (48%) patients experience a non-hematologic grade 3 AE. The most common non-hematologic AEs (all grades) were irregular menses 20/21 (95%) and hand-foot-skin reactions 20/21 (95%). No increase cardiac abnormalities were noted. The DFS at data cut off was 87.5%. Conclusion: The provocative pCR and DFS results in this high risk locally advanced patient population should be viewed with caution given results of the Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation study (ALTTO) clinical trial.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"17 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2017-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88580241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0