Salivary proline rich peptide decreases cell growth in HCC38 triple negative breast cancer cell line

Abstract

Objective: The objective of this study is to determine the effects of p1978 on the growth rate of a triple receptor negative breast cancer cell line. Methods: Three cell lines, 185B5 normal tissue, HCC38, and AU585, were seeded with peptide p1978. Corresponding plates were seeded with PBS to serve as controls. Baseline line cell counts were taken at 30% confluence prior to seeding. Counts were again made 48 hours later. Results: The HCC38 cell line showed decreased growth when exposed to the low and high dose of p1978 peptide. Conclusion: The results suggest that p1978 may have potential in treating triple receptor negative breast cancer.