Journal of Solid Tumors最新文献_第7页

Acute and late adverse effects of breast cancer radiation: Two hypo-fractionation protocols 乳腺癌放疗的急性和晚期不良反应:两种低分级方案

Journal of Solid Tumors Pub Date : 2016-11-22 DOI: 10.5430/JST.V7N2P1

M. Aboziada, S. Shehata

{"title":"Acute and late adverse effects of breast cancer radiation: Two hypo-fractionation protocols","authors":"M. Aboziada, S. Shehata","doi":"10.5430/JST.V7N2P1","DOIUrl":"https://doi.org/10.5430/JST.V7N2P1","url":null,"abstract":"Background: Hypofractionated radiotherapy delivered a lower total dose of radiation in larger dose per-fraction over 3 weeks.Many randomized trials supported the comparable efficacy and toxicities of conventional radiotherapy schedule to differenthypofractionated regimens. Patients and methods: One hundred female patients having breast cancer post-surgery randomized into two arms of acceleratedhypofractionation; 39 Gy/13 fractions (group A) and 42.4 Gy/16 fractions (group B) both regimens given as 5 fractions per week. Results: There was a significant increase of incidence of acute radiation dermatitis in patients receiving 39 Gy. Grade I and IIdermatitis reported in 82% and 46% for 39 Gy group and 42.4 Gy group respectively. In-addition, increased chronic subcutaneousfibrosis among patients with group A (28%) compared with (18%) to group B that was statistical significance. Breast conservativesurgery is the only factor that had significant effect on incidence of acute radiation dermatitis and chronic subcutaneous fibrosis. Conclusion: Thirty-nine Gy in 13 fractions has higher acute dermatitis and chronic subcutaneous fibrosis for patients underwentbreast conservative surgery. We need longer follow up to evaluate the efficacy of both regimens as regard of local control andsurvival.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":" 1197","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91409273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synchronous isolated ipsilateral salivary gland metastasis from a primary breast cancer – A case report 原发性乳腺癌同侧离体涎腺转移1例

Journal of Solid Tumors Pub Date : 2016-11-08 DOI: 10.5430/JST.V7N1P16

Ashmitha Srinivasan

引用次数: 0

Baseline γH2AX foci, 53BP1 values and late morbidity after definitive radio-chemotherapy in head and neck carcinoma patients 基线γ - h2ax病灶、53BP1值与头颈部癌患者明确放化疗后晚期发病率的关系

Journal of Solid Tumors Pub Date : 2016-09-29 DOI: 10.5430/JST.V7N1P11

A. Buchali, L. Heiserich, P. Bauer, M. Tregel, D. Roggenbuck, A. Franzen

{"title":"Baseline γH2AX foci, 53BP1 values and late morbidity after definitive radio-chemotherapy in head and neck carcinoma patients","authors":"A. Buchali, L. Heiserich, P. Bauer, M. Tregel, D. Roggenbuck, A. Franzen","doi":"10.5430/JST.V7N1P11","DOIUrl":"https://doi.org/10.5430/JST.V7N1P11","url":null,"abstract":"Purpose: Can double strand breaks in peripheral lymphocytes measured as baseline γH2AX and 53BP1 values be used as a signal for reduced DNA repair capacity and an increased late radiation morbidity? Methods and materials: Of 357 patients, homogenously treated with a definitive radio-chemotherapy, 11 patients without any relevant comorbidity concerning baseline DNA double strand breaks, a follow up of more than 3.5 years and different levels of late morbidity were selected. γH2AX and 53BP1 foci were analyzed, using the fully automated AKLIDES ® system (Medipan). For foci detection, images of different z-planes throughout the nucleus were obtained. For further evaluation mean focus number/cell as well as percentage of γH2AX/ 53BP1 focus-positive cells were used. Results: Patients with late toxicity levels 0°, I° and III° showed median numbers of γH2AX foci per peripheral mononuclear cell of 0.26, 0.34 and 0.73 respectively. The corresponding median values of 53BP1 foci per cell were 0.13, 0.06 and 0.40, respectively and concordant percentages of γH2AX positive cells for the 3 different late toxicity groups were 10.85, 14.30 and 30.67 as well as of 53BP1 positive cells 8.5, 5.7 and 25.37, respectively. Despite the wide interindividual range of all values, patients with severe late morbidity showed increased values for γH2AX as well as 53BP1 foci compared to the other groups, whereas no differences between groups with no or mild toxicity were seen. Conclusions: The determination of baseline γH2AX foci in peripheral blood mononuclear cells could be suited as a marker for late morbidity after definitive radio-chemotherapy of head and neck carcinoma. Blood sampling at the time of treatment i.e. moment of origin of the late effect should be more effective rather than a retrospective study. To address this question a prospective trial with a larger cohort of patients and a long term follow up is needed.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"134 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84709837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Paraganglioma of maxillary sinus associated with Addison’s disease mimicking a vascular tumour: A case report 上颌窦副神经节瘤合并Addison病(血管性肿瘤)1例

Journal of Solid Tumors Pub Date : 2016-09-13 DOI: 10.5430/JST.V7N1P7

Sami A Alkindy

引用次数: 1

Retrospective analysis of the clinical efficacy of concurrent weekly cisplatinum - radiotherapy for patients with laryngeal carcinoma 回顾性分析每周顺铂同步放疗治疗喉癌患者的临床疗效

Journal of Solid Tumors Pub Date : 2016-09-07 DOI: 10.5430/JST.V7N1P1

M. Aboziada, Ashraf Elyamany

{"title":"Retrospective analysis of the clinical efficacy of concurrent weekly cisplatinum - radiotherapy for patients with laryngeal carcinoma","authors":"M. Aboziada, Ashraf Elyamany","doi":"10.5430/JST.V7N1P1","DOIUrl":"https://doi.org/10.5430/JST.V7N1P1","url":null,"abstract":"Introduction and aim: Laryngeal preservation with concurrent chemo-radiation is an effective, alternative management forcancer larynx. Three weekly cis-platinum concurrent with radiotherapy (RT) considered the standard. However, weekly cisplatinumhas proven very effective for advanced head and neck carcinoma. We review our data to prove the efficacy and safety ofweekly cis-platinum plus RT for laryngeal preservation. Patients and methods: Untreated 64 patients with advanced laryngeal carcinoma were retrospectively analyzed. Patients offeredfor 6 weeks of cis-platinum 40 mg/m 2 concurrent with conformal RT; 70 Gy delivered to gross primary and lymph nodes. Results: Forty-six (71.8%) patients had complete remission (CR). Early stages had better CR than late stages. Median follow upwas 40 months. Three years DFS and OS were 69% and 77% respectively. Larynx preservation survival at 3 years was 73%.Protocol of treatment was tolerable, grade 3 or 4 acute and late toxic effects were reported in 25% of the included cases. Conclusion: Weekly cis-platinum could be effective and safe. We need to evaluate this protocol prospectively and compare itwith three-weekly high dose cis-platinum with concomitant radiotherapy.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"23 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2016-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91483207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Different strategies of gene delivery for treatment of cancer and other disorders 基因传递治疗癌症和其他疾病的不同策略

Journal of Solid Tumors Pub Date : 2016-08-25 DOI: 10.5430/JST.V6N2P76

Elnaz Agi, Z. Mosaferi, Sepideh Khatamsaz, P. Cheraghi, Nooshin Samadian, A. Bolhassani

引用次数: 5

Melanocyte-endothelial melanomas: Plasticity and transdifferentiation in melanomas 黑色素细胞内皮黑色素瘤:黑色素瘤的可塑性和转分化

Journal of Solid Tumors Pub Date : 2016-08-17 DOI: 10.5430/JST.V6N2P66

B. Iyengar

{"title":"Melanocyte-endothelial melanomas: Plasticity and transdifferentiation in melanomas","authors":"B. Iyengar","doi":"10.5430/JST.V6N2P66","DOIUrl":"https://doi.org/10.5430/JST.V6N2P66","url":null,"abstract":"Melanomas with extensive metastasis can rarely regress on the appearance of a halo nevus (HN). This study explores the possiblefactors involved. The component melanocytes of HN, flatten, depigment and line vascular spaces to replace and result in theinvolution of the nevus. This simulates vasculogenesis in amelanotic melanomas, malignant melanocytes differentiating intoendothelial cells. The reverse is seen in pigmented tumors. Nestin positive endothelial cells lining angiogenic tubes, enter thetumor margins, show glial differentiation and form transient tumor vascular complexes (TVC) with stepwise neural differentiationand pigment laden cells, suggesting transdifferentiation of endothelial cells to melanocytes. During development, a range ofmolecular tools are used by blood vessels as well as nerves, including ephrins/Eph, NP-I and Notch signalling. This is vindicatedby morphologic evidence of melanocyte/endothelial transdifferentiation as shown in this study. These observations, suggesta common multipotent stem cell, differentiating into vascular and melanocyte/neural stem cell depending on the surroundingmicroenviroment. Concurrent tumor regression may involve a rapid transdifferentiation triggered by a molecular switch or shutdown of the common stem cell and/or presence of circulating antibodies to melanomas released on the appearance of HN.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"5 1","pages":"66"},"PeriodicalIF":0.0,"publicationDate":"2016-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87361946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nausea and vomiting masquerading heart cancer 恶心呕吐伪装成心脏病

Journal of Solid Tumors Pub Date : 2016-07-18 DOI: 10.5430/JST.V6N2P62

J. Shapiro, V. Vasile, K. Klarich, H. Schaff

引用次数: 0

Impact of a teaching program on outcome quality of white light transurethral resection for bladder tumor: A cohort study 教学计划对经尿道白光膀胱肿瘤切除术疗效质量的影响:一项队列研究

Journal of Solid Tumors Pub Date : 2016-07-11 DOI: 10.5430/JST.V6N2P56

R. Hurle, R. Peschechera, N. Buffi, G. Lughezzani, E. Morenghi, A. Saita, L. Pasini, P. Casale, M. Seveso, Silvia Zandegiacomo, G. Taverna, A. Benetti, I. Vavassori, P. Colombo, M. Lazzeri, G. Guazzoni

{"title":"Impact of a teaching program on outcome quality of white light transurethral resection for bladder tumor: A cohort study","authors":"R. Hurle, R. Peschechera, N. Buffi, G. Lughezzani, E. Morenghi, A. Saita, L. Pasini, P. Casale, M. Seveso, Silvia Zandegiacomo, G. Taverna, A. Benetti, I. Vavassori, P. Colombo, M. Lazzeri, G. Guazzoni","doi":"10.5430/JST.V6N2P56","DOIUrl":"https://doi.org/10.5430/JST.V6N2P56","url":null,"abstract":"Objective: To test the hypothesis that a teaching program improves the quality of transurethral resection of bladder tumor(TURBT) and decreases the risk of early recurrence. Material and methods: This is an observational retrospective cohort study of prospectively recorded data of patients withfirst clinical diagnosis of non-muscle-invasive bladder cancer (NMIBC), scheduled for TURBT. In 2005 a systematic TURBTteaching program was introduced in our Department. We reviewed the charts of patients who underwent TURBT in the years1998-2004, when no tutoring was applied, and those who underwent TURBT in the years 2005-2010. The outcomes of interestwere: presence/absence of detrusor muscle (DM), carcinoma in situ (CIS) detection, complication rate and recurrence rate at thefirst follow-up cystoscopy (RRFF-C). Results: Complete data from 427 patients were available: 199 before and 228 after the introduction of the teaching program.Multivariable logistic analysis showed that the training program was an independent prognostic factor for DM (presence) rate(OR = 3.92, 95%CI = 2.42-6.33), CIS detection rate (OR = 4.36, 95%CI = 1.92-9.86), and complication rate (OR = 0.28, 95%CI= 0.15-0.55), but not for RRFF-C (OR = 0.79, 95%CI = 0.52-1.20). Between 1998-2004, RRFF-C was correlated with tumornumber, pathological stage, DM presence, presence of complication, CIS detection and surgeon experience. After the introductionof the teaching program, only tumor number, DM presence and surgeon experience influenced the RRFF-C. Conclusion: Our findings suggest the hypothesis that the teaching program might have an impact of quality of TURBT, but itfailed to improve the RRFF-C.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"59 1","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2016-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86781597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A bio-psychosocial intervention program for improving quality of life in breast cancer survivors: Results of a prospective randomized trial 改善乳腺癌幸存者生活质量的生物-社会心理干预方案:一项前瞻性随机试验的结果

Journal of Solid Tumors Pub Date : 2016-06-11 DOI: 10.5430/JST.V6N2P48

Janine Pettiford, Sharon Felts, Edna Wischkaemper, Debbie Miller, S. Crawford, R. Rahman

{"title":"A bio-psychosocial intervention program for improving quality of life in breast cancer survivors: Results of a prospective randomized trial","authors":"Janine Pettiford, Sharon Felts, Edna Wischkaemper, Debbie Miller, S. Crawford, R. Rahman","doi":"10.5430/JST.V6N2P48","DOIUrl":"https://doi.org/10.5430/JST.V6N2P48","url":null,"abstract":"Background: Given the 3.1 million breast cancer survivors in America, quality of life (QoL) is a vital issue. Bio-psychosocialmilieu of survivorship is increasingly important. This study assesses the impact of bio-psychosocial intervention (BPSI) on theQoL of breast cancer survivors utilizing Functional Assessment of Cancer Therapy – Breast (FACT-B) instrument. Methods: A prospective randomized trial was designed; intervention arm included a 4-hour BPSI coping skills class; control armreceived standard of cancer (SOC) and follow up care. Women diagnosed within 2 years of study initiation were eligible. Samplesize was based on 8-point difference in FACT-B score, 90% power, 5% type I error, and 20% attrition. FACT-B questionnaire wasadministered to all patients at baseline and at 6-month intervals. SAS 9.3 software was used to analyze data using Chi-square testfor categorical and Wilcoxon rank sum for ordinal data; linear mixed modeling was used for longitudinal analysis. Results: One hundred and three of 120 (86%) patients were available for analysis. Forty-seven patients were in BSPI arm, and 56received SOC. For BPSI arm vs. SOC arm, the median (interquartile) age [60 (52, 68) vs. 58 (52, 68)yrs. P = .9135], cancer-stage(0: 1: 2: 3 = 11%: 41%: 35%: 13% vs. 18%: 46%: 22%: 15%, P = .4645), and biology (triple-negative: HER2+ : ER+ =9%: 74%: 17% vs. 8%: 72%: 20%, P = .8454), respectively, was similar. Mean (SE) FACT-B scores in BPSI vs. SOC arms at6 months and 1 year were 115.1 (2.2) vs. 114.6 (2.0) ( P = .8731) and 124.7(2.8) vs. 101.4 (2.4) ( P = .0001). The inter-groupdifference significantly expanded at 1 year ( P = .0001). The 12-month difference persisted when confounding baseline variableswere adjusted for in in multivariate modeling. Conclusion: BPSI coping skills class significantly improved the QoL of breast cancer survivors by one year post-interventiontime point.","PeriodicalId":17174,"journal":{"name":"Journal of Solid Tumors","volume":"41 1","pages":"48"},"PeriodicalIF":0.0,"publicationDate":"2016-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77747216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0