Journal of Skin Cancer最新文献_第6页

A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma. Sonidegib和Vismodegib治疗晚期基底细胞癌的间接比较。

IF 1.1

Journal of Skin Cancer Pub Date : 2017-01-01 Epub Date: 2017-05-21 DOI: 10.1155/2017/6121760

Dawn Odom, Deirdre Mladsi, Molly Purser, James A Kaye, Eirini Palaka, Alina Charter, Jo Annah Jensen, Dalila Sellami

{"title":"A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma.","authors":"Dawn Odom, Deirdre Mladsi, Molly Purser, James A Kaye, Eirini Palaka, Alina Charter, Jo Annah Jensen, Dalila Sellami","doi":"10.1155/2017/6121760","DOIUrl":"10.1155/2017/6121760","url":null,"abstract":"Objectives: Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE). We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparison (MAIC) versus an unadjusted indirect comparison.Methods: After comparing trials and identifying potential prognostic factors, an MAIC was conducted to adjust for differences in key patient baseline characteristics. Due to BOLT's small sample size, the number of matching variables was restricted to two. Efficacy results for sonidegib were generated so that selected baseline characteristics matched those from ERIVANCE and were compared with published ERIVANCE results.Results: Matching variables were baseline percentages of patients receiving prior radiotherapy and surgery. After weighting, sonidegib objective response rate (ORR) and median progression-free survival (PFS) were effectively unchanged (prematched versus postmatched ORR and PFS, 56.1% versus 56.7% and 22.1 versus 22.1 months, resp.). Vismodegib's ORR and PFS were 47.6% and 9.5 months.Conclusions: Comparative effectiveness of sonidegib versus vismodegib remains unchanged after adjusting BOLT patient-level data to match published ERIVANCE baseline percentages of patients receiving prior surgery and radiotherapy.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2017 ","pages":"6121760"},"PeriodicalIF":1.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6121760","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35084092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Perceptions and Practices of the Iranian Population regarding Skin Cancers: A Literature Review. 伊朗人对皮肤癌的看法和做法:文献综述。

IF 1.1

Journal of Skin Cancer Pub Date : 2017-01-01 Epub Date: 2017-11-19 DOI: 10.1155/2017/4934108

Vinayak K Nahar, Zachria Hasani, Brian Martin, Javier F Boyas, Rosa Chabok, Leena S Philip, Ghazal Ghafari, Leila Seidfaraji, Stacy Chelf, Ram Lakhan, Amanda H Wilkerson, Marcelle Savoy, Manoj Sharma

{"title":"Perceptions and Practices of the Iranian Population regarding Skin Cancers: A Literature Review.","authors":"Vinayak K Nahar, Zachria Hasani, Brian Martin, Javier F Boyas, Rosa Chabok, Leena S Philip, Ghazal Ghafari, Leila Seidfaraji, Stacy Chelf, Ram Lakhan, Amanda H Wilkerson, Marcelle Savoy, Manoj Sharma","doi":"10.1155/2017/4934108","DOIUrl":"https://doi.org/10.1155/2017/4934108","url":null,"abstract":"Despite being preventable, more than 15% of all cancer cases in Iran occur in the skin, making them the most commonly diagnosed malignancy in the country. The purpose of this study is to gain an insight into the current skin cancer related knowledge, attitudes, beliefs, and practices among the Iranian population. A systematic computer based literature search was conducted using databases for articles published through April 2017. Research studies included those that measured skin cancer or sun protection related knowledge, attitudes, beliefs, and behaviors in different Iranian population groups. Exclusion criteria for the articles included (1) irrelevant topics to the review article's aim, (2) articles that focused on the treatment of skin cancers instead of prevention practices, and (3) similar studies conducted on populations not indigenous to Iran. A total of 25 articles that met the eligibility criteria were included in the review. Predominant data were collected via questionnaires. Skin cancer related knowledge varied from low to high across the studies. Moreover, there was a pattern of low perceived skin cancer susceptibility and severity. Overall, there was low usage of sun protection methods among the Iranian population. The findings of this study show that efforts to prevent skin cancer are needed. Education concerning the dangers of sun exposure as well as strategies used to prevent or lower the risk of developing skin cancer should be stressed.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2017 ","pages":"4934108"},"PeriodicalIF":1.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4934108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35749491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma. BEREP4免疫组化染色在基底细胞癌检测中的应用。

IF 1.1

Journal of Skin Cancer Pub Date : 2017-01-01 Epub Date: 2017-12-31 DOI: 10.1155/2017/2692604

Anthony Paulo Sunjaya, Angela Felicia Sunjaya, Sukmawati Tansil Tan

{"title":"The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma.","authors":"Anthony Paulo Sunjaya, Angela Felicia Sunjaya, Sukmawati Tansil Tan","doi":"10.1155/2017/2692604","DOIUrl":"https://doi.org/10.1155/2017/2692604","url":null,"abstract":"Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3-10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs. Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin. This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls. BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells. Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2017 ","pages":"2692604"},"PeriodicalIF":1.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/2692604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35849384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

A Qualitative Study of Quality of Life Concerns following a Melanoma Diagnosis. 黑色素瘤诊断后生活质量问题的定性研究。

IF 1.1

Journal of Skin Cancer Pub Date : 2017-01-01 Epub Date: 2017-05-28 DOI: 10.1155/2017/2041872

Rachel I Vogel, Lori G Strayer, Rehana L Ahmed, Anne Blaes, DeAnn Lazovich

{"title":"A Qualitative Study of Quality of Life Concerns following a Melanoma Diagnosis.","authors":"Rachel I Vogel, Lori G Strayer, Rehana L Ahmed, Anne Blaes, DeAnn Lazovich","doi":"10.1155/2017/2041872","DOIUrl":"https://doi.org/10.1155/2017/2041872","url":null,"abstract":"The goal of this study was to identify a relevant and inclusive list of quality of life issues among long-term survivors of melanoma. Individuals diagnosed with stage I-III cutaneous melanoma and had survived 1-5 years, ages 18-65 years at diagnosis, were recruited. Five focus groups were conducted with 33 participants in total. Discussions centered on participants' experiences at diagnosis, as well as ongoing physical, emotional, and social concerns, and behavioral changes since diagnosis. The majority of participants reported shock, fear, and feeling overwhelmed at the time of diagnosis. Some reported lingering physical concerns, including pain, numbness, and lymphedema, while a few reported no lasting issues. Emotional concerns were common, with most reporting anxiety. Several also noted feeling lonely and isolated. Social concerns included alteration of activities to avoid sun exposure, issues with family communication, and frustration with the lack of appreciation of the seriousness of melanoma by others. Finally, while many participants reported changes to their sun exposure and UV-protection behaviors, some reported little to no change. The shared experiences among participants in this study confirm the unique nature of melanoma and the need for interventions designed to improve the health and quality of life of melanoma survivors.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2017 ","pages":"2041872"},"PeriodicalIF":1.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/2041872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35105957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

College Students' Perceptions of Worry and Parent Beliefs: Associations with Behaviors to Prevent Sun Exposure. 大学生忧虑感知与父母信念:与防晒行为的关系

IF 1.1

Journal of Skin Cancer Pub Date : 2017-01-01 Epub Date: 2017-07-19 DOI: 10.1155/2017/4985702

Robert A Yockey, Laura A Nabors, Oladunni Oluwoye, Kristen Welker, Angelica M Hardee

{"title":"College Students' Perceptions of Worry and Parent Beliefs: Associations with Behaviors to Prevent Sun Exposure.","authors":"Robert A Yockey, Laura A Nabors, Oladunni Oluwoye, Kristen Welker, Angelica M Hardee","doi":"10.1155/2017/4985702","DOIUrl":"https://doi.org/10.1155/2017/4985702","url":null,"abstract":"More research is needed to understand how attitudes impact behaviors that afford sun protection. The current study examined the impact of students' perceptions of parental beliefs about sun exposure and its influence on their practiced sun protection behaviors and worry about sun exposure. Participants were college students (N = 462) at a large Midwestern university. They completed a survey to examine their perceptions of risks and messages about sun exposure and sun exposure behaviors. Results indicated that gender and students' perceptions of parental beliefs about sun exposure were related to sun protection behaviors and their own worry over sun exposure. Specifically, males showed lower levels of sun protection behaviors, with the exception of wearing a hat with a brim, and lower levels of worry about sun exposure compared to females. Roughly a third of our sample had a family history of skin cancer, and this variable was related to worry about sun exposure and parental beliefs. Prevention messages and interventions to reduce sun risk for college students should address risks of sun exposure as well as educating young adults about the importance of wearing sunscreen, protective clothing, and hats to improve sun protection.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2017 ","pages":"4985702"},"PeriodicalIF":1.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4985702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35265184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Comment on “Gender-Based Differences and Barriers in Skin Protection Behaviors in Melanoma Survivors” 评论“黑色素瘤幸存者皮肤保护行为的性别差异和障碍”

IF 1.1

Journal of Skin Cancer Pub Date : 2016-11-14 DOI: 10.1155/2016/1345726

V. Nahar, Amanda K Hutcheson, Javier F. Boyas, Stephanie K. Jacks, R. Brodell

引用次数: 2

Responsiveness of the Spanish Version of the “Skin Cancer Index” 西班牙语版“皮肤癌指数”的回应程度

IF 1.1

Journal of Skin Cancer Pub Date : 2016-10-09 DOI: 10.1155/2016/8180348

M. Troya-Martín, F. Rivas-Ruíz, N. Blázquez-Sánchez, I. Fernández-Canedo, M. Aguilar-Bernier, J. B. Repiso-Jiménez, J. C. Toribio-Montero, M. Jones‐Caballero, J. Rhee

{"title":"Responsiveness of the Spanish Version of the “Skin Cancer Index”","authors":"M. Troya-Martín, F. Rivas-Ruíz, N. Blázquez-Sánchez, I. Fernández-Canedo, M. Aguilar-Bernier, J. B. Repiso-Jiménez, J. C. Toribio-Montero, M. Jones‐Caballero, J. Rhee","doi":"10.1155/2016/8180348","DOIUrl":"https://doi.org/10.1155/2016/8180348","url":null,"abstract":"Background. Skin Cancer Index (SCI) is a specific questionnaire measuring health related quality of life (HRQL) in patients with cervicofacial non-melanoma skin cancer (CFNMSC). The original scale has recently been adapted and validated into Spanish. Objectives. Evaluate the responsiveness of the Spanish version of SCI. Methods. Patients with CFNMSC candidate for surgical treatment were administered the questionnaire at time of diagnostic (t 0), 7 days after surgery (t 1), and 5 months after surgery (t 2). The scale and subscales scores (C1: social/appearance, C2: emotional) were then evaluated. Differences between t 0-t 1, t 1-t 2, and t 0-t 2 were determined and a gender-and-age segmented analysis was performed. Results. 88 patients, 54.8% male, mean age 62.5 years, completed the study. Differences between t 0-t 1 and t 1-t 2 scores were statistically significant (p < 0.05). The lowest values were found at time of diagnosis and postsurgery. Women and patients under 65 years showed the lowest values at the three times. Limitations. Concrete geographic and cultural area. Clinical and histological variables are not analysed. Conclusions. Our results confirm responsiveness of the Spanish version of the SCI. Further development of the instrument in Spanish-speaking countries and populations will make it possible to extend worldwide research and knowledge horizons on skin cancer.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2016-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83637514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Melanoma Disparities among US Hispanics: Use of the Social Ecological Model to Contextualize Reasons for Inequitable Outcomes and Frame a Research Agenda 美国西班牙裔人的黑色素瘤差异:使用社会生态模型来背景化不公平结果的原因并制定研究议程

IF 1.1

Journal of Skin Cancer Pub Date : 2016-08-29 DOI: 10.1155/2016/4635740

V. Harvey, Charlene W. Oldfield, Jarvis T. Chen, K. Eschbach

引用次数: 16

Gender-Based Differences and Barriers in Skin Protection Behaviors in Melanoma Survivors 黑色素瘤幸存者皮肤保护行为的性别差异和障碍

IF 1.1

Journal of Skin Cancer Pub Date : 2016-08-25 DOI: 10.1155/2016/3874572

Jeffrey Chen, J. Shih, Andrew Tran, Aaron Mullane, C. Thomas, N. Aydin, S. Misra

{"title":"Gender-Based Differences and Barriers in Skin Protection Behaviors in Melanoma Survivors","authors":"Jeffrey Chen, J. Shih, Andrew Tran, Aaron Mullane, C. Thomas, N. Aydin, S. Misra","doi":"10.1155/2016/3874572","DOIUrl":"https://doi.org/10.1155/2016/3874572","url":null,"abstract":"Purpose. Skin protection behaviors and environmental exposure play a crucial role in the development and subsequent management of melanoma. This study investigates gender-based differences in skin protection behaviors after melanoma treatment. Methods. Patients diagnosed and surgically treated for cutaneous melanomas over the last six years in a geographically high risk area were surveyed over telephone using a standardized script. Results. Of 150 survey results obtained, there were 82 males and 68 females. Overall, 87% of participants reported skin self-examination for abnormal markings more often and 94% reported wearing skin protective clothing more often, with females being more than males. Females limited outdoor activity more often than males, 79% to 54%, p < 0.05. When outside, females sought shade more often than males, 75% to 56%, p < 0.05. However, males wore a wide brim hat more often than females, 52% to 28%, p < 0.05. Interestingly, 60% of participants reported wearing SPF 30 sunscreen less often, p < 0.05. Conclusion. Larger percentage of females adopted behavioral changes to prevent future melanoma. Those living in high risk areas and with outdoor occupations need particular attention to skin care. Population based screening should be adopted to deal with this rising public health crisis.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"21 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2016-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86483387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Kaposi Sarcoma among HIV Infected Patients in Lagos University Teaching Hospital, Nigeria: A 14-Year Retrospective Clinicopathological Study 尼日利亚拉各斯大学教学医院HIV感染患者中的卡波西肉瘤:14年回顾性临床病理研究

IF 1.1

Journal of Skin Cancer Pub Date : 2016-03-13 DOI: 10.1155/2016/9368023

O. Akinde, O. Obadofin, T. Adeyemo, O. Omoseebi, N. Ikeri, I. Okonkwo, Olatunji Afolayan

{"title":"Kaposi Sarcoma among HIV Infected Patients in Lagos University Teaching Hospital, Nigeria: A 14-Year Retrospective Clinicopathological Study","authors":"O. Akinde, O. Obadofin, T. Adeyemo, O. Omoseebi, N. Ikeri, I. Okonkwo, Olatunji Afolayan","doi":"10.1155/2016/9368023","DOIUrl":"https://doi.org/10.1155/2016/9368023","url":null,"abstract":"Background. Despite the increased incidence of Kaposi sarcoma (KS) resulting from the Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) pandemic, there is still significant underreporting of KS in this environment. Objectives. This study was aimed at determining the incidence and clinicopathologic patterns of KS among HIV infected patients in Lagos University Teaching Hospital (LUTH), Nigeria, over a 14-year period: January 2000 to December 2013. Methodology. The materials for this study included patients' hospital clinical files, duplicate copies of histopathologic reports, and tissue blocks and corresponding archival slides in the Anatomic and Molecular Pathology Department and the HIV/AIDS unit of the Department of Haematology. Results. Within the study period, 182 cases of KS were diagnosed, accounting for 1.2% of all patients managed for HIV/AIDS and 2.99% of solid malignant tumours. The male-to-female ratio and modal age group were 1 : 1.3 and 5th decade, respectively. Most cases (90%) had purely mucocutaneous involvement with the lower limb being the commonest site (65.8%). The majority of lesions were plaques (65.8%). Vascular formation was the predominant histologic type seen (43.5%). Conclusion. KS in Lagos followed the same epidemiologic trend as other centers in Nigeria, with an increasing incidence in this era of HIV/AIDS.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"74 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2016-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81226408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6