Journal of research in health sciences最新文献

{"title":"Association Between Household Food Insecurity and Low Birth Weight: A Population-Based Case-Control Study.","authors":"Zahra Amiri, Masoumeh Sadeghi, Amin Moradi, Maryam Paydar, Mehdi Norouzi, Ehsan Mosafarkhani","doi":"10.34172/jrhs.2024.165","DOIUrl":"10.34172/jrhs.2024.165","url":null,"abstract":"<p><strong>Background: </strong>Low birth weight (LBW) is a major public health issue associated with increased neonatal morbidity and mortality. This study aimed to examine the association between household food insecurity and LBW in Mashhad, Iran. <b>Study Design:</b> A population-based case-control study.</p><p><strong>Methods: </strong>This study involved 6294 mothers (3247 cases and 3247 controls) who visited healthcare centers affiliated with Mashhad University of Medical Sciences for term births between March 2019 and March 2022. Cases included women who delivered neonates weighing<2500 g, while controls delivered babies≥2500 g. Food security was measured using the validated Household Food Insecurity Access Scale. Logistic regression models examined the associations between food insecurity and LBW. Geographic information system techniques mapped LBW distribution in Mashhad.</p><p><strong>Results: </strong>Household food insecurity was significantly associated with higher odds of LBW (adjusted odds ratio [AOR]=1.25, 95% confidence interval [CI]: 1.03, 1.53). Other risk factors included younger maternal age (AOR=1.03, 95% CI: 1.01, 1.04), lower maternal education (AOR=0.55, 95% CI: 0.43, 0.71), cesarean delivery (AOR=1.70, 95% CI: 1.40, 2.06), and exposure to secondhand smoke (AOR=1.68, 95% CI: 1.02, 2.75). Gestational diabetes demonstrated a protective effect (AOR=0.37, 95% CI: 0.15, 0.91). Geographic mapping revealed that regions with higher food insecurity had elevated LBW prevalence.</p><p><strong>Conclusion: </strong>These findings underscore the importance of addressing food insecurity among pregnant women to reduce the risk of LBW and improve newborn outcomes.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 4","pages":"e00630"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Risk Factors Associated with Recurrence and Death in Patients with Thyroid Cancer From 2008 to 2023 in the West of Iran.","authors":"Salman Khazaei, Soheil Abdollahi Yeganeh, Seyed Ahmad Raza Salim Bahrami, Shiva Borzouei","doi":"10.34172/jrhs.2024.167","DOIUrl":"10.34172/jrhs.2024.167","url":null,"abstract":"<p><strong>Background: </strong>Thyroid carcinoma (TC) is a global clinical concern, and its incidence has progressively increased worldwide. Early detection of TC and subsequently decreased age at the diagnosis seem to result from extensive employment of imaging modalities, biopsy techniques, and improvements in the healthcare system. <b>Study Design:</b> A retrospective cohort study.</p><p><strong>Methods: </strong>Overall, 400 patients diagnosed with TC following thyroidectomy in the Endocrinology Clinic, who were followed for fifteen years, were investigated in this study. The checklist included patients' demographic characteristics, clinical information, and response to treatment, recurrence, and death.</p><p><strong>Results: </strong>There were 19.25% men and 80.75% women. The mean age was 41.005±15.58 years. The risk of death and recurrence was significantly higher in men, patients>65 years, smokers, patients with a family history of TC, undifferentiated cancer, multifocality, and stages III and IV (<i>P</i><0.001). Each additional year of life was associated with a 21% increase in the risk of death (<i>P</i><0.001). Smoking was associated with a 4.36-fold increase in the risk of death (<i>P</i>=0.05). For each additional year of life, the probability of recurrence increased by 3% (<i>P</i>=0.009). Men were 4.73 times more likely to recur (<i>P</i><0.001) than women.</p><p><strong>Conclusion: </strong>To employ the proper therapeutic intervention and perform meticulous postoperative surveillance, it is crucial to consider the predictive influence of pertinent elements. Diagnosing TC in its early stages is essential for the healthcare system because of the increased incidence, younger age at diagnosis, and overall favorable prognosis of TC.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 4","pages":"e00632"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>ERCC1</i> Gene Polymorphisms (rs3212986 and rs11615) With the Risk of Lung Cancer in a Population From Southeast Iran.","authors":"Ali Khalouei, Yaser Masoumi-Ardakani, Abdollah Jafarzaheh, Behjat Kalantari Khandani, Farnaz Sedghy, Arezu Khosravi Mashizi, Mohammad Mehdi Yaghoobi, Mohammadreza Zangouey, Beydolah Shahouzehi","doi":"10.34172/jrhs.2024.166","DOIUrl":"10.34172/jrhs.2024.166","url":null,"abstract":"<p><strong>Background: </strong>Polymorphisms within the excision repair cross-complementation group 1 (<i>ERCC1</i>), an essential component of DNA repair mechanisms, have been associated with various malignancies. This study aimed to evaluate the association of the single-nucleotide polymorphisms (SNPs) rs3212986 and rs11615 within the <i>ERCC1</i> gene in non-small cell lung cancer (NSCLC) patients. <b>Study Design:</b> A case-control study.</p><p><strong>Methods: </strong>Genomic DNA was extracted from the peripheral blood samples of 83 NSCLC patients and 119 healthy individuals. The genetic diversity of SNPs rs3212986 and rs11615 was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The RFLP results were confirmed through sequencing.</p><p><strong>Results: </strong>The TT genotype of the rs11615 SNP was associated with a higher risk of NSCLC development (odds ratio: 3.900, 95% confidence interval: 0.603, 22.866, P=0.050). Furthermore, the AA genotype of rs3212986 was related to a higher risk of NSCLC development (OR: 2.531, 95% CI: 1.017, 6.300, <i>P</i>=0.046). A significant association was observed between smoking and lung cancer (OR: 3.072, 95% CI: 1.715, 5.503, <i>P</i><0.001). Moreover, among non-smokers, there was an association between lung cancer risk and the AA (OR: 6.825, 95% CI: 1.722, 27.044, <i>P</i>=0.006) and AC (OR: 2.503, 95% CI: 0.977, 6.412, <i>P</i>=0.056) genotypes of rs3212986. However, no correlation was found between the genotypes of these SNPs and patients' sensitivity to cisplatin and carboplatin (<i>P</i> ˃ 0.05).</p><p><strong>Conclusion: </strong>The rs11615-related TT genotype and the rs3212986-related AA genotype may be associated with a higher risk of lung cancer development.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 4","pages":"e00631"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Human Papillomavirus (HPV) Infection and its Association With Pap Smear Findings Among Women Attending a Gynecology Clinic in Khorasan Razavi-Iran.","authors":"Sareh Etemad, Amir Mohammad Asghari Baghalan, Bita Naeimi, Shadi Mehrzad, Saina Adib Amin, Mohammad Soudyab, Reza Jafarzadeh Esfehani","doi":"10.34172/jrhs.2024.164","DOIUrl":"10.34172/jrhs.2024.164","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) infection is the most common sexual transmitted disease and Pap smears and HPV testing are crucial for early detection. Advancements in HPV testing improve accuracy, but optimal screening strategies are still debated. This cross-sectional study explores HPV genotypes and predictors of infection among Iranian women undergoing gynecological screening. <b>Study Design:</b> A retrospective cross-sectional study.</p><p><strong>Methods: </strong>Women undergoing their initial cervical screening enrolled in this study. Cervical cytology samples for Pap smear analysis were collected from women referred to the genetic laboratory of Academic Center for Education Culture and Research (ACECR), Khorasan Razavi, during gynecological visits, adhering to standardized liquid-based cytology protocols. These samples were obtained over a one-year period since January 2023. Statistical analyses were conducted using SPSS version 21.0, with a significance level set at <i>P</i><0.05.</p><p><strong>Results: </strong>A total of 328 women enrolled in this study. The mean age of participants was 36±11 years and the overall HPV prevalence was 37.5% (n=123). Among HPV-positive women, nearly half (48.7%) had a single HPV genotype. Genotypes 6 (13%), 16 (12.3%), and 53 (6.7%) were the most prevalent types. Notably, high-risk HPV genotypes (16 and 18 among all) were identified in one-fourth of the study population. Women with endocervical/transformation zone cells had 25% higher odds of having HPV infection, and having mild, moderate, and severe inflammation increased the odds of having HPV infection by 14%, 11%, and 20%, respectively.</p><p><strong>Conclusion: </strong>The considerably high prevalence of HPV infection highlights the significance of HPV prevention programs in this population. Neither bacterial vaginosis nor candida infection showed a direct link to HPV positivity.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 4","pages":"e00629"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Link Between Food Assistance Programs and Physical Activity Among Children and Adolescents.","authors":"Pardis Noormohammadpour, Nicole Robertson","doi":"10.34172/jrhs.2024.162","DOIUrl":"10.34172/jrhs.2024.162","url":null,"abstract":"<p><strong>Background: </strong>While the direct benefits of food assistance programs are well-documented, there is a need to explore indirect benefits like increased physical activity. This study examined whether participation in the Supplemental Nutrition Assistance Program (SNAP) was associated with improved physical activity levels in children and adolescents aged 2-17 in the United States during 2017-2018. <b>Study Design:</b> A cross-sectional study.</p><p><strong>Methods: </strong>This cross-sectional study used a subset of National Health and Nutrition Examination Survey (NHANES) data (n=2620). In the NHANES 2017-2018 dataset, physical activity was measured through self-report questionnaires, which captured participants' frequency, duration, and intensity of various activities. We used weighted logistic regression and the Hosmer - Lemeshow - Sturdivant forward model - building strategy to investigate this hypothesized association using SAS version 9.4.</p><p><strong>Results: </strong>In the adjusted model, controlling for the other variables in the model, we found that children and adolescents from households that had received SNAP/Food Stamps had 1.53 times higher odds (odds ratio [OR]=1.53, 95% CI: 1.24-1.89) of achieving the recommended guidelines of 60 minutes of daily physical activity compared to those who had not received benefits. Each additional year of age resulted in 0.82 times lower odds (OR=0.82; 95% CI: 0.79, 0.85) of meeting the recommended amounts of physical activity. Additionally, each unit increase in BMI was associated with 0.96 times lower odds (OR=0.96, 95% CI: 0.93, 0.98) of engaging in recommended physical activity.</p><p><strong>Conclusion: </strong>These findings suggest that participation in the SNAP/Food Stamps program may indirectly benefit participants by increasing physical activity levels.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 4","pages":"e00627"},"PeriodicalIF":1.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retention in Care Among People Living with HIV in Nigeria: A Systematic Review and Meta-analysis.","authors":"John O Olawepo, Katherine O'Brien, Julia Papasodoro, Philip E Coombs, Neha Singh, Shubhi Gupta, Aarushi Bhan, Babayemi O Olakunde, Echezona E Ezeanolue","doi":"10.34172/jrhs.2024.153","DOIUrl":"10.34172/jrhs.2024.153","url":null,"abstract":"<p><strong>Background: </strong>In 2021, Nigeria had an estimated 1.9 million people living with the human immunodeficiency virus (PLHIV) and 1.7 million (90%) on antiretroviral therapy (ART). <b>Study Design:</b> A systematic review and meta-analysis.</p><p><strong>Methods: </strong>This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 guidelines. We searched PubMed, Embase, PsychINFO, CINAHL, Global Index Medicus, and Cochrane Library. Studies were included if they reported on ART retention in care among PLHIV in Nigeria. The random-effects meta-analyses were used to combine the studies that had complete retention data. The I² statistic was used to assess the heterogeneity of the studies. A sensitivity analysis was then done by conducting a leave-one-out analysis. Afterward, data were analyzed using STATA version 18.</p><p><strong>Results: </strong>The search yielded 966 unique articles, of which 52 studies met the inclusion criteria for the meta-analysis, and four experimental studies were split into their component arms. The total number of study participants was 563,410, and the pooled retention rate was 72% (95% CI: 67%, 76%; I²=99.9%; n=57). Sub-analysis showed that the Southeast region of Nigeria had the highest retention of 86% (95% CI: 78%, 92%), and the South-South had the lowest retention (58%; 95% CI: 38%, 79%).</p><p><strong>Conclusion: </strong>In Nigeria, the pooled ART retention rate is less than optimal to achieve the UNAIDS goal of 95%, thus developing new models for ART retention is needed.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 3","pages":"e00618"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lag -Effects of Air Pollutants and Meteorological Factors on COVID-19 Infection Transmission and Severity: Using Machine Learning Techniques.","authors":"Nadia Mohammadi Dashtaki, Alireza Mirahmadizadeh, Mohammad Fararouei, Reza Mohammadi Dashtaki, Mohammad Hoseini, Mohammad Reza Nayeb","doi":"10.34172/jrhs.2024.157","DOIUrl":"10.34172/jrhs.2024.157","url":null,"abstract":"<p><strong>Background: </strong>Exposure to air pollution is a major health problem worldwide. This study aimed to investigate the effect of the level of air pollutants and meteorological parameters with their related lag time on the transmission and severity of coronavirus disease 19 (COVID-19) using machine learning (ML) techniques in Shiraz, Iran. <b>Study Design:</b> An ecological study.</p><p><strong>Methods: </strong>In this ecological research, three main ML techniques, including decision trees, random forest, and extreme gradient boosting (XGBoost), have been applied to correlate meteorological parameters and air pollutants with infection transmission, hospitalization, and death due to COVID-19 from 1 October 2020 to 1 March 2022. These parameters and pollutants included particulate matter (PM2), sulfur dioxide (SO₂ ), nitrogen dioxide (NO₂ ), nitric oxide (NO), ozone (O₃ ), carbon monoxide (CO), temperature (T), relative humidity (RH), dew point (DP), air pressure (AP), and wind speed (WS).</p><p><strong>Results: </strong>Based on the three ML techniques, NO₂ (lag 5 day), CO (lag 4), and T (lag 25) were the most important environmental features affecting the spread of COVID-19 infection. In addition, the most important features contributing to hospitalization due to COVID-19 included RH (lag 28), T (lag 11), and O₃ (lag 10). After adjusting for the number of infections, the most important features affecting the number of deaths caused by COVID-19 were NO₂ (lag 20), O₃ (lag 22), and NO (lag 23).</p><p><strong>Conclusion: </strong>Our findings suggested that epidemics caused by COVID-19 and (possibly) similarly viral transmitted infections, including flu, air pollutants, and meteorological parameters, can be used to predict their burden on the community and health system. In addition, meteorological and air quality data should be included in preventive measures.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 3","pages":"e00622"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Frequency of Rotavirus Gastroenteritis in Children from West of Iran and Genotyping of Rotavirus Isolates: A Suggestion for Further Changes in Childhood Immunization Program.","authors":"Parinaz Sedighi, Manoochehr Karami, Mehta Razzaghi, Maryam Emamjamaat, Abdollah Karimi, Roxana Mansour Ghanaiee, Masoud Alebouyeh, Iraj Sedighi","doi":"10.34172/jrhs.2024.156","DOIUrl":"10.34172/jrhs.2024.156","url":null,"abstract":"<p><strong>Background: </strong>Rotavirus is the most common cause of gastroenteritis among children. Currently, four oral live-attenuated vaccines are available to prevent rotavirus infection. The World Health Organization (WHO) has recommended including rotavirus vaccination in national immunization programs; however, it has not been introduced to the Iranian national immunization program. The study aimed to assess the frequency of rotavirus gastroenteritis in the west of Iran and investigate the necessity of rotavirus vaccination. <b>Study Design:</b> A case series study.</p><p><strong>Methods: </strong>In this case series study, 284 cases under six years of age who presented with acute gastroenteritis from March 2021 to 2022 to a referral hospital in the west of Iran were evaluated. Data on baseline characteristics, clinical manifestations, results of stool test, ELISA for rotavirus detection, and polymerase chain reaction (PCR) test for genotyping of rotavirus-positive samples were recorded.</p><p><strong>Results: </strong>Results showed that the prevalence of rotavirus infection was 36.6%. The highest frequency was observed among children aged 6-12 months and during the autumn. According to the PCR results, G1P[8], G9P[8], G9P[4], and G1P [4] were the dominant genotypes, and 33.75% of samples were infected with multiple rotavirus genotypes.</p><p><strong>Conclusion: </strong>The study highlights the considerable prevalence of rotavirus infection among cases of acute gastroenteritis in children under six years of age who were referred to a referral hospital in the west of Iran and the high diversity of rotavirus genotypes in the targeted community. Consequently, physicians and health policymakers should prioritize strategies for the prevention and control of this infection, particularly by considering the rotavirus vaccine as a priority for the Iranian national immunization program.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 3","pages":"e00621"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The Role of Social Support in Preventing Suicidal Ideations and Behaviors: A Systematic Review and Meta-Analysis.","authors":"Nahid Darvishi, Mehran Farhadi, Jalal Poorolajal","doi":"10.34172/jrhs.2024.160","DOIUrl":"10.34172/jrhs.2024.160","url":null,"abstract":"<p><p>In the article titled \"The Role of Social Support in Preventing Suicidal Ideations and Behaviors: A Systematic Review and Meta-Analysis,\"1 published as e00609 on June 1, 2024, in the Journal of Research in Health Sciences, corrections have been made to the author list and affiliations. The second affiliation of the first author, Nahid Darvishi, was omitted. The order of the corresponding author, Mehran Farhadi, has been changed from fourth to second. Additionally, the third author has withdrawn from the article due to personal reasons, prompting adjustments in the order of co-authors and their affiliations. These corrections have been applied to both the PDF and HTML versions of the article.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 3","pages":"e00625"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Inflammatory Index and Head and Neck Cancer: A Multicenter Case-Control Study in Iran.","authors":"Saba Narmcheshm, Monireh Sadat Seyyedsalehi, Bahareh Sasanfar, Hamideh Rashidian, Maryam Hadji, Elham Mohebbi, Ahmad Naghibzadeh-Tahami, Paolo Boffetta, Fatemeh Toorang, Kazem Zendehdel","doi":"10.34172/jrhs.2024.159","DOIUrl":"10.34172/jrhs.2024.159","url":null,"abstract":"<p><strong>Background: </strong>The inflammatory potential of diet may affect carcinogenesis. This study aimed to determine the association between dietary inflammatory index (DII) and the risk of head and neck cancer (HNC), as well as the interaction between DII and cigarette smoking in HNC development within the Iranian population. <b>Study Design:</b> This is a case-control study.</p><p><strong>Methods: </strong>In this multicenter case-control study, participants' dietary intake was assessed using a validated 130-item food frequency questionnaire, from which DII was computed. The study recruited 876 new cases from referral hospitals across 10 provinces and 3409 healthy controls who were frequency-matched based on age, gender, and residential place. Logistic regression was used to obtain odds ratios (ORs) for HNC across tertiles of DII, which were adjusted for confounding variables.</p><p><strong>Results: </strong>A higher pro-inflammatory diet was associated with an increased risk of all HNC (OR T3 vs. T1 [95% CI]: 1.31 [1.06, 1.62]; <i>P</i>-trend=0.013). There was a significant association between lip and oral cavity cancers and DII (OR T3 vs. T1 [95% CI]: 1.56 [1.16, 1.66]; <i>P</i>-trend=0.004). Furthermore, an inflammatory diet was associated with an increased risk of pharynx cancer (OR T3 vs. T1 [95% CI]: 2.08 [1.14, 3.79]; <i>P</i>-trend=0.02). Additionally, no significant association was observed between DII and larynx cancer, while an interaction was found between DII and tobacco use on the risk of HNC (OR T3 vs. T1 [95% CI]: 2.52 [1.78, 3.57]; <i>P</i>-interaction=0.03).</p><p><strong>Conclusion: </strong>DII was positively associated with HNC risk. There was a significant association between DII and the risk of lip, oral cavity, and pharynx cancers. Additionally, there was an interaction between tobacco use and DII in determining the risk of HNC.</p>","PeriodicalId":17164,"journal":{"name":"Journal of research in health sciences","volume":"24 3","pages":"e00624"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}