Multivariate Joint Analysis of Blood Pressure Measurements and Time to Remission: A Case Study of Hypertensive Patients Receiving Treatment at Jimma University Medical Center.
IF 1.4 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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引用次数: 0
Abstract
Background: Hypertension (HTN) elevates blood pressure (BP) in the arteries. It is defined as systolic BP (SBP)>140 mm Hg and/or diastolic BP (DBP)>90 mm Hg. This study aimed to identify determinant risk factors of longitudinal change of SBP and DBP with time to first remission of hypertensive patients. Study Design: A retrospective cohort study.
Methods: A descriptive and inferential analysis was employed to explore the determinant risk factors, and a multivariate joint model was applied to test the significant association of the possible risk factors.
Results: Of all 369 patients, 235 (63.7%) had first remission with a median survival time of five months. The patients demonstrated shorter first remission time when they had no history of comorbidity, resided in urban areas, took a combination of drugs, and were younger. Similarly, residence, age, treatment, history of diabetes mellitus (DM), history of stroke, and observation time were determinant risk factors of SBP. On the other hand, age, treatment, history of DM, chronic kidney diseases, and observation time were identified as determinant risk factors of DBP. The result revealed a strong positive association between changes in SBP and DBP (P=0.9923). In addition, a significant association was observed between the value of SBP and time to first remission (γ_1=-0.0693, HR=0.993).
Conclusion: Having good follow-ups, receiving control of comorbidity, and taking a combination of drugs show several opportunities for decreasing BP. Consequently, this compels patients to experience the first remission early.
背景：高血压（HTN）使动脉血压（BP）升高。它被定义为收缩压(SBP)>140 mm Hg和/或舒张压(DBP)>90 mm Hg。本研究旨在确定高血压患者首次缓解时收缩压和舒张压纵向变化的决定性危险因素。研究设计：回顾性队列研究。方法：采用描述性和推理分析的方法探讨决定因素，并采用多因素联合模型检验可能危险因素的显著相关性。结果：在所有369例患者中，235例（63.7%）首次缓解，中位生存时间为5个月。当患者没有合并症史，居住在城市地区，服用联合药物，年龄较小时，首次缓解时间较短。同样，居住地、年龄、治疗、糖尿病史、脑卒中史、观察时间是收缩压的决定性危险因素。另一方面，年龄、治疗、糖尿病史、慢性肾脏疾病和观察时间被确定为DBP的决定性危险因素。结果显示收缩压和舒张压变化呈正相关（P=0.9923）。此外，收缩压值与首次缓解时间有显著相关性（γ_1=-0.0693， HR=0.993）。结论：随访良好、合并症得到控制、联合用药有降低血压的机会。因此，这迫使患者尽早经历第一次缓解。
期刊介绍：
The Journal of Research in Health Sciences (JRHS) is the official journal of the School of Public Health; Hamadan University of Medical Sciences, which is published quarterly. Since 2017, JRHS is published electronically. JRHS is a peer-reviewed, scientific publication which is produced quarterly and is a multidisciplinary journal in the field of public health, publishing contributions from Epidemiology, Biostatistics, Public Health, Occupational Health, Environmental Health, Health Education, and Preventive and Social Medicine. We do not publish clinical trials, nursing studies, animal studies, qualitative studies, nutritional studies, health insurance, and hospital management. In addition, we do not publish the results of laboratory and chemical studies in the field of ergonomics, occupational health, and environmental health
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