Journal of Stroke最新文献

{"title":"Circulating Extracellular-Vesicle-Incorporated MicroRNAs as Potential Biomarkers for Ischemic Stroke in Patients With Cancer.","authors":"Oh Young Bang,&nbsp;Eun Hee Kim,&nbsp;Mi Jeong Oh,&nbsp;Jaein Yoo,&nbsp;Gyun Sik Oh,&nbsp;Jong-Won Chung,&nbsp;Woo-Keun Seo,&nbsp;Gyeong-Moon Kim,&nbsp;Myung-Ju Ahn,&nbsp;Seong Wook Yang","doi":"10.5853/jos.2022.02327","DOIUrl":"https://doi.org/10.5853/jos.2022.02327","url":null,"abstract":"<p><strong>Background and purpose: </strong>This study aimed to evaluate whether extracellular-vesicle-incorporated microRNAs (miRNAs) are potential biomarkers for cancer-related stroke.</p><p><strong>Methods: </strong>This cohort study compared patients with active cancer who had embolic stroke of unknown sources (cancer-stroke group) with patients with only cancer, patients with only stroke, and healthy individuals (control groups). The expression profiles of miRNAs encapsulated in plasma exosomes and microvesicles were evaluated using microarray and validated using quantitative real-time polymerase chain reaction. The XENO-QTM miRNA assay technology was used to determine the absolute copy numbers of individual miRNAs in an external validation cohort.</p><p><strong>Results: </strong>This study recruited 220 patients, of which 45 had cancer-stroke, 76 were healthy controls, 39 were cancer controls, and 60 were stroke controls. Three miRNAs (miR-205-5p, miR-645, and miR-646) were specifically incorporated into microvesicles in patients with cancer-related stroke, cancer controls, and stroke controls. The area under the receiver operating characteristic curves of these three miRNAs were 0.7692-0.8510 for the differentiation of patients with cancer-stroke from cancer-controls and 0.8077-0.8846 for the differentiation of patients with cancer-stroke from stroke controls. The levels of several miRNAs were elevated in the plasma exosomes of patients with cancer, but were lower than those in plasma microvesicles. An in vivo study showed that systemic injection of miR-205-5p promoted the development of arterial thrombosis and elevation of D-dimer levels.</p><p><strong>Conclusion: </strong>Stroke due to cancer-related coagulopathy was associated with deregulated expression of miRNAs, particularly microvesicle-incorporated miR-205-5p, miR-645, and miR-646. Further prospective studies of extracellular-vesicle-incorporated miRNAs are required to confirm the diagnostic role of miRNAs in patients with stroke and to screen the roles of miRNAs in patients with cancer.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"251-265"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/60/jos-2022-02327.PMC10250879.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9961308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of Ischemic Stroke in Patients With Atrial Fibrillation Receiving Non-Vitamin K Oral Anticoagulants: Causes and Prevention Strategies.","authors":"Oh Young Bang,&nbsp;Kyoung-Min Park,&nbsp;Dong Seop Jeong","doi":"10.5853/jos.2022.03552","DOIUrl":"https://doi.org/10.5853/jos.2022.03552","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is a leading cause of cardioembolic stroke, which is often fatal or disabling. Prevention of stroke is crucial in AF management, and anticoagulation with non-vitamin K oral anticoagulants (NOACs) is the mainstay of AF management for stroke prevention. Because NOAC prescriptions have been surging worldwide, the development of acute ischemic stroke in patients with AF who receive NOAC treatment is an increasingly important issue in clinical practice. Moreover, these patients show a high risk of recurrence, with more than a 50% higher risk, than do patients with AF and no prior anticoagulation therapy. Careful evaluation is mandatory to determine possible causes of ischemic stroke during NOAC therapy. Differentiation of AF-unrelated stroke and demonstration of combined cardiac disease/systemic coagulopathy are important in these patients and may provide improved results in their treatment. In addition, ensuring appropriate dosing and good adherence to NOAC treatment is important. Cardioembolism, despite sufficient anticoagulation and no other causes, is the most common and challenging complication because switching to anticoagulants or adding antiplatelets to the treatment regimen does not reduce the risk of recurrent stroke, and there are no guidelines for this specific situation. This review article aimed to present the most updated data on the prevalence, causes, and secondary prevention strategies, specifically focusing on non-pharmacological approaches, together with relevant cases of AF in patients who developed ischemic stroke on NOAC therapy.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"199-213"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/fc/jos-2022-03552.PMC10250874.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9608278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Genetically Proxied AMPK Activation, the Target of Metformin, on Functional Outcome Following Ischemic Stroke.","authors":"Mengmeng Wang,&nbsp;Zhizhong Zhang,&nbsp;Marios K Georgakis,&nbsp;Ville Karhunen,&nbsp;Dandan Liu","doi":"10.5853/jos.2022.03230","DOIUrl":"https://doi.org/10.5853/jos.2022.03230","url":null,"abstract":"<p><strong>Background and purpose: </strong>We performed a two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of genetically proxied AMP-activated protein kinase (AMPK) activation, which is the target of metformin, on functional outcome following ischemic stroke onset.</p><p><strong>Methods: </strong>A total of 44 AMPK-related variants associated with HbA1c (%) were used as instruments for AMPK activation. The primary outcome was the modified Rankin Scale (mRS) score at 3 months following the onset of ischemic stroke, evaluated as a dichotomous variable (3-6 vs. 0-2) and subsequently as an ordinal variable. Summary-level data for the 3-month mRS were obtained from the Genetics of Ischemic Stroke Functional Outcome network, including 6,165 patients with ischemic stroke. The inverse-variance weighted method was used to obtain causal estimates. The alternative MR methods were used for sensitivity analysis.</p><p><strong>Results: </strong>Genetically predicted AMPK activation was significantly associated with lower odds of poor functional outcome (mRS 3-6 vs. 0-2, odds ratio [OR]: 0.06, 95% confidence interval [CI]: 0.01-0.49, P=0.009). This association was maintained when 3-month mRS was analyzed as an ordinal variable. Similar results were observed in the sensitivity analyses, and there was no evidence of pleiotropy.</p><p><strong>Conclusion: </strong>This MR study provided evidence that AMPK activation by metformin may exert beneficial effects on functional outcome following ischemic stroke.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"266-271"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/44/jos-2022-03230.PMC10250876.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9655328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Thrombectomy for Large Ischemic Strokes: A Living Systematic Review and Meta-Analysis of Randomized Trials.","authors":"Rami Z Morsi,&nbsp;Mohamed Elfil,&nbsp;Hazem S Ghaith,&nbsp;Mohammad Aladawi,&nbsp;Ahmad Elmashad,&nbsp;Sachin Kothari,&nbsp;Harsh Desai,&nbsp;Shyam Prabhakaran,&nbsp;Fawaz Al-Mufti,&nbsp;Tareq Kass-Hout","doi":"10.5853/jos.2023.00752","DOIUrl":"https://doi.org/10.5853/jos.2023.00752","url":null,"abstract":"<p><strong>Background and purpose: </strong>New studies have shown that endovascular thrombectomy (EVT) is safe and effective for acute ischemic stroke (AIS) patients with large ischemic areas. The aim of our study is to conduct a living systematic review and meta-analysis of randomized trials comparing EVT versus medical management only.</p><p><strong>Methods: </strong>We searched MEDLINE, Embase, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing EVT versus medical management alone in AIS patients with large ischemic regions. We conducted our meta-analysis using fixed-effect models to compare functional independence, mortality, and symptomatic intracranial hemorrhage (sICH) between EVT and standard medical management only. We assessed the risk of bias using the Cochrane risk-of-bias tool and the certainty of evidence for each outcome using the Grading of Recommendations, Assessment, Development, and Evaluations approach.</p><p><strong>Results: </strong>Of 14,513 citations, we included 3 RCTs with a total of 1,010 participants. We found low-certainty evidence of possibly a large increase in the proportion of patients with functional independence (risk difference [RD] 30.3%, 95% CI 15.0% to 52.3%), low-certainty evidence of possibly a small non-significant decrease in mortality (RD -0.7%, 95% CI -3.8% to 3.5%), and low-certainty evidence of possibly a small non-significant increase in sICH (RD 3.1%, 95% CI -0.3% to 9.8%) for AIS patients with large infarcts who underwent EVT compared to medical management only.</p><p><strong>Conclusion: </strong>Low-certainty evidence shows that there is possibly a large increase in functional independence, a small non-significant decrease in mortality, and a small non-significant increase in sICH amongst AIS patients with large infarcts undergoing EVT compared to medical management only.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"214-222"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/db/jos-2023-00752.PMC10250873.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9655327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation: A Pilot Randomized Trial.","authors":"Jong S Kim,&nbsp;Kyung-Bok Lee,&nbsp;Dae-Il Chang,&nbsp;Jae-Kwan Cha,&nbsp;Ji Sung Lee","doi":"10.5853/jos.2023.00325","DOIUrl":"https://doi.org/10.5853/jos.2023.00325","url":null,"abstract":"Without anticoagulation, the risk of early recurrence in the first 14 days after atrial fibrillation (AF)-related ischemic stroke is approximately 0.5%–1.3% per day. Anticoagulation is an essential strategy for preventing recurrent stroke in patients with AF-related stroke. However, it increases the incidence of intracranial hemorrhage (ICH) in the early stages of stroke. For the timing of anticoagulation, the “1–3–6–12 days rule” has been used: administration of anticoagulant at day 1 for transient ischemic attack (TIA), day 3 for mild stroke (National Institutes of Health Stroke Scale [NIHSS] &lt;8), day 6 for moderate stroke (NIHSS 8–16), and day 12 for severe stroke (NIHSS &gt;16). However, this rule was established when vitamin K-dependent anticoagulation was used. Non-vitamin K-dependent oral anticoagulants (NOACs) have a similar efficacy and are associated with a lower bleeding risk; they may be administered earlier than warfarin in patients with acute ischemic stroke (AIS). However, no randomized controlled trials have focused on the timing of NOAC administration in patients with AF-related AIS. The purpose of this study was to examine the feasibility and possible efficacy of NOAC administration at timepoints earlier than the conventional rules. Considering that early recurrent infarcts identified using diffusion-weighted imaging (DWI) and ICH identified using gradient-echo imaging (GRE) are common in patients with AF-related AIS, we used these imaging endpoints in this pilot study. This was a multicenter, randomized, open-label, blinded endpoint trial. Patients with AIS identified by DWI were included if they (1) were ≥20 years old, (2) had cardioembolic infarction (due to AF) identified before randomization, (3) had mild to moderately severe stroke (TIA and severe strokes were excluded), and (4) could be administered edoxaban within 48 hours of symptom onset. The exclusion criteria are summarized in Supplementary Table 1. Patients were randomized to either the conventional edoxaban treatment group (C-group) or the early edoxaban treatment group (E-group). In the C-group, a standard dose of edoxaban was administered to patients on day 3 for mild stroke and on day 6 for moderate stroke after symptom onset. Before administration of edoxaban, the use of anticoagulants was prohibited. In the E-group, a half-dose of edoxaban was administered from onset until day 3 (for mild stroke) or day 6 (for moderate stroke), and a standard dose of edoxaban was then administered as in the C-group. Baseline magnetic resonance imaging (MRI) was performed 24–48 hours after symptom onset, and follow-up MRI was performed between days 10 and 14. MRI images, including DWI, GRE, fluid-attenuated inversion recovery, and magnetic resonance angiography, were collected at the Asan Medical Center Central Image Laboratory and read by neuroradiologists blinded to treatment allocation. Thrombolysis or endovascular therapy was permitted if appropriate. Edoxaban was administered","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"311-314"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/f6/jos-2023-00325.PMC10250868.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9599862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Amyloid Cerebral Deposits and Cognitive Outcome After Stroke: The IDEA3 Study.","authors":"Olivier Godefroy,&nbsp;Mélanie Barbay,&nbsp;Jeanne Martin,&nbsp;Trevor Shields,&nbsp;Chantal Lamy,&nbsp;Audrey Courselle-Arnoux,&nbsp;Sandrine Canaple,&nbsp;Claire Leclercq,&nbsp;Martine Roussel,&nbsp;Marc-Etienne Meyer,&nbsp;Etienne Marchal,&nbsp;Frank A Wollenweber","doi":"10.5853/jos.2022.03391","DOIUrl":"https://doi.org/10.5853/jos.2022.03391","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"315-319"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/2f/jos-2022-03391.PMC10250875.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9602151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplatelet Therapy May Be Insufficient to Prevent Stroke Recurrence Before Percutaneous Patent Foramen Ovale Closure.","authors":"Hiroyuki Kawano,&nbsp;Yuko Honda,&nbsp;Takashi Johno,&nbsp;Hibiku Maruoka,&nbsp;Kaoru Nakanishi,&nbsp;Mikito Saito,&nbsp;Kensuke Ogata,&nbsp;Atsushi Yamamichi,&nbsp;Ayane Kawatake,&nbsp;Teruyuki Hirano","doi":"10.5853/jos.2022.04084","DOIUrl":"https://doi.org/10.5853/jos.2022.04084","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"307-310"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/d3/jos-2022-04084.PMC10250881.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9602146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Treatment of Distal-M2 Segment Occlusions: A Clinical Registry and Meta-Analysis.","authors":"Sacha Bensoussan,&nbsp;Stephanos Nikolaos Finitsis,&nbsp;Bertrand Lapergue,&nbsp;Gaultier Marnat,&nbsp;Igor Sibon,&nbsp;Solène Moulin,&nbsp;Jean-Marc Olivot,&nbsp;Sébastien Richard,&nbsp;Charlotte Rosso,&nbsp;Benjamin Gory,&nbsp;Frédéric Clarençon","doi":"10.5853/jos.2022.03692","DOIUrl":"https://doi.org/10.5853/jos.2022.03692","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"299-302"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/d8/jos-2022-03692.PMC10250883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-Phenotype Correlation of the <I>RNF213</I> R4810K Variant in Moyamoya Disease.","authors":"Taedong Ok,&nbsp;Yo Han Jung,&nbsp;Kyung-Yul Lee","doi":"10.5853/jos.2023.00297","DOIUrl":"https://doi.org/10.5853/jos.2023.00297","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"303-306"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/af/jos-2023-00297.PMC10250872.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9605218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration.","authors":"Christopher Traenka,&nbsp;Johannes Lorscheider,&nbsp;Christian Hametner,&nbsp;Philipp Baumgartner,&nbsp;Jan Gralla,&nbsp;Mauro Magoni,&nbsp;Nicolas Martinez-Majander,&nbsp;Barbara Casolla,&nbsp;Katharina Feil,&nbsp;Rosario Pascarella,&nbsp;Panagiotis Papanagiotou,&nbsp;Annika Nordanstig,&nbsp;Visnja Padjen,&nbsp;Carlo W Cereda,&nbsp;Marios Psychogios,&nbsp;Christian H Nolte,&nbsp;Andrea Zini,&nbsp;Patrik Michel,&nbsp;Yannick Béjot,&nbsp;Andreas Kastrup,&nbsp;Marialuisa Zedde,&nbsp;Georg Kägi,&nbsp;Lars Kellert,&nbsp;Hilde Henon,&nbsp;Sami Curtze,&nbsp;Alessandro Pezzini,&nbsp;Marcel Arnold,&nbsp;Susanne Wegener,&nbsp;Peter Ringleb,&nbsp;Turgut Tatlisumak,&nbsp;Paul J Nederkoorn,&nbsp;Stefan T Engelter,&nbsp;Henrik Gensicke","doi":"10.5853/jos.2022.03370","DOIUrl":"https://doi.org/10.5853/jos.2022.03370","url":null,"abstract":"<p><strong>Background and purpose: </strong>This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD).</p><p><strong>Methods: </strong>This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015-2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0-2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching.</p><p><strong>Results: </strong>Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10-19] vs. 4 [2-7], P<0.001). The frequency of favorable 3-month outcome did not differ significantly between both groups (EVT: 64.0% vs. IVT: 86.8%; ORadjusted 0.56 [0.24-1.32]). EVT was associated with higher rates of recanalization (80.5% vs. 40.7%; ORadjusted 8.85 [4.28-18.29]) compared to IVT. All secondary analyses showed higher recanalization rates in the EVT-group, which however never translated into better functional outcome rates compared to the IVT-group.</p><p><strong>Conclusion: </strong>We observed no signal of superiority of EVT over IVT regarding functional outcome in CeAD-patients with AIS and LVO despite higher rates of complete recanalization with EVT. Whether pathophysiological CeAD-characteristics or their younger age might explain this observation deserves further research.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"25 2","pages":"272-281"},"PeriodicalIF":8.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/56/jos-2022-03370.PMC10250869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}