Journal of Stroke最新文献

{"title":"Pupillometer-Based Neurological Pupil Index Differential: A Potential Predictor of Post-Stroke Delirium.","authors":"Kotaro Noda, Tomotaka Tanaka, Soichiro Abe, Ryo Usui, Misa Matsumoto, Yoshito Arakaki, Hiroyuki Kida, Ryoma Inui, Kaoru Kohama, Kazuo Washida, Sonu M M Bhaskar, Masatoshi Koga, Kazunori Toyoda, Masafumi Ihara","doi":"10.5853/jos.2023.04406","DOIUrl":"10.5853/jos.2023.04406","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 2","pages":"321-324"},"PeriodicalIF":8.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Concept of Intracranial Arterial Diseases: The Role of High Resolution Vessel Wall MRI.","authors":"Dong-Wan Kang, Do Yeon Kim, Jonguk Kim, Sung Hyun Baik, Cheolkyu Jung, Nishita Singh, Jae W Song, Hee-Joon Bae, Beom Joon Kim","doi":"10.5853/jos.2023.02481","DOIUrl":"10.5853/jos.2023.02481","url":null,"abstract":"<p><p>Intracranial arterial disease (ICAD) is a heterogeneous condition characterized by distinct pathologies, including atherosclerosis. Advances in magnetic resonance technology have enabled the visualization of intracranial arteries using high-resolution vessel wall imaging (HR-VWI). This review summarizes the anatomical, embryological, and histological differences between the intracranial and extracranial arteries. Next, we review the heterogeneous pathophysiology of ICAD, including atherosclerosis, moyamoya or RNF213 spectrum disease, intracranial dissection, and vasculitis. We also discuss how advances in HR-VWI can be used to differentiate ICAD etiologies. We emphasize that one should consider clinical presentation and timing of imaging in the absence of pathology-radiology correlation data. Future research should focus on understanding the temporal profile of HR-VWI findings and developing quantitative interpretative approaches to improve the decision-making and management of ICAD.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 1","pages":"26-40"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombectomy in Stroke Patients With Low Alberta Stroke Program Early Computed Tomography Score: Is Modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 Superior to mTICI 2b?","authors":"Sameh Samir Elawady, Brian Fabian Saway, Hidetoshi Matsukawa, Kazutaka Uchida, Steven Lin, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Edgar A Samaniego, Adam Arthur, Shinichi Yoshimura, Hugo Cuellar, Jonathan A Grossberg, Ali Alawieh, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Joshua Osbun, Roberto Crosa, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Travis Dumont, Richard Williamson, Pedro Navia, Peter Kan, Reade De Leacy, Shakeel Chowdhry, Mohamad Ezzeldin, Alejandro M Spiotta, Sami Al Kasab","doi":"10.5853/jos.2023.02292","DOIUrl":"10.5853/jos.2023.02292","url":null,"abstract":"<p><strong>Background and purpose: </strong>Outcomes following mechanical thrombectomy (MT) are strongly correlated with successful recanalization, traditionally defined as modified Thrombolysis in Cerebral Infarction (mTICI) ≥2b. This retrospective cohort study aimed to compare the outcomes of patients with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS; 2-5) who achieved mTICI 2b versus those who achieved mTICI 2c/3 after MT.</p><p><strong>Methods: </strong>This study utilized data from the Stroke Thrombectomy and Aneurysm Registry (STAR), which combined databases from 32 thrombectomy-capable stroke centers between 2013 and 2023. The study included only patients with low ASPECTS who achieved mTICI 2b, 2c, or 3 after MT for internal carotid artery or middle cerebral artery (M1) stroke.</p><p><strong>Results: </strong>Of the 10,229 patients who underwent MT, 234 met the inclusion criteria. Of those, 98 (41.9%) achieved mTICI 2b, and 136 (58.1%) achieved mTICI 2c/3. There were no significant differences in baseline characteristics between the two groups. The 90-day favorable outcome (modified Rankin Scale score: 0-3) was significantly better in the mTICI 2c/3 group than in the mTICI 2b group (adjusted odds ratio 2.35; 95% confidence interval [CI] 1.18-4.81; P=0.02). Binomial logistic regression revealed that achieving mTICI 2c/3 was significantly associated with higher odds of a favorable 90-day outcome (odds ratio 2.14; 95% CI 1.07-4.41; P=0.04).</p><p><strong>Conclusion: </strong>In patients with low ASPECTS, achieving an mTICI 2c/3 score after MT is associated with a more favorable 90-day outcome. These findings suggest that mTICI 2c/3 is a better target for MT than mTICI 2b in patients with low ASPECTS.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 1","pages":"95-103"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Intravenous Thrombolysis Prior to Mechanical Thrombectomy According to the Location of M1 Occlusion.","authors":"Jae-Chan Ryu, Boseong Kwon, Yunsun Song, Deok Hee Lee, Jun Young Chang, Dong-Wha Kang, Sun U Kwon, Jong S Kim, Bum Joon Kim","doi":"10.5853/jos.2023.01529","DOIUrl":"10.5853/jos.2023.01529","url":null,"abstract":"<p><strong>Background and purpose: </strong>The additive effects of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) remain unclear. We aimed to investigate the efficacy and safety of IVT prior to MT depending on the location of M1 occlusion.</p><p><strong>Methods: </strong>We reviewed the cases of patients who underwent MT for emergent large-vessel occlusion of the M1 segment. Baseline characteristics as well as clinical and periprocedural variables were compared according to the location of M1 occlusion (i.e., proximal and distal M1 occlusion). The main outcome was the achievement of functional independence (modified Rankin Scale score, 0-2) at 3 months after stroke. The main outcomes were compared between the proximal and distal groups based on the use of IVT before MT.</p><p><strong>Results: </strong>Among 271 patients (proximal occlusion, 44.6%; distal occlusion, 55.4%), 33.9% (41/121) with proximal occlusion and 24.7% (37/150) with distal occlusion underwent IVT prior to MT. Largeartery atherosclerosis was more common in patients with proximal M1 occlusion; cardioembolism was more common in those with distal M1 occlusion. In patients with proximal M1 occlusion, there was no association between IVT before MT and functional independence. In contrast, there was a significant association between the use of IVT prior to MT (odds ratio=5.30, 95% confidence interval=1.56-18.05, P=0.007) and functional independence in patients with distal M1 occlusion.</p><p><strong>Conclusion: </strong>IVT before MT was associated with improved functional outcomes in patients with M1 occlusion, especially in those with distal M1 occlusion but not in those with proximal M1 occlusion.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":" ","pages":"75-86"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White Matter Structural Connectivity Associated With Visual Field Recovery After Stroke.","authors":"Eun Namgung, Eun-Jae Lee, Yong-Hwan Kim, Dong-Wha Kang","doi":"10.5853/jos.2023.02222","DOIUrl":"10.5853/jos.2023.02222","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":" ","pages":"116-120"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion.","authors":"Yorito Hattori, Yoshinori Kakino, Yuji Hattori, Mari Iwashita, Hitoshi Uchiyama, Kotaro Noda, Takeshi Yoshimoto, Hidehiro Iida, Masafumi Ihara","doi":"10.5853/jos.2023.02733","DOIUrl":"10.5853/jos.2023.02733","url":null,"abstract":"<p><strong>Background and purpose: </strong>Carotid artery stenosis or occlusion (CASO) is a causative disease of vascular cognitive impairment (VCI) attributed to cerebral hypoperfusion, even without the development of symptomatic ischemic stroke. Preclinically, resveratrol has been demonstrated to play an important role in improving cognitive function in rodent CASO models. This study investigated the association between long-term resveratrol intake and improvements in cognitive and cerebral hemodynamic impairments in patients with CASO.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on patients with asymptomatic carotid artery stenosis of ≥50% or occlusion who underwent 15O-gas positron emission tomography (15O-gas PET) and neuropsychological tests such as Montreal Cognitive Assessment (MoCA) and Alzheimer's Disease Assessment Scale-Cognitive Subscale 13 (ADAS-Cog) twice between July 2020 and March 2022 allowing >125-day interval. Patients were administered 30 mg/day resveratrol after the first 15O-gas PET and neuropsychological tests were compared with those who were not.</p><p><strong>Results: </strong>A total of 79 patients were enrolled in this study; 36 received resveratrol and 43 did not. Over a mean follow-up of 221.2 and 244.8 days, long-term resveratrol treatment significantly improved visuospatial/executive function (P=0.020) in MoCA, and memory domain (P=0.007) and total score (P=0.019) in ADAS-Cog. Cerebral blood flow demonstrated improvement in the right frontal lobe (P=0.027), left lenticular nucleus (P=0.009), right thalamus (P=0.035), and left thalamus (P=0.010) on 15O-gas PET. No adverse events were reported.</p><p><strong>Conclusion: </strong>Long-term daily intake of oral resveratrol may prevent or treat VCI by improving the cerebral blood flow in asymptomatic patients with CASO.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 1","pages":"64-74"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Daily Diastolic Blood Pressure Predicts Incident Stroke, Lacune, and Cerebral Microbleeds in CADASIL.","authors":"Chih-Hao Chen, Yi-Chu Liao, Yu-Wen Cheng, Chih-Ping Chung, Yi-Chung Lee, Sung-Chun Tang","doi":"10.5853/jos.2023.02880","DOIUrl":"10.5853/jos.2023.02880","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":" ","pages":"112-115"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality.","authors":"Thanh N Nguyen, Muhammad M Qureshi, Piers Klein, Hiroshi Yamagami, Mohamad Abdalkader, Robert Mikulik, Anvitha Sathya, Ossama Yassin Mansour, Anna Czlonkowska, Hannah Lo, Thalia S Field, Andreas Charidimou, Soma Banerjee, Shadi Yaghi, James E Siegler, Petra Sedova, Joseph Kwan, Diana Aguiar de Sousa, Jelle Demeestere, Violiza Inoa, Setareh Salehi Omran, Liqun Zhang, Patrik Michel, Davide Strambo, João Pedro Marto, Raul G Nogueira","doi":"10.5853/jos.2022.00752.e1","DOIUrl":"10.5853/jos.2022.00752.e1","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 1","pages":"129"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update of Anticoagulation Use in Cardioembolic Stroke With a Special Reference to Endovascular Treatment.","authors":"Apostolos Safouris, Klearchos Psychogios, Lina Palaiodimou, Peter Orosz, George Magoufis, Odysseas Kargiotis, Aikaterini Theodorou, Theodore Karapanayiotides, Stavros Spiliopoulos, Sándor Nardai, Amrou Sarraj, Thanh N Nguyen, Shadi Yaghi, Silke Walter, Simona Sacco, Guillaume Turc, Georgios Tsivgoulis","doi":"10.5853/jos.2023.01578","DOIUrl":"10.5853/jos.2023.01578","url":null,"abstract":"<p><p>Cardioembolic stroke is a major cause of morbidity, with a high risk of recurrence, and anticoagulation represents the mainstay of secondary stroke prevention in most patients. The implementation of endovascular treatment in routine clinical practice complicates the decision to initiate anticoagulation, especially in patients with early hemorrhagic transformation who are considered at higher risk of hematoma expansion. Late hemorrhagic transformation in the days and weeks following stroke remains a potentially serious complication for which we still do not have any established clinical or radiological prediction tools. The optimal time to initiate therapy is challenging to define since delaying effective secondary prevention treatment exposes patients to the risk of recurrent embolism. Consequently, there is clinical equipoise to define and individualize the optimal timepoint to initiate anticoagulation combining the lowest risk of hemorrhagic transformation and ischemic recurrence in cardioembolic stroke patients. In this narrative review, we will highlight and critically outline recent observational and randomized relevant evidence in different subtypes of cardioembolic stroke with a special focus on anticoagulation initiation following endovascular treatment. We will refer mainly to the commonest cause of cardioembolism, non-valvular atrial fibrillation, and examine the possible risk and benefit of anticoagulation before, during, and shortly after the acute phase of stroke. Other indications of anticoagulation after ischemic stroke will be briefly discussed. We provide a synthesis of available data to help clinicians individualize the timing of initiation of oral anticoagulation based on the presence and extent of hemorrhagic transformation as well as stroke severity.</p>","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 1","pages":"13-25"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding Tirofiban on Top of Recombinant Tissue Plasminogen Activator May Improve Clinical Outcome in Acute Stroke Patients.","authors":"Ruhui Liu, Zhigang Liang, Wei Li, Yan Zhan, Luyao Xu, Shaowan Yang, Guomin Zheng, Li Jiang, Liwen Xie, Zhongwen Sun, Yinbao Hu","doi":"10.5853/jos.2023.02250","DOIUrl":"10.5853/jos.2023.02250","url":null,"abstract":"","PeriodicalId":17135,"journal":{"name":"Journal of Stroke","volume":"26 1","pages":"121-124"},"PeriodicalIF":8.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}