Здоровье населения и среда обитания - ЗНиСО最新文献

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PHYSIOLOGICALDETERMINATION OF ADAPTIVE RESPONSES LEVEL TO STRESS TO THELABOUR AND EDUCATIONAL PROCESSES IN MIGRANTS AND STUDENTS 移民和学生对劳动和教育过程压力的适应性反应水平的生理学测定
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-03-01 DOI: 10.35627/2219-5238/2019-312-3-22-28
М. Khodzhiev, L. Prokopenko, O. Yushkova, A. Kapustina, R. A. Gulomova
{"title":"PHYSIOLOGICAL\u0000DETERMINATION OF ADAPTIVE RESPONSES LEVEL TO STRESS TO THE\u0000LABOUR AND EDUCATIONAL PROCESSES IN MIGRANTS AND STUDENTS","authors":"М. Khodzhiev, L. Prokopenko, O. Yushkova, A. Kapustina, R. A. Gulomova","doi":"10.35627/2219-5238/2019-312-3-22-28","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-312-3-22-28","url":null,"abstract":"The paper presents the physiological researches results of nine migrant professional groups who arrived from south republics of Central Asia to Moscow region of the Russian Federation. We studied the characteristics of adaptation process in labour migrants by the parameters of the cardiovascular and neuromuscular systems. Peculiarities of regulation for heart rate variability (HRV) (changes in the stress-index Sl, AMo values, VLF spectrum power, PARS index) in migrants depending on the neuroemotional nature of labour activity and the amount of muscle loads are revealed. A pronounced decrease in dynamometric indices of endurance and maximum performance of arms, body and legs muscles by the end of work process has been established. We have developed a method to determine the adaptation process stages with the combined effects of physical severity and neuro-emotional labour intensity, at the same time, poor adaptation increases health disorders risks.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"44 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115816871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
HYGIENICASSESSMENT OF AMBIENT AIR AND NON-CARCINOGENIC RISK FOR PUBLICHEALTH LIVING ON BORDER TERRITORIES 居住在边境领土上的环境空气和非致癌风险的卫生评估
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-03-01 DOI: 10.35627/2219-5238/2019-312-3-29-35
V. M. Boev, E. Kryazheva, L.Kh. Kudusova, D. A. Kryazhev, S. Perepelkin
{"title":"HYGIENIC\u0000ASSESSMENT OF AMBIENT AIR AND NON-CARCINOGENIC RISK FOR PUBLIC\u0000HEALTH LIVING ON BORDER TERRITORIES","authors":"V. M. Boev, E. Kryazheva, L.Kh. Kudusova, D. A. Kryazhev, S. Perepelkin","doi":"10.35627/2219-5238/2019-312-3-29-35","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-312-3-29-35","url":null,"abstract":"The purpose of the research study was the identification and quantitative assessment of ambient air\u0000pollution with risk assessment to public health on the territories of the Orenburg region, bordering the\u0000Republic of Kazakhstan. A hygienic assessment of thirteen border municipalities of the Orenburg region\u0000was carried out in the paper. We conducted an ambient air analysis for 23 substances, which are under\u0000long-term dynamic observation and a non-carcinogenic risk to public health was calculated. It was\u0000established that the Western and Central parts of the border territories differing in the qualitative\u0000composition of pollutants have the highest level of anthropogenic air pollution. At the same time, the\u0000qualitative composition of pollutants in the Western part of the border territory is mainly represented by\u0000substances that originate from gas and oil refining facilities. Priority pollutants in the Central part of\u0000the border territory are substances that originate from non-ferrous and ferrous metallurgy facilities.\u0000Climatic data analysis in the study territory has shown that conditions for the transboundary transfer of\u0000atmospheric pollution, both from Kazakhstan and from the Russian Federation can be created with\u0000certain meteorological parameters. Non-carcinogenic health risk analysis showed the probability of\u0000adverse effects development on organs and systems, as well as the probability of malignant neoplasms\u0000occurrence in the population living on the border territories. The study justifies and confirms the need to\u0000develop a system for monitoring and to assess the probability for transboundary transport of\u0000atmospheric pollution, as well as practical recommendations and preventive measures to reduce\u0000anthropogenic load.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131387673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASSESSMENT OF WATER SUPPLY AND RECREATIONALWATER USE CONDITIONS UNDER DETERMINING THE EPIDEMIC POTENTIALOF THE ADMINISTRATIVE REGION 在确定该行政区域的流行病潜力的情况下,对供水和娱乐用水条件进行评估
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-45-50
E. Moskvitina, E. Yanovich
{"title":"ASSESSMENT OF WATER SUPPLY AND RECREATIONAL\u0000WATER USE CONDITIONS UNDER DETERMINING THE EPIDEMIC POTENTIAL\u0000OF THE ADMINISTRATIVE REGION","authors":"E. Moskvitina, E. Yanovich","doi":"10.35627/2219-5238/2019-311-2-45-50","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-45-50","url":null,"abstract":"We presented the assessment results of the potential epidemic risk level (PERL) of conditions for\u0000centralized drinking water supply and recreational water use, as potential epidemiological risks for 85\u0000subjects of the Russian Federation. High level of potential epidemic risk of centralized drinking water\u0000supply conditions for 21 subjects of the Russian Federation and increased level taking into account\u0000water quality, water supply of the population, isolation of pathogenic bacteria, virus markers and\u0000registration of the morbidity rate of acute intestinal infections with the implementation of water factor of\u0000pathogens transmission for 60 subjects have been established. When assessing recreational water use, a\u0000high level of potential epidemic risk was determined in 39 subjects, an increased level of potential\u0000epidemic risk was determined in 30 subjects, which indicates the probability of the waterway for the\u0000spread of the cholera pathogen and other acute intestinal infections of bacterial and viral etiology. It is\u0000planned to use in conjunction with other data in determining the epidemic potential of the subject.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"8 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114052212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
CHEMICAL CONTAMINATION OF THE ENVIRONMENT ANDHEALTH STATUS OF PRESCHOOL CHILDREN BASED ON SOCIO-HYGIENICMONITORING DATA 基于社会卫生监测数据的环境化学污染与学龄前儿童健康状况
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-9-14
E. P. Kadnikova
{"title":"CHEMICAL CONTAMINATION OF THE ENVIRONMENT AND\u0000HEALTH STATUS OF PRESCHOOL CHILDREN BASED ON SOCIO-HYGIENIC\u0000MONITORING DATA","authors":"E. P. Kadnikova","doi":"10.35627/2219-5238/2019-311-2-9-14","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-9-14","url":null,"abstract":"High levels of industrial development of the region’s areas caused long-term and continuous of habitat\u0000objects pollution. Based on socio-hygienic monitoring data, over 70 per cent of the Sverdlovsk Region\u0000population is exposed to a set of various chemicals, and children constitute the most sensitive risk group.\u0000Lead, cadmium and arsenic are priority contaminants of the habitat in industrial cities and towns of the\u0000region. According to the integral estimates, chemical contamination of the habitat by these toxicants forms\u0000non-carcinogenic risks to public health. The established non-carcinogenic health risks are confirmed by\u0000social and hygienic monitoring indicators of the children chronic morbidity level in organized groups\u0000and indicate a statistically significant excess compared with the average regional indicators. According\u0000to the mathematical modeling data, statistically significant interrelations were found between the\u0000content of lead, cadmium, arsenic in environmental objects and the biomonitoring results.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122539038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
HYGIENIC EFFICIENCY OF WASTEWATER TREATMENT USINGPOLYMERIC ION-EXCHANGE MATERIALS 高分子离子交换材料处理废水的卫生效率
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-40-44
S. V. Skupnevskiy
{"title":"HYGIENIC EFFICIENCY OF WASTEWATER TREATMENT USING\u0000POLYMERIC ION-EXCHANGE MATERIALS","authors":"S. V. Skupnevskiy","doi":"10.35627/2219-5238/2019-311-2-40-44","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-40-44","url":null,"abstract":"Polymeric fibrous ion-exchange materials based on polyacrylonitrile matrix, produced in the form of\u0000cation-exchanger KN-1 and anion-exchanger AS-1 were the object of the study. We studied the sorption\u0000properties of these materials to heavy metal salts and products of their chemical transformation with\u0000flotation reagents. According to obtained results, exchange processes have high speed and materials are\u0000characterized by high value of absorption – up to 250 mg/g. The introduction of a cascade filtration\u0000scheme ensures the treatment of highly contaminated multicomponent industrial wastewater to levels\u0000that comply with the hygienic requirements. The advantages of the materials under study are the\u0000possibility of their repeated regeneration (by acid and alkali) without losing their original properties and\u0000the possibility of concentrating the desorbed metals for the purpose of their recycling again.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122959503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VARIABILITYOF THE ERYTHROID INDICES IN PERIPHERAL BLOOD IN CHILDREN OF THEFIRST YEAR OF LIFE AS A MANIFESTATION OF GENOTYPE ECOLOGICALEFFECTS 一岁儿童外周血红细胞指数的变异性作为基因型生态效应的表现
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-26-31
G. Chernova, V. Sidorov, L. V. Shiryaeva, M. Timofeeva, V. Petrosyan
{"title":"VARIABILITY\u0000OF THE ERYTHROID INDICES IN PERIPHERAL BLOOD IN CHILDREN OF THE\u0000FIRST YEAR OF LIFE AS A MANIFESTATION OF GENOTYPE ECOLOGICAL\u0000EFFECTS","authors":"G. Chernova, V. Sidorov, L. V. Shiryaeva, M. Timofeeva, V. Petrosyan","doi":"10.35627/2219-5238/2019-311-2-26-31","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-26-31","url":null,"abstract":"The paper presents the study results of the dynamics in the erythroid indices of peripheral blood in\u0000children of the early postnatal period ontogenesis. All of them were healthy, showed no developmental\u0000defects. Based on the results of biometric analysis of the data obtained, the significance of genetic and\u0000environmental factors in the identified dynamics was determined. It was largely caused by the influence\u0000of natural factors caused by cosmophysical processes during children's development years, such as an\u0000increase in the indicators of various types of radiation and basic indexes of solar activity. We conducted\u0000a quantitative assessment of their influence on the variability of all erythrocyte indices.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114752423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CORRELATION BETWEEN FEMALE WORKERS' REPRODUCTIVE HEALTH DISORDERS AND THEIR WORKING CONDITIONS DURING CONCENTRATING ON NONFERROUS METAL ORE 有色金属选矿女工生殖健康障碍与工作条件的关系
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-32-35
M. K. Gainullina, E. Shaikhlislamova, E. V. Lozovaya, L. Karimova
{"title":"CORRELATION BETWEEN FEMALE WORKERS' REPRODUCTIVE HEALTH DISORDERS AND THEIR WORKING CONDITIONS DURING CONCENTRATING ON NONFERROUS METAL ORE","authors":"M. K. Gainullina, E. Shaikhlislamova, E. V. Lozovaya, L. Karimova","doi":"10.35627/2219-5238/2019-311-2-32-35","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-32-35","url":null,"abstract":"We presented the data on the study of the working conditions of female workers engaged during concentrating on non-ferrous metal ores at the mining and processing plant, the frequency of gynecological pathology, as well as the retrospective analysis results of the course of pregnancy and labor. It has been established that the working conditions during concentrating on non-ferrous metal ores increase the risk of gynecological diseases and complications in the course of pregnancy and labor.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131971250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
IMMUNOLOGICAL MARKERS OF CHILDREN HEALTHPROBLEMS LIVING IN THE CONDITIONS OF ATMOSPHERIC AIR POLLUTIONBY ALUMINUM 大气铝污染条件下儿童健康问题的免疫学指标
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-15-18
O. Dolgikh, E. Otavina, А.V. Krivtsov, I. G. Zhdanova, М.А. Guselnikov, I. Alikina, N. Nikonoshina
{"title":"IMMUNOLOGICAL MARKERS OF CHILDREN HEALTH\u0000PROBLEMS LIVING IN THE CONDITIONS OF ATMOSPHERIC AIR POLLUTION\u0000BY ALUMINUM","authors":"O. Dolgikh, E. Otavina, А.V. Krivtsov, I. G. Zhdanova, М.А. Guselnikov, I. Alikina, N. Nikonoshina","doi":"10.35627/2219-5238/2019-311-2-15-18","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-15-18","url":null,"abstract":"We analyzed the characteristics of the immunoregulatory parameters of the child population (94 people)\u0000aged 5 to 10 years exposed to aluminum. The control group included 45 children, matched by age and sex,\u0000living in areas not exposed to aluminum. The study consisted of determining the content of IgG specific\u0000to aluminum, total IgE (hypersensitivity indicators) and phagocytic-active cells. A study of CD-markers\u0000of cell differentiation and intracellular markers for assessing the apoptosis system (absolute and relative\u0000suppressor T-cell receptors CD127–, Bax, anti-apoptotic protein Bcl-2 and proapoptotic cell death receptor\u0000CD95+) was performed. As a result of the research, it was reliably established that in the examined child\u0000population there are violations of the cellular immunity, which manifest themselves in a decrease in\u0000phagocytic activity by the criterion of absolute phagocytosis (42 per cent), relative phagocytosis (56 per\u0000cent) and phagocytic number (75 per cent) (for example, decrease in phagocytic activity of cells\u0000compared with control was 1.2-1.5 times), activation of absolute and relative suppressor T-cell receptors\u0000CD127–, Bax deficiency, antiapoptotic protein Bcl -2 and the proapoptotic cell death receptor CD95+\u0000(p < 0.05) responsible for apoptosis, relative to the reference values. There is a significant increase\u0000compared with the norm of specific IgG to aluminum in 44 per cent of children of the observed group\u0000and an increase in the level of total IgE by more than 1.4 times compared to the control group (p < 0.05)","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130260437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
HYGIENIC ASSESSMENT OF HEMODYNAMIC PARAMETERS OFSCHOOLCHILDREN AND STUDENTS WITH DIFFERENT MOTOR ACTIVITYLEVEL 小学生及不同运动水平学生血流动力学参数的卫生评价
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-19-25
T. R. Zulkarnayev, A. Agafonov, A. Kazak, I. Khisamiev, Povargo Ea, A. T. Zulkarnaeva
{"title":"HYGIENIC ASSESSMENT OF HEMODYNAMIC PARAMETERS OF\u0000SCHOOLCHILDREN AND STUDENTS WITH DIFFERENT MOTOR ACTIVITY\u0000LEVEL","authors":"T. R. Zulkarnayev, A. Agafonov, A. Kazak, I. Khisamiev, Povargo Ea, A. T. Zulkarnaeva","doi":"10.35627/2219-5238/2019-311-2-19-25","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-19-25","url":null,"abstract":"We studied the functional state of the cardiovascular system in 997 schoolchildren of Ufa and 597\u0000students of the Bashkir State Medical University with different levels of physical activity. All subjects\u0000were divided into 3 groups depending on the level of physical activity: the first group (control) consisted\u0000of schoolchildren and students, which do not involve in sports outside the school and university programs,\u0000with the lowest physical activity compared with other groups; the second group included persons with\u0000an average level of physical activity, who in addition to physical education classes independently engage\u0000in physical culture: running, walking, outdoor games and daily morning exercises; the third group\u0000consisted of schoolchildren and students regularly engaged in sports clubs and sections, having the\u0000highest level of physical activity. The following hemodynamic parameters were calculated: systolic blood\u0000volume, minute blood volume, pulse pressure, fatigue coefficient, blood circulation efficiency ratio, Robinson\u0000index. The data obtained for each group were subjected to statistical analysis separately for males and\u0000females in the age aspect. We have established the positive influence of regular physical education and\u0000sports on the metabolic and energy processes in the heart, which in turn leads to an improvement in the\u0000main indicators of the cardiovascular system. Thus, among schoolchildren and students regularly\u0000engaged in physical culture and sports, significantly lower values of minute blood volume, blood\u0000circulation efficiency ratio, endurance coefficient, Robinson index and high values of systolic blood\u0000volume, pulse pressure were noted. The presence of reliable direct correlation of the weak degree of\u0000physical culture and sports with the majority of studied hemodynamic parameters was revealed.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114372658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
SHELF LIFE PREDICTION OF DIAGNOSTIC FLUORESCENTTULAREMIA DRY IMMUNOGLOBULINS 诊断性荧光血症干免疫球蛋白的保质期预测
Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-02-01 DOI: 10.35627/2219-5238/2019-311-2-56-60
O. L. Startseva, S. A. Kurcheva
{"title":"SHELF LIFE PREDICTION OF DIAGNOSTIC FLUORESCENT\u0000TULAREMIA DRY IMMUNOGLOBULINS","authors":"O. L. Startseva, S. A. Kurcheva","doi":"10.35627/2219-5238/2019-311-2-56-60","DOIUrl":"https://doi.org/10.35627/2219-5238/2019-311-2-56-60","url":null,"abstract":"We described the results of studying the stability of the main indicators of medical product quality for in\u0000vitro diagnostics - diagnostic fluorescent tularemia dry immunoglobulins RIF-Tul-StavNIPCHI,\u0000developed on the basis of Stavropol Anti-Plague Institute of Rospotrebnadzor to justify the shelf life and\u0000recommended storage conditions when used on a real scale time and accelerated research methods. At the\u0000same time, one of the main criteria for the study of stability is its study during sample storage not only\u0000in the primary packaging of an industrial output, but also after the first opening of the package, during\u0000the use period of the reconstituted preparation. On the basis of data obtained in both long-term and\u0000accelerated trials, a shelf life of three years is recommended. It was experimentally proved that during\u0000this period of time, the quality indicators of the drug remain at a level one that complies with the\u0000requirements of technical and operational documentation. In the course of application the recovered\u0000product demonstrates stability of its biological and physical-and-chemical properties within 5 days at a\u0000storage temperature of 2 to 8°С.","PeriodicalId":171066,"journal":{"name":"Здоровье населения и среда обитания - ЗНиСО","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124108472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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