Journal of separation science最新文献

{"title":"Fe3O4@Cellulose Nanofiber Modified by 1,2-Phenylenediamine Schiff Base/Melamine for Magnetic Solid Phase Extraction of Parabens From Cosmetic Products","authors":"Maryam Kashanian,&nbsp;Milad Ghani,&nbsp;Tahere Khezeli,&nbsp;Behrooz Maleki,&nbsp;Pouya Ghamari Kargar","doi":"10.1002/jssc.70179","DOIUrl":"https://doi.org/10.1002/jssc.70179","url":null,"abstract":"<div>\u0000 \u0000 <p>In this work, a new magnetic sorbent, named Fe₃O₄@CNF@NNSM, using Fe₃O₄ nanoparticles modified with cellulose nanofiber (CNF) and 1,2-phenylenediamine Schiff base/melamine (NNSM) applied to extract methyl, ethyl, propyl, and butyl parabens based on magnetic solid-phase extraction method followed by high-performance liquid chromatography-ultraviolet detection. Characterization of synthesized materials was conducted using Fourier-transform infrared spectroscopy, field emission-scanning electron microscopy, X-ray powder diffraction, transmission electron microscope, energy dispersion spectroscopy, and vibrating sample magnetometry. Factors affecting the extraction efficiency were screened with the Plackett-Burman design and then analyzed by the Box-Behnken design. This method exhibited an impressive linear range (0.50–200.00 µg/L R² &gt; 0.9921), and detection limits of 0.12–0.15 µg/L for mentioned parabens. The Enrichment factors were obtained from 120 to 175. The practical application of this method was confirmed by evaluating analyte recovery from cosmetic products, achieving over 90% recovery and a relative standard deviation of less than 5.1%, demonstrating the proposed method's commendable accuracy and precision.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe3O4@Cellulose Nanofiber Modified by 1,2-Phenylenediamine Schiff Base/Melamine for Magnetic Solid Phase Extraction of Parabens From Cosmetic Products","authors":"Maryam Kashanian,&nbsp;Milad Ghani,&nbsp;Tahere Khezeli,&nbsp;Behrooz Maleki,&nbsp;Pouya Ghamari Kargar","doi":"10.1002/jssc.70179","DOIUrl":"https://doi.org/10.1002/jssc.70179","url":null,"abstract":"<div>\u0000 \u0000 <p>In this work, a new magnetic sorbent, named Fe₃O₄@CNF@NNSM, using Fe₃O₄ nanoparticles modified with cellulose nanofiber (CNF) and 1,2-phenylenediamine Schiff base/melamine (NNSM) applied to extract methyl, ethyl, propyl, and butyl parabens based on magnetic solid-phase extraction method followed by high-performance liquid chromatography-ultraviolet detection. Characterization of synthesized materials was conducted using Fourier-transform infrared spectroscopy, field emission-scanning electron microscopy, X-ray powder diffraction, transmission electron microscope, energy dispersion spectroscopy, and vibrating sample magnetometry. Factors affecting the extraction efficiency were screened with the Plackett-Burman design and then analyzed by the Box-Behnken design. This method exhibited an impressive linear range (0.50–200.00 µg/L R² &gt; 0.9921), and detection limits of 0.12–0.15 µg/L for mentioned parabens. The Enrichment factors were obtained from 120 to 175. The practical application of this method was confirmed by evaluating analyte recovery from cosmetic products, achieving over 90% recovery and a relative standard deviation of less than 5.1%, demonstrating the proposed method's commendable accuracy and precision.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal Migration and Release of 16 Characteristic Flavor Compounds in Tobaccos Analyzed by GC-MS and GC-MS/MS","authors":"Wei Jiang,&nbsp;Yangzhou Xie,&nbsp;Xinru Cheng,&nbsp;Xinlin Wang,&nbsp;Haocheng Cai,&nbsp;Yuanxing Duan,&nbsp;Fengmei Zhang,&nbsp;Jianyun Yang,&nbsp;Mengnan Yin,&nbsp;Qiyuan Peng,&nbsp;Xiaoxi Si,&nbsp;Wei Liu,&nbsp;Zhigang Xu","doi":"10.1002/jssc.70195","DOIUrl":"https://doi.org/10.1002/jssc.70195","url":null,"abstract":"<div>\u0000 \u0000 <p>This study advances the understanding of flavor compound migration and release in heat-not-burn (HNB) cigarettes by systematically comparing the effects of central and circumferential heating on release kinetics. It reveals the coupling relationship between spatial heat transfer modes and release mechanisms. GC-MS and GC-MS/MS were used for compound identification and quantification. GC-MS employed a DB-5MS column in full-scan mode. GC-MS/MS also used a DB-5MS column with MRM mode. A total of 16 key aromatic components from eight categories (acids, ketones, esters, phenols, alcohols, aldehydes, heterocyclics, and lactones) were analyzed. The results showed consistent high release levels for valeric acid, 3-methylvaleric acid, and linalool. Central heating led to peak releases around 350°C, while circumferential heating showed a release trend peaking at 250°C. Kinetic analysis revealed different models, and activation energy analysis indicated varying release difficulties between the heating methods. The release mechanisms of different aromatic raw compounds were jointly analyzed using zero-order, pseudo-first-order, and pseudo-second-order models. Under central heating, acids/aldehydes followed the zero-order model, while under circumferential heating, ketones/esters/phenols were more suited to the zero-order model.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust In Situ Growth of Epitaxially Oriented Titanium Dioxide Microplates on Titanium Fiber for Selective and Efficient Solid-Phase Microextraction of Polycyclic Aromatic Hydrocarbons From Water Samples Prior to HPLC-UV","authors":"Jiayu Li,&nbsp;Huirong Li,&nbsp;Jinxin Guo,&nbsp;Hua Zhou,&nbsp;Xuemei Wang,&nbsp;Xinzhen Du","doi":"10.1002/jssc.70196","DOIUrl":"https://doi.org/10.1002/jssc.70196","url":null,"abstract":"<div>\u0000 \u0000 <p>Well-defined TiO₂ microplates (TiO₂MPs) were directly achieved on a titanium fiber by the hydrothermal treatment in alkaline solution. The hydrothermal in situ growth of TiO₂MPs greatly depended on the alkali concentration and hydrothermal temperature. The results proved the formation of epitaxially oriented TiO₂MPs with rutile structure. The Ti@TiO₂MPs fiber exhibited improved adsorption selectivity and enhanced adsorption capability for PAHs. After optimizing adsorption conditions, the developed method with Ti@TiO₂MPs fiber presented good linearity of PAHs in the ranges of 0.05–200 ng/mL with LODs of 0.012–0.161 ng/mL and LOQs of 0.039–0.537 ng/mL. The intra-day and inter-day RSDs for the developed method with a single fiber were 2.59%–4.32% and 3.29%–6.31%, respectively. Moreover, RSDs were found to be 5.48%–8.35% for the developed method with five pieces of fibers fabricated in different batches. Finally, the developed method was applied to selective preconcentration and sensitive determination of target PAHs in environmental water samples. The relative recoveries of target PAHs in real water samples spiked at the concentrations of 5.0 and 10.0 ng/mL were in the ranges of 87.20%–110.6% with RSDs lower than 7.16%. Furthermore, the Ti@TiO₂MPs fiber was highly stable without loss of adsorption efficiency after 200 adsorption and desorption cycles.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Profiling of Chemical Constituents and Metabolites of the Angelica sinensis–Sophora flavescens Herbal Pair in Plasma and Urine via UHPLC-Q-TOF-MS Coupled With Multi-Platform Data Integration","authors":"Lincheng Bai,&nbsp;Pengyi Chen,&nbsp;Jiaqi Xu,&nbsp;Zeyu Yi,&nbsp;Tiantian Wang,&nbsp;Hua Han,&nbsp;Peiliang Dong","doi":"10.1002/jssc.70201","DOIUrl":"https://doi.org/10.1002/jssc.70201","url":null,"abstract":"<div>\u0000 \u0000 <p>The traditional Chinese Danggui–Kushen herbal pair (DKHP) has garnered widespread attention in the treatment of myocardial ischemia. However, the intricate nature of traditional Chinese medicine components and the ambiguity in their constituent analyses have considerably impeded further clinical advancements. Therefore, it is crucial to clarify the principal constituents of DKHP and its metabolic byproducts in the body. In this study, various mass spectrometry (MS) optimization software were used to analyze the chemical characteristics of <i>Angelica sinensis</i>–Sophora sophora (DKHP) and identify the chemical constituents entering rat serum and urine after oral gavage administration in rats. A total of 10 male Sprague–Dawley rats were used in this study. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight MS was performed. Based on this, we developed a method to identify chemical constituents using UNIFI for the acquired MS data. Subsequently, MS-DIAL was utilized to process the complex MS data, including peak detection, fitting, and alignment. A feature-based molecular networking was constructed on the Global Natural Product Social molecular networking platform, establishing correlations for individual nodes, including common neutral losses and product ions, which serve as important tools for inferring unknown compounds. A multi-stage intelligent data annotation strategy was developed. In addition, molecular simulations were performed using density functional theory to determine the plausibility of the compound cleavage reactions and further confirm the compound structures. Finally, molecular docking technology was employed to evaluate the binding affinity and identify potential active metabolites.</p>\u0000 <p>DKHP analysis resulted in the identification or preliminary characterization of 109 chemical constituents, primarily flavonoids, alkaloids, and phenolic acid compounds. In addition, 11 prototype products and 99 metabolites were detected in rat serum and urine.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal Migration and Release of 16 Characteristic Flavor Compounds in Tobaccos Analyzed by GC-MS and GC-MS/MS","authors":"Wei Jiang,&nbsp;Yangzhou Xie,&nbsp;Xinru Cheng,&nbsp;Xinlin Wang,&nbsp;Haocheng Cai,&nbsp;Yuanxing Duan,&nbsp;Fengmei Zhang,&nbsp;Jianyun Yang,&nbsp;Mengnan Yin,&nbsp;Qiyuan Peng,&nbsp;Xiaoxi Si,&nbsp;Wei Liu,&nbsp;Zhigang Xu","doi":"10.1002/jssc.70195","DOIUrl":"https://doi.org/10.1002/jssc.70195","url":null,"abstract":"<div>\u0000 \u0000 <p>This study advances the understanding of flavor compound migration and release in heat-not-burn (HNB) cigarettes by systematically comparing the effects of central and circumferential heating on release kinetics. It reveals the coupling relationship between spatial heat transfer modes and release mechanisms. GC-MS and GC-MS/MS were used for compound identification and quantification. GC-MS employed a DB-5MS column in full-scan mode. GC-MS/MS also used a DB-5MS column with MRM mode. A total of 16 key aromatic components from eight categories (acids, ketones, esters, phenols, alcohols, aldehydes, heterocyclics, and lactones) were analyzed. The results showed consistent high release levels for valeric acid, 3-methylvaleric acid, and linalool. Central heating led to peak releases around 350°C, while circumferential heating showed a release trend peaking at 250°C. Kinetic analysis revealed different models, and activation energy analysis indicated varying release difficulties between the heating methods. The release mechanisms of different aromatic raw compounds were jointly analyzed using zero-order, pseudo-first-order, and pseudo-second-order models. Under central heating, acids/aldehydes followed the zero-order model, while under circumferential heating, ketones/esters/phenols were more suited to the zero-order model.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Molecularly Imprinted Polymers for Extraction of Four Amphetamine-Type Stimulants From Sewage and Urine","authors":"Haocheng Fan,&nbsp;Dongqin Tan,&nbsp;Yue Wang,&nbsp;Yanying Li,&nbsp;Degao Wang","doi":"10.1002/jssc.70197","DOIUrl":"https://doi.org/10.1002/jssc.70197","url":null,"abstract":"<div>\u0000 \u0000 <p>Magnetic molecularly imprinted polymers (MMIPs) were synthesized by bulk polymerization using N-methylphenethylamine as a dummy template for selective extraction of four amphetamine-type stimulants (ATSs) in sewage and urine. The MMIPs were characterized by scanning electron microscopy, vibrating sample magnetometer, Fourier transform infrared spectroscopy and thermogravimetric analysis, revealing a porous structure (35–60 µm) with a saturation magnetization of 1.8 emu/g, enabling rapid magnetic separation within 1 min. Adsorption kinetics followed a pseudo-second-order model, achieving over 80% adsorption within 10 min and an imprinting factor of 2.4–3.3, demonstrating high selectivity for ATSs over structural analogs. Optimized magnetic solid-phase extraction (MSPE) conditions yielded recoveries over 81% with relative standard deviation (RSD) below 5.5%. Coupled with high performance liquid chromatography-tandem mass spectrometry, the proposed MMIPs–MSPE method exhibited a linear range of 1–100 ng/mL, low detection limits (5.2–19 ng/L), and quantification limits (17.0–65.0 ng/L). The pre-concentration factor of ATSs was 19.3–19.9. Successful application to real sewage and urine samples confirmed robust matrix interference resistance and reliability (recoveries: 82.1%–116%, RSD &lt; 6.4%). This study provides a sensitive, reusable, and environmentally friendly approach for monitoring ATSs in environmental and forensic matrices.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Profiling of Chemical Constituents and Metabolites of the Angelica sinensis–Sophora flavescens Herbal Pair in Plasma and Urine via UHPLC-Q-TOF-MS Coupled With Multi-Platform Data Integration","authors":"Lincheng Bai,&nbsp;Pengyi Chen,&nbsp;Jiaqi Xu,&nbsp;Zeyu Yi,&nbsp;Tiantian Wang,&nbsp;Hua Han,&nbsp;Peiliang Dong","doi":"10.1002/jssc.70201","DOIUrl":"https://doi.org/10.1002/jssc.70201","url":null,"abstract":"<div>\u0000 \u0000 <p>The traditional Chinese Danggui–Kushen herbal pair (DKHP) has garnered widespread attention in the treatment of myocardial ischemia. However, the intricate nature of traditional Chinese medicine components and the ambiguity in their constituent analyses have considerably impeded further clinical advancements. Therefore, it is crucial to clarify the principal constituents of DKHP and its metabolic byproducts in the body. In this study, various mass spectrometry (MS) optimization software were used to analyze the chemical characteristics of <i>Angelica sinensis</i>–Sophora sophora (DKHP) and identify the chemical constituents entering rat serum and urine after oral gavage administration in rats. A total of 10 male Sprague–Dawley rats were used in this study. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight MS was performed. Based on this, we developed a method to identify chemical constituents using UNIFI for the acquired MS data. Subsequently, MS-DIAL was utilized to process the complex MS data, including peak detection, fitting, and alignment. A feature-based molecular networking was constructed on the Global Natural Product Social molecular networking platform, establishing correlations for individual nodes, including common neutral losses and product ions, which serve as important tools for inferring unknown compounds. A multi-stage intelligent data annotation strategy was developed. In addition, molecular simulations were performed using density functional theory to determine the plausibility of the compound cleavage reactions and further confirm the compound structures. Finally, molecular docking technology was employed to evaluate the binding affinity and identify potential active metabolites.</p>\u0000 <p>DKHP analysis resulted in the identification or preliminary characterization of 109 chemical constituents, primarily flavonoids, alkaloids, and phenolic acid compounds. In addition, 11 prototype products and 99 metabolites were detected in rat serum and urine.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust In Situ Growth of Epitaxially Oriented Titanium Dioxide Microplates on Titanium Fiber for Selective and Efficient Solid-Phase Microextraction of Polycyclic Aromatic Hydrocarbons From Water Samples Prior to HPLC-UV","authors":"Jiayu Li,&nbsp;Huirong Li,&nbsp;Jinxin Guo,&nbsp;Hua Zhou,&nbsp;Xuemei Wang,&nbsp;Xinzhen Du","doi":"10.1002/jssc.70196","DOIUrl":"https://doi.org/10.1002/jssc.70196","url":null,"abstract":"<div>\u0000 \u0000 <p>Well-defined TiO₂ microplates (TiO₂MPs) were directly achieved on a titanium fiber by the hydrothermal treatment in alkaline solution. The hydrothermal in situ growth of TiO₂MPs greatly depended on the alkali concentration and hydrothermal temperature. The results proved the formation of epitaxially oriented TiO₂MPs with rutile structure. The Ti@TiO₂MPs fiber exhibited improved adsorption selectivity and enhanced adsorption capability for PAHs. After optimizing adsorption conditions, the developed method with Ti@TiO₂MPs fiber presented good linearity of PAHs in the ranges of 0.05–200 ng/mL with LODs of 0.012–0.161 ng/mL and LOQs of 0.039–0.537 ng/mL. The intra-day and inter-day RSDs for the developed method with a single fiber were 2.59%–4.32% and 3.29%–6.31%, respectively. Moreover, RSDs were found to be 5.48%–8.35% for the developed method with five pieces of fibers fabricated in different batches. Finally, the developed method was applied to selective preconcentration and sensitive determination of target PAHs in environmental water samples. The relative recoveries of target PAHs in real water samples spiked at the concentrations of 5.0 and 10.0 ng/mL were in the ranges of 87.20%–110.6% with RSDs lower than 7.16%. Furthermore, the Ti@TiO₂MPs fiber was highly stable without loss of adsorption efficiency after 200 adsorption and desorption cycles.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Molecularly Imprinted Polymers for Extraction of Four Amphetamine-Type Stimulants From Sewage and Urine","authors":"Haocheng Fan,&nbsp;Dongqin Tan,&nbsp;Yue Wang,&nbsp;Yanying Li,&nbsp;Degao Wang","doi":"10.1002/jssc.70197","DOIUrl":"https://doi.org/10.1002/jssc.70197","url":null,"abstract":"<div>\u0000 \u0000 <p>Magnetic molecularly imprinted polymers (MMIPs) were synthesized by bulk polymerization using N-methylphenethylamine as a dummy template for selective extraction of four amphetamine-type stimulants (ATSs) in sewage and urine. The MMIPs were characterized by scanning electron microscopy, vibrating sample magnetometer, Fourier transform infrared spectroscopy and thermogravimetric analysis, revealing a porous structure (35–60 µm) with a saturation magnetization of 1.8 emu/g, enabling rapid magnetic separation within 1 min. Adsorption kinetics followed a pseudo-second-order model, achieving over 80% adsorption within 10 min and an imprinting factor of 2.4–3.3, demonstrating high selectivity for ATSs over structural analogs. Optimized magnetic solid-phase extraction (MSPE) conditions yielded recoveries over 81% with relative standard deviation (RSD) below 5.5%. Coupled with high performance liquid chromatography-tandem mass spectrometry, the proposed MMIPs–MSPE method exhibited a linear range of 1–100 ng/mL, low detection limits (5.2–19 ng/L), and quantification limits (17.0–65.0 ng/L). The pre-concentration factor of ATSs was 19.3–19.9. Successful application to real sewage and urine samples confirmed robust matrix interference resistance and reliability (recoveries: 82.1%–116%, RSD &lt; 6.4%). This study provides a sensitive, reusable, and environmentally friendly approach for monitoring ATSs in environmental and forensic matrices.</p>\u0000 </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}