Journal of separation science最新文献

In-tube solid-phase microextraction of polycyclic aromatic hydrocarbons from refinery water samples using UiO-66/polyacrylonitrile electrospun nanofibers followed by high-performance liquid chromatography-ultraviolet detection 使用 UiO-66/ 聚丙烯腈电纺纳米纤维对炼油厂水样中的多环芳烃进行管内固相微萃取，然后进行高效液相色谱-紫外检测

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-09-14 DOI: 10.1002/jssc.202400296

Seyedeh Sara Nasrollahi, Yadollah Yamini

{"title":"In-tube solid-phase microextraction of polycyclic aromatic hydrocarbons from refinery water samples using UiO-66/polyacrylonitrile electrospun nanofibers followed by high-performance liquid chromatography-ultraviolet detection","authors":"Seyedeh Sara Nasrollahi, Yadollah Yamini","doi":"10.1002/jssc.202400296","DOIUrl":"10.1002/jssc.202400296","url":null,"abstract":"A simple and quick fiber-in-tube solid-phase microextraction (FIT-SPME) was introduced for the extraction and determination of nine polycyclic aromatic hydrocarbons followed by a high-performance liquid chromatography-ultraviolet detector in refinery water samples. For this purpose, a water-resistant metal-organic framework with a high surface area called UiO-66 has been applied in the form of an electrospun coating on stainless steel wires. After that, all the fibers were packed in the lumen of a stainless-steel tube to make the extraction phase. Both one variable at a time and experimental design methods have been used to optimize effective parameters on FIT-SPME. Under optimum conditions, the method demonstrated good linearity between 0.5 and 1000.0 µg/L with a coefficient of determination greater than 0.9906. Furthermore, the limits of detection values ranged from 0.2 to 1.5 µg/L. The intra-day and inter-day relative standard deviations were < 8.4% and < 9.7%, respectively. Lastly, the proposed method was applied to extract and determine analytes in four refinery water samples as well as surface water containing high total dissolved solids, and well waters where satisfactory results have been obtained.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The analysis of e-liquids: A study on chemical diversity and metal content using gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry 电子液体分析：使用气相色谱-质谱法和电感耦合等离子体-质谱法研究化学多样性和金属含量

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-09-10 DOI: 10.1002/jssc.202400443

Matjaž Rantaša, David Majer, Matjaž Finšgar

{"title":"The analysis of e-liquids: A study on chemical diversity and metal content using gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry","authors":"Matjaž Rantaša, David Majer, Matjaž Finšgar","doi":"10.1002/jssc.202400443","DOIUrl":"https://doi.org/10.1002/jssc.202400443","url":null,"abstract":"This work aimed to determine the chemical composition of 22 e-liquids available on the Slovenian market. Four different gas chromatography (GC) sample introduction techniques; headspace-GC-mass spectrometry (HS-GC-MS), liquid injection-GC-MS (LI-GC-MS), HS-solid-phase microextraction-GC-MS (HS-SPME-GC-MS), and direct-immersion-SPME-GC-MS (DI-SPME-GC-MS) were employed for qualitative analysis. Various experimental parameters were assessed for each GC sample introduction technique to maximize compound identification. Despite e-liquid packaging reporting a maximum of eight compounds, GC-MS identified more compounds in most samples, especially in menthol-flavored (58 identifiable compounds by HS-SPME-GC-MS), followed by nicotine-containing and fruit-flavored samples. HS-SPME-GC-MS identified the highest number of compounds, followed by HS-GC-MS, DI-SPME-GC-MS, and LI-GC-MS. Nicotine quantification in six samples was performed by LI-GC-MS with dilution in methanol. Nicotine concentration in samples ranged from 16.5 ± 0.5 to 18.5 ± 0.4 mg/mL, which was below the declared concentration of 20 mg/mL. Additionally, quantitative analysis of metals in e-liquids was performed by inductively coupled plasma-MS after microwave-assisted wet acid digestion. Iron was the most abundant metal, with its content ranging from 0.024 to 0.354 µg/g. Barium, bismuth, copper, and tin were also determined in several e-liquids.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.202400443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The analysis of e-liquids: A study on chemical diversity and metal content using gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry 电子液体分析：使用气相色谱-质谱法和电感耦合等离子体-质谱法研究化学多样性和金属含量

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-09-10 DOI: 10.1002/jssc.202400443

Matjaž Rantaša, David Majer, Matjaž Finšgar

{"title":"The analysis of e-liquids: A study on chemical diversity and metal content using gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry","authors":"Matjaž Rantaša, David Majer, Matjaž Finšgar","doi":"10.1002/jssc.202400443","DOIUrl":"https://doi.org/10.1002/jssc.202400443","url":null,"abstract":"This work aimed to determine the chemical composition of 22 e-liquids available on the Slovenian market. Four different gas chromatography (GC) sample introduction techniques; headspace-GC-mass spectrometry (HS-GC-MS), liquid injection-GC-MS (LI-GC-MS), HS-solid-phase microextraction-GC-MS (HS-SPME-GC-MS), and direct-immersion-SPME-GC-MS (DI-SPME-GC-MS) were employed for qualitative analysis. Various experimental parameters were assessed for each GC sample introduction technique to maximize compound identification. Despite e-liquid packaging reporting a maximum of eight compounds, GC-MS identified more compounds in most samples, especially in menthol-flavored (58 identifiable compounds by HS-SPME-GC-MS), followed by nicotine-containing and fruit-flavored samples. HS-SPME-GC-MS identified the highest number of compounds, followed by HS-GC-MS, DI-SPME-GC-MS, and LI-GC-MS. Nicotine quantification in six samples was performed by LI-GC-MS with dilution in methanol. Nicotine concentration in samples ranged from 16.5 ± 0.5 to 18.5 ± 0.4 mg/mL, which was below the declared concentration of 20 mg/mL. Additionally, quantitative analysis of metals in e-liquids was performed by inductively coupled plasma-MS after microwave-assisted wet acid digestion. Iron was the most abundant metal, with its content ranging from 0.024 to 0.354 µg/g. Barium, bismuth, copper, and tin were also determined in several e-liquids.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.202400443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low swelling and high mechanical strength organosilane hybrid polydivinylbenzene microspheres for hydrophilic interaction chromatography applications 用于亲水相互作用色谱的低膨胀、高机械强度有机硅杂化聚二乙烯基苯微球

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-09-09 DOI: 10.1002/jssc.202400462

Yang Yang, Yuexin Li, Yang Zhao, Changyu Cai, Xinmiao Liang, Yanxiong Ke

引用次数: 0

Construction of amine-rich coating utilizing amine curing reaction of triglycidyl isocyanate with triethylenetetramine on the surface of poly(styrene-divinylbenzene) microspheres for preparation of anion exchange stationary phase 利用异氰酸三缩水甘油酯与三乙烯四胺在聚（苯乙烯-二乙烯基苯）微球表面的胺固化反应构建富胺涂层，用于制备阴离子交换固定相

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-09-09 DOI: 10.1002/jssc.202400369

Junwei Liu, Yuqi Yan, Haojie Li, Shiting Zhang, Guoqing Wang, Yu-an Sun, Yan Zhu

{"title":"Construction of amine-rich coating utilizing amine curing reaction of triglycidyl isocyanate with triethylenetetramine on the surface of poly(styrene-divinylbenzene) microspheres for preparation of anion exchange stationary phase","authors":"Junwei Liu, Yuqi Yan, Haojie Li, Shiting Zhang, Guoqing Wang, Yu-an Sun, Yan Zhu","doi":"10.1002/jssc.202400369","DOIUrl":"10.1002/jssc.202400369","url":null,"abstract":"Epoxy resins, as important thermosetting polymers, exhibit excellent adhesion to various substrates. In view of this, reticulate coating of triglycidyl isocyanate with triethylenetetramine was introduced onto the surface of poly(styrene-divinylbenzene) utilizing amine curing reaction to obtain poly(styrene-divinylbenzene)@triglycidyl isocyanate-triethylenetetramine composite microspheres. The amino groups and epoxy groups of triglycidyl isocyanate-triethylenetetramine endowed poly(styrene-divinylbenzene) with good reactivity, which could be quaternized under mild conditions to obtain an anion exchange chromatographic stationary phase. The quaternized poly(styrene-divinylbenzene)@triglycidyl isocyanate-triethylenetetramine was characterized by scanning electron microscope, Fourier-transform infrared spectroscopy, N2 adsorption-desorption experiment, et al. The chromatographic performance of the customized column was evaluated by separating seven conventional anions, organic weak acids, and carbohydrates. Poly(styrene-divinylbenzene)@triglycidyl isocyanate-triethylenetetramine possesses the uniform size of poly(styrene-divinylbenzene) microspheres and good reactivity of triglycidyl isocyanate-triethylenetetramine, which offers a flexible strategy for the preparation of anion exchange stationary phase. The column exhibits excellent chemical and mechanical stability and chromatographic performance. Finally, the column was successfully applied for the determination of nitrite in pickles.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a pre-column derivatization ultra-high-performance liquid chromatography method for polysaccharide and monosaccharide quantification in Lycium barbarum 开发用于枸杞中多糖和单糖定量的柱前衍生超高效液相色谱法。

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-09-04 DOI: 10.1002/jssc.202400507

Zhilong Zhao, Yunfeng Bai, Huan Chen, Weibiao Wang, Shuqin Ding, Yue Zhang, Yuping Sa, Guoning Chen, Xueqin Ma

{"title":"Development of a pre-column derivatization ultra-high-performance liquid chromatography method for polysaccharide and monosaccharide quantification in Lycium barbarum","authors":"Zhilong Zhao, Yunfeng Bai, Huan Chen, Weibiao Wang, Shuqin Ding, Yue Zhang, Yuping Sa, Guoning Chen, Xueqin Ma","doi":"10.1002/jssc.202400507","DOIUrl":"10.1002/jssc.202400507","url":null,"abstract":"Given the limited specificity and accuracy observed in the current official colorimetric quantification of polysaccharide in Lycium barbarum, our study aims to establish a novel, specific, accurate, and economic pre-column derivatization ultra-high-performance liquid chromatography (UHPLC) method for determining the monosaccharide and polysaccharide content in L. barbarum. The optimization of extraction, hydrolysis, and derivatization (using 1-phenyl-3-methyl-5-pyrazolone) processes for polysaccharide from L. barbarum was conducted initially, followed by separation of nine monosaccharides within 20 min using UHPLC with a C18 column. Subsequently, a novel method known as quantitative analysis of multiple components by single marker was developed, utilizing either additive 2-deoxy-D-ribose or any monosaccharide present in the sample as a single reference standard to simultaneously detect the contents of polysaccharide and nine monosaccharides in L. barbarum. To validate the accuracy of the established method, the quantitative results of our approach were compared to both external and internal standard method methods. The minimal relative errors in the quantitative determination of monosaccharides among the three methods confirmed the dependability of the method. By analyzing 20 batches of L. barbarum samples, D-galacturonic acid exhibited the highest content and the polysaccharide levels ranged from 3.02 to 13.04 mg/g. All data implied the specificity and accuracy of the method.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction model for retention volumes of the three-phase solvent system in high-speed countercurrent chromatography 高速逆流色谱中三相溶剂系统保留体积的预测模型

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-08-31 DOI: 10.1002/jssc.202400385

Jules Muhire, Fu-Xin Zhang, Xiao Sun, Xing-Cui Wang, Dong Pei, Xin-Yi Huang, Duo-Long Di

{"title":"Prediction model for retention volumes of the three-phase solvent system in high-speed countercurrent chromatography","authors":"Jules Muhire, Fu-Xin Zhang, Xiao Sun, Xing-Cui Wang, Dong Pei, Xin-Yi Huang, Duo-Long Di","doi":"10.1002/jssc.202400385","DOIUrl":"https://doi.org/10.1002/jssc.202400385","url":null,"abstract":"Owing to its ability to separate substances with a broad scope of polarities, exploring the three-phase solvent systems (TPSSs) with high-speed countercurrent chromatography is a topic of interest in separation science, and their retention volumes should be more concerned. This study primarily investigates the behavior of retention volumes while examining the isolation abilities of the TPSS in the technique above. We took standard compounds, including sophoricoside, Sudan red 7B, and rotenone, which have a broad range of polarity, for investigation in this study and separated them using different four-liquid TPSSs made up of water, acetonitrile, methyl acetate, and n-hexane (WAMH). Our findings show that the retention volumes gradually alter in response to changes in phase polarity within the proposed solvent systems. With TPSSs, we preliminarily studied compound isolation and the promising formula of their retention volumes. The proposed solvent systems WAMH in different ratios showed high correlations and adjusted correlation coefficients above 0.9978 and 0.9913 for the actual and calculated retention volumes. This study will be particularly beneficial for researchers focusing on countercurrent chromatography with TPSSs, as it offers valuable time-saving insights.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive strategy of lipidomics and pharmacokinetics based on ultra-high-performance liquid chromatography-mass spectrometry of Shaoyao Gancao Decoction 基于超高效液相色谱-质谱联用技术的芍药甘草煎汁脂质组学与药代动力学综合研究策略

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-08-31 DOI: 10.1002/jssc.202400421

Xin Li, Juan Xie, Yuhan Li, Wenxuan Cui, Tongrui Zhang, Qing Li, Kaishun Bi, Ran Liu

{"title":"A comprehensive strategy of lipidomics and pharmacokinetics based on ultra-high-performance liquid chromatography-mass spectrometry of Shaoyao Gancao Decoction","authors":"Xin Li, Juan Xie, Yuhan Li, Wenxuan Cui, Tongrui Zhang, Qing Li, Kaishun Bi, Ran Liu","doi":"10.1002/jssc.202400421","DOIUrl":"https://doi.org/10.1002/jssc.202400421","url":null,"abstract":"Shaoyao Gancao Decoction (SGD), a traditional Chinese medicine, has been proven to have a good liver protection effect, but the mechanism and pharmacodynamic substances of SGD in the treatment of acute liver injury are still unclear. In this study, an ultra-high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was established to characterize 107 chemical components of SGD and 12 compounds absorbed in rat plasma samples after oral administration of SGD. Network pharmacology was applied to construct a component-target-pathway network to screen the possible effective components of SGD in acute liver injury. Using lipidomics based on UHPLC-Q-TOF-MS coupled with a variety of statistical analyses, 20 lipid biomarkers were screened and identified, suggesting that the improvement of acute liver injury by SGD was involved in cholesterol metabolism, glycerol-phospholipid metabolism, sphingolipid signaling pathways and fatty acid biosynthesis. In addition, the UHPLC-tandem MS method was established for pharmacokinetics analysis, and 10 potential active components were determined simultaneously within 12 min through the optimization of 0.1% formic acid water and acetonitrile as a mobile phase system. A Pharmacokinetics study showed that paeoniflorin, albiflorin, oxypaeoniflorin, liquiritigenin, isoliquiritigenin, liquiritin, ononin, formononetin, glycyrrhizic acid, and glycyrrhetinic acid as the potential active compounds of SGD curing acute liver injury.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of analytical method for determination of 1,3-dimethylamylamine in sports nutrition and bodybuilding supplements using pH-switchable deep eutectic solvents followed by high-performance liquid chromatography-diode array detector 利用 pH 值可切换的深共晶溶剂和高效液相色谱-二极管阵列检测器建立运动营养品和健美补充剂中 1,3-二甲基胺的分析方法

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-08-31 DOI: 10.1002/jssc.202400340

Dijun Shen, Jie Zhang, Ying Zhang, Xiru Du

{"title":"Development of analytical method for determination of 1,3-dimethylamylamine in sports nutrition and bodybuilding supplements using pH-switchable deep eutectic solvents followed by high-performance liquid chromatography-diode array detector","authors":"Dijun Shen, Jie Zhang, Ying Zhang, Xiru Du","doi":"10.1002/jssc.202400340","DOIUrl":"https://doi.org/10.1002/jssc.202400340","url":null,"abstract":"In this work, an easy, safe, simple, and efficient pH-switchable deep eutectic solvents (DESs)-based liquid phase microextraction followed by high-performance liquid chromatography-diode array detector analysis was developed for the determination of 1,3-dimethylamylamine (DMAA). The switchability of the obtained DESs was investigated by changing the pH. Then the best-selected DES was characterized and the application of the selected DES in the extraction of DMAA from sports nutrition and bodybuilding supplements was investigated. The DES synthesized from l-menthol: oleic acid in a molar ratio of 1:2 had the highest efficiency in the extraction of the target compound. Under the optimum conditions, (50 µL of DES, 100 µL of 4 mol/L KOH, 100 µL of 4 mol/L HCl, extraction time of 40 s and without salt addition) the calibration graph was linear in the range of 0.05–100 µg/kg and limit of detection was 0.02 µg/kg. The relative standard deviations including intra-day and inter-day for 10.0 µg/kg of DMAA in real samples were 2.7% (n = 7) and 5.3% (n = 7), respectively. The enrichment factor and percentage extraction recovery of the method were 283 and 85%, respectively. The relative recoveries for DMAA in different samples were in the range of 90%–109%.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of analytical method for determination of 1,3-dimethylamylamine in sports nutrition and bodybuilding supplements using pH-switchable deep eutectic solvents followed by high-performance liquid chromatography-diode array detector 利用 pH 值可切换的深共晶溶剂和高效液相色谱-二极管阵列检测器建立运动营养品和健美补充剂中 1,3-二甲基胺的分析方法

IF 2.8 3区工程技术

Journal of separation science Pub Date : 2024-08-31 DOI: 10.1002/jssc.202400340

Dijun Shen, Jie Zhang, Ying Zhang, Xiru Du

{"title":"Development of analytical method for determination of 1,3-dimethylamylamine in sports nutrition and bodybuilding supplements using pH-switchable deep eutectic solvents followed by high-performance liquid chromatography-diode array detector","authors":"Dijun Shen, Jie Zhang, Ying Zhang, Xiru Du","doi":"10.1002/jssc.202400340","DOIUrl":"https://doi.org/10.1002/jssc.202400340","url":null,"abstract":"In this work, an easy, safe, simple, and efficient pH-switchable deep eutectic solvents (DESs)-based liquid phase microextraction followed by high-performance liquid chromatography-diode array detector analysis was developed for the determination of 1,3-dimethylamylamine (DMAA). The switchability of the obtained DESs was investigated by changing the pH. Then the best-selected DES was characterized and the application of the selected DES in the extraction of DMAA from sports nutrition and bodybuilding supplements was investigated. The DES synthesized from l-menthol: oleic acid in a molar ratio of 1:2 had the highest efficiency in the extraction of the target compound. Under the optimum conditions, (50 µL of DES, 100 µL of 4 mol/L KOH, 100 µL of 4 mol/L HCl, extraction time of 40 s and without salt addition) the calibration graph was linear in the range of 0.05–100 µg/kg and limit of detection was 0.02 µg/kg. The relative standard deviations including intra-day and inter-day for 10.0 µg/kg of DMAA in real samples were 2.7% (n = 7) and 5.3% (n = 7), respectively. The enrichment factor and percentage extraction recovery of the method were 283 and 85%, respectively. The relative recoveries for DMAA in different samples were in the range of 90%–109%.","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0