Journal of Research in Clinical Medicine最新文献_第6页

Elizabethkingia meningoseptica: An emerging pathogen causing septicemia in an Immunocompromised patient 伊莉莎白氏脑膜炎败血症:一种新出现的病原体，可引起免疫功能低下患者的败血症

Journal of Research in Clinical Medicine Pub Date : 2022-12-04 DOI: 10.34172/jrcm.2022.025

Pallaavi Goel, E. Rajni, P. Rijhwani

引用次数: 0

COVID-19 and conjunctivitis: A contemporary literature review COVID-19与结膜炎:当代文献综述

Journal of Research in Clinical Medicine Pub Date : 2022-12-04 DOI: 10.34172/jrcm.2022.024

Siamak Khavandi, Elsa Tabibzadeh, Saeed Shoar, Mahdi Mohamadkhani, S. Khavandi

{"title":"COVID-19 and conjunctivitis: A contemporary literature review","authors":"Siamak Khavandi, Elsa Tabibzadeh, Saeed Shoar, Mahdi Mohamadkhani, S. Khavandi","doi":"10.34172/jrcm.2022.024","DOIUrl":"https://doi.org/10.34172/jrcm.2022.024","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a viral respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since its first appearance in December 2019, COVID-19 has been responsible for a number of global outbreaks and has claimed the lives of nearly three million people as of April 2021. High infection rate, loss of taste and smell, fever, cough, and severely adverse effects on the respiratory system have been the chief attributes of the virus. However, SARS-CoV-2 has been linked to other symptoms, many of which are extra-pulmonary or not directly related to the respiratory system. The impact of SARS-CoV-2 on various ophthalmic outcomes has been manifested in many reports and literature tracing the link between COVID-19 and ocular findings in patients suffering from COVID-19. One recurrent case report presented in the literature is related to the presentation of conjunctivitis in COVID-19 patients. Conjunctivitis is a viral infection causing inflammation in conjunctiva, episclera and eyelids resulting in a change of color in eyes, called pink eyes. Swelling, itching, pain, and eye burn are some of the common symptoms. The present study reviews the latest literature on the subject by focusing on the reports of conjunctivitis symptoms in patients with COVID-19.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72725928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatigue in multiple sclerosis is a diagnostic challenge: A cross-sectional study 疲劳在多发性硬化症是一个诊断挑战:一项横断面研究

Journal of Research in Clinical Medicine Pub Date : 2022-11-06 DOI: 10.34172/jrcm.2022.023

S. Hosseini, M. Yazdchi, M. Sahraian, Sadra Majidi, S. Taher, S. Hassannezhad, Reza Mosaddeghi Heris

{"title":"Fatigue in multiple sclerosis is a diagnostic challenge: A cross-sectional study","authors":"S. Hosseini, M. Yazdchi, M. Sahraian, Sadra Majidi, S. Taher, S. Hassannezhad, Reza Mosaddeghi Heris","doi":"10.34172/jrcm.2022.023","DOIUrl":"https://doi.org/10.34172/jrcm.2022.023","url":null,"abstract":"Introduction: Multiple sclerosis (MS) is a chronic and unpredictable demyelinating disease of the central nervous system (CNS). While MS is mostly known for muscle weakness, numbness, and pain, but fatigue is the most common complaint of this condition. Despite this fact, MS related fatigue is one of the most misunderstood symptoms. Methods: A non-interventional study of 100 individuals was conducted in the MS clinic, Tabriz University of Medical Sciences. Patients were divided into groups with and without complaints of fatigue. The course of the disease was determined for all patients. To quantify fatigue, the Modified Fatigue Impact Scale (MFIS) was used. Furthermore, mood disorders, pain, disability, nocturia, insomnia, and spasticity were evaluated among the patients. Results: Overall, fatigue was diagnosed in 61 through 100 patients. Depression was reported in 23 patients of whom 19 had fatigue (P=0.015). 40 patients showed anxiety 33 of which had fatigue (P>0.001). 53 patients of whom reported to have pain (76 patients) showed fatigue (P=0.001). Insomnia was reported in 27 patients, where 21 of them had fatigue (P=0.036). Nocturia was reported in 10 patients, of whom 9 had fatigue (P=0.047). Spasticity was detected in 9 patients, all of whom had fatigue (P=0.012). Conclusion: There are several factors directly and indirectly associated with fatigue that are either fatigue-induced, caused by fatigue, or showing a two-way relationship with it. Understanding these links and attempting to reduce them will improve the quality of life for these patients.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82162377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mesenchymal stem cell secretome induced the acquisition of anti-inflammatory phenotype in rat cortical microglia in vitro 间充质干细胞分泌组诱导大鼠皮质小胶质细胞体外获得抗炎表型

Journal of Research in Clinical Medicine Pub Date : 2022-11-02 DOI: 10.34172/jrcm.2022.022

Babak Davand-Barenji, M. Eskandani, R. Rahbarghazi, M. H. Geranmayeh

{"title":"Mesenchymal stem cell secretome induced the acquisition of anti-inflammatory phenotype in rat cortical microglia in vitro","authors":"Babak Davand-Barenji, M. Eskandani, R. Rahbarghazi, M. H. Geranmayeh","doi":"10.34172/jrcm.2022.022","DOIUrl":"https://doi.org/10.34172/jrcm.2022.022","url":null,"abstract":"Introduction: Here, we aimed to address the impact of mesenchymal stem cells-conditioned medium (MSCs-CM) on M1/M2 phenotype shifting of rat microglia after 48 hours in vitro. Methods: Rat neonatal cortical microglia were randomly allocated into four different groups as follows: Control; MSC-CM; IL-4; and Anti-IL-4 groups. In the MSC-CM, microglia were treated with MSC condition media. In the interleukin-4 (IL-4), cells received 20 ng/mL IL-4; conceived as a positive M2 control group). In the Anti-IL-4, the combination of IL-4 peptide and anti-IL-4 antibody was used. After 48 hours, protein levels of Iba1, CD86, and CD206 were monitored using immunofluorescence imaging and flow cytometry analysis. Results: According to immunofluorescence imaging, 48-hour incubation of rat cortical microglia with stem cells condition media increased protein levels of CD206 and decreased CD86, showing the polarization of microglia toward M2 type lineage compared to the non-treated control group. We found a similar trend in the group that received IL-4. By contrast, the incubation of microglia with anti-IL-4 antibody blunted the stimulatory effect of IL-4 to promote M2-type microglia. Similar to the immunofluorescence data, flow cytometry analysis revealed a significant increase of CD206 positive microglia after exposure to MSC-CM and IL-4 (P<0.05). Treatment with anti-IL-4 antibody significantly reduced the percent of CD206 positive cells, showing the inhibition of M1-to-M2 phenotype acquisition. Conclusion: The current study highlighted a notable anti-inflammatory effect of MSC secretome on cortical microglia by promoting M1-to-M2 phenotype acquisition.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90353870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of quality of life in patients with lower limb osteoarthritis 下肢骨关节炎患者的生活质量评估

Journal of Research in Clinical Medicine Pub Date : 2022-10-29 DOI: 10.34172/jrcm.2022.021

K. Esalatmanesh, Roozbeh Esalatmanesh, Z. Soleimani, Dariush Mahmoodian Darvishani, A. Khabbazi, A. Malek Mahdavi

{"title":"Assessment of quality of life in patients with lower limb osteoarthritis","authors":"K. Esalatmanesh, Roozbeh Esalatmanesh, Z. Soleimani, Dariush Mahmoodian Darvishani, A. Khabbazi, A. Malek Mahdavi","doi":"10.34172/jrcm.2022.021","DOIUrl":"https://doi.org/10.34172/jrcm.2022.021","url":null,"abstract":"Introduction: Osteoarthritis (OA) is a progressive disease, which directly influences individual’s quality of life (QOL). In current study, we decided to assess the QOL in patients with lower limb OA to find an association between patients’ QOL and demographic factors. Methods: In this cross-sectional study, a total of 203 OA patients aged over 50 years and 200 healthy controls matched with regard to age and gender were included. Short Form 12-item Health Survey (SF-12) was used to evaluate QOL. Results: The mean±standard deviation (SD) age of OA patients and control group was 69.82±11.49 and 68.18±10.54 years, respectively. 63% of patients and 56% of control group were females. Most of SF-12 domains including physical functioning, role physical, general health, social functioning, and role emotional were significantly lower in OA patients compared with the control group (P<0.05). Moreover, bodily pain domain was significantly higher in OA patients compared with the control group (P=0.038). There was a considerable correlation between most SF-12 domains with age and sex (P<0.05); whereas considerable correlation was just noticed between role physical domain with body mass index (BMI) (P<0.001). Additionally, Vitality considerably was associated with marital status (P=0.038). Conclusion: QOL in lower limb OA patients was compared with healthy subjects and this impairment was in association with some demographic factors.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88755856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The incidence of retinopathy of prematurity in different gestational ages 不同胎龄早产儿视网膜病变的发生率

Journal of Research in Clinical Medicine Pub Date : 2022-10-29 DOI: 10.34172/jrcm.2022.020

Amir Eftekhari Milani, V. Manouchehri, Mohamad Reza Niyusha, Sadra Eftekhari Milani

{"title":"The incidence of retinopathy of prematurity in different gestational ages","authors":"Amir Eftekhari Milani, V. Manouchehri, Mohamad Reza Niyusha, Sadra Eftekhari Milani","doi":"10.34172/jrcm.2022.020","DOIUrl":"https://doi.org/10.34172/jrcm.2022.020","url":null,"abstract":"Introduction: Since retinopathy of prematurity (ROP) is a preventable cause of blindness in children, evaluation of declared criteria for their screening is crucial. The aim of this study is to evaluate the incidence of the disease in Nikukari Eye Hospital according to gestational age and neonatal birth weight. Methods: In this cross-sectional study, after determining the frequency of neonatal retinopathy based on patients referred to the ROP clinic, neonates were divided into groups of 500 to 1000 g, 1001 to 1500 g, 1501 to 2000 g, and above 2000 g, and 28 weeks, 28-30 weeks, 30-32 weeks, 32-34 weeks, and over 34 weeks, and the frequency of ROP in each group was compared. Results: In the present study, 661 cases were evaluated, of which 93 infants (14.1%) had ROP. The mean±standard deviation of birth weight of patients with ROP was 1199.51±406.80 g and was significantly lower than those without ROP who had a mean birth weight of 2022.69±649.73 g (P=0.001). The mean±standard deviation (SD) of gestational age of patients with ROP was 29.22±2.67 weeks and was significantly lower than non-ROP patients, who had a mean gestational age of 33.41±2.73 weeks (P=0.001). Conclusion: The results of our study showed that 13 newborns weighing between 1500 and 2000 g were affected by the disease, which indicates the importance of ongoing screening in this group of children.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82229655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between maternal periodontal and dental health status and preterm birth: A case-control study 母亲牙周和牙齿健康状况与早产的关系:一项病例对照研究

Journal of Research in Clinical Medicine Pub Date : 2022-10-27 DOI: 10.34172/jrcm.2022.019

Z. Aghazadeh, Ehsan Habibivand, K. Katebi, Eisa Javanvatan

{"title":"The relationship between maternal periodontal and dental health status and preterm birth: A case-control study","authors":"Z. Aghazadeh, Ehsan Habibivand, K. Katebi, Eisa Javanvatan","doi":"10.34172/jrcm.2022.019","DOIUrl":"https://doi.org/10.34172/jrcm.2022.019","url":null,"abstract":"Introduction: The idea that oral infections spread to other systems has long been of interest to clinicians. On the other hand, there are researches suggesting the possibility of periodontitis and dental caries being a risk factor for low birth weight (LBW) and preterm birth (PTB). The purpose of this study is to investigate the relationship between periodontal and dental health status with PTB. Methods: In this case-control study, 82 pregnant women were evaluated. The case group included mothers with preterm infants (gestational age of less than 37 weeks), while the control group involved mothers who had term labors (gestational age of 37-42 weeks). Oral examinations were carried out up to 48 hours after delivery. Periodontal and dental health indicators, including decayed, missed, filled teeth (DMFT), periodontal pocket depth, clinical attachment loss (CAL), bleeding on probing (BOP) and gingival index (GI) were recorded. The data were analyzed using SPSS 17 software through Kolmogorov–Smirnov, Mann-Whitney U and Fisher exact tests. Results: DMFT was 7.34±4.45 and 5.68±4.29 for mothers with preterm infants and mothers in control group, respectively (P=0.023). CAL (P=0.001) and BOP (P=0.012) were significantly higher in mothers with preterm infants, but there was no significant difference in Pocket depth (P=0.57) and GI (P=0.51) between the studied groups. Conclusion: There is a relationship between some maternal periodontal and dental health indicators and PTBs signifying that elimination of any oral sources of inflammation may reduce the risk of premature birth.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74887230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accommodative spasm as the main manifestation of topical eye contact with insecticide 适性痉挛是局部眼接触杀虫剂的主要表现

Journal of Research in Clinical Medicine Pub Date : 2022-10-22 DOI: 10.34172/jrcm.2022.018

Siamak Khavandi, Elsa Tabibzadeh, S. Khavandi, Hamid Soltani Zangbar, Tahereh Ghadiri

引用次数: 0

Gray area; a novel strategy to confront COVID-19 in emergency departments 灰色区域;在急诊科应对COVID-19的新策略

Journal of Research in Clinical Medicine Pub Date : 2022-10-09 DOI: 10.34172/jrcm.2022.017

Rouzbeh Rajaei Ghafouri, Samad Shams Vahdati, S. Ahmadi, Zahra Hosseinnejad, M. Khalilzad, A. Naseri

{"title":"Gray area; a novel strategy to confront COVID-19 in emergency departments","authors":"Rouzbeh Rajaei Ghafouri, Samad Shams Vahdati, S. Ahmadi, Zahra Hosseinnejad, M. Khalilzad, A. Naseri","doi":"10.34172/jrcm.2022.017","DOIUrl":"https://doi.org/10.34172/jrcm.2022.017","url":null,"abstract":"Introduction: Coronavirus disease 2019 (COVID-19) pandemic, affects almost every aspect of human life. To confront this crisis, a separate ward called gray area was designed for emergency departments (EDs) and applied at the provincial level in East-Azerbaijan, Iran. This study aimed to evaluate the effectiveness of this project, increase the serviceability and segregation of the location of infected patients, and show how feasible and fruitful it can be. Methods: This study is an analytical study. The statistical data collection from 39 hospitals was performed between 20 March to 21 September 2020. Descriptive Statistics as well as correlation coefficients were calculated using the 26th version of IBM SPSS. Results: Among 77489 COVID-19 patients admitted to the EDs, approximately 0.38% of patients died in EDs. 22.63% of EDs area was allocated to COVID-19 patients and 70.46% of ED nurses, worked in the gray area. There was no significant correlation between area, number of patients, number of nurses, number of shifts of nurses, number of nurses for each patient, number of nurse shifts for each patient, and area for each patient with mortality rate and rates of disposition in 6 and 12 hours. Conclusion: Gray area is an appropriate strategy to confront COVID-19 in EDs and if more studies approve these results, this strategy can be used to confront this pandemic and future similar conditions in resource-limited countries.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"225 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75512675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring the strategies to overcome diabetes-related stigma in patients’ family: A qualitative study 探讨克服患者家庭中糖尿病相关污名的策略:一项定性研究

Journal of Research in Clinical Medicine Pub Date : 2022-09-07 DOI: 10.34172/jrcm.2022.016

Mehri Doosti-Irani, K. Noorian, S. Abdoli

{"title":"Exploring the strategies to overcome diabetes-related stigma in patients’ family: A qualitative study","authors":"Mehri Doosti-Irani, K. Noorian, S. Abdoli","doi":"10.34172/jrcm.2022.016","DOIUrl":"https://doi.org/10.34172/jrcm.2022.016","url":null,"abstract":"Introduction: Asian countries, including Iran, experience diabetes-related stigma. Since a stigma-free identity is necessary for optimal diabetes management, the necessity of efforts to reduce diabetes-related stigma has been emphasized. This study aimed to explore the strategies to overcome diabetes-related stigma at the family level in Iran. Methods: Seventy-four volunteered people (people with diabetes, family members, non-diabetic people, and healthcare personnel) participated in a qualitative content analysis study to extract the anti-stigma strategies. Data collection was done until data saturation through unstructured in-depth face-to-face interviews, focus groups, Email, short message service (SMS), and telephone interviews. All audio-recorded and transcribed verbatim data were analyzed using the conventional content analysis approach. Results: Participants were raised \"empowering families of people with diabetes\" that would be possible through \"family education\" and \"family-group formation\". Educating families about \"stigmatizing behavior\", \"coping skills\", \"accepting the person with diabetes as the main responsible person for disease control\", and \"diabetes\" is necessary to help families by creating a free-stigma atmosphere. All the training could be programmed in peer groups of families to facilitate goal achievement. Conclusion: Some obtained strategies have been suggested for other stigmatizing conditions like tuberculosis or mental health. However, it must be noticed that every condition is specific and also each stigmatized person is unique and is affected by complex factors. So it is impossible to develop generic stigma reduction interventions for all health conditions. Most studies on stigma have considered families a part of society and have proposed general strategies for them.","PeriodicalId":17071,"journal":{"name":"Journal of Research in Clinical Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75252369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0