Journal of Reproductive Immunology最新文献

2023 ISIR Meeting as the Impetus for Centers for Reproductive Sciences (CERES): Driving reproductive health research forward in Germany 2023年ISIR会议作为生殖科学中心（CERES）的推动力：推动德国生殖健康研究的发展

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-06-16 DOI: 10.1016/j.jri.2025.104618

Sandra M. Blois , Anke Diemert

{"title":"2023 ISIR Meeting as the Impetus for Centers for Reproductive Sciences (CERES): Driving reproductive health research forward in Germany","authors":"Sandra M. Blois , Anke Diemert","doi":"10.1016/j.jri.2025.104618","DOIUrl":"10.1016/j.jri.2025.104618","url":null,"abstract":"<div><div>Reproductive health is crucial for individual well-being, societal advancement, and the health of future generations, encompassing biological, medical, and psychosocial dimensions. However, research in reproductive health in Germany has remained limited, with significant gaps that demand attention. To address these gaps, there is an urgent need for focused research, particularly among emerging scientists in academic medical institutions. In response to this need, the Federal Ministry of Education and Research (BMBF) established five interdisciplinary centers dedicated to reproductive health in late 2023, following the ISIR 2023 conference. These centers include SRHOO at UKE, which explores the intersection of obesity and reproductive health; LE-REP, studying the long-term effects of fertility treatments; CEPRE, supporting healthy pregnancies through clinical and research collaboration; ReproTrack.MS, investigating male infertility at the molecular level; and FePro-Ulm, advancing fertility preservation techniques. This special issue showcases research from these centers, providing valuable insights into innovative treatments and the influence of lifestyle on reproductive health. The initiative also seeks to inspire young scientists to pursue careers in reproductive medicine and promote international collaboration aimed at improving maternal and child health worldwide.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104618"},"PeriodicalIF":2.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic endometritis: A neglected risk factor for recurrent pregnancy loss (RPL) 慢性子宫内膜炎：复发性妊娠丢失（RPL）的一个被忽视的危险因素

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-06-16 DOI: 10.1016/j.jri.2025.104617

Ettore Cicinelli, Pierpaolo Nicolì, Amerigo Vitagliano, Sergio Haimovich

引用次数: 0

Decreased membrane-bound suppressor of tumorigenicity 2 (ST2) but not soluble ST2 was associated with women with recurrent pregnancy loss and recurrent implantation failure compared to controls 与对照组相比，降低的膜结合抑瘤性2 （ST2）但不溶性ST2与复发性妊娠丢失和复发性植入失败的妇女有关

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-06-14 DOI: 10.1016/j.jri.2025.104619

Thanh Vinh Luu , Amy Thees , Umida Ganieva , Svetlana Dambaeva , Joanne Kwak-Kim

{"title":"Decreased membrane-bound suppressor of tumorigenicity 2 (ST2) but not soluble ST2 was associated with women with recurrent pregnancy loss and recurrent implantation failure compared to controls","authors":"Thanh Vinh Luu , Amy Thees , Umida Ganieva , Svetlana Dambaeva , Joanne Kwak-Kim","doi":"10.1016/j.jri.2025.104619","DOIUrl":"10.1016/j.jri.2025.104619","url":null,"abstract":"<div><div>Increased infiltration of immune effectors, including mast cells and natural killer cells in the mid-luteal endometrium was reported in women with recurrent pregnancy loss and repeated implantation failure. Interleukin-33 plays an important role in the cellular activation of mast cells and natural killer cells. This study investigated the endometrial IL-33/<em>ST2</em> axis and its role in mast cell activation in women with RPL and RIF during the mid-luteal phase. Gene expression of <em>ST2</em> was significantly decreased in RPL and RIF patients compared to normal fertile controls (Mean ± SE, 0.46 ± 0.08, 0.44 ± 0.09, 1.25 ± 0.46, P < 0.007). No differences were found in <em>ST2/IL-33</em> mRNA expression ratios, IL-33, and <em>TPSAB1</em> mRNA expression. Western blot analysis revealed a decreased amount of membrane-bound ST2 in RPL and RIF in the endometrium compared to controls (0.09 ± 0.02, 0.12 ± 0.08, 0.28 ± 0.07, P < 0.05). No difference was found in soluble ST2 levels. Evaluation of the ST2/IL-33 protein ratios showed no significance between groups. No differences were found in IL-33 or tryptase protein levels. A correlation analysis was performed between mRNA expression levels of IL-33, ST2, and <em>TPSAB1</em> in relation to genes associated with decidualization; IL-33 was correlated with <em>CD3E, GZMB, NCAM1, PRF1, RORC, SGK1,</em> and <em>TGFB1</em> in the RPL group and associated with <em>CDKN2A, IL18, SLC2A1</em>, and <em>VEGFA</em> in controls. Decreased amount of membrane-bound ST2 may lead to the decreased physiologic activity of IL-33 on immune cells within patients with RPL and RIF; this may lead to alterations in uNK cells contributing to immune dysregulation in the endometrium.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104619"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Characteristics and functions of memory regulatory T cells in normal pregnancy cycle and pregnancy complications” [J. Reprod. Immunol. 163 (2024) 104235] 记忆调节性T细胞在正常妊娠周期和妊娠并发症中的特征和功能[J]。天线转换开关。[免疫学]. 163 (2024)104235]

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-06-12 DOI: 10.1016/j.jri.2025.104552

Zeyang Chen , Xiaojiao Zhou , Hongmei Qu , Xiaolu Zhang , Joanne Kwak-Kim , Wenjuan Wang

引用次数: 0

Complex causal association between immunophenotypes and adenomyosis: Univariable, bidirectional, and multivariable Mendelian randomization 免疫表型和子宫腺肌症之间复杂的因果关系：单变量、双向和多变量孟德尔随机化

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-06-02 DOI: 10.1016/j.jri.2025.104551

Qi Wu , Wenwen Shao , Jia Zhen , Ze Li , Ziyuan Zhao , Wei Shi

{"title":"Complex causal association between immunophenotypes and adenomyosis: Univariable, bidirectional, and multivariable Mendelian randomization","authors":"Qi Wu , Wenwen Shao , Jia Zhen , Ze Li , Ziyuan Zhao , Wei Shi","doi":"10.1016/j.jri.2025.104551","DOIUrl":"10.1016/j.jri.2025.104551","url":null,"abstract":"<div><div>This study aimed to explore the causal link between immunophenotypes and adenomyosis using Mendelian randomization (MR). We conducted a bidirectional MR analysis on 731 immunophenotypes, employing inverse-variance weighted (IVW) as the primary method, supplemented by MR-Egger, weighted mode, and weighted median analyses. Sensitivity analyses were performed to ensure result robustness. Multivariable MR was also used to control for confounding among immune cells. Results showed that 16 immunophenotypes were positively associated with adenomyosis (p < 0.05, OR > 1), while 10 had a negative correlation (p < 0.05, OR < 1). Reverse MR revealed 16 positive and 4 negative correlations with adenomyosis (P < 0.05, OR > 1 or < 1). Multivariable MR identified 5 risk factors and 8 protective factors for adenomyosis (P < 0.05, OR > 1 or < 1). This study clarifies the significant correlation between immune cells and adenomyosis, offering valuable insights for future clinical research.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"170 ","pages":"Article 104551"},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lucidation of the mechanism of pregnancy maintenance from reproductive immunity and treatment of pregnancy complications 生殖免疫维持妊娠的机制及妊娠并发症的治疗

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-05-29 DOI: 10.1016/j.jri.2025.104468

Shigeru saito , Tomoko Shima , Sayaka Tsuda , Akitoshi Nakashima

引用次数: 0

The significance of NK cell measurement in reproductive medicine and its clinical application NK细胞检测在生殖医学中的意义及其临床应用

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-05-29 DOI: 10.1016/j.jri.2025.104469

Atsushi Fukui

引用次数: 0

Transferrin receptor (Tfrc) deficiency causes abnormal sperm morphology and male infertility in mice 转铁蛋白受体（Tfrc）缺乏导致小鼠精子形态异常和雄性不育

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-05-29 DOI: 10.1016/j.jri.2025.104483

Saki Uehara , Atsuko Kageyama , Hibiki Sugita , Shunsuke Takarabe , Mana Otomo , Tomohide Imada , Yui Kawata , Naoki Iwashita , Makoto Sugiyama , Yasuhisa Yamashita , Junpei Terakawa , Junya Ito , Naomi Kashiwazaki

引用次数: 0

Efficacy of intralipid therapy in patients with repeated implantation failure and previous miscarriage. 脂质内治疗反复着床失败及既往流产患者的疗效。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-05-29 DOI: 10.1016/j.jri.2025.104478

Shinichiro Saeki, Hiroaki Shibahara, Kohji Yamada, Nao Hayashi, Satoshi Yamada, Yuri Mizusawa, Shoji Kokeguchi, Masahide Shiotani

引用次数: 0

Does Administration of Pravastatin to AMA Mouse Model Improve Long-Term Prognosis in HDP? 给药普伐他汀能改善HDP小鼠模型的长期预后吗？

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-05-29 DOI: 10.1016/j.jri.2025.104487

Kazunari Nemoto , Keiichi Kumasawa , Motoaki Kinugawa , Risa Miyatake , Kei Inaba , Masako Kanda , Kiichiro Furuya , Takayuki Iriyama , Yasushi Hirota , Yutaka Osuga

引用次数: 0