Journal of Reproductive Immunology最新文献_第2页

The relation of anti-phosphatidylserine/prothrombin antibodies and premature rupture of membranes: A retrospective cohort study. 抗磷脂酰丝氨酸/凝血酶原抗体与胎膜早破的关系：一项回顾性队列研究。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-02-01 Epub Date: 2024-12-24 DOI: 10.1016/j.jri.2024.104421

Jie Zhang, Ge Zheng, Liqiong Chen, Xueke Guo, Xia Fang, Wenmei Zhang, Yan Tu, Kexin Sun, Zhuhua Cai

{"title":"The relation of anti-phosphatidylserine/prothrombin antibodies and premature rupture of membranes: A retrospective cohort study.","authors":"Jie Zhang, Ge Zheng, Liqiong Chen, Xueke Guo, Xia Fang, Wenmei Zhang, Yan Tu, Kexin Sun, Zhuhua Cai","doi":"10.1016/j.jri.2024.104421","DOIUrl":"10.1016/j.jri.2024.104421","url":null,"abstract":"Background: Existing literature supports the association between atypical phospholipid antibodies - anti-phosphatidylserine/prothrombin antibodies (aPS/PT) and adverse pregnancy outcomes. This study aimed to investigate the relationship between aPS/PT and premature rupture of membranes (PROM).Methods: A retrospective cohort study analysis was conducted on 408 pregnant women who had experienced at least one unexplained miscarriage. They were tested for aPS/PT IgM and IgG, and clinical data, test results, and follow-up pregnancy outcomes were collected.Results: A positive correlation was observed between aPS/PT IgM or IgG and PROM in both single-factor and multi-factor regression analysis. After adjusting for potential confounders, the odds ratio (OR) values for aPS/PT IgM and aPS/PT IgG were 1.03 (95 % CI: 1-1.05, P = 0.025) and 1.03 (95 % CI: 1.01-1.06, P = 0.016) respectively. When aPS/PT was divided in three groups, djusted OR values for aPS/PT IgG of the third tertiles compared to the first tertiles (were 2.11(95 % CI: 1.11-4, P = 0.022). Subgroup analysis supported these findings. Curve fitting revealed a linear relationship between aPS/PT IgM and aPS/PT IgG with PROM.Conclusion: This study suggests that aPS/PT IgG and aPS/PT IgM are independent risk factors for premature rupture of membranes, with aPS/PT IgG showing a higher significance compared to aPS/PT IgM.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"167 ","pages":"104421"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating systemic immune-inflammation indices as predictive markers for endometriosis diagnosis: A retrospective observational study. 评估全身免疫炎症指标作为子宫内膜异位症诊断的预测指标：一项回顾性观察研究。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1016/j.jri.2024.104416

Ying Zhou, Gaona Liu, Lin Yuan, Yumeng Qiao, Qi Chen

{"title":"Evaluating systemic immune-inflammation indices as predictive markers for endometriosis diagnosis: A retrospective observational study.","authors":"Ying Zhou, Gaona Liu, Lin Yuan, Yumeng Qiao, Qi Chen","doi":"10.1016/j.jri.2024.104416","DOIUrl":"10.1016/j.jri.2024.104416","url":null,"abstract":"Endometriosis is a chronic inflammatory disease for which there is currently no accurate screening test to identify or predict the probability of the disease in individuals. This can often lead to delays in diagnosis. Several systemic immune-inflammation indices are currently used as predictive or supportive markers for several inflammation-associated diseases. In this study, we investigated whether these immune-inflammation indices, such as systemic immune inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), and pan-immune inflammation value (PIV) could serve as predictive or supplementary markers for diagnosing endometriosis. A total of 434 women with confirmed endometriosis and 517 controls were included in this study. Data on peripheral blood tests, including total counts of white cells, neutrophils, monocytes, lymphocytes, and platelets, were collected, and systemic immune-inflammation indices were calculated. SII, SIRI, NLR, and PIV values were significantly higher in women diagnosed with endometriosis compared to controls. Using the cut-off values of 538 for SII, 0.814 for SIRI, 2.03 for NLR, and 210 for PIV, we achieved 76 % sensitivity and 70 % specificity. When the four indices were combined, the area under the ROC curve (AUC) was 0.796 (95 % CI: 0.766, 0.827), with 76 % sensitivity and 70 % specificity. In conclusion, while ultrasonography or MRI remains the gold standard for visualizing the lesions in diagnosing endometriosis, followed by laparoscopy and histologic verification, routine peripheral blood tests in combination with clinical symptoms, could provide additional clinical diagnostic value for endometriosis as a non-invasive and cost-effective test.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"167 ","pages":"104416"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of miR-125b-5p in modulating placental SIRT7 expression and its implications for lipid metabolism in gestational diabetes. miR-125b-5p在妊娠糖尿病胎盘SIRT7表达调控中的作用及其对脂质代谢的影响

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-02-01 Epub Date: 2024-12-25 DOI: 10.1016/j.jri.2024.104422

K L Milan, M Anuradha, Kunka Mohanram Ramkumar

{"title":"Role of miR-125b-5p in modulating placental SIRT7 expression and its implications for lipid metabolism in gestational diabetes.","authors":"K L Milan, M Anuradha, Kunka Mohanram Ramkumar","doi":"10.1016/j.jri.2024.104422","DOIUrl":"10.1016/j.jri.2024.104422","url":null,"abstract":"Gestational diabetes is marked impaired glucose tolerance, poses various adverse outcomes including increased BMI and obesity. These outcomes results from excess lipid accumulation which is marked by elevated triglycerides. In GDM, placenta exhibits altered lipid metabolism, including reduced fatty acid oxidation and increased triglyceride accumulation. These elevated triglycerides can also contribute to oxidative stress in GDM. SIRT7 plays an important role in regulating lipid metabolism and triglycerides levels. This study aimed to investigate the potential of miRNA to regulate the placental SIRT7 in GDM. PCR analysis reveals that SIRT7 expression along with oxidative stress markers elevated in GDM placenta. These elevated SIRT7 levels were positively correlated with BMI and triglycerides levels in GDM subjects. miR-125b-5p was identified to regulate SIRT7 mRNA using in-silico approaches. Expression levels of miR-125b-5p were found to be downregulated in GDM placenta and found to be negatively correlated with SIRT7 mRNA expression. To confirm the hypothesis BeWo cells were transfected with anti-miR-125b and miR-125b-mimic. Anti-miR overexpressed the SIRT7 expression where mimic dysregulated it. Additionally, overexpressing miR-125b-5p controlled the elevated SIRT7 caused by the exposure of high glucose in BeWo cells. Collectively this study indicated that miR-125b-5p may regulate lipid metabolism via SIRT7 contributing to GDM. These findings highlights the warrant of further research to develop the therapeutic approaches that target miR-125b-5p to reduce lipid accumulation and obesity in GDM.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"167 ","pages":"104422"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human embryo implantation: The complex interplay between endometrial receptivity and the microbiome.

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-22 DOI: 10.1016/j.jri.2025.104440

Shiyang Peng, Amu Qingsan Meri, Min Zhou, Yuan Yu, Dongmei Tian, Shaomi Zhu

{"title":"Human embryo implantation: The complex interplay between endometrial receptivity and the microbiome.","authors":"Shiyang Peng, Amu Qingsan Meri, Min Zhou, Yuan Yu, Dongmei Tian, Shaomi Zhu","doi":"10.1016/j.jri.2025.104440","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104440","url":null,"abstract":"The endometrial and vaginal microbiota have co-evolved with the reproductive tract and play a key role in both health and disease. However, the difference between endometrial and vaginal microbiota, as well as their association with reproductive outcomes in women undergoing frozen embryo transfer, remains unclear. 120 women who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and whole embryo freezing were enrolled. The vaginal and uterine microbiome were sequenced during the first frozen thawed embryo transfer. Based on whether or not they were pregnant after embryo transfer, women were assigned into two groups, and the microbiome of their reproductive tract was compared. The V3-V4 regions of the 16S rRNA gene were examined in the samples using the Next Generation Sequencing method. In the vagina, the non-pregnant group had higher bacterial species richness and diversity, with significantly lower Lactobacillus levels (91.66 % & 74.50 %) and higher Gardnerella levels (3.92 % & 12.12 %) than pregnant group (P < 0.05). In the uterine cavity, the diversity of uterine microbiome between pregnant group and non-pregnant group showed no significant differences. However, dramatic decrease in Lactobacillus (37.27 % & 33.45 %) and Pseudomonas (9.80 % & 4.08 %) were observed in the non-pregnant group (P < 0.05). There may be a correlation between the composition of female reproductive tract microbiome and the reproductive outcomes of patients with frozen-thawed embryo transfer. Lactobacillus-dominated microbiome in reproductive tract is more likely to be associated with higher clinical and ongoing pregnancy rate.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104440"},"PeriodicalIF":2.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and identification of potential biomarkers for dysfunctional uterine bleeding.

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-16 DOI: 10.1016/j.jri.2025.104427

N Zhang, Y Liang, Y Q Meng, Y C Li, X Lu, L Li, T Ye

{"title":"Analysis and identification of potential biomarkers for dysfunctional uterine bleeding.","authors":"N Zhang, Y Liang, Y Q Meng, Y C Li, X Lu, L Li, T Ye","doi":"10.1016/j.jri.2025.104427","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104427","url":null,"abstract":"Clinical evidence increasingly suggests that traditional treatments for dysfunctional uterine bleeding (DUB) have limited success. In this study, blood samples from 10 DUB patients and 10 healthy controls were collected for transcriptome sequencing. Then, the differentially expressed genes (DEGs) were screened and crossed with the DUB-related module genes to obtain the target genes. These target genes were analyzed for functional enrichment. Further, the biomarkers were screened by protein-protein interaction (PPI) analysis and analyzed by the gene set enrichment analysis (GSEA) and ingenuity pathway analysis (IPA). To explore the pathogenesis of DUB, immune microenvironment analyses were also performed. Potential drugs targeting these biomarkers were predicted for clinical treatment. The expression of these biomarkers was validated using quantitative real-time polymerase chain reaction (qRT-PCR). The results showed that, a total of 754 target genes were found to be related to cell proliferation and senescence. Five biomarkers-CENPE, KIF11, PIK3R1, SMC3, and SMC4-were identified, all of which were down-regulated in the DUB group, and most of these findings were confirmed by qRT-PCR. Notably, CENPE expression showed a negative association with activated NK cells and a positive association with resting NK cells. In addition, 44 potential drugs were predicted for DUB treatment. In conclusion, five DUB biomarkers were identified, enhancing understanding of gene regulation in DUB and providing a theoretical foundation for clinical diagnosis and treatment.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104427"},"PeriodicalIF":2.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Earlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns.

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-16 DOI: 10.1016/j.jri.2025.104431

Veera Hurme, Reetta Honkanen, Katri Backman, Anne M Karvonen, Pirkka Kirjavainen, Leea Keski-Nisula

{"title":"Earlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns.","authors":"Veera Hurme, Reetta Honkanen, Katri Backman, Anne M Karvonen, Pirkka Kirjavainen, Leea Keski-Nisula","doi":"10.1016/j.jri.2025.104431","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104431","url":null,"abstract":"New paternity has been related to placenta-associated complications in pregnancy. We evaluated whether a lack of earlier pregnancies or deliveries with a current father are associated with the pregnancy, prenatal, and early neonatal outcomes after controlling for the most common maternal confounders in prospective birth cohort study. An online questionnaire was used to survey 4459 pregnant women from the Kuopio Birth Cohort in their third trimester. The topics included their history of paternity in current and earlier pregnancies. Data were combined with prenatal, perinatal, and early neonatal information. A multivariable logistic regression analysis was performed to compare the possible associations between selected pregnancy and early neonatal outcomes with respect to paternal change. Pregnant women with changed partners had higher rates of smoking during pregnancy and hypertension before pregnancy. In the adjusted analysis, primigravidas and nulliparous multigravidas with different father had the highest risks for preeclampsia (adjusted odds ratios (aORs) 4.46 and 2.69, respectively), low birth weight (aORs 3.15 and 2.25), and smallness for gestational age (aORs 2.23 and 2.16) compared to the parous controls. Nulliparous women who had earlier pregnancies with the current father had less preeclampsia or gestational hypertension, as well as low birth weight (aOR 0.42, 95 % confidence interval (CI) 0.21-0.82 and aOR 0.26, 95 % CI 0.08-0.87, respectively) compared to other nulliparas. Among parous women, most of the pregnancy, obstetric, and early neonatal outcomes were similar in the adjusted analysis, regardless of new changes in paternity.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104431"},"PeriodicalIF":2.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of anti-phosphatidylserine/prothrombin antibodies with adverse in vitro fertilization outcomes.

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-16 DOI: 10.1016/j.jri.2025.104429

Dongyan Liu, Yanshi Wang, Yu Zhang, Haoyu Wang, Wenjuan Tang, Xiaoyu Duan, Ru Wang, Meihong Hu, Fangting Lu, Joanne Kwak-Kim, Li Wu

{"title":"Association of anti-phosphatidylserine/prothrombin antibodies with adverse in vitro fertilization outcomes.","authors":"Dongyan Liu, Yanshi Wang, Yu Zhang, Haoyu Wang, Wenjuan Tang, Xiaoyu Duan, Ru Wang, Meihong Hu, Fangting Lu, Joanne Kwak-Kim, Li Wu","doi":"10.1016/j.jri.2025.104429","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104429","url":null,"abstract":"Anti-phosphatidylserine/prothrombin antibodies (aPS/PT) are classified as non-criteria antiphospholipid antibodies (aPL), and are strongly associated with thrombosis and pregnancy complications linked to antiphospholipid syndrome (APS). This study aimed to investigate whether aPS/PT positivity is associated with adverse outcomes in vitro fertilization (IVF). The study included infertile women who tested positive aPS/PT and underwent IVF cycles, as well as infertile controls with pure tubal etiology. We compared the impact of aPS/PT on baseline and clinical characteristics, immune-related indicators, IVF laboratory metrics, and pregnancy outcomes. Women with aPS/PT exhibited lower numbers of retrieved oocytes, embryos, and both perfect and available embryos, as well as reduced rates of blastocyst formation. Furthermore, an imbalanced Th17/Treg ratio and significantly elevated serum IL-17A levels were observed in women with aPS/PT compared to controls. In conclusion, the presence of aPS/PT is associated with adverse IVF and pregnancy outcomes. Early screening for aPS/PT and appropriate consultation for couples undergoing IVF-ET should be considered. Additionally, specific immune and inflammatory mechanisms related to aPS/PT warrant further investigation.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104429"},"PeriodicalIF":2.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of lymphocyte immunotherapy (LIT) on fertility rates in recurrent pregnancy loss (RPL) women with antinuclear antibodies: A randomized clinical trial.

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-15 DOI: 10.1016/j.jri.2025.104432

Mohsen Dashti, Amin Kamrani, Zahra Shahir-Khajeh, Javad Ahmadian Heris, Leili Aghebati-Maleki, Shahla Danaii, Forough Chakari-Khiavi, Behnam Shahriar, Mehrin Sadough, Sina Baharaghdam, Elham Badihi, Amir Mehdizadeh, Mehdi Yousefi

{"title":"Impact of lymphocyte immunotherapy (LIT) on fertility rates in recurrent pregnancy loss (RPL) women with antinuclear antibodies: A randomized clinical trial.","authors":"Mohsen Dashti, Amin Kamrani, Zahra Shahir-Khajeh, Javad Ahmadian Heris, Leili Aghebati-Maleki, Shahla Danaii, Forough Chakari-Khiavi, Behnam Shahriar, Mehrin Sadough, Sina Baharaghdam, Elham Badihi, Amir Mehdizadeh, Mehdi Yousefi","doi":"10.1016/j.jri.2025.104432","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104432","url":null,"abstract":"To further evaluate the effects of lymphocyte immunotherapy (LIT) for the treatment of RPL patients this study aimed to utilize this type of treatment in RPL patients with positive antinuclear antibodies (ANA) in comparison to ANA-negative RPL women. To this aim, 84 ANA-positive, 114 ANA negative, and 50 healthy pregnant women were recruited. To examine the frequency of cells before and after LIT, flowcytometry technique was employed. The levels of cytokines gene expression were also measured using real-time PCR. The ELISA technique was employed to assess the level of secreted cytokines in serum. Initial evaluation before LIT showed significantly lower NK cells and Th1/Th2 ratio in healthy pregnant women compared to both ANA-negative, and positive patients. Moreover, healthy pregnant women had significantly lower pro-inflammatory cytokine (IFN-γ) and higher anti-inflammatory cytokines (TGF-β and IL-4) compared to RPL patients. After LIT, NK cells frequency significantly decreased in both ANA-negative and -positive groups, however, reduced Th1/Th2 ratio was only significant in ANA-negative group. Significantly increased and decreased IL-4 and IFN-γ were only observed in ANA-negative patients. Furthermore, patients receiving routine treatment did not experience any remarkable changes in terms of cell frequency and cytokine levels. This study showed a significant improvement in pregnancy outcomes including increased pregnancy rate and live birth, and decreased miscarriages in both ANA-negative and positive RPL patients, which were notably higher in ANA-negative group.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104432"},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relationships between immune cells, inflammatory factors, and preeclampsia: A two-step, two-sample mendelian randomization study.

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-15 DOI: 10.1016/j.jri.2025.104428

Yuxiu Wang, Shijun Ni, Feng Liu, Lining Guo, Cha Han

{"title":"Causal relationships between immune cells, inflammatory factors, and preeclampsia: A two-step, two-sample mendelian randomization study.","authors":"Yuxiu Wang, Shijun Ni, Feng Liu, Lining Guo, Cha Han","doi":"10.1016/j.jri.2025.104428","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104428","url":null,"abstract":"Background: Preeclampsia (PE) is a complex hypertensive disorder that occurs during pregnancy, with the immune system playing a key role. Although immune modulation is implicated in PE progression, the roles of specific immune cells and inflammatory mediators remain unclear.Methods: We conducted a two-sample, two-step Mendelian randomization (MR) analysis, primarily using the inverse-variance weighted method, to investigate the causal effect of immune cell traits on PE. Additionally, we assessed the potential mediation effects of inflammatory factors.Results: The MR analyses revealed that 22 immune cell traits exert protective effects against PE, whereas 19 are associated with an increased risk. Additionally, four inflammatory factors were suggested to be linked to PE. Mediation analysis identified the absolute count (AC) of CD33 + HLA DR+ cells, including the CD14 - subset, as causally related to PE. Both the total effect of the CD33 + HLA DR+ AC (odds ratio [OR] = 0.977, 95 % confidence interval [CI], 0.960-0.994; P = 0.010) and the effect of CD33 + HLA DR+ CD14 - cells (OR = 0.977, 95 % CI, 0.963-0.991; P = 0.001) were significant. These effects were partially mediated by STAM-binding protein levels, contributing 16.7 % and 15.0 % to the total effects of the CD33 + HLA DR+ AC and CD33 + HLA DR+ CD14 - AC, respectively.Conclusion: This study establishes a causal relationship between specific immune cells and PE, potentially mediated by inflammatory factors, highlighting the importance of these traits in PE pathogenesis. Further research is needed to validate these findings based on larger, more diverse cohorts.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104428"},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of low-dose aspirin therapy initiation timing on pregnancy outcomes after frozen-thawed blastocyst transfer. 低剂量阿司匹林起始时间对冻融囊胚移植后妊娠结局的影响。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2025-01-13 DOI: 10.1016/j.jri.2025.104430

Keiji Kuroda, Azusa Moriyama, Ryo Tsutsumi, Rutsuko Hobo, Hiroshi Motoyama, Yasushi Kuribayashi, Shuko Nojiri, Tetsuo Maruyama, Rikikazu Sugiyama

{"title":"Impact of low-dose aspirin therapy initiation timing on pregnancy outcomes after frozen-thawed blastocyst transfer.","authors":"Keiji Kuroda, Azusa Moriyama, Ryo Tsutsumi, Rutsuko Hobo, Hiroshi Motoyama, Yasushi Kuribayashi, Shuko Nojiri, Tetsuo Maruyama, Rikikazu Sugiyama","doi":"10.1016/j.jri.2025.104430","DOIUrl":"https://doi.org/10.1016/j.jri.2025.104430","url":null,"abstract":"Clinical effects of low-dose aspirin (LDA) on embryo implantation still remains controversial; therefore, we investigated the appropriate timing for starting LDA in frozen-thawed embryo transfer (ET) cycles. A cross-sectional study was conducted on 885 infertile women who underwent thrombophilia screening between 2020 and 2023. We recruited first frozen-thawed blastocyst transfer cycles in 553 consecutive women aged < 40 years. LDA was started on the day of ET from 2020 to 2021 in 79 women (day 0 group) and at 5 days after ET from 2021 to 2023 in 215 women (day 5 group). We also recruited 259 consecutive women who underwent first frozen-thawed blastocyst transfer without LDA treatment from 2020 to 2023 (control). We compared pregnancy outcomes after frozen-thawed ET between the three groups. In results, clinical pregnancy and livebirth rates after frozen-thawed ET in the day 0 group were significantly lower than those in the other two groups (clinical pregnancy rates: 57.5 %, 40.5 %, and 61.4 %, p = 0.005 and livebirth rates: 48.6 %, 34.2 %, and 54.0 %, p = 0.01 in the control, day 0, and day 5 groups, respectively). Multivariable logistic regression analysis showed that livebirth rate in the day 0 group was significantly lower than those in the other groups (odds ratio [OR]: 0.54, 95 % confidential interval [CI]: 0.31 -0.95); however, no significant difference in livebirth rates was found between the day 5 and control groups (OR: 1.13, 95 %CI: 0.70 -1.80). Starting LDA prior to implantation may decrease pregnancy and livebirth rates after frozen-thawed blastocyst transfer.","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"168 ","pages":"104430"},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0