Journal of Reproductive Immunology最新文献_第2页

LPS-induced TLR4 activation enhances NF-κB signalling in human ovarian granulosa-like tumor cell line and induced primordial Follicle activation in mouse ex vivo ovary assay lps诱导的TLR4激活可增强人卵巢颗粒样肿瘤细胞系的NF-κB信号传导，并诱导小鼠卵巢原始卵泡激活

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jri.2026.104856

M.D. Andreassen , L. Adolphsen , M. Brüner , T.W. Kragstrup , K. Lykke-Hartmann

{"title":"LPS-induced TLR4 activation enhances NF-κB signalling in human ovarian granulosa-like tumor cell line and induced primordial Follicle activation in mouse ex vivo ovary assay","authors":"M.D. Andreassen , L. Adolphsen , M. Brüner , T.W. Kragstrup , K. Lykke-Hartmann","doi":"10.1016/j.jri.2026.104856","DOIUrl":"10.1016/j.jri.2026.104856","url":null,"abstract":"<div><div>The immune system is increasingly recognized as a regulator of ovarian function, yet its role in early folliculogenesis remains unclear. Ovulation exhibits inflammatory-like processes involving Toll-like receptors, which is expressed in early follicles and may influence their activation. This study aims to demonstrate how the TLR4 inhibitor C34 reduces primordial follicle activation in an <em>ex vivo</em> ovary assay. We further examine how this effect relates to LPS stimulation and its interaction with the well-known primordial follicle activation pathway, the AKT signaling pathway. Using Western blotting, we observe increased phosphorylation of AKT. In KGN cells, LPC-induced TLR4 activation triggers NF-κB signalling and ELISA reveals production of the monocyte chemoattractant protein 1 (MCP-1). MCP-1 enhances AKT phosphorylation and cell proliferation, suggesting a link between immune signalling and follicle activation. These findings indicate that LPS-induced activation of TLR4 may interact with PI3K-AKT signalling to regulate primordial follicle activation and ovarian reserve maintenance.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104856"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astaxanthin improves assisted reproductive outcomes in patients with poor ovarian response by alleviating oxidative stress and regulating granulosa cell mitochondrial function 虾青素通过减轻氧化应激和调节颗粒细胞线粒体功能改善卵巢反应不良患者的辅助生殖结果。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-02-17 DOI: 10.1016/j.jri.2026.104864

Dongmei Tian , Haonan Ju , Xinghan Cheng , Xin Liang , Shaomi Zhu

{"title":"Astaxanthin improves assisted reproductive outcomes in patients with poor ovarian response by alleviating oxidative stress and regulating granulosa cell mitochondrial function","authors":"Dongmei Tian , Haonan Ju , Xinghan Cheng , Xin Liang , Shaomi Zhu","doi":"10.1016/j.jri.2026.104864","DOIUrl":"10.1016/j.jri.2026.104864","url":null,"abstract":"<div><div>Poor ovarian response (POR) is a barrier to assisted reproductive technology (ART) success because oxidative stress damages granulosa cells. Follicular fluid samples were prospectively collected from 156 poor ovarian response (POR) patients. A retrospective 1:1 matched analysis was subsequently performed on 60 selected patients (30 with astaxanthin use and 30 without), with the aim of evaluating astaxanthin’s impact on reproductive outcomes and exploring its regulatory effects on oxidative stress and cell survival pathway. Patients who received 37.5 mg astaxanthin (Haematococcus pluvialis oil) twice daily for 60–90 days before ovarian stimulation were compared with those who did not. Baseline characteristics and stimulation indices were similar. The astaxanthin group achieved a higher cumulative clinical pregnancy rate (72.0 % vs. 41.7 %, P = 0.032), while oocyte yield, fertilization and embryo quality were comparable. In follicular fluid, astaxanthin supplementation reduced superoxide dismutase and malondialdehyde, increased catalase and showed a trend towards higher glutathione. Granulosa cells from supplemented patients displayed lower reactive oxygen species and apoptosis. Pro‑apoptotic proteins (Bax, caspase‑3, caspase‑9 and cytochrome c) were down‑regulated and anti‑apoptotic Bcl‑2 and mitophagy markers (LC3B, PINK1 and Parkin) were up‑regulated. Astaxanthin supplementation was associated with improved cumulative pregnancy rates in POR patients undergoing ART. The benefit may involve reduced oxidative stress, upregulation of mitophagy-related markers, and inhibition of granulosa-cell apoptosis, supporting its potential as an adjunct therapy for poor ovarian responders.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104864"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory T cells and decidual vascular remodelling – A new piece in the preeclampsia puzzle 调节性T细胞和蜕膜血管重构——子痫前期之谜的新发现。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jri.2026.104847

Sarah A Robertson, Alison S Care

{"title":"Regulatory T cells and decidual vascular remodelling – A new piece in the preeclampsia puzzle","authors":"Sarah A Robertson, Alison S Care","doi":"10.1016/j.jri.2026.104847","DOIUrl":"10.1016/j.jri.2026.104847","url":null,"abstract":"<div><div>Improperly constrained inflammation at the placental-uterine interface is strongly implicated as a causal factor in preeclampsia. Inflammatory mediators and leukocytes in the decidua are key features of the underlying pathophysiology, with potential to cause uterine vascular anomalies that give rise to compromised placental function, particularly in the severe, early onet form of the disease. While uterine natural killer (uNK) cells are clearly involved, a critical question has been whether and how T cells might also contribute. Regulatory T (Treg) cells, immune-regulatory T cells that counteract inflammation and promote robust placentation, are commonly perturbed in preeclampsia, and systemic Treg cell insufficiency often precedes symptom onset. This review summarizes recent evidence from preclinical studies that collectively point to Treg cells as critical regulators of decidual spiral artery adaptation in early pregnancy, in part through modulating uNK cells. Transient depletion of Treg cells during early placental morphogenesis in mice causes fetal growth restriction and fetal loss associated with impaired remodeling of decidual spiral arteries, compromised uterine artery function, and uNK cell defects. Together with RNA sequencing data to evaluate the effects of Treg cell depletion on decidual biology, the findings provide compelling evidence to implicate Treg cells as essential upstream drivers of uterine vascular adaptation to pregnancy, through a mechanism involving regulation of uNK cells and trophoblast invasion. This new insight provides an important link between adaptive immune tolerance and spiral artery remodeling to better understand the origins of preeclampsia.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104847"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FTO genotype, thiamine dietary intake, and risk of spontaneous abortion: A case-control study FTO基因型、硫胺素饮食摄入与自然流产风险：一项病例对照研究

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.jri.2026.104845

Elaheh Havaei , Masoomeh Alsadat Mirshafaei , Sheyda Nami , Fatemeh Hana Rahimi , Shiva Khodarahmi , Majid Kamali , Khadijeh Abbasi Mobarakeh , Seyfaddin Mehrara , Mohammadtaghi Ghorbani Hesari , Sara Khoshdooz , Saeid Doaei , Marjan Ajami , Maryam Gholamalizadeh

{"title":"FTO genotype, thiamine dietary intake, and risk of spontaneous abortion: A case-control study","authors":"Elaheh Havaei , Masoomeh Alsadat Mirshafaei , Sheyda Nami , Fatemeh Hana Rahimi , Shiva Khodarahmi , Majid Kamali , Khadijeh Abbasi Mobarakeh , Seyfaddin Mehrara , Mohammadtaghi Ghorbani Hesari , Sara Khoshdooz , Saeid Doaei , Marjan Ajami , Maryam Gholamalizadeh","doi":"10.1016/j.jri.2026.104845","DOIUrl":"10.1016/j.jri.2026.104845","url":null,"abstract":"<div><h3>Background</h3><div>Spontaneous Abortion (SA) is a prevalent challenge for maternal health. Polymorphism in some genes as well as deficiency of some vitamins can be effective in causing SA. This study aimed to investigate the relationship between SA and dietary intake of thiamine in individuals with different genotypes of <em>FTO</em> rs9939609 polymorphism.</div></div><div><h3>Methods</h3><div>This case–control study was conducted in Tehran, Iran, and included 539 adult women between 20 and 40 years of age. The study included 192 women with a history of SA and 347 women without a history of abortion. Genotyping of FTO rs9939609 was performed using 5 mL of blood per participant and the Tetra ARMS-PCR method. The dietary intake of thiamin was assessed using a 168-item semi-quantitative food frequency questionnaire (FFQ).</div></div><div><h3>Result</h3><div>Among carriers of the AA/AT genotype, an inverse association was observed between SA and dietary thiamine intake (OR = 0.315, 95 % CI: 0.115–0.858, P = 0.024), which remained significant after adjustment for age, BMI, calorie intake, physical activity, and history of diabetes. No significant association was found among carriers of the TT genotype.</div></div><div><h3>Conclusions</h3><div>These findings suggest that higher thiamine intake may reduce the risk of spontaneous abortion specifically among women carrying the AA/AT FTO genotype, but not among those with the TT genotype. Further studies are warranted.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104845"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miRNA-mediated control of TLR–NLR interplay in the uterus: A hidden corner of recurrent pregnancy loss mirna介导的子宫中TLR-NLR相互作用的控制：复发性妊娠丢失的一个隐藏角落。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jri.2026.104849

Majid S. Jabir , Mahmood Yaseen Mukhlif , Zuhair Mohammed Ali Jeddoa , Irfan Ahmad , Renuka Jyothi. S , Vishal Thakur , Mehul Manu , G.Nancy Priscilla , Munthir Abdulwahid Abdulhussain , Sajad A. Alghazali

{"title":"miRNA-mediated control of TLR–NLR interplay in the uterus: A hidden corner of recurrent pregnancy loss","authors":"Majid S. Jabir , Mahmood Yaseen Mukhlif , Zuhair Mohammed Ali Jeddoa , Irfan Ahmad , Renuka Jyothi. S , Vishal Thakur , Mehul Manu , G.Nancy Priscilla , Munthir Abdulwahid Abdulhussain , Sajad A. Alghazali","doi":"10.1016/j.jri.2026.104849","DOIUrl":"10.1016/j.jri.2026.104849","url":null,"abstract":"<div><div>Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are crucial pattern recognition receptors that initiate inflammatory responses and immunological activation upon detecting pathogen- or damage-associated molecular patterns (PAMPs/DAMPS) in the female reproductive tract, thereby maintaining homeostasis and supporting pregnancy success. Their signaling pathways play a significant role in reproductive disorders by mediating the immune response to various pathogenic stimuli. Recurrent pregnancy loss (RPL), defined as the natural ending of two or more pregnancies before 24 weeks of gestation, approximately half of these patients remain idiopathic without precise prognostic, diagnostic, and therapeutic plans. Emerging data point that microRNAs are essential for immunological control in the female reproductive tract. MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to mRNA and preventing translation into protein. miRNAs play a role in many biological processes, including the development and differentiation of trophoblasts, the activation and implantation of embryos, immune tolerance, and the receptivity of the endometrium during implantation. Given their capacity to regulate up to 30 % of the human genome, miRNAs offer a promising avenue for understanding the immunopathogenesis of pregnancy complications. Recent research has detected differential expression of specific miRNAs in reproductive system pathologies. This review focuses on microRNAs and their association with idiopathic recurrent miscarriage, a condition characterized by considerable heterogeneity. Future studies identifying the precise mechanisms linking miRNA-mediated immune dysregulation in RPL immunopathogenesis could open the way for novel personalized therapeutic and diagnostic strategies.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104849"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testicular immune privilege maintained in incidental testicular microlithiasis: Evidence from 1755 infertile men 偶发性睾丸微石症维持睾丸免疫特权：来自1755名不育男性的证据。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-02-06 DOI: 10.1016/j.jri.2026.104857

Daniele Tienforti , Luca Spagnolo , Giuliana Cordeschi , Marco Giorgio Baroni , Arcangelo Barbonetti

引用次数: 0

Cushing's disease and autoimmune thyroid disorders in women: Impacts on fertility, pregnancy, and menopause 女性库欣病和自身免疫性甲状腺疾病：对生育、怀孕和更年期的影响。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.1016/j.jri.2026.104870

Anu Shibi Anilkumar , Sheena Mariam Thomas , Ramakrishnan Veerabathiran

{"title":"Cushing's disease and autoimmune thyroid disorders in women: Impacts on fertility, pregnancy, and menopause","authors":"Anu Shibi Anilkumar , Sheena Mariam Thomas , Ramakrishnan Veerabathiran","doi":"10.1016/j.jri.2026.104870","DOIUrl":"10.1016/j.jri.2026.104870","url":null,"abstract":"<div><div>Cushing's disease (CD) and autoimmune thyroid diseases (AITDs) are two distinct but interconnected endocrinopathies affecting predominantly women. A primary cause of CD is excess adrenocorticotropic hormone (ACTH) secretion, which leads to hypercortisolism and profound hormonal and immune changes. As with AITDs, Hashimoto's thyroiditis and Graves' disease are caused by a loss of immune tolerance and frequently coexist with female reproductive dysfunction. Emerging evidence suggests that chronic hypercortisolism in CD suppresses immunity as well as alters hypothalamic-pituitary-thyroid (HPT) axis activity, which may mask or exacerbate thyroid autoimmunity after disease remission. Coexisting CD and AITD has significant effects on women's reproductive health, pregnancy outcomes, and menopausal transitions, as thyroid and adrenal hormones play a crucial role in regulating ovulatory cycles, placental development, bone formation, and cardiovascular health. In this review, shared pathophysiological pathways are explored, clinical and therapeutic challenges are highlighted, and integrated management strategies are discussed. To improve early diagnosis, tailor treatment approaches, and guide future endocrine research, it is essential to understand the compounded risks of dual endocrinopathy.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104870"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the emerging role of endometrial microbiota with the coordination of cytokines and growth factors at the maternal-fetal interface. 揭示子宫内膜微生物群与细胞因子和生长因子在母胎界面的协调的新作用。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.jri.2026.104842

Arab Lund , Run Zhang , Miao Xuelan , Zhu Lingxi , Ming Zhang

{"title":"Unveiling the emerging role of endometrial microbiota with the coordination of cytokines and growth factors at the maternal-fetal interface.","authors":"Arab Lund , Run Zhang , Miao Xuelan , Zhu Lingxi , Ming Zhang","doi":"10.1016/j.jri.2026.104842","DOIUrl":"10.1016/j.jri.2026.104842","url":null,"abstract":"<div><div>Early embryonic loss is a common issue in all mammalian species, particularly due to implantation failure. This is a significant concern not only for farmers but also for couples who experience infertility. Recurrent implantation failure (RIF) can be addressed by better understanding the key factors that influence embryo implantation. This review comprehensively elucidates the roles of essential factors, including cytokines, growth factors, and the endometrial microbiome, in the implantation process. Disruption of any of these factors can lead to implantation failure, which is a crucial determinant for a successful pregnancy. The maternal immune system must adapt to accept semi-allogenic embryos. The uterine environment becomes challenging to accept the embryo while combating foreign antigens. This requires changes in the physiology, immunology, and morphology of the endometrial tissue. The endometrial microbiome is emerging as a key contributor in modulating the maternal immune response, providing antibacterial metabolites, and creating an anaerobic environment that is favorable for the early embryo. Furthermore, cytokines and growth factors are widely recognized for their critical roles in embryo implantation. Supplementing these factors before natural breeding or artificial insemination has been shown to reduce reproductive complications, particularly embryo implantation failure.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104842"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sucrose consumption increases M2 CD163 + Macrophage accumulation and the tumor necrosis factor alpha expression in pubococcygeus and iliococcygeus muscles of male rats 蔗糖摄入增加雄性大鼠耻骨尾骨肌和髂尾骨肌M2 CD163 + 巨噬细胞积累和肿瘤坏死因子α表达。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI: 10.1016/j.jri.2026.104866

Laura G. Hernández-Aragón , Saret Dávila-Santacruz , Adriana Sánchez-Rivas , Eliut Pérez-Sánchez , Elvia Ortiz-Ortiz , Francisco Castelán , Leticia Nicolás-Toledo , Estela Cuevas-Romero , Jorge Rodríguez-Antolín

{"title":"Sucrose consumption increases M2 CD163 + Macrophage accumulation and the tumor necrosis factor alpha expression in pubococcygeus and iliococcygeus muscles of male rats","authors":"Laura G. Hernández-Aragón , Saret Dávila-Santacruz , Adriana Sánchez-Rivas , Eliut Pérez-Sánchez , Elvia Ortiz-Ortiz , Francisco Castelán , Leticia Nicolás-Toledo , Estela Cuevas-Romero , Jorge Rodríguez-Antolín","doi":"10.1016/j.jri.2026.104866","DOIUrl":"10.1016/j.jri.2026.104866","url":null,"abstract":"<div><div>Maternal malnutrition impacts offspring development by predisposing to immunological, metabolic, and structural changes in pelvic floor muscle. In this context, striated muscles are essential for male reproductive physiology as well as urinary and fecal continence. This study examined how fetal programming influences macrophage infiltration and inflammation status in the pubococcygeus and iliococcygeus muscles during adulthood. In adult male rats, anti-inflammatory M2 CD163 + macrophage infiltration and tumor necrosis factor alpha (TNF-α) expression were used as markers of inflammation after consuming sucrose-containing water throughout gestation, lactation and post-weaning. Sugar water consumption during both pre- and postnatal periods increased TNF-α expression and M2 CD163 + macrophage infiltration in the pubococcygeus and iliococcygeus muscle in adult males. Overall, chronic consumption of sugar-sweetened beverages during fetal development and post-weaning stages maintains both proinflammatory and anti-inflammatory activation that persists into early adulthood.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104866"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal dysbiosis-related infertility: Effectiveness of probiotics and synbiotics supplementation 肠道失调相关不孕症：益生菌和合成菌补充的有效性。

IF 2.9 3区医学

Journal of Reproductive Immunology Pub Date : 2026-03-01 Epub Date: 2026-02-16 DOI: 10.1016/j.jri.2026.104862

Samaneh Abdolmohammadi-Vahid , Vida Ebrahimi , Mohammad Sadegh Soltani-Zangbar , Alireza Mansouri , Leili Aghebati-Maleki

{"title":"Intestinal dysbiosis-related infertility: Effectiveness of probiotics and synbiotics supplementation","authors":"Samaneh Abdolmohammadi-Vahid , Vida Ebrahimi , Mohammad Sadegh Soltani-Zangbar , Alireza Mansouri , Leili Aghebati-Maleki","doi":"10.1016/j.jri.2026.104862","DOIUrl":"10.1016/j.jri.2026.104862","url":null,"abstract":"<div><div>Infertility, which impacts around 17 % of couples globally, is becoming more closely associated with gut dysbiosis and an imbalance in immune and metabolic functions. Probiotics like <em>Lactobacillus</em> and <em>Bifidobacterium</em> can help restore the balance of gut bacteria, boost insulin sensitivity, and regulate reproductive hormones. On the other hand, synbiotics, combinations of probiotics and prebiotics, work to enhance microbial diversity, increase the production of short-chain fatty acids, and improve immune-endocrine function. Research indicates that synbiotics could be more effective than probiotics in enhancing metabolic, hormonal, and inflammatory parameters related to infertility, especially in women with PCOS; however, evidence supporting superiority in terms of definitive reproductive outcomes such as pregnancy or live birth rates remains limited. Nevertheless, the favorable safety profiles of both interventions support their further exploration within personalized, microbiota-based infertility strategies.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"174 ","pages":"Article 104862"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0