Journal of Renal Injury Prevention最新文献

{"title":"On the occasion of World Cancer Day 2024; focus on hypertension and anti-cancer agents","authors":"Parisa Tajdini, M. Foroutan","doi":"10.34172/jrip.2024.32259","DOIUrl":"https://doi.org/10.34172/jrip.2024.32259","url":null,"abstract":"Oncohypertension is a relatively recent concept that refers to the development of elevated blood pressure in patients with cancer, which is driven by the tumor itself. This review article aims to provide an overview of oncohypertension, including its pathophysiology, clinical implications, diagnostic approaches, and management strategies. The study discusses the association between oncological disorders and hypertension, highlighting the underlying mechanisms responsible for the development of oncohypertension. Furthermore, various diagnostic methods, including imaging techniques and laboratory tests, are discussed in detail. Finally, treatment options for oncohypertension, including both pharmacological and non-pharmacological approaches, are thoroughly reviewed to optimize blood pressure control and improve patient outcomes.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of inflammatory markers and growth factors in progression of chronic kidney disease in patients with diabetes mellitus","authors":"V. Vasilkova, I. Pchelin, V. Bayrasheva, N. Khudyakova, I. Savasteeva, T. Mokhort","doi":"10.34172/jrip.2023.32188","DOIUrl":"https://doi.org/10.34172/jrip.2023.32188","url":null,"abstract":"Introduction: A Diabetes mellitus (DM) and chronic kidney disease (CKD) are two chronic non-communicable diseases that have exceeded epidemic thresholds in all countries of the world. The problem of early diagnosis, prevention and treatment of CKD continues to be relevant for modern medicine, and assessment of the severity of CKD and associated cardiovascular complications is of great practical importance for primary and secondary prevention. Objectives: The aim of the study was to assess the role of proinflammatory cytokines, chemokines and growth factors in progression of CKD in patients with DM. Patients and Methods: We screened 155 type 2 DM patients aged 65.00 (55.00-71.00) years. Control group included 21 healthy people with the same age. Renal function was assessed based on the levels of serum creatinine, cystatin C, estimated glomerular filtration rate (eGFR), which was calculated according to the CKD-EPI (chronic kidney disease epidemiology collaboration) equation, and albuminuria, which was assessed as albumin/creatinine ratio (A/C). The analysis of serum and urine biomarkers was carried out by enzyme immunoassay using commercial test systems. Results: Patients with DM had significantly higher levels of proinflammatory cytokines in comparison with the control group. The levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), vascular endothelial growth factor A (VEGF-A), fibroblast growth factor-23 (FGF-23), regulated upon activation, normal T cell expressed and presumably secreted (RANTES), MIG, CRP, kidney injury molecule-1 (KIM-1) and homocysteine gradually increased with decreasing GFR. According to the results of univariate linear regression analysis, there were significant relationships between the levels of VEGF-A, FGF-23, RANTES, tumor necrosis factor alpha (TNF-alpha), MIG, CRP, hs-CRP, IL-6 and renal function. By multiple linear regression analysis adjusted for confounding factors, serum creatinine was significantly correlated with FGF-23 (β=0.40, P<0.001) and Il-6 (β=0.29, P<0.001). Conclusion: Our study demonstrated the important role of growth factors and proinflammatory cytokines in the development and progression of CKD in DM. However, despite these data, the pathogenesis of diabetic changes in the kidneys remains not fully understood and, in order to clarify the possibility of pathogenetic influences on the progression of diabetic nephropathy, it is necessary to study various aspects of its development, including genetic factors.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between urinary albumin excretion and nutrient status in patients with type 2 diabetes mellitus","authors":"Minh Pham Duc, Kien Xuan Nguyen, Tien Tran Viet, Tuan Dinh Le, Nga Phi Thi Nguyen, Nui Minh Nguyen, Thuc Luong Cong, Son Tien Nguyen, Ba Van Nguyen, An Van Nguyen, Thang Ba Ta","doi":"10.34172/jrip.2023.32179","DOIUrl":"https://doi.org/10.34172/jrip.2023.32179","url":null,"abstract":"Introduction: Diet plays an important role in blood glucose control and management of vascular complications in patients with type 2 diabetes mellitus (T2DM). Excess food intake can be a burden to kidney function and, therefore increase diabetic nephropathy in T2DM. Objectives: To determine the nutritional status and the association between nutrition regime and urinary albumin excretion in patients with T2DM in Vietnam. Patients and Methods: The study was carried out on 594 outpatients with T2DM at military hospital 103, Hanoi, Vietnam from December 2020 to April 2021. Nutrient regime was calculated based on the guidelines of Vietnam national institute of nutrition. Urinary albumin concentrations were measured by enzymatic turbidimeter autoanalyzer. Results: Twenty-four hours nutrient intake is as follows: mean total calorie intake of 1913.72 ± 235.87 kcal; protein of 80.76 ± 14.56 g, fat of 51.10 ± 13.97 g, carbohydrate of 284.83 ± 47.71 g, fiber of 7.35 g (5.85-8.87). Calorie, protein, fat, and carbohydrate intakes per kilogram of body weight (BW) are lower in men compared with women. In the univariate analysis, urinary albumin concentrations correlated with 24-hour protein intake (r = 0.391, P=0.02). In the univariate linear regression analysis, urinary albumin significantly correlated with protein intake (standardized B=0.616, P=0.004); fat intake (standardized B=0.601, P=0.002); diabetes duration (standardized B=0.441, P=0.028), and energy intake (standardized B=- 0.467, P=0.039). Microalbuminuria (MAU) significantly correlated with protein intake (OR=1.042, P=0.006) and HbA1c (OR = 1.664, P=0.013). Conclusion: In patients with T2DM in Vietnam, 24-hour calory intake is 1913.72 ± 235.87 kcal, fat and carbohydrate intakes are within the normal range. Urinary albumin concentrations and MAU had a significant correlation with protein, fat and calory intakes.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose derived mesenchymal stem cells and their role in management of kidney diseases","authors":"F. Dadras, F. Khoshjou","doi":"10.34172/jrip.2024.32244","DOIUrl":"https://doi.org/10.34172/jrip.2024.32244","url":null,"abstract":"Kidney diseases are universal and researchers are trying to figure out how to manage them. Meanwhile, stem cells are a promising source of therapy that has been considered for various kinds of illnesses. Here, we are going to present the newest studies allocated to the role of adipose-derived stem cells in the management of kidney diseases (e.g. acute and chronic kidney diseases, diabetic nephropathy, and rejection). By searching in PubMed, 34 paper related to the topic were reviewed. Various diseases and pathophysiologic aspects of them have been considered in their presentation, as well. Route of injection, combination therapy, and scaffolds are among the other subjects.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the potential association between hypertension and cancer: unveiling onco-hypertension as an innovative concept","authors":"Mohsen Jafari, Ali Rastegar-Kashkouli, Pourya Yousefi, Farzaneh Moammer, Amir Mohammad Taravati, Seyedeh Ghazal Shahrokh, Koushan Rostami, Mohammad Reza Jafari","doi":"10.34172/jrip.2024.32281","DOIUrl":"https://doi.org/10.34172/jrip.2024.32281","url":null,"abstract":"Hypertension and cancer show a possible association, with hypertension being a result of cancer and its treatments and also serving as a potential risk factor for the development of cancer. The term \"onco-hypertension\" describes the presence of hypertension in individuals who have been diagnosed with cancer. Among individuals with cancer, hypertension is the most common coexisting medical condition, occurring in 38% of cases. Cancer-related hypertension involves various mechanisms, including tumor-related factors, coexisting conditions, renal dysfunction, hormonal abnormalities, and stress-related inflammation. Cancer treatments like chemotherapy-targeted therapies and immunotherapies have the potential to influence the regulation of blood pressure through the renin-angiotensin-aldosterone system (RAAS), sodium balance, and fluid retention. Epidemiological studies suggest a potential link between hypertension and specific types of cancer, although the exact reasons and underlying mechanisms remain uncertain. Antihypertensive medications have varying associations with cancer risk. Diuretics are linked to renal cell carcinoma (RCC), thiazide medications to squamous cell carcinoma (SCC), and angiotensin-converting enzyme (ACE) inhibitors to a potential increased risk of lung cancer. However, studies on angiotensin receptor blockers (ARBs) show inconclusive results. Managing onco-hypertension may require pharmacological interventions in addition to lifestyle modifications. Antihypertensive medications commonly used include ACE inhibitors, ARBs, diuretics, calcium channel blockers, and beta-blockers. Factors such as overall health, cancer stage, concomitant medications, treatment interactions, efficacy, tolerability, and side effects guide medication selection.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the association between the administration of SGLT-2 inhibitors and the risk of urinary tract infection; a systematic review and meta-analysis","authors":"Ramin Haghighi, Nasim Zaman Samghabadi, Roya Raeisi Jaski, Sonia Razmjou, Alireza Habibzadeh, Ahmad Maleki Ahmadabadi, Babak Gholamine, Mahdi Behi, Zahra Tavassoli","doi":"10.34172/jrip.2024.32276","DOIUrl":"https://doi.org/10.34172/jrip.2024.32276","url":null,"abstract":"Introduction: Sodium-glucose transporter 2 (SGLT-2) inhibitors induce glycosuria. Therefore, using a meta-analysis study, this study aimed to evaluate the correlation between SGLT2 inhibitor administration and urinary tract infection (UTI) risk. Materials and Methods: In this systematic review and meta-analysis, we conducted searches on Scopus, PubMed, Web of Science, Cochrane, and Google Scholar without time limitations up to October 16, 2023. Data were analyzed using STATA 14 software, and a significance level of P < 0.05 was considered. Results: The combination of 11 studies revealed that the use of SGLT2 inhibitors, when compared to glucagon-like peptide-1 (GLP-1) receptor agonists, reduced the risk of UTI (OR = 0.77; 95% CI: 0.62, 0.95) and when compared to insulin (OR = 0.74; 95% CI: 0.63, 0.87). However, the administration of SGLT2 inhibitors, when compared to dipeptidyl peptidase‐4 (DPP‐4) inhibitors (OR = 1.09; 95% CI: 0.90, 1.32), sulfonylureas (OR = 1.35; 95% CI: 0.88, 2.05), biguanide initiators (OR = 1.14; 95% CI: 1.05, 1.24), thiazolidinediones (OR = 1.19; 95% CI: 0.58, 2.44), and other antidiabetic drugs (OR = 1.20; 95% CI: 0.92, 1.57), did not increase the risk of UTI. The administration of dapagliflozin (OR = 1.51; 95% CI: 0.60, 3.81), canagliflozin (OR = 1.22; 95% CI: 0.47, 3.15), and empagliflozin (OR = 3.22; 95% CI: 2.97, 3.48) showed associations with UTI risk. Furthermore, the correlation between SGLT2 inhibitors use and UTI risk was observed in cohort studies (OR = 1.14; 95% CI: 0.98, 1.32), cross-sectional studies (OR = 0.86; 95% CI: 0.64, 1.14), in males (OR = 1; 95% CI: 0.72, 1.40), and females (OR = 1.17; 95% CI: 0.91, 1.52). Conclusion: Empagliflozin, in contrast to dapagliflozin and canagliflozin, increases the risk of UTI. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023479548) and Research Registry (UIN: reviewregistry1742) Websites","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal failure following the administration of proton pump inhibitors; a mini-review article on recent findings","authors":"Parisa Tajdini, M. Foroutan","doi":"10.34172/jrip.2024.32260","DOIUrl":"https://doi.org/10.34172/jrip.2024.32260","url":null,"abstract":"Proton pump inhibitors (PPIs) are frequently administered for the treatment of acid-related disorders such as gastroesophageal reflux disease (GERD). However, there is growing concern about their capability of adverse effects, including renal failure. Several studies have described a relationship between PPI administration and an increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). The mechanism behind this association is not fully understood, but it may involve changes in renal blood flow and tubular function. The risk of renal failure appears to be higher in patients who use PPIs for extended periods of time or at high doses. It is also higher in patients with pre-existing kidney disease or other risk factors for renal impairment. Clinicians should be aware of the potential risks of PPI use and consider alternative treatment options in patients with renal impairment or other risk factors for AKI or CKD. Regular monitoring of kidney function may also be warranted in patients on long-term PPI therapy.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cinacalcet on the serum phosphorus, calcium and PTH levels in dialysis patients; a systematic review and meta-analysis","authors":"Mehdi Yarahmadi, M. Moonesan","doi":"10.34172/jrip.2024.32235","DOIUrl":"https://doi.org/10.34172/jrip.2024.32235","url":null,"abstract":"Introduction: Cinacalcet is a medication prescribed to manage hypercalcemia and hyperparathyroidism in patients with chronic kidney diseases. The present study aims to evaluate the impact of cinacalcet on serum levels of calcium, phosphorus, and parathyroid hormone (PTH) in patients undergoing dialysis using a systematic review and meta-analysis approach. Materials and Methods: This study was conducted based on the PRISMA guidelines. A literature search without time restriction was performed on international databases, including Cochrane, Web of Science, Scopus, and PubMed. Data were analyzed using STATA 14 software at a significance level of P<0.05 for all tests. Results: The present meta-analysis involved twelve studies with a sample size of 1131 patients. A reduction was noted in the serum levels of calcium [SMD: -1.32 (95% CI: -2.64, -0.01)], PTH [SMD: -3.95 (95% CI: -6.53, -1.37)], phosphorus [SMD: -1.61 (95% CI: -3.01, -0.20)] and Ca×P [SMD: -5.33 (95% CI: -10.16, -0.49)] after cinacalcet use in dialysis patients. However, the variations in serum levels of alkaline phosphatase were non-significant [SMD: -0.09 (95% CI: -0.94, 0.77)]. In addition, the effectiveness of cinacalcet use on calcium serum level reduction in dialysis patients was verified at a daily dose of 30-60 mg [SMD: -0.83 (95% CI: -1.25, -0.42)] and consumption duration of 24 months [SMD: -1.26 (95% CI: -1.66, -0.87)]. Conclusion: The administration of cinacalcet significantly decreased the serum calcium, phosphorous, PTH, and Ca×P product in dialysis patients. The lowest and highest effects of cinacalcet were found for calcium and Ca×P products, respectively. The prescription of this drug appears more effective in improving hypercalcemia in dialysis patients. Registration: This investigation has been conducted in accordance with the PRISMA checklist, and its protocol was registered on the PROSPERO platform (ID: CRD42023428774).","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal involvement in Takayasu’s arteritis; a mini-review study","authors":"Mansour Salesi, Sarah Hosseinpoor","doi":"10.34172/jrip.2024.32267","DOIUrl":"https://doi.org/10.34172/jrip.2024.32267","url":null,"abstract":"Takayasu’s arteritis is a chronic inflammatory disease affecting the aorta and its branches. It can also involve other organs, such as the kidneys. Inflammation of the renal artery can lead to hypertension, proteinuria, and progressive loss of kidney function over time. This condition is known as renovascular hypertension. The treatment for Takayasu’s arteritis involves managing symptoms with medications like corticosteroids, immunosuppressants, and antihypertensive drugs. Surgical intervention may be necessary if there are complications, such as aneurysms or blockages in the affected blood vessels. Lifestyle modifications such as maintaining a healthy weight, regular exercise, and smoking cessation can also help manage better disease management.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140510508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the level of uric acid and peritonitis in peritoneal dialysis patients; a retrospective cohort study","authors":"N. Shamspour, Zeinab Jafarian, Maryam Alsadat Mousavi, H. Ahmadipour, Jalal Azmandian","doi":"10.34172/jrip.2023.32150","DOIUrl":"https://doi.org/10.34172/jrip.2023.32150","url":null,"abstract":"Introduction: Peritonitis is a cause of mortality among peritoneal dialysis (PD) patients. Some studies suggested that uric acid (UC) levels may be effective in inflammatory processes. Objectives: We have examined the relationship between serum UC and peritonitis in PD patients. Patients and Methods: A retrospective cohort study was conducted over six years. The statistical population was all PD patients who underwent PD for at least six months. The sample size included 151 patients based on serum UC levels (less than or equal to 6.5 mg/dL, more than 6.5 mg/dL) and was divided into two groups. Both groups were compared using inflammatory factors and peritonitis. Results: In total, around 100 patients (66.2%) had UC levels ≤6.5 mg/dL, and 51 patients (33.7%) had serum UC levels >6.5 mg/dL. Peritonitis was observed in 72 (47.6%) patients. The frequency of peritonitis in the patients with greater levels of serum UC (51%) was higher compared to the other group (46%), but this difference was not statistically significant (P=0.56). The average hemoglobin level was lower in higher serum UC levels group (P=0.002). The mean levels of serum albumin (P=0.002), phosphorus (P=0.004), and creatinine (P=0.02) were lower in the group with serum UC below 6.5 mg/dL group. Conclusion: There was no correlation discovered between peritonitis and serum UC levels. However, it seems that serum UC can serve as a marker among PD patients to predict the occurrence of anemia and malnutrition.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}