电子显微镜对肾脏疾病的诊断作用综述,2006年伊朗本地肾脏活检的研究

IF 0.2 Q4 UROLOGY & NEPHROLOGY
S. Owji, Farshad Dehghani, S. Torabinezhad, Seyed Hossein Owji, H. Raeisi Shahraki, A. Karami
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引用次数: 0

摘要

肾脏疾病影响着全世界数百万人。几十年来,电子显微镜一直是肾活检研究的一个组成部分。目的:在本研究中,我们评估了电子显微镜在肾脏疾病诊断中的作用。患者和方法:这是一项在转诊中心进行的回顾性横断面研究,为期16年(2001-2016)。评估患者的电子显微镜(EM),光镜(LM)和免疫荧光(IF)谱。最终诊断基于EM,并将LM的初步结果与EM的结果进行比较,以评估EM对最终诊断的贡献率。电子商务的作用被分为必要的、有益的和非贡献的。结果:共行肾活检2006例。男性占44.3%,成人占74.1%。最常见的诊断是狼疮性肾炎(LN)(20.7%),其次是局灶节段性肾小球硬化(FSGS)(15.7%)和膜性肾小球肾炎(MGN)(14.5%)。EM在遗传性肾炎和微小改变病(MCD)中最重要。总的来说,在2006年所有病例中,EM在25.2%中是必需的,在17.4%中是有用的,在57.4%中是非贡献性的。结论:伊朗该地区常见的肾脏疾病为LN、FSGS和MGN。在大约一半的患者中,EM研究在更准确地诊断肾脏疾病和防止误诊方面发挥了重要作用。研究发现,这种作用在遗传性疾病中更为突出。我们建议在可能的情况下,电子显微镜作为常规病理检查必不可少的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An overview on the diagnostic role of electron microscopy for kidney diseases, study of 2006 native kidney biopsies in Iran
Introduction: Kidney diseases affect millions of people worldwide. Over several decades, electron microscopy has been an integral part of the kidney biopsy study repertoire. Objectives: In this study, we assessed the role of electron microscopy in the diagnosis of kidney diseases. Patients and Methods: This was a retrospective cross-sectional study conducted at a referral center over a 16-year period (2001-2016). The electron microscopy (EM), light microscopy (LM), and immunofluorescence (IF) profiles of the patients were assessed. The final diagnosis was based on EM, and the primary LM results were compared to those of EM in order to assess the contribution rate of EM to the final diagnosis. The role of EM was categorized as essential, helpful, or non-contributory. Results: A total of 2006 kidney biopsies were performed. Male subjects accounted for 44.3%, and adults for 74.1% of the cases. The most common diagnosis was lupus nephritis (LN) (20.7%), followed by focal segmental glomerulosclerosis (FSGS) (15.7%) and membranous glomerulonephritis (MGN) (14.5%). EM was the most contributory in hereditary nephritis and minimal change disease (MCD). Overall, EM was essential in 25.2%, helpful in 17.4%, and non-contributory in 57.4% of all 2006 cases. Conclusion: The common kidney disorders in this geographic area of Iran are LN, FSGS, and MGN. In about half of the patients, EM study played an important role in the more accurate diagnosis of kidney diseases and prevented misdiagnosis. This role has been found to be more prominent in inherited diseases. We recommend EM as a useful and indispensable tool for routine pathologic study of biopsies when possible.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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