百草枯中毒;印度一家三级医疗中心的经验

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Nisha Jose, Indhumathi Elayaperumal, Devia Arumugam, Jayakumar Matcha
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引用次数: 0

摘要

简介:百草枯中毒是印度次大陆常用的一种毒素。尽管医疗保健取得了一些进展,但百草枯中毒的死亡率仍然很高,在理想的管理方面存在争议。目的:本研究的目的是阐明这些患者在当前情况下的临床过程,并评估一些新的治疗选择,如血液灌流在百草枯中毒的情况下。患者和方法:本研究是一项回顾性观察性研究,检查了印度南部三级保健中心过去五年中所有百草枯中毒的成年患者。从在线医院记录中分析了人口统计学特征、临床和实验室概况、治疗方案和结果。结果:13例患者除1例外,均为故意摄入百草枯。所有患者均发生急性肾损伤(AKI)(100%)。7例(54%)AKI患者需要透析。63.5% (n=8)的患者出现肺损伤,92.3%(12例)的患者出现多器官功能障碍综合征(MODS)。30.8%的患者接受了血液灌流治疗,在住院时间或死亡时间方面没有太大益处。常规适应症给予血液透析和持续肾替代治疗(CRRT)。发现透析与死亡时间有显著关系。结论:百草枯是一种高致死性除草剂,治疗效果不佳。大多数患者出现多器官功能障碍,并因循环衰竭而死亡。透析可以延缓百草枯中毒的死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Paraquat poisoning; an experience from a tertiary care center in India
Introduction: Paraquat poisoning is a commonly used toxin within the Indian sub-continent. Despite several advances in medical care, mortality in cases of paraquat poisoning continues to be high with controversies in the ideal management. Objectives: The aim of this study was to throw light on the clinical course of these patients in the current setting and evaluate some of the novel therapeutic options such as hemoperfusion in the setting of paraquat poisoning. Patients and Methods: This study is a retrospective observational study examining all adult patients with paraquat poisoning over the last five years from a tertiary care centre in Southern India. Demographic characteristics, clinical and laboratory profile, treatment options, and outcome were analysed from online hospital records. Results: Of 13 patients, all patients, except one, had ingested paraquat deliberately. Acute kidney injury (AKI) occurred in all patients (100%). Dialysis was required in 7 patients (54%) with AKI. Lung injury was seen in 63.5% of patients (n=8) and most patients i.e. 92.3% (12 patients) had multi-organ dysfunction syndrome (MODS). Hemoperfusion was provided to 30.8% of patients without much benefit in terms of duration of hospitalisation or time to death. Hemodialysis and continuous renal replacement therapy (CRRT) were offered for conventional indications. Dialysis was found to have significant bearing on time to death. Conclusion: Paraquat is a highly lethal herbicide with few effective therapeutic options. The majority of patients develop multi-organ dysfunction and succumb to death owing to circulatory collapse. Dialysis may be able to delay mortality in paraquat poisoning.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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