吡格列酮对糖尿病肾病患者蛋白尿及心血管事件的影响

IF 0.2 Q4 UROLOGY & NEPHROLOGY
S. M. Hejazian, S. Zununi Vahed, Nooshin Khadem Haghighi, Bahram Niknafs, F. Farnood
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引用次数: 0

摘要

近年来,减缓糖尿病向DN的进展已经引起了人们极大的兴趣。目的:考虑到管理糖尿病患者的巨大成本和缺乏对伊朗人群的类似研究,本研究旨在调查吡格列酮对DN进展和心血管事件患病率的影响。患者和方法:本前瞻性研究对55例2型糖尿病患者进行了研究,他们被分为两组。1组患者在其他降糖药物的基础上,每日给予吡格列酮30mg。第二组患者接受其他抗糖尿病药物治疗。在六个月的随访期间,评估了蛋白尿和心血管事件的发生。结果:与第2个月相比,第1组在6个月的随访中24小时尿蛋白尿下降,组内差异显著(P<0.001)。与2组相比,1组的心血管事件发生率无显著差异。结论:吡格列酮在其他降糖药物的基础上加用30 mg可降低2型糖尿病患者的蛋白尿;然而,它对心血管事件的风险没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of pioglitazone on proteinuria and cardiovascular events in patients with diabetic nephropathy
Introduction: Slowing the progression of diabetes to DN has established a great deal of interest in recent years. Objectives: Considering the enormous costs of managing patients with diabetes and the lack of similar studies on the Iranian population, the present study aimed at investigating the effect of pioglitazone on the progression of DN and the prevalence of cardiovascular events. Patients and Methods: The present prospective study was undertaken on 55 patients with type 2 diabetes who were divided into two groups. The group 1 patients received 30 mg of pioglitazone daily in addition to other blood sugar-controlling drugs. Patients in the group 2 recieved other anti-diabetic medications. During a six-month follow-up period, proteinuria and the occurrence of cardiovascular events were assessed. Results: The 24-hour urinary proteinuria decreased within the group 1 and these intragroup differences were significant (P<0.001) during six months of follow-up compared to month two. There was no significant difference in the ratio of cardiovascular events in the group 1 compared to the group 2. Conclusion: Adding 30 mg of pioglitazone to other blood sugar-lowering medications could lower proteinuria in individuals with type 2 diabetes; however, it had no impact on the risk of cardiovascular events.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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