Journal of Orthopaedic Science最新文献

{"title":"Wrong-level spine surgery: A multicenter retrospective study","authors":"Ryohei Saito ,&nbsp;Shunsuke Fujibayashi ,&nbsp;Takayoshi Shimizu ,&nbsp;Koichi Murata ,&nbsp;Bungo Otsuki ,&nbsp;Eijiro Onishi ,&nbsp;Shuichi Matsuda ,&nbsp;Tadashi Yasuda","doi":"10.1016/j.jos.2023.11.005","DOIUrl":"10.1016/j.jos.2023.11.005","url":null,"abstract":"<div><h3>Background</h3><div>Wrong-level spine surgery is a rare but serious complication of spinal surgery that increases patient harm and legal risks. Although such surgeries have been reported by many spine surgeons, they have not been adequately investigated. Therefore, this study aimed to examine the causes and preventive measures for wrong-level spine surgeries.</div></div><div><h3>Methods</h3><div>This study analyzed cases of wrong-level spine surgeries from 10 medical centers. Factors such as age, sex, body mass index, preoperative diagnosis, surgical details, surgeon’s experience, anatomical variations, responses, and causes of the wrong-level spine surgeries were studied. The methods used by the surgeons to confirm the surgical level were also surveyed using a questionnaire for each surgical procedure and site.</div></div><div><h3>Results</h3><div>Eighteen cases (13 men and 5 women; mean age, 61.2 years; mean body mass index, 24.5 kg/m²<span>) of wrong-level spine surgeries were evaluated in the study. Two cases involved emergency surgeries, three involved newly introduced procedures, and five showed anatomical variations. Wrong-level spine surgeries occurred more frequently in patients who underwent posterior thoracic surgery<span> than in those who underwent other techniques (p &lt; 0.01). Twenty-two spinal surgeons described the methods used to confirm the levels preoperatively and intraoperatively. In posterior thoracic laminectomies<span>, half of the surgeons used preoperative markers to confirm the surgical level and did not perform intraoperative fluoroscopy. In posterior thoracic fusion, all surgeons confirmed the level using fluoroscopy preoperatively and intraoperatively.</span></span></span></div></div><div><h3>Conclusions</h3><div><span>Wrong-level spine surgeries occurred more frequently in posterior thoracic surgeries. The thoracic spine<span> lacks the anatomical characteristics observed in the cervical and lumbar spine. The large drop in the </span></span>spinous process<span> can make it challenging for surgeons to determine the positional relationship between the spinous process and the vertebral body. Moreover, unfamiliarity with the technique and anatomical variations were also risk factors for wrong-level spine surgeries.</span></div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1359-1363"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miRNA-122 is associated with knee osteoarthritis progression: A 6-year longitudinal cohort study in the Yakumo study","authors":"Hiroto Funahashi ,&nbsp;Yasuhiko Takegami ,&nbsp;Yusuke Osawa ,&nbsp;Hiroaki Nakashima ,&nbsp;Shinya Ishizuka ,&nbsp;Ryosuke Fujii ,&nbsp;Hiroya Yamada ,&nbsp;Koji Suzuki ,&nbsp;Yukiharu Hasegawa ,&nbsp;Shiro Imagama","doi":"10.1016/j.jos.2023.10.004","DOIUrl":"10.1016/j.jos.2023.10.004","url":null,"abstract":"<div><h3>Objective</h3><div><span><span>The association between knee osteoarthritis (OA) and </span>miRNAs<span> has been widely reported. However, the utility of miRNAs<span> as predictors of knee osteoarthritis (KOA) progression in longitudinal studies has not been reported. We aimed to identify </span></span></span>circulating miRNAs (c-miRNAs) associated with KOA progression in the general population and to examine their potential use as predictors of KOA progression.</div></div><div><h3>Methods</h3><div><span>In 2012 and 2018, 66 participants (128 knees) took part in a resident health check-up in the Yakumo study. If the KL classification progressed two or more levels, the patient was classified as having progressive OA<span>. Quantitative real-time polymerase chain reaction was used to screen 21 c-miRNAs. The expression levels of those c-miRNAs were compared between the progressive OA group and non-progressive OA group using student-t-test. Logistic analysis was performed in c-miRNAs less than p &lt; 0.10 in </span></span>univariate analysis.</div></div><div><h3>Results</h3><div><span>The progressive OA group consisted of 78 knees. The results of the comparison between the progressive OA group and the non-progressive OA group showed that six c-miRNAs as follows; let7d (p = 0.030), c-miRNA-122 (p &lt; 0.001), 150 (p = 0.070), 199 (p = 0.078), 21 (p = 0.016) and 320 (p = 0.093) were extracted as factors related to the progression of knee OA. In addition, </span>logistic regression analysis identified c-miRNA-122 as an independent factor involved in the progression of knee osteoarthritis (odds ratio: 1.510, 95% confidence interval: 1.060–2.140, p = 0.023). The ROC curve showed by c-miRNA-122 for the progression of OA risk had an area under the curve of 0.702 (95% CI: 0.609–0.795). The threshold of c-miRNA-122 was −4.609.</div></div><div><h3>Conclusion</h3><div>The expression level of c-miRNA-122 was associated with the risk of KOA progression in community dwelling Japanese people.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1411-1416"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of back pain in patients with adolescent idiopathic scoliosis: Considerations in candidates for corrective surgery","authors":"Yuta Kusabe ,&nbsp;Toru Hirano ,&nbsp;Ren Kikuchi ,&nbsp;Masayuki Ohashi ,&nbsp;Hideki Tashi ,&nbsp;Yohei Shibuya ,&nbsp;Tatsuo Makino ,&nbsp;Kazuhiro Hasegawa ,&nbsp;Naohito Tanabe ,&nbsp;Kei Watanabe","doi":"10.1016/j.jos.2023.11.014","DOIUrl":"10.1016/j.jos.2023.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have demonstrated that the point prevalence of back pain<span><span> ranges from 12 % to 33 % and that the lifetime prevalence of back pain ranges from 28 % to 51 % in adolescents. However, few studies on back pain in patients with </span>Adolescent idiopathic scoliosis (AIS) have been conducted, and these studies had significant limitations, including a lack of comparative controls and detailed information about scoliotic deformity or pain location. This study aimed to determine whether adolescents with AIS experience back pain in specific regions.</span></div></div><div><h3>Methods</h3><div><span>This retrospective case-control study included 189 female adolescents with AIS who underwent corrective fusion from 2008 to 2020. Questionnaires on back pain and health-related quality of life (HRQOL) using the </span>Scoliosis Research Society Outcomes Instrument-22 (SRS-22) were conducted preoperatively. The control group included 2909 general female adolescents.</div></div><div><h3>Results</h3><div>The mean Cobb angles in the main thoracic and thoracolumbar/lumbar curves were 51.4 ± 15.3° and 40.4 ± 12.9°. Back pain characteristics included higher point prevalence (25.9 %) and lifetime prevalence (64.6 %) compared to healthy controls. Adolescents with back pain showed lower scores in the pain and mental health domains of the SRS-22. Adolescents with major thoracic AIS showed more back pain in the upper and middle right back compared to adolescents with major thoracolumbar/lumbar AIS.</div></div><div><h3>Conclusion</h3><div>The point and lifetime prevalence of back pain were definitely higher in patients with AIS, which affected their HRQOL. There was a relationship between pain around the right scapula and the right major thoracic curve with a rib hump deformity.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1364-1369"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and characteristics of diffuse idiopathic skeletal hyperostosis in the community-living middle-aged and elderly population: The Yakumo study","authors":"Kazuma Ohshima ,&nbsp;Hiroaki Nakashima ,&nbsp;Naoki Segi ,&nbsp;Sadayuki Ito ,&nbsp;Jun Ouchida ,&nbsp;Yasuhiko Takegami ,&nbsp;Shinya Ishizuka ,&nbsp;Yukiharu Hasegawa ,&nbsp;Shiro Imagama","doi":"10.1016/j.jos.2023.10.005","DOIUrl":"10.1016/j.jos.2023.10.005","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of diffuse idiopathic skeletal hyperostosis (DISH) is increasing with the aging of the population. Asymptomatic DISH can decrease the spinal range of motion (ROM) and cause fractures. However, the prevalence or physical function of patients with DISH before experiencing fractures and other serious conditions is unclear. This study aimed to investigate the prevalence of DISH in the community residents on the basis of age and sex and characterize their physical function, ROM, and bone fragility.</div></div><div><h3>Methods</h3><div>The subjects were community volunteers who attended a health checkup in 2018 and 2019. Overall, 455 subjects (mean age, 64.2 ± 9.7 years; 177 men) were included for analysis. We performed whole-spine lateral radiography for detecting DISH according to the criteria reported by Resnick. We compared the age, sex, body mass index<span> (BMI), results of muscle strength and walking tests, ROM measured by SpinalMouse®, and quantitative ultrasound (QUS) of calcaneus with and without DISH.</span></div></div><div><h3>Results</h3><div>DISH was detected in 83 (18.2%) cases. The DISH group was older (69.8 y.o. vs. 63.0 y.o.; p &lt; 0.05) and comprised more men (prevalence: men, 27.7%; women, 12.2%; p &lt; 0.001). BMI was high in the DISH group (24.8 vs. 23.3 kg/m²<span>, p &lt; 0.05). SpinalMouse measurements showed the DISH group had a significantly decreased ROM in the lumbar spine (43.2°, 57.2°, p &lt; 0.05). The DISH group had a significantly lower T-score on the QUS measurement in the calcaneus (−2.0, −1.5, p &lt; 0.05). There were, however, no significant differences between groups in both muscle strength test and walking test.</span></div></div><div><h3>Conclusion</h3><div>Subjects with DISH had decreased ROM in the lumbar spine and bone mineral density in calcaneal QUS. However, physical functions such as muscle strength and walking ability were similar among subjects with and without DISH without subjective symptoms.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1346-1352"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49691067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of conversion surgery after conservative treatment for pyogenic spondylitis","authors":"Tetsuhiko Inoue ,&nbsp;Naomi Kobayashi ,&nbsp;Noriyuki Baba ,&nbsp;Manabu Ide ,&nbsp;Takayuki Higashi ,&nbsp;Yutaka Inaba","doi":"10.1016/j.jos.2023.10.015","DOIUrl":"10.1016/j.jos.2023.10.015","url":null,"abstract":"<div><h3>Background</h3><div><span>Patient demographic and clinical characteristics may be factors associated with the success of conservative treatment for pyogenic spondylitis<span>. The ability of imaging findings at initial diagnosis to predict patient outcomes remains unclear. The aim of this study was to investigate the risk factors associated with conversion surgery after conservative treatment for pyogenic spondylitis, with a special focus on the initial </span></span>computed tomography (CT) findings.</div></div><div><h3>Methods</h3><div>This study enrolled 35 patients with pyogenic spondylitis who underwent CT and magnetic resonance imaging (MRI) at diagnosis and were followed-up for more than 6 months. Patients were diagnosed by MRI, and the degree of bone destruction was assessed on CT cross-sectional images. Vertebral body destruction was classified as grades 0 (almost normal), 1 (endplate irregularity), 2 (vertebral body destruction not involving the posterior wall), and 3 (destruction involving the posterior wall). Patients were divided into four groups based on grade of bone destruction and their clinical characteristics were compared.</div></div><div><h3>Results</h3><div>1, 11, 11, and 12 patients were classified as grades 0, 1, 2, and 3, respectively. Univariate analysis<span> showed no significant differences in the demographic and clinical characteristics of the four groups. Eighteen (51.4 %) patients had been treated surgically, with the rate of surgical treatment being significantly higher in patients with grade 3 (83.3 %) than in those with grades 0 + 1 (25 %) and grade 2 (45.5 %) (P &lt; 0.05). Multivariate analysis<span> showed that epidural abscess on MRI (odds ratio [OR] 10.8, 95 % confidence interval [CI] 1.68–69.7), grade 3 bone destruction on CT (OR 3.97, 95 % CI 1.21–13.0), and C-reactive protein (CRP) improvement rate after 1 week of treatment (OR 0.95, 95 % CI 0.91–0.99) were risk factors for surgery.</span></span></div></div><div><h3>Conclusions</h3><div>Early surgical treatment should be considered for patients with pyogenic spondylitis who present with an epidural abscess on MRI and bone destruction extending to the posterior wall on CT at the time of diagnosis.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1376-1381"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone formation of the coracoid bone graft after the Bristow procedure assessed using three-dimensional computed tomography","authors":"So Minokawa ,&nbsp;Yozo Shibata ,&nbsp;Terufumi Shibata ,&nbsp;Hidetomo Kosaka ,&nbsp;Teruaki Izaki","doi":"10.1016/j.jos.2023.11.010","DOIUrl":"10.1016/j.jos.2023.11.010","url":null,"abstract":"<div><h3>Background</h3><div>The Bristow procedure has been shown to be a reliable method to prevent recurrent anterior shoulder<span><span> instability by compensating for glenoid bone loss and producing the sling effect. The degree of postoperative morphological change in the coracoid </span>bone graft<span><span> is speculated to influence glenohumeral joint stability; however, the details of these changes after the Bristow procedure remain unknown. This study was performed to quantify the postoperative change in the coracoid bone graft volume as assessed by three-dimensional </span>computed tomography (3D-CT).</span></span></div></div><div><h3>Methods</h3><div>The Bristow procedure was performed on 17 shoulders in 17 patients from August 2018 to January 2020. All patients were men, and their mean age at surgery was 17.9 years. The mean follow-up duration was 21.4 months. Within the first week after the operation (Time 0) and at the final follow-up, 3D-CT was used to determine the total coracoid bone graft volume. The clinical outcomes were evaluated using the Japanese Orthopaedic Association (JOA) shoulder score, the University of California Los Angeles (UCLA) shoulder score, and the Western Ontario Shoulder Instability Index (WOSI).</div></div><div><h3>Results</h3><div>The mean volume of the total coracoid bone graft was 1.26 ± 0.29 cm³ at Time 0 and 1.90 ± 0.36 cm³ at the final follow-up (<em>p</em><span> &lt; 0.0001). The mean JOA score, UCLA score, and WOSI were significantly better at the final follow-up than preoperatively (</span><em>p</em><span> &lt; 0.001). No postoperative infection, neurovascular injury, or recurrent instability of the glenohumeral joint occurred.</span></div></div><div><h3>Conclusions</h3><div>In the Bristow procedure, the volume of the total coracoid bone graft as shown by 3D-CT was significantly greater at the final follow-up than at Time 0, and bone formation of the coracoid bone graft was found after the Bristow procedure.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1382-1388"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment experience with continuous local antibiotic perfusion for periprosthetic joint infection","authors":"Yoshiaki Miyake,&nbsp;Toru Takagi","doi":"10.1016/j.jos.2023.12.001","DOIUrl":"10.1016/j.jos.2023.12.001","url":null,"abstract":"<div><h3>Background</h3><div><span>Antibiotic concentrations 100–1000 times higher than the </span>minimum inhibitory concentration<span> are necessary for eradicating biofilms in periprosthetic joint infections (PJI). Achieving this with intravenous antibiotics is challenging, but continuous local antibiotic perfusion (CLAP) can increase the local concentration of antibiotics. Although there are several reports on CLAP therapy in the fracture-related infection, there are only few reports on its application in PJI. Here, we report our experience with CLAP therapy for PJI.</span></div></div><div><h3>Methods</h3><div>Eight patients with PJI (two males and six females, with mean age of 73.5 years [±11.6]) were treated at our department, and their clinical characteristics were analyzed. The parameters considered were the classification of PJI, surgical procedure, duration of CLAP, duration of transvenous antibiotic administration, time of CRP-negative status, whether the infection resolved or recurred, and whether there were complications due to CLAP.</div></div><div><h3>Results</h3><div>Initial surgery included total knee arthroplasty<span><span><span><span><span> in five cases, unicompartmental knee </span>arthroplasty in one case, and </span>total hip arthroplasty in two cases. There were four cases of early </span>postoperative infection<span><span>, two of acute delayed infection, and two of chronic delayed infection. The surgical procedures performed were two-stage revision for two patients, and debridement, antibiotics, and implant retention (DAIR) for the other six. The mean durations of CLAP and transvenous antibiotic administration were 8.5 (±2.4) and 22.4 days (±13.7), respectively, and the mean time to CRP-negative status was 23.3 days (±10.7). All eight patients successfully resolved without additional irrigation or debridement, and no recurrence was observed at the last follow-up after discontinuation of oral antibiotics. No systemic </span>side effects of </span></span>gentamicin or other complications associated with CLAP were observed.</span></div></div><div><h3>Conclusion</h3><div>All patients achieved infection resolution with the combined use of CLAP. This suggests that CLAP is a useful treatment option for PJI.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1469-1476"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138681635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow edema in the acromioclavicular joint after arthroscopic rotator cuff repair","authors":"Yukihiro Kajita ,&nbsp;Ryosuke Takahashi ,&nbsp;Ryosuke Sagami ,&nbsp;Yohei Harada ,&nbsp;Yusuke Iwahori","doi":"10.1016/j.jos.2023.12.003","DOIUrl":"10.1016/j.jos.2023.12.003","url":null,"abstract":"<div><h3>Background</h3><div><span>Bone marrow edema (BME) in the </span>acromioclavicular joint<span> (ACj) may occur after arthroscopic rotator cuff<span> repair (ARCR), resulting in persistent postoperative ACj pain. We investigated the incidence and clinical characteristics of BME in ACj after ARCR.</span></span></div></div><div><h3>Methods</h3><div><span>Patients exhibiting ACj-related symptoms prior to ARCR surgery, no BME in the ACj on MRI, and an ability to undergo 2-year postoperative physical and MRI examinations of the ACj were included. Patients who underwent distal clavicle resection or osteophyte resection below the ACj and those unable to achieve primary repair of the rotator cuff were excluded. MRI evaluation was performed preoperatively and at 3, 6, 12, and 24 months postoperatively. Patients who showed BME in ACj on fat-suppressed T2 MRI at 24 months postoperatively were classified into the BME + group, and those with no BME were classified into the BME− group. Patient background, operation time, Japanese Orthopedic Association (JOA) score, re-tear rate, ACj tenderness, and cross-body </span>adduction test were compared between groups. In addition, we examined the time of occurrence of BME.</div></div><div><h3>Results</h3><div>A total of 345 ARCRs were performed during the study period. After the exclusion of 114 shoulders, the remaining 231 shoulders were included in this study. There were 208 cases in the BME− group and 23 cases in the BME + group. The incidence of BME was 9.96 %. Although the JOA scores of both groups showed a significant improvement postoperatively compared to preoperatively, there was no significant difference between the two groups. In terms of re-tear, there was 1 case in the BME + group and 7 in the BME− group. Positive ACj tenderness and cross-body adduction test were significantly higher in the BME + group (<em>P</em> &lt; 0.001). BME occurred in 6 cases at 3 months, 9 cases at 6 months, and 8 cases at 1 year postoperatively. None of the patients developed BME at more than 1 year postoperatively. BME was observed on MRI in all cases at 2 years postoperatively.</div></div><div><h3>Conclusions</h3><div>The rate of occurrence of BME in the ACj after ARCR was 9.96 %. Patients with BME were significantly more likely to have ACj tenderness and positive cross-body adduction test. BME in the ACj often occurs within 6 months to 1 year after ARCR of small-to-medium rotator cuff tears<span>, suggesting a relationship with postoperative functional improvement of the shoulder joint. The ACj should be considered as a potential site of persistent pain after ARCR for small-to-medium rotator cuff tears.</span></div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1389-1394"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139027251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term antibacterial activity of silver-containing hydroxyapatite coatings against Staphylococcus aureus in vitro and in vivo","authors":"Sakumo Kii ,&nbsp;Hiroshi Miyamoto ,&nbsp;Masaya Ueno ,&nbsp;Iwao Noda ,&nbsp;Akira Hashimoto ,&nbsp;Takema Nakashima ,&nbsp;Takeo Shobuike ,&nbsp;Shunsuke Kawano ,&nbsp;Motoki Sonohata ,&nbsp;Masaaki Mawatari","doi":"10.1016/j.jos.2023.10.009","DOIUrl":"10.1016/j.jos.2023.10.009","url":null,"abstract":"<div><h3>Background</h3><div><span>The potential of silver-containing hydroxyapatite (Ag-HA) coatings to prevent orthopaedic implant-associated infection was explored previously; however, the resistance of Ag-HA coatings to late-onset orthopaedic infections is unknown. This study aimed to evaluate the long-term Ag</span>⁺<span> elution and antibacterial properties of the Ag-HA coatings through </span><em>in vitro</em> and <em>in vivo</em> experiments.</div></div><div><h3>Methods</h3><div><span>Ag-HA-coated disc specimens were immersed in fetal bovine serum<span> (FBS) for six months. Ag concentration was measured over time using inductively coupled plasma-mass spectrometry to evaluate Ag release. The hydroxyapatite (HA)- or Ag-HA-coated disc specimens were immersed in FBS for 3 months to elute Ag</span></span>⁺ for <em>in vitro</em> experiments. Methicillin-resistant <em>Staphylococcus aureus</em><span> (MRSA) suspensions were inoculated onto each disc; after 48 h, the number of colonies and the biofilm volume were measured. HA- or Ag-HA-coated disc specimens were inserted under the skin of Sprague-Dawley rats for three months for </span><em>in vivo</em> experiments. In <em>in vivo</em> experiment 1, specimens were inoculated with MRSA and the number of colonies was counted after 48 h. In <em>in vivo</em> experiment 2, the specimens were inoculated with bioluminescent <em>S. aureus</em><span> Xen36 cells, and bioluminescence was measured using an </span><em>in vivo</em> imaging system.</div></div><div><h3>Results</h3><div>The Ag-HA-coated disc specimens continued to elute Ag⁺ after six months. The biofilm volume in the Ag-HA group was lower than in the HA group. In <em>in vitro</em> and <em>in vivo</em><span> experiment 1, the bacterial counts in the Ag-HA group were lower than those in the HA group. In </span><em>in vivo</em><span> experiment 2, the bioluminescence in the Ag-HA group was lower than that in the HA group on days 1–7 after inoculation.</span></div></div><div><h3>Conclusions</h3><div>The Ag-HA-coated discs continued to elute Ag⁺<span> for a long period and exhibited antibacterial activity and inhibition of biofilm formation against </span><em>S. aureus</em>. The Ag-HA coatings have the potential to reduce late-onset orthopaedic implant-associated infections.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1503-1512"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71482768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do standardization of the procedure reduce measurement variability of the sonographic anterior drawer test of the ankle?","authors":"Shuhei Iwata ,&nbsp;Satoshi Yamaguchi ,&nbsp;Seiji Kimura ,&nbsp;Soichi Hattori ,&nbsp;Jun Sasahara ,&nbsp;Ryuichiro Akagi ,&nbsp;Kentaro Amaha ,&nbsp;Tomonori Atsuta ,&nbsp;Noriyuki Kanzaki ,&nbsp;Koji Noguchi ,&nbsp;Hirokazu Okada ,&nbsp;Toru Omodani ,&nbsp;Hiroshi Ohuchi ,&nbsp;Hiroyuki Sato ,&nbsp;Satoshi Takada ,&nbsp;Kenji Takahashi ,&nbsp;Yuichi Yamada ,&nbsp;Tetsuro Yasui ,&nbsp;Takuji Yokoe ,&nbsp;Shun Fukushima ,&nbsp;Seiji Ohtori","doi":"10.1016/j.jos.2023.11.006","DOIUrl":"10.1016/j.jos.2023.11.006","url":null,"abstract":"<div><h3>Background</h3><div>In quantitative ankle stress sonography, different examiners use different techniques, which may cause measurement variability. This study aimed to clarify whether standardizing stress sonography techniques reduces variability in the quantitative measurement of anterior talofibular ligament length change.</div></div><div><h3>Methods</h3><div>Fourteen examiners with a mean ultrasound experience of 8.7 years participated in this study. Each examiner performed stress ultrasonography of the ankle using their preferred method on one patient with an intact anterior talofibular ligament (Patient 1) and on two patients with chronic ankle instability (Patient 2 and 3). Changes in the ligament length between the resting and stressed positions were determined. A consensus meeting was then conducted to standardize the sonographic technique, which was used by the examiners during a repeat stress sonography on the same patients. The variance and measured values were compared between the preferred and standardized techniques using F-tests and paired t-tests, respectively.</div></div><div><h3>Results</h3><div>At a consensus meeting, a sonographic technique in which the examiner pushed the lower leg posteriorly against the fixed foot was adopted as the standardized technique. In Patient 1, the change in the anterior talofibular ligament length was 0.4 (range, −2.3–1.3) mm and 0.6 (−0.6–1.7) mm using the preferred and standardized techniques, respectively, with no significant difference in the variance (<em>P</em> = 0.51) or the measured value (<em>P</em> = 0.52). The length changes in Patient 2 were 2.0 (0.3–4.4) mm and 1.7 (−0.9–3.8) mm using the preferred and standardized techniques, respectively. In Patient 3, the length changes were 1.4 (−2.7–7.1) mm and 0.7 (−2.0–2.3) mm. There were no significant differences between the techniques in either patient group.</div></div><div><h3>Conclusion</h3><div>Variability in the quantitative measurement of ankle stress sonography was not reduced despite the standardization of the technique among examiners. Hence, comparing the measured values between different examiners should be avoided.</div></div>","PeriodicalId":16939,"journal":{"name":"Journal of Orthopaedic Science","volume":"29 6","pages":"Pages 1438-1444"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}