Journal of Pre-Clinical and Clinical Research最新文献_第9页

Influence of selected autoimmunological diseases on phonation devices, diagnostics and treatment 某些自身免疫性疾病对发声装置、诊断和治疗的影响

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-01-17 DOI: 10.26444/jpccr/159126

Daria Markowska, Krzysztof Jurkiewicz

引用次数: 0

Tooth agenesis: genes and syndromic diseases –literature review 牙齿发育不全:基因与综合征疾病-文献综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-12-27 DOI: 10.26444/jpccr/157097

Dagmara Klupś, Julia Kaźmierczak, Natalia Torlińska-Walkowiak

引用次数: 0

Evaluation of the level of alloantibodies and selected cytokines in kidney recipients 肾受体异体抗体和选定细胞因子水平的评价

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-12-22 DOI: 10.26444/jpccr/157283

I. Wojciechowska-Koszko, M. Nowosiad-Magda, B. Krasnodębska-Szponder, P. Roszkowska, Michał Sławiński, P. Kwiatkowski

引用次数: 0

The role of flavonoids in the treatment of periodontal diseases – literature review 黄酮类化合物在牙周病治疗中的作用-文献综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-12-19 DOI: 10.26444/jpccr/156979

J. Adamczyk, Martyna Chwałowska, N. Gębka, Krzysztof Stós, Natalia Jakubowicz, Agnieszka Gabryś-Kwolek, Rafał Rój

{"title":"The role of flavonoids in the treatment of periodontal diseases – literature review","authors":"J. Adamczyk, Martyna Chwałowska, N. Gębka, Krzysztof Stós, Natalia Jakubowicz, Agnieszka Gabryś-Kwolek, Rafał Rój","doi":"10.26444/jpccr/156979","DOIUrl":"https://doi.org/10.26444/jpccr/156979","url":null,"abstract":"Introduction and Objective. Periodontal disease is one of the many diseases of the oral cavit. Periodontium is defined as the tissues that surround and hold the tooth in the socket. Periodontitis may lead to the loss of hard and soft tissues, resulting in the loss of dentition. The current standards for the treatment of periodontal disease are based on both surgical treatment and non-surgical treatment. The subject of research among many scientists is the effect of flavonoids – substances of plant origin, on periodontal diseases. This literature review aims to present the possibility of using flavonoids as adjunctive treatment in periodontal diseases. Review Methods. Articles in English were searched using PubMed databases to evaluate the effect of flavonoids in the prevention and treatment of periodontal disease. The bibliography was reviewed to eliminate duplicate works. Brief description of the state of knowledge. The anti-inflammatory, antibacterial and antiresorptive properties of flavonoids are the main factors influencing their use in the prevention of periodontal disease. Thanks to these three properties, the risk of periodontal disease is significantly reduced, which is why extracts from plants with a high flavonoid content are increasingly used in products for daily oral hygiene. Summary. The antibacterial, anti-inflammatory and antiresorptive effects of flavonoids make them an important factor in the treatment of periodontal disease. Further research in the use of natural medicinal substances of plant origin is an important aspect for the development of modern medicine.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47786984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Is gene therapy in spinal muscular atrophy safe? A casereport of thrombotic microangiopathy following onasemnogene abeparvovec 基因治疗脊髓性肌萎缩症安全吗?onasemnogene abparvovec致血栓性微血管病变1例报告

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-10-12 DOI: 10.26444/jpccr/154984

Aleksandra Ziółkiewicz, Michał Bielak, Iwona Welian, Magdalena Chrościńska- Krawczyk

引用次数: 0

Diagnostic difficulties in a paediatric patient with shoulder pain: Parsonage-Turner syndrome – Case Report 儿科肩痛患者的诊断困难：Parsonage-Turner综合征——病例报告

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-09-30 DOI: 10.26444/jpccr/155035

Bartłomiej Syzdoł, Wiktoria Sielwanowska, A. Rzewuska, Monika Żybowska, M. Chrościńska-Krawczyk

引用次数: 0

Glioblastoma mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) syndrome – case Report 模拟慢性淋巴细胞炎的胶质母细胞瘤伴桥桥血管周围增强对类固醇反应(CLIPPERS)综合征-病例报告

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-09-26 DOI: 10.26444/jpccr/154733

Katarzyna Szklener, Weronika Kuryło, Anna Rodzajewska, S. Mańdziuk

引用次数: 0

An enigmatic case of central nervous system infection and superior sagittal sinus thrombosis in an adolescent with COVID-19 新冠肺炎青少年中枢神经系统感染和上矢状窦血栓形成的神秘病例

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-09-15 DOI: 10.26444/jpccr/153542

Michał Bielak, Natalia Biel, Karolina Urbańska, M. Chrościńska-Krawczyk

引用次数: 0

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-09-06 DOI: 10.26444/jpccr/153391

Tomasz Jurys, B. Burzyński, Andrzej Kupilas

{"title":"Health-related quality of life in prostate cancer patients in the Silesian Province (Poland) before and after radical prostatectomy – a longitudinal observational pilot study","authors":"Tomasz Jurys, B. Burzyński, Andrzej Kupilas","doi":"10.26444/jpccr/153391","DOIUrl":"https://doi.org/10.26444/jpccr/153391","url":null,"abstract":"Introduction. In recent years, patient-reported outcomes have played an increasingly important role in the evaluation of the effectiveness of treatments as aspects of health-related quality of life (e.g. physical, emotional, and psychosocial), and are taken into account in the selection of treatment methods and complementary management (e.g. nursing care or physiotherapy). Objective . The aim of this pilot study was to assess changes in the health-related quality of life in a prostate cancer population before and 3 months after radical prostatectomy. The main motivation for the study is the small number of studies using validated tools to assess the quality of life of men in the Polish population suffering from prostate cancer. Materials and method . The study concerned 31 newly-diagnosed prostate cancer patients who qualified for radical prostatectomy. Quality of life assessment was performed twice – first before surgery, and then 3 months afterwards – using the EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. Results . Comparison of baseline and 3-month follow-up results revealed significant deteriorations in patients’ quality of life across various domains, with the clinically and statistically most significant changes being observed on the emotional, social, and role functioning scales. Conclusions. Radical prostatectomy contributed to decreased quality of life 3 months postoperatively. The psychosocial domains of the quality of life are more strongly affected than the physical domains.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44189330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of flavonoids in skin cancer prevention and treatment 黄酮类化合物在皮肤癌防治中的应用

Journal of Pre-Clinical and Clinical Research Pub Date : 2022-08-31 DOI: 10.26444/jpccr/153023

N. Gębka, Barbara Gębka-Kępińska, J. Adamczyk, Elżbieta Mizgała-Izworska

{"title":"The use of flavonoids in skin cancer prevention and treatment","authors":"N. Gębka, Barbara Gębka-Kępińska, J. Adamczyk, Elżbieta Mizgała-Izworska","doi":"10.26444/jpccr/153023","DOIUrl":"https://doi.org/10.26444/jpccr/153023","url":null,"abstract":"Introduction and Objective. Known for their strong antioxidant properties, flavonoids are the major polyphenolic compounds found in a wide variety of plants, vegetables, and fruits. A growing number of reports has indicated their anticancer effect. Affecting numerous cellular pathways, polyphenols suppress carcinogenesis which allows for new strategies developed to fight skin cancer. Given the high morbidity and mortality rates due to skin cancer, the aim of the review is to summarize earlier studies on the role of flavonoids in skin cancer prevention and treatment. Review Methods. A search was conducted using the PubMed databases. Using keywords related to flavonoids and skin cancer, articles in Polish and English were manually searched. Duplicate papers were removed, and the bibliographies of selected studies as well as bibliographies from other reviews were reviewed in order to incorporate additional relevant studies into the review. knowledge. Flavonoids are effective immunomodulators since they modulate cell growth, induce apoptosis, and reduce reactive oxygen species production. They have DNA repair abilities that can be used to prevent various skin diseases caused by excessive sun exposure. They can prevent, postpone, or completely stop photocarcinogenesis. Summary. Because of their effect on numerous cellular pathways, flavonoids have been studied extensively to confirm their preventive and therapeutic potential in skin cancer. Flavonoids have been shown in studies to shrink cancerous tumours and prevent metastasis. Their use in prevention and anticancer therapies may contribute to lower skin cancer mortality rates.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48700649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1