Journal of Pre-Clinical and Clinical Research最新文献_第9页

Abortifacient activity of Aegle marmelos and Laurus nobilis leaf extracts 蜜桔和月桂叶提取物的流产活性

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-05-03 DOI: 10.4081/pcr.2023.9657

Supriya Jillelamudi, Narendra Babu Ankem, Naga Lakshmi Jada

{"title":"Abortifacient activity of Aegle marmelos and Laurus nobilis leaf extracts","authors":"Supriya Jillelamudi, Narendra Babu Ankem, Naga Lakshmi Jada","doi":"10.4081/pcr.2023.9657","DOIUrl":"https://doi.org/10.4081/pcr.2023.9657","url":null,"abstract":"Rapid elevation of population in India is the one of the major problems, which directly influence the economy of country and may lead to poverty. Government implemented number of family planning programs through the various surgical operations (tubectomy and laproscopy) and oral contraceptives. Usage of oral contraceptive pills may lead serious complications, and may induce congenital abnormalities. The primary goal of this research is to assess the abortifacient activity in rat models of two historically used medicinal plants, Laurus nobilis L. and Aegle marmelos (L.) Corr. Restructure the paragraph as the study included 18 female wistar rats (150-200 g) and six male wistar rats (male wistar rats were used only for copulation). Female rats in proestrous phase were isolated and allowed to mate with males of proven fertility using the mass mating technique in a 3:1 ratio for an overnight. Control animals received an equivalent volume of the dosing vehicle (1% tween 80) orally. Aqueous extract of Laurus nobilis (AQLN) leaves and Ethanolic Extract of Aegle Marmelos leaves (EEAM) at doses of 175 mg/kg and 250 mg/ kg of were orally administrated daily for 10 days from day 0 of pregnancy to day 9. On day 20th of pregnancy, all the animals were sacrificed under euthanasia and the uterine horns were isolated, later they were examined for number of abortifacient sites and deformities of fetuses. The number of live fetuses in animals treated with EEAM at two doses was substantially lower in Group-4 at 175mg/kg (2.63 + 0.36) and Group-5 at 250mg/kg (1.87 + 0.40) compared to the vehicle control group (p 0.05, p 0.01). The survival ratio decreased considerably from 52.2% to 28.8% as the dose increased. Similarly, the abortion rate was higher in group 5 compared to Group-4. AQLN demonstrated to have 100% abortifacient efficacy at 250mg/kg, while EEAM has 83.3%.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83053818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compartment syndrome – a complex and insidious medical problem 隔室综合征——一个复杂而隐蔽的医学问题

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-04-28 DOI: 10.26444/jpccr/163321

Michał Miciak, Krzysztof Jurkiewicz

引用次数: 0

Evaluation of metabolism and cytochrome P450 mediated interaction liabilities of naringenin 柚皮素代谢和细胞色素P450介导的相互作用的评价

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-04-13 DOI: 10.4081/pcr.2023.9686

Mallik Samarla, Ramachandra Sangana

{"title":"Evaluation of metabolism and cytochrome P450 mediated interaction liabilities of naringenin","authors":"Mallik Samarla, Ramachandra Sangana","doi":"10.4081/pcr.2023.9686","DOIUrl":"https://doi.org/10.4081/pcr.2023.9686","url":null,"abstract":"Naringenin is one of the major components of grapefruit juice. It has a broad spectrum of pharmacological activities, and many studies report that grapefruit juice inhibits cytochrome P450 (CYP) 3A4 leading to drug interactions. Naringenin was profiled through various in vitro studies like metabolic stability and glucuronidation in rat and human liver microsomes while, CYP inhibition using human liver microsomes. In addition, pharmacokinetic profiling was conducted upon intravenous (i.v.) and oral administration in rats. Naringenin undergoes both phase I and phase II metabolism in rat liver microsomes, and in human liver microsomes, it is predominantly metabolized by phase II. Glucuronidation which is addition (conjugation) of glucuronic acid to various functional groups is one of the major metabolic pathways of Naringenin. Naringenin, at 1.0 μM and 10.0 μM, did not elicit any appreciable inhibition of the 5 major CYP isoforms (CYP1A2, CYP3A4, CYP2C9, CYP2C19, and CYP2D6). Oral pharmacokinetic studies at 100, 300,and 1000 mg/kg dose and intravenous pharmacokinetic studies at 1 mg/kg dose were performed in male SD rats. Naringenin exhibited very short half-life (0.27 h) and rapid elimination (Clearance=110.65 mL/min/kg) after i.v. administration. There was saturation in Cmax and exposure beyond 100 mg/kg, and the absolute bioavailability was found to be ≤ 5% at the tested oral doses. This present experiment suggests that naringenin does not substantially inhibit CYP3A4 (or any of the tested five isoforms) isoforms per se. Given the minimal involvement of CYP enzymes in the metabolism of naringenin and minimal inhibition of CYP enzymes (IC50> 10 μM), the potential for drug-drug interactions involving CYP substrates and inhibitors is very minimal in humans.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79393725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental evaluation of anti-ulcer potential of Nigella sativa oil in gastric ulcers in Albino rats Nigella sativa油抗Albino大鼠胃溃疡作用的实验评价

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-03-22 DOI: 10.26444/jpccr/162337

Shaima Khan, Ghulam Subhani, Ayesha Vaseem, Neeraj Sadiq, M. Mohsin

引用次数: 0

Three dimensions of printing – deleting pitfalls in endodontic practice 牙髓治疗中打印删除缺陷的三维分析

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-03-21 DOI: 10.26444/jpccr/162012

Sonu Gupta, S. Sodhi, R. Bansal, G. Brar

引用次数: 0

Meningococcal meningitis in a young adult – case report and literature review 青年人脑膜炎球菌性脑膜炎病例报告及文献复习

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-03-13 DOI: 10.26444/jpccr/161678

Natalia Biedroń, Zuzanna Paluch, M. Borys

引用次数: 0

Photobiomodulation in aspects of muscle function – a scoping review 光生物调节在肌肉功能方面的研究综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-03-09 DOI: 10.26444/jpccr/161689

Isabela Cubas, Joana Eckert, Leticia Canalli, A. Carvalho, Gladson Bertolini

引用次数: 0

Trapped diaphragmatic hernia with necrosis of the gastric wall – Case Report and literature review 腹膜疝伴胃壁坏死1例并文献复习

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-03-02 DOI: 10.26444/jpccr/161337

Julia Siek, M. Borys

引用次数: 0

Modulation of haloperidolinduced catalepsy in wistar rats by foxtail millet (Setaria italica) 谷子对氟哌啶醇致wistar大鼠猝倒的调节作用

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-03-02 DOI: 10.4081/pcr.2023.9554

Shaik Kareemun, Deepthi Rapaka, V. Bitra, A. Akula

引用次数: 0

Experimental models of migraine both in vitro and in vivo 体外和体内偏头痛的实验模型

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-02-28 DOI: 10.4081/pcr.2023.7772

Uday Bhaskar Narra, Siva Reddy Challa

引用次数: 0