Modulation of haloperidolinduced catalepsy in wistar rats by foxtail millet (Setaria italica)

Abstract

The current study looked at the behavioral and antioxidant activity of Foxtail Millet (FM) against haloperidol-induced catalepsy in Parkinson’s Disease (PD) patients. It has been demonstrated that the antipsychotic drug haloperidol, which has a high capacity to block D2-type receptors, can cause motor impairments similar to those seen in people with PD. Catalepsy can develop when animals are placed in abnormal or unusual postures for an extended period of time. Foxtail millet significantly reduced lipid peroxidation (p 0.001) increased the antioxidant enzymes SOD (p 0.05) and GSH (p 0.05), and significantly improved motor deficits such as catalepsy, motor coordination, and locomotor activity in our study. These results show that foxtail millet can protect against the motor deficits (catalepsy) associated with PD and epilepsy.