Journal of Pre-Clinical and Clinical Research最新文献

The role of THC and CBD in dentistry – a review of impacts on oral health THC 和 CBD 在牙科中的作用--回顾对口腔健康的影响

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-08-08 DOI: 10.26444/jpccr/191337

Piotr Suski, O. Tokarczuk, Faustyna Nieroda, Karolina Thum-Tyzo

引用次数: 0

Distant metastases from the uterine leiomyoma – case report of a pulmonary benign metastasizing leiomyoma 子宫良性转移性肌瘤的远处转移--肺良性转移性肌瘤病例报告

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-19 DOI: 10.26444/jpccr/190538

N. Szczęsny, Karolina Karoń, Ewelina Bornio, Krzysztof Piątkowski, Wojciech Grabowski, Hanna Plata, S. Piątek

引用次数: 0

Penetrating eye injuries- case description 穿透性眼外伤--病例描述

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-18 DOI: 10.26444/jpccr/190536

Natalie Papachristoforou, Aleksandra Kocjan, Ismael Alsoubie, Jakub Smyk, Alicja Kamińska, Maciej Kozak, Ilona Pawlicka, Agnieszka Piskorz

引用次数: 0

Piriformis syndrome – anatomical causes. Diagnosis and treatment 腓肠肌综合征 - 解剖学原因。诊断和治疗

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-17 DOI: 10.26444/jpccr/189967

Julianna Cholewa, Jagoda Niczyporuk, Maciej Onyśk, Maciej Samczuk, Kaja Iwaniuk, Aleksander Daniluk, Zuzanna Białkowska, Jakub Buczek, Hubert Stachowicz, Jan Ostański

{"title":"Piriformis syndrome – anatomical causes. Diagnosis and treatment","authors":"Julianna Cholewa, Jagoda Niczyporuk, Maciej Onyśk, Maciej Samczuk, Kaja Iwaniuk, Aleksander Daniluk, Zuzanna Białkowska, Jakub Buczek, Hubert Stachowicz, Jan Ostański","doi":"10.26444/jpccr/189967","DOIUrl":"https://doi.org/10.26444/jpccr/189967","url":null,"abstract":"Introduction and Objective. Sciatica is a clinical condition characterized by pain radiating along the roots of the sciatic nerve, extending from the lumbosacral spine and buttock, through the posterior surface of the thigh and lower leg down to the foot. One of the frequent cause is piriformis syndrome where the sciatic nerve is compressed by the piriformis muscle. There are many diagnostic tests and imaging studies available, but the most crucial aspect is to exclude other causes of sciatica. The aim of the review is to present the literature describing causes, diagnosis and treatment of the piriformis syndrome. Review Methods. The review is based on 46 papers found in PubMed and PubMedCentral databases using key words: ‘piriformis syndrome’ and ‘anatomical causes/diagnosis/treatment’, published between 1947–2023. Brief description of the state of knowledge. The variability in the course of the sciatic nerve and anatomical variations of the piriformis muscle have different impacts on the onset of piriformis syndrome. The diagnosis of this condition primarily aims to exclude other causes of sciatica, as there are no precisely confirmed diagnostic criteria. The preferred treatment is non-operative. When this is unsuccessful, surgical intervention may be considered. Summary. There are numerous causes of piriformis syndrome. There is a discrepancy in the results of various studies regarding the impact of different anatomical variations of the sciatic nerve on the onset of symptoms of this condition. The primary goal of research should now be to conduct a large, representative study on patients diagnosed with sciatica, focusing on the presence of anatomical variations.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic kidney disease and obesity - pathomechanisms and treatment – literature review 慢性肾病与肥胖--病理机制与治疗--文献综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-17 DOI: 10.26444/jpccr/190537

Natalia Pijas, Aleksandra Domańska, Barbara Pieniążek, Daria Piekarz, Jolanta Szeliga-Król, Wojciech Załuska

{"title":"Chronic kidney disease and obesity - pathomechanisms and treatment – literature review","authors":"Natalia Pijas, Aleksandra Domańska, Barbara Pieniążek, Daria Piekarz, Jolanta Szeliga-Król, Wojciech Załuska","doi":"10.26444/jpccr/190537","DOIUrl":"https://doi.org/10.26444/jpccr/190537","url":null,"abstract":"Introduction and Objective. Chronic kidney disease (CKD) is a major health issue worldwide affecting 10–14% of the globe’s population, with a climbing trend. CKD is associated with a variety of factors, including obesity, which has grown increasingly prevalent and adds to the pathogenesis of the disease. The aim of the review is to summarise pathomechanism and current treatment methods of chronic kidney disease. Additionally, using this knowledge, treatment suggestions are provided for different patient groups. Review Methods. A literature search was conducted in the PubMed database with inclusion criteria ‘English language’ and ‘free full texts’, and publications date between 2018 – 2023. A total of 1,172 results were found; 28 publications were ultimately included in the review. Brief description of the state of knowledge. The pathomechanisms include haemodynamic changes, oxidative stress, adipokine dysregulation, and correlations to insulin resistance and diabetes. Weight loss by proper nutrition and exercise is a beneficial approach to manage CKD in obese patients. Bariatric surgery has proven a realistic alternative due to improvements in kidney function and obesity-related comorbidities. There are several options for pharmacotherapy in CKD and obesity, including SGLT2 inhibitors, GLP-1 analogues, agents targeting the renin-angiotensin-aldosterone system and bardoxolone methyl. Addressing obesity plays an essential role in alleviating CKD risk and progression. Conclusions. Early intervention involving lifestyle changes, weight reduction strategies, surgical procedures, and medication provides a holistic approach to addressing CKD in obese people. Recognizing the complex interplay of variables that contribute to CKD enables targeted therapy approaches and better patient outcomes.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ketogenic diet on epilepsy in children 生酮饮食对儿童癫痫的影响

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-09 DOI: 10.26444/jpccr/190539

Anna Oleszczuk, Julia Kozieł, Szymon Kosmala, Noemi Kowalczyk, Zuzanna Drozd, Maja Kowalska, Klaudia Szukała, M. Chrościńska-Krawczyk

{"title":"Effects of ketogenic diet on epilepsy in children","authors":"Anna Oleszczuk, Julia Kozieł, Szymon Kosmala, Noemi Kowalczyk, Zuzanna Drozd, Maja Kowalska, Klaudia Szukała, M. Chrościńska-Krawczyk","doi":"10.26444/jpccr/190539","DOIUrl":"https://doi.org/10.26444/jpccr/190539","url":null,"abstract":"Introduction and Objective. The Ketogenic Diet (KD) is a diet consisting of the restriction of protein, carbohydrates, and fluids. KD is used in the treatment of epilepsy and is currently the foundation for a therapeutic approach for drug-resistant epilepsy. The aim of the study was to review the current literature, and provide information about the application of the Ketogenic Diet in children with treatment-resistant epilepsy. Review Methods. Literature in English and Polish was reviewed via PubMed, Google Scholar and The Wiley Library. 250 publications were taken into consideration from which 50 were selected: meta-analysis publications, review articles, randomised controlled trials, and research articles, with emphasis on the most recent information on the topic. About 88% of the publications selected were published in 2017 or later. Brief description of the state of knowledge. Taking into consideration randomised controlled trials of 472 children with drug-resistant epilepsy, the results indicate a statistically significant reduction in seizure frequency (SFR ≥ 50%) in the KD-treated group, compared to the control group. The greatest improvement was observed in patients following a KD with a ketogenic ratio of 2.5/3:1 and the optimal time to initiate KD being before the age of two years. The highest chance of success was noted in the infant population in whom a complete elimination of epileptic seizures is possible. Summary. Randomised controlled trials indicate that the Ketogenic Diet has a positive effect on reducing the occurrence of seizures in paediatric patients with drug-resistant epilepsy.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"93 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spirulina maxima supplementation: benefits and limitations – results of latest studies 补充最大螺旋藻：益处和局限性--最新研究结果

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-02 DOI: 10.26444/jpccr/189444

Natalia Dąbrowska, Krzysztof Marcinkowski, Agata Mazur, Sylwia Mazur, Magdalena Madera, Karolina Strus, Aleksy Bizan, Emilia Nagórska, Roksana Zdunek, Aleksandra Kublińska

引用次数: 0

Current treatments for recurrent Clostridium difficile infection 目前治疗复发性艰难梭菌感染的方法

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-07-02 DOI: 10.26444/jpccr/189968

Jan Kowalewski, Karolina Recka, Daria Michałka, Aleksandra Grzelak, Oliwia Jędrocha, Damian Bęben, Sara Godyńska, Ewa Obacz, Joanna Miliwek, Zuzanna Grodek

{"title":"Current treatments for recurrent Clostridium difficile infection","authors":"Jan Kowalewski, Karolina Recka, Daria Michałka, Aleksandra Grzelak, Oliwia Jędrocha, Damian Bęben, Sara Godyńska, Ewa Obacz, Joanna Miliwek, Zuzanna Grodek","doi":"10.26444/jpccr/189968","DOIUrl":"https://doi.org/10.26444/jpccr/189968","url":null,"abstract":"Introduction. Clostridium difficile infection most commonly manifests in patients with antibiotic-associated diarrhea, ranging from very mild to severe pseudomembranous colitis. Recurrent C. difficile infections remain a serious clinical problem, occurring in approximately one in five patients. Recurrence of infection despite antibiotic therapy is often due to disruption of the intestinal microbiota. Objective The aim of this review is to summarize knowledge of current treatments and explore new therapies for Clostridium difficile infection, excluding vaccines under development and bacteriophage therapy, with a particular focus on patients with recurrent infections. Review Methods. The review is based on 59 articles on the pathophysiology, epidemiology and treatment of clostridium difficile infections found in PubMed databases published between 2009–2024. Brief description of the state of knowledge. Current treatments are mainly based on antibiotic therapy, or, for severe antibiotic-resistant forms, the faecal microbiota transplantation (FMT) method. In patients with recurrent infections, prolonged antibiotic therapy or sequential therapy with vancomycin and rifaximin is used. FMT is suggested for second or subsequent recurrent infections. Hopes are pinned on oral microbiome preparations, antibodies, new antibiotics, non-toxic strains or antibiotic degraders. Summary. The treatment of recurrent infections is a difficult problem that requires a broader view. Emerging therapies with promising results focus both on antibiotic therapy that eliminates toxin-producing bacteria, and on modifying the microbiota and reducing the conversion of spore forms of these bacteria into toxin-producing forms.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast cancer associated with pregnancy – a review of therapeutic approaches 与妊娠有关的乳腺癌--治疗方法综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-06-14 DOI: 10.26444/jpccr/189445

Julia Piekarz, Natalia Picheta, Oliwia Burdan, Katarzyna Szklener

引用次数: 0

Diffuse alveolar haemorrhage – case report and literature review 弥漫性肺泡出血--病例报告和文献综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2024-06-04 DOI: 10.26444/jpccr/188771

Marika Jerzak, Jan Bindas, Marta Szczukocka

引用次数: 0