Journal of Pre-Clinical and Clinical Research最新文献_第7页

Risk factors for carpal tunnel syndrome 腕管综合征的危险因素

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-10 DOI: 10.26444/jpccr/168559

Weronika Nowak, Patrycja Znamirowska, Natalia Szmigielska, Katarzyna Zemsta, Joanna Miśkiewicz, Hanna Plata, Monika Pałatyńska, B. Kulesza

{"title":"Risk factors for carpal tunnel syndrome","authors":"Weronika Nowak, Patrycja Znamirowska, Natalia Szmigielska, Katarzyna Zemsta, Joanna Miśkiewicz, Hanna Plata, Monika Pałatyńska, B. Kulesza","doi":"10.26444/jpccr/168559","DOIUrl":"https://doi.org/10.26444/jpccr/168559","url":null,"abstract":"Introduction and Objective. Carpal tunnel syndrome (CTS) is a common condition characterized by the compression of the median nerve in the wrist. Left untreated, it leads to significant discomfort and loss of motor function in the hand. The aim of this systematic review is to identify and evaluate recent research on risk factors associated with CTS. Review Methods. A systematic search of the PubMed/MEDLINE database was conducted, focusing on studies published within the last 5 years. The search strategy used relevant key words related to CTS and risk factors. Studies were included if they provided information on risk factors associated with CTS in the adult population. Review articles, systematic reviews and meta-analyses were excluded. Brief description of the state of knowledge. Risk factors for CTS include repetitive hand movements in occupations that require typing, certain anatomical and physiological characteristics (e.g., smaller carpal tunnel size), age (risk increases with age), gender (higher risk in women), pregnancy, medical conditions (e.g., obesity, diabetes, arthritis, metabolic syndrome), and previous trauma or injury to the wrist. On-going research continues to shed light on the subject. Summary. The systematic review found that physical labour, working in pain, and certain co-morbidities were strongly associated with an increased risk of developing CTS. Occupations such as grocery store workers, hairdressers, telephone operators and manual labourers (blue-collar workers) showed a significant association with the development of CTS, compared to the general population. Further studies are needed to investigate the potential impact of bilateral ovarian resection and alcohol consumption as risk factors. These findings underscore the importance of considering occupational factors and co-morbidities when assessing the risk of CTS.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49590742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of high-fat diet-induced oxidative stress on micro RNA’s in various tissues 高脂饮食诱导的氧化应激对各组织微RNA的影响

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-02 DOI: 10.4081/pcr.2023.9529

Manikanta Vinay Jayavaram, D. R. Gaddam, V. N. K. Godlaveti, Pullaiah Chitikela, Vara Prasad Saka

{"title":"The impact of high-fat diet-induced oxidative stress on micro RNA’s in various tissues","authors":"Manikanta Vinay Jayavaram, D. R. Gaddam, V. N. K. Godlaveti, Pullaiah Chitikela, Vara Prasad Saka","doi":"10.4081/pcr.2023.9529","DOIUrl":"https://doi.org/10.4081/pcr.2023.9529","url":null,"abstract":"Stress is the body’s reaction to any kind of injury or danger. It is linked to the production of oxidative free radicals, which are responsible for a variety of acute, chronic, and potentially fatal illnesses and diseases. Free radicals, due to their extreme reactivity, can harm or even kill cells. A High-Fat Diet (HFD) causes “oxidative stress”, which is characterized by an increase in the body’s generation of Reactive Oxygen Species (ROS) as a result of higher levels of triglycerides and Free Fatty Acids (FFA). HFD-induced oxidative stress alters cellular function by affecting transcriptional factors and mitochondrial enzymes (synthesis/inhibition). ROS and FFA damage the receptors of the epithelium, resulting in epithelial damage that impairs cellular function. ROS levels can harm cells by altering the expression of microRNA (miRNA), a sign of RNA damage. MiRNAs are non-coding RNAs found in animals, plants, and some viruses that play a role in the post-transcriptional regulation of gene expression. These three pathways—RNA cleavage, RNA destabilization, and RNA translation into proteins— all play a role in mRNA expression. The miRNA regulates the up- and downregulation of mRNA expression for cellular function, enzyme synthesis, and receptor modulation. MiRNA regulates cell function by maintaining the balance between cellular ROS levels and cellular damage.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77097094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary tract infection as cause of a septic miscarriage and disseminated intravascular coagulation – case report and literature review 尿路感染是脓毒性流产和弥散性血管内凝血的原因——一例报告及文献复习

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-06-27 DOI: 10.26444/jpccr/168416

Zuzanna Paluch, Milena Krawczyk, Piotr Duda, E. Rypulak, Oksana Wichowska

引用次数: 0

Evaluation of the Dental Aesthetic Index among patients with cleft palate and cleft lip, with or without cleft palate 腭裂和唇腭裂患者口腔美学指标的评价

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-06-27 DOI: 10.26444/jpccr/168354

Monika Blicharz, K. Bernat, A. Lasota

{"title":"Evaluation of the Dental Aesthetic Index among patients with cleft palate and cleft lip, with or without cleft palate","authors":"Monika Blicharz, K. Bernat, A. Lasota","doi":"10.26444/jpccr/168354","DOIUrl":"https://doi.org/10.26444/jpccr/168354","url":null,"abstract":"Introduction and Objective . The Dental Aesthetic Index (DAI) is a commonly-used dental indicator for determining patients’ orthodontic treatment needs. It is simple to use and can be measured by dentists and trained assistants. It allows the ranking of patients from the least to those most in need of treatment, and is therefore often used in epidemiological studies. DAI is practical because it takes into account both aesthetic and functional aspects of malocclusions. The aim of this study was to determine the usefulness of the Dental Aesthetic Index in evaluating the results of orthodontic treatment among patients with cleft palate, and patients with cleft lip with or without cleft palate, who completed orthodontic treatment. Materials and method . Twenty-three diagnostic models of patients with cleft palate and patients with cleft lip, with or without cleft palate, after orthodontic treatment were measured by a single examiner.The DAI score was measured as the sum of 10 components multiplied by their weight by adding the constant of 13. Results . The DAI index scores ranged from 17–42 points. Of all the components, the most frequently observed were: lack of teeth, spacing in incisial segments, and maxillary overjet. Conclusions . The results of the study indicate that DAI can be successfully used in cleft patients and that such patients require not only orthodontic treatment, but also further prosthetic treatment to replace missing teeth. The DAI index can be used in the group of cleft palate and cleft lip patients, with or without cleft palate, and demonstrates high values due to the presence. absence of numerous teeth. Therefore, in these patients it presents the need for prosthetic treatment rather than orthodontic.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43695006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lyme borreliosis – state of the knowledge among medical students 医学生莱姆病知识现状

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-06-20 DOI: 10.26444/jpccr/166589

Bartosz Borowski, Zuzanna Kupisz, Patrycja Długosz, Małgorzata Kozioł

{"title":"Lyme borreliosis – state of the knowledge among medical students","authors":"Bartosz Borowski, Zuzanna Kupisz, Patrycja Długosz, Małgorzata Kozioł","doi":"10.26444/jpccr/166589","DOIUrl":"https://doi.org/10.26444/jpccr/166589","url":null,"abstract":"Introduction and Objective. Lyme disease (LD) is becoming a serious problem worldwide. It is a bacterial infection caused by Gram-negative spirochaetes Borrelia burgdorferi sensu lato which are spread by tick bite, and are recognized as one of the most important tick-borne diseases. People spending time in the forests, meadows, and parks, or working in such environments are endangered to tick bites, which may cause the infection. Even though not each one of the parasites carries the disease, the illness itself is a serious condition and can simulate many other diseases, which is why it is often called ‘the great imitator’. Therefore, it is very important to know the early symptoms of LD, as it can be cured effectively by antibiotics. The aim of this study was to determine whether young adults have sufficient knowledge regarding LD, how often tick bites occur within this population, and how many of them have been diagnosed with the illness in the past. Materials and method. Data was collected with the use of a survey completed by 201 first-year medical students. Results. The majority of the students had basic knowledge regarding the etiology, symptoms, and vectors of LD. There is a necessity to improve knowledge in the field of treatment, prophylaxis, and tick removal techniques. Half of the study participants had been bitten by a tick and some of them were diagnosed with LD. Conclusions. Most of the participants reported a tick bite in the past, and/or confirmed an infection. The awareness level regarding the sickness needs to be improved in some aspects, with the use of social campaigns or advertisements. This would help with better recognition of the disease in the future.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46494011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genistein increases blood pressure in pre-treated normotensive rats 染料木黄酮使预处理的血压正常的大鼠血压升高

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-06-16 DOI: 10.26444/jpccr/166675

F. Awobajo, John Ihayi Ogbu, A. Adejare, G. Akpanika, Chiamaka Egede, Bukola Timothy

{"title":"Genistein increases blood pressure in pre-treated normotensive rats","authors":"F. Awobajo, John Ihayi Ogbu, A. Adejare, G. Akpanika, Chiamaka Egede, Bukola Timothy","doi":"10.26444/jpccr/166675","DOIUrl":"https://doi.org/10.26444/jpccr/166675","url":null,"abstract":"Introduction and Objective. High blood pressure is an important risk factor for heart-related disease. Combining dietary adjustments with standard drugs in the therapy of heart diseases have gained attention. Genistein, a soy isoflavone, has many biological effects but its role in blood pressure is inconclusive. The aim of the study was to investigate the effect of genistein on blood pressure in normotensive rats pre-treated with standard drugs. Materials and method. Twenty healthy adult male Sprague Dawley rats (body weight 160–180g) were administered with genistein, and SBP, DBP, PP, MABP and HR were recorded. Subsequently, the rats (5 each) were treated with Indomethacin, a non-steroidal, anti-inflammatory and a cyclooxygenase (COX-2) enzyme inhibitor (5 mg/kg subcutaneously), methylene blue,an inhibitor of nitric oxide synthase and guanylate cyclase (7.5 mg/kg, by infusion), nifedipine,a calcium channel blocker (0.75 mg/kg intravenously), and tetraethylammonium, a voltage-gated K+ channels blocker (60 mg/kg intravenously). Genistein was administered intravenously in graded doses after the administration of these blockers. SPB, DBP, PP and MABP were significantly increased following genistein administration only, as well as in the methylene blue and tetraethylammonium groups each. Results. Higher doses of genistein significantly decreased SBP, DBP and PP after indomethacin treatment. Falling DBP and MABP were reversed in the nifedipine group. Conclusions. Results suggests that genistein elevates blood pressure in experimental normotensive male rats. This has implications for alternative therapy in the management of hypertension, and implications for blood pressure in cardiovascular related diseases","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42411410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal mixture-induced non-transgenic animal model of Alzheimer’s disease: Pros and cons 金属混合物诱导的阿尔茨海默病非转基因动物模型:利弊

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-06-14 DOI: 10.4081/pcr.2023.7768

Anushruti Ashok, N. Rai

{"title":"Metal mixture-induced non-transgenic animal model of Alzheimer’s disease: Pros and cons","authors":"Anushruti Ashok, N. Rai","doi":"10.4081/pcr.2023.7768","DOIUrl":"https://doi.org/10.4081/pcr.2023.7768","url":null,"abstract":"Alzheimer’s disease (AD) is a multifaceted and heterogeneous age-related disease and represents the most common cause of dementia among the elderly. Over the past two decades, transgenic models of AD appreciably contribute to the understanding of the molecular mechanisms involved in the onset and progression of AD. However, transgenic models generally identify with the familial form of AD that accounts for just 5% of AD cases. Thus, non-transgenic models are also essential to thoroughly understand AD pathophysiology. Environmental exposure to heavy metals has been linked to the pathogenesis of the non-familial, sporadic form of AD. This review summarizes our previously published research that showed a mixture of heavy metals, i.e. Arsenic (As), cadmium (Cd) and lead (Pb) at environmentally relevant doses induced AD-parameters and AD-like pathology in the young rats. Our previous findings suggest that the amyloid beta-42 (Aβ1-42) levels in the As+Cd+Pbmixture treated Postnatal-90 day rat brain were comparable with the intracerebroventricular Aβ1-42 infusion rat model, which is well- established non-transgenic model of AD. Additionally, As+Cd+Pb-mixtureinduced Aβ and amyloid precursor protein could be attenuated by known AD-directed drugs, memantine, and donepezil. These findings helped us to conclude that As+Cd+Pb-treated animals could be utilized as a non-transgenic model of AD. This review also summarizes the merits of a nontransgenic animal model of AD, generated through environmental doses of As, Cd and Pb-mixture and its demerits.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82945390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A 69-year-old patient with Ogilvie’s syndrome –case report 69岁奥吉维氏综合征1例报告

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-06-01 DOI: 10.26444/jpccr/166507

A. Zimna, Hubert Wróblewski, Kinga Wróblewska, Błażej Dziurowicz, Ewelina Zygmunt

引用次数: 0

Paediatric inguinal hernia anatomical classifications – new perspectives for study design 小儿腹股沟疝解剖分类-研究设计的新视角

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-05-30 DOI: 10.26444/jpccr/166130

Agata Maria Kawalec

引用次数: 0

Intraosseous schwannoma of upper limb –review 我还不确定

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-05-29 DOI: 10.26444/jpccr/166152

Katarzyna Kopcik, A. Koberling, Franciszek Rzymkowski, Magda Bichalska-Lach

引用次数: 0