Journal of Pre-Clinical and Clinical Research最新文献_第6页

Preventive effects of Trigonella foenum-graecum and Allium sativum against Triton induced hyperlipidaemia in rabbits 静脉三角蜂的预防作用和葱抗Triton诱导的家兔高脂血症

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-09-04 DOI: 10.26444/jpccr/170902

HINA IMRAN, Tehmina Sohail, Rashid Ali Khan, Shahla Basit, Shazia Syed

引用次数: 0

Unlocking the future of drug discovery: navigating challenges and embracing opportunities 开启药物发现的未来:应对挑战，拥抱机遇

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-08-22 DOI: 10.4081/pcr.2023.9822

Siva Reddy Challa

引用次数: 0

Three-dimensional individual planning for treatment of ameloblastoma of the mandible – clinical study 下颌骨成釉细胞瘤三维个体化治疗的临床研究

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-08-11 DOI: 10.26444/jpccr/170251

Krystian Kuźniarz, E. Kwiatkowska, Remigiusz Czerkies, A. Lasota, J. Sierocińska-Sawa, T. Tomaszewski

引用次数: 0

Nipple trauma in lactation - literature review 哺乳期乳头创伤的文献综述

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-08-08 DOI: 10.26444/jpccr/170191

A. Koberling, Katarzyna Kopcik, J. Koper, Magda Bichalska-Lach, M. Rudzki

{"title":"Nipple trauma in lactation - literature review","authors":"A. Koberling, Katarzyna Kopcik, J. Koper, Magda Bichalska-Lach, M. Rudzki","doi":"10.26444/jpccr/170191","DOIUrl":"https://doi.org/10.26444/jpccr/170191","url":null,"abstract":"Introduction and Objective . Breastfeeding is beneficial for both mother and her newborn. Nipple trauma is a common problem in breastfeeding women. It negatively affects the quality of life of the new mothers and may be a reason for early weaning. The main aim of the paper is to summarize current knowledge about nipple wounds and trauma in lactation, based on recent literature. Review Methods. A search was undertaken of the PubMed, Web of Science, Google Scholar and Wiley databases for articles in English regarding nipple wounds in lactation. Key words “nipple wound lactation”, “nipple wound breastfeeding”, “nipple trauma lactation”, “nipple trauma breastfeeding”, “nipple injury lactation”, “nipple injury breastfeeding”, “nipple candidiasis”, “ankyloglossia breastfeeding” were used. Evaluation was based on the titles of articles, abstracts and full text. Main criteria for including the publications were whether they raised the problem of nipple trauma in lactation. Brief description of the state of knowledge . Breastfeeding is physically and mentally beneficial for both mothers and infants. Pain and damage to the nipple may affect the lactation period negatively and cause early cessation of breastfeeding. Nipple damages that may occur in lactation are cracks and fissures, abscesses, blisters, scabbing, erosion of the tissue or bleeding. Open wounds may also be present. Summary . Awareness, early detection and proper management of nipple trauma occurring in lactation is the key to successful and painless breastfeeding. New mothers should be educated about lactation as a process, breastfeeding techniques regarding both their position and baby positioning, and early symptoms of potential nipple trauma by trained personnel. Choice of treatment is based on the type of nipple trauma.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42801561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular rupture as a consequence of blunt trauma – case report and literature review 钝性创伤致左心室破裂病例报告及文献复习

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-08-03 DOI: 10.26444/jpccr/170084

Kamila Derlatka, Marika Kulczycka, Zuzanna Paluch, Jakub Hamouta, Kamil Baczewski, J. Stążka

引用次数: 0

Assessment of the prevalence of lower back pain syndromes among students during the remote teaching period 远程教学期间学生腰痛综合征患病率的评估

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-31 DOI: 10.26444/jpccr/169356

Klaudia Kuliga, M. Kuliga

{"title":"Assessment of the prevalence of lower back pain syndromes among students during the remote teaching period","authors":"Klaudia Kuliga, M. Kuliga","doi":"10.26444/jpccr/169356","DOIUrl":"https://doi.org/10.26444/jpccr/169356","url":null,"abstract":"Introduction and Objective. The COVID-19 pandemic has significantly affected the lives of students. The epidemic situation promoted the development of civilization diseases, among them lower back pain syndromes. These syndromes are the most common reasons for visits to the offices of doctors and physiotherapists The aim of this study was to demonstrate the relationship between physical activity and the incidence of lower back pain among students of the University of Rzeszów, south-eastern Poland, during the COVID-19 pandemic. Materials and method. A cross-sectional study was conducted among students of the University of Rzeszów. The criterion for inclusion was the current status of the student, age between 19–26 years and good general health. Persons with physical disabilities, sick and staying for the last 7 days in hospital, and pregnant women were excluded from the survey. A total of 179 responses were obtained and 176 students were included in the study. The study was conducted using an author’s questionnaire containing own questions and questions from the Polish version of the short International Physical Activity Questionnaire (IPAQ). Results. The intensity of lower back pain had no statistically significant effect on the metabolic equivalent measured by the IPAQ questionnaire. Decreased physical activity in the study group resulted in a statistically significant change in body weight. Year of study had a statistically significant effect on the onset of lower back pain. Conclusions. The level of lower back pain does not affect the physical activity of the students in the study. The field of study had a significant influence on physical activity. The duration of lower back pain in the study group had a significant effect on the level of pain in the VAS scale.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44121847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Phase I study evaluating the pharmacokinetic profile of a novel oral analgesic propoxazepam 一项评估新型口服镇痛药丙氧西泮药代动力学特征的I期研究

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-31 DOI: 10.26444/jpccr/169426

M. Golovenko, A. Reder, I. Zupanets, N. Bezugla, V. Larionov, Irina Valivodz`

{"title":"A Phase I study evaluating the pharmacokinetic profile of a novel oral analgesic propoxazepam","authors":"M. Golovenko, A. Reder, I. Zupanets, N. Bezugla, V. Larionov, Irina Valivodz`","doi":"10.26444/jpccr/169426","DOIUrl":"https://doi.org/10.26444/jpccr/169426","url":null,"abstract":"Introduction and Objective. Propoxazepam, 7-bromo-5 - (o-chlorophenyl)-3-propoxy – 1,2-dihydro – 3H-1,4- benzodiazepin-2-one, in the models of nociceptive and neuropathic pain showed significant analgesic activity. The aim of the study was to investigate the pharmacokinetics of propoxazepam and its metabolites after a single oral dose in healthy volunteers. Materials and method. 12 volunteers were orally dosed with 5 mg propoxazepam under fasting conditions. Blood samples were collected up to 72 hours after administration and propxazepam extracted with liquid-phase extraction and analyzed with high-performance liquid chromatography–tandem mass spectrometry. Results. Maximum propoxazepam concentration (22.276 ng/mL) was reached in blood by 4 hours after administration. It had a large volume of distribution (~6.3 L/kg), the elimination half-life 30.11 hours, MRT 37.77 hours, common clearance – 9062.929 mL/hour. Both propoxazepam and its metabolites (3-hydroxy derivative and glucuronide) were detected in the urine of volunteers. The urinary excretion rate of propoxazepam is proportional to its concentration in plasma. Only a small amount of unchanged propoxazepam was excreted with urine – 0.062 % of the administered dose. Renal clearance – 6.46 mL/hour. Conclusions. A single dose (5 mg) of Propoxazepam administered orally showed good tolerability, pharmacokinetically characterized by rapid absorption, slow elimination and low quantities of unchanged parent urinary excreted. The oxidized metabolite (3-hydroxypropoxazepam) and its glucuronide were excreted with urin, a total of up to 10.5% of the administered dose, which indicates a high degree of metabolism and possible hepatointestinal circulation.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45047573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary healthcare antibiotic therapy in Poland: a patient perspective – preliminary survey study 波兰初级保健抗生素治疗：患者视角——初步调查研究

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-27 DOI: 10.26444/jpccr/169613

Arkadiusz Adamiszak, Sylwia Adamiszak, Ł. Dobrek, O. Fedorowicz, A. Bienert

{"title":"Primary healthcare antibiotic therapy in Poland: a patient perspective – preliminary survey study","authors":"Arkadiusz Adamiszak, Sylwia Adamiszak, Ł. Dobrek, O. Fedorowicz, A. Bienert","doi":"10.26444/jpccr/169613","DOIUrl":"https://doi.org/10.26444/jpccr/169613","url":null,"abstract":"Introduction and Objective. Growing resistance to commonly used antibiotics has challenged 21st-century medicine. To date, antibiotic policy has induced bacterial resistance and isolation of multi-drug resistant superbugs insensitive to known antibiotics. The aim of the study was to investigate the knowledge of primary healthcare patients about antibiotic usage, and to identify incorrect patient habits. Materials and method. The research was based on a proprietary, anonymous Internet survey consisting of 21 questions, in which only adults could participate. The survey selected nine questions to assess the respondents’ knowledge. Results. 201 patients participated in the study. About 50% of participants based their knowledge about antibiotics on information obtained during a medical visit, 16.4% on consultations with a pharmacist, 24.9% on the Internet, and 11.4% exchanged experiences with friends. Every third respondent was not satisfied with the information obtained from a doctor. People with higher education reported this issue more often (p<0.05). Nearly 35% of people living in the countryside (p<0.05) admitted to using the part of a drug left after previous antibiotic therapy, and 10% administered antibiotics obtained from friends or relatives. Every fourth patient believed that antibiotics were effective against colds and flu. The average knowledge test result was 5.49 out of 9 points, and a positive score of 6 or more was obtained by nearly 60% of the respondents. Conclusions. The results of this preliminary study indicate that more focus should be given to improving patients’ education and compliance with treatment recommendations.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45284177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of ketogenic diet in therapy of drug-resistant epilepsies – current state of knowledge 生酮饮食在耐药性癫痫治疗中的应用——目前的知识状况

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-11 DOI: 10.26444/jpccr/168678

Marcin Miłosz Jezierzański, Tomasz Furgoł, Michał Miciak

{"title":"The use of ketogenic diet in therapy of drug-resistant epilepsies – current state of knowledge","authors":"Marcin Miłosz Jezierzański, Tomasz Furgoł, Michał Miciak","doi":"10.26444/jpccr/168678","DOIUrl":"https://doi.org/10.26444/jpccr/168678","url":null,"abstract":"Introduction and Objective. Epilepsy is a neurological disorder where a desynchronization occurs in the discharge of neurons of specific brain areas. Clinically, this manifests as epileptic seizures with possible disturbances of consciousness. Therapy of epilepsy is based on pharmacotherapy, but in cases of drug resistance, alternative methods, such as ketogenic diet (KD) should be explored. The aim of this review is to present the current state of knowledge concerning the use of KD in epilepsy and the clinical results of such therapy. Review Methods. PubMed, PubMed Central and Google Scholar databases were searched using key words related to epilepsy, ketogenic diet, metabolic mechanisms of ketosis and antiepileptic effects of ketone bodies. Articles and book sections in English were searched and reviewed. Articles were selected after analyzing abstracts and those that matched and described the topic in a proper way were used. The types of articles included prospective studies, retrospective studies, reviews and meta-analyses. Brief description of the state of knowledge. From the initial search, 20 articles strictly concerning the KD mechanisms of action, its antiepileptic effects and the results of the therapy conducted were retrieved for final analysis. Available data provide the information specifically on the definition of KD, adverse effects, anti-seizure mechanisms and therapy results mainly from recent years. KD is currently being used as an alternative therapy in drug-resistant epilepsies. The reduction in seizures after its use averages about 50%, and some studies have shown up to 90% effectiveness in seizure reduction. Summary. Understanding the mechanisms of brain metabolism allowed the use of KD in the treatment of epilepsy and other neuropsychiatric diseases. The results of the therapy appear to be satisfactory and provide hope for future epilepsy therapy.","PeriodicalId":16886,"journal":{"name":"Journal of Pre-Clinical and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44360627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of co-existence of hereditary multiple exostoses and steroid-sensitive nephrotic syndrome 遗传性多发性外泌体病与激素敏感型肾病综合征并存的罕见病例

Journal of Pre-Clinical and Clinical Research Pub Date : 2023-07-10 DOI: 10.26444/jpccr/168133

Tomasz Szawłoga, Anna Strzoda, Aleksandra Sobieszczańska

引用次数: 0