Journal of Poultry Science最新文献

{"title":"Osmotic Stress-induced Gene Expression in the Diencephalon, Kidney, Liver, and Breast Muscle of Chicks.","authors":"Yuhui Zhang, Kaoruko Murata, Junya Takegaki, Takaoki Saneyasu, Kazuhisa Honda","doi":"10.2141/jpsa.2025016","DOIUrl":"10.2141/jpsa.2025016","url":null,"abstract":"<p><p>Endogenous water production is an important response for inducing water acquisition in birds, with proteins and lipids being major sources of endogenous water. However, the roles of protein and lipid metabolism-related gene expression in the regulation of their body fluid balance have not been investigated. This study aimed to clarify the roles of protein and lipid metabolism-related genes in osmoregulation in chicks. In Experiment 1, we examined the effects of 12 h of water deprivation on the mRNA levels of protein and lipid metabolism-related genes and feed intake in chicks. Feed intake was significantly decreased by water deprivation throughout the experimental period. The mRNA levels of vasotocin in the diencephalon were significantly increased by water deprivation. The mRNA levels of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid oxidation, were significantly increased by water deprivation in the liver, breast muscle, and diencephalon of the chicks. The mRNA levels of atrogin-1, a regulatory enzyme of the ubiquitin proteasome-system, were significantly increased by water deprivation in the breast muscle of the chicks. In contrast, the mRNA levels of fatty acid synthase, the rate-limiting enzyme of fatty acid synthesis, were significantly decreased by water deprivation in the liver of the chicks. In Experiment 2, the effects of intraperitoneal administration of hypertonic saline were examined under feed and water-deprived conditions. The mRNA levels of renal aquaporin 1, breast muscle atrogin-1, and diencephalon CPT1A were significantly increased 1 h after hypertonic saline injection. These results suggest that osmotic stress may induce protein catabolism in the skeletal muscle and fatty acid catabolism in the diencephalon of the chicks.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025016"},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dietary Energy Levels on the Reproductive Performance in Breeding Pigeons, and Growth Performance and Intestinal Health in Squabs.","authors":"Kang Cheng, Jingyi Niu, Daizi Hu, Jinxiu Yao, Hongyue Zhao, Mingjun Yang, Jinrong Wang, Yong Zhang","doi":"10.2141/jpsa.2025015","DOIUrl":"https://doi.org/10.2141/jpsa.2025015","url":null,"abstract":"<p><p>The present study evaluated the effect of different dietary energy levels on reproductive performance in breeding pigeons, as well as growth performance and intestinal health in squabs. In total, 180 pairs of 12-month-old White King breeding pigeons were randomly assigned to five dietary treatments, each with six replicates of six pairs of birds, and fed diets containing 11.60, 11.80, 12.00, 12.20, and 12.40 MJ/kg for 46 days, respectively. Energy content beyond 12.00 MJ/kg shortened the laying interval (linear and quadratic, <i>P</i><0.05), while boosting 38-day, 42-day, and 46-day laying rates (linear, <i>P</i><0.05) in breeding pigeons. Except for the early stage of lactation, feed intake showed a linear and/or quadratic negative relationship with dietary energy content (<i>P</i><0.05). Body weight at 1 week of age, average daily gain during the early growth stages, and serum total protein of squabs increased with increasing dietary energy content (linear, <i>P</i><0.05); whereas alanine aminotransferase activity decreased (quadratic, <i>P</i><0.05). Jejunal villus height and villus height to crypt depth ratio in squabs increased with increasing dietary energy levels (linear and quadratic, <i>P</i><0.05), particularly in the 12.40 MJ/kg group. Higher dietary energy content increased jejunal malondialdehyde content (linear, <i>P</i><0.05), total superoxide dismutase (T-SOD), and glutathione peroxidase activities (linear, <i>P</i><0.05), as well as ileal T-SOD (linear and quadratic, <i>P</i><0.05) and catalase (quadratic, <i>P</i><0.05) activities in squabs. Hence, intakes greater than 12.00 MJ/kg altered the jejunal redox status. Finally, higher dietary energy content improved reproduction in breeding pigeons and intestinal morphology in squabs. Overall, 12.00 MJ/kg strikes the right balance as it promotes reproductive performance in breeding pigeons and intestinal health in squabs.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025015"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injury and Fibrosis at the Myoaponeurotic Junction of Pectoralis Major and Supracoracoideus Muscles in Broiler Chickens.","authors":"Takeshi Kawasaki, Tomohito Iwasaki, Takafumi Watanabe, Michi Yamada, Naoyuki Maeda, Yasuhiro Hasegawa, Naoki Takahashi, Ryosuke Kobayashi","doi":"10.2141/jpsa.2025014","DOIUrl":"10.2141/jpsa.2025014","url":null,"abstract":"<p><p>In this study, we aimed to identify the mechanism responsible for tissue degeneration and fibrosis in pectoral and supracoracoideus muscles. Ten chickens fed ad libitum broiler feed (Bro) were compared to 10 chickens fed breeding feed (Adj), which has lower metabolizable energy. The median body weight of Bro and Adj birds at 48 days of age was 4.9 and 0.9 kg, respectively. In Bro birds, hind legs were farther apart and tended to abduct, whereas their standing posture was often tilted forward, making them unstable. The two Bro males were heavier than the average, markedly less stable when standing or walking, and often flapped their wings vigorously to maintain balance. Myofiber damage and fibrosis were observed at the myoaponeurotic junction of the pectoralis major and supracoracoideus muscles in Bro birds. Myofiber damage and fibrosis were detected also in areas distal to the myoaponeurotic junction in the two heavier males but were otherwise less evident. By contrast, in Adj birds, almost no degeneration or fibrosis of muscle tissue was observed at the myoaponeurotic junction. In addition, the supracoracoideus muscle of one of the Bro birds showed coagulative necrosis of muscle tissue, surrounded by prominent fibrous tissue. Numerous incompletely formed blood vessels with irregular shapes and prominent branching proliferated in the fibrous tissue. These findings suggest that injury at the myoaponeurotic junction and abnormal capillary proliferation may be closely related to the formation of lesions, along with prominent fibrosis in the pectoralis major and supracoracoideus muscles.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025014"},"PeriodicalIF":1.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function of Amino Acids and Neuropeptides in Feeding Behavior in Chicks.","authors":"Phuong V Tran","doi":"10.2141/jpsa.2025013","DOIUrl":"https://doi.org/10.2141/jpsa.2025013","url":null,"abstract":"<p><p>Regulation of food intake, especially during the neonatal period, is important to ensure optimal nutrition and meet the metabolic requirements of growing and healthy animals. However, many problems associated with neonatal chicks remain unsolved. Feeding behavior during the neonatal stage is characterized by short resting periods between very brief times spent taking up food. Accordingly, neuropeptides, which take time to synthesize and release, as well as nutrients that are taken up via feeding, may be involved in feeding regulation. The present review summarizes current knowledge about the role of amino acids and their interaction with neuropeptides on the regulation of food intake in neonatal chicks with special emphasis on L-arginine metabolism and neuropeptide Y. Fasting and subsequent short-term refeeding influence amino acid metabolism in the brain. Short-term refeeding induces a rapid increase in the concentrations of several amino acids, which may contribute to satiety signals in the neonatal chick brain. The function of L-arginine is related to its metabolite, L-ornithine, which acts as an innate satiety signal in the control of food intake. Co-injection with L-ornithine attenuates the orexigenic effect of neuropeptide Y in a dose-dependent manner. This implies a potent interaction in the brain between the regulation of food intake by neuropeptide Y and acute satiety signals by L-ornithine. The roles of other amino acids in feeding and their relationship with the stress response are also discussed in this review. In conclusion, endogenous neuropeptides and endogenous and/or exogenous nutrients such as amino acids are believed to coordinate the feeding behavior of neonatal chicks.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025013"},"PeriodicalIF":1.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Unique Dwarfism on Growth, Production, and Reproduction Performance of the Nicobari Chicken Breed.","authors":"Santosh Haunshi, Shanmugam Murugesan, Prince L L Leslie, Rajkumar Ullengala, Chatterjee R Nath","doi":"10.2141/jpsa.2025012","DOIUrl":"10.2141/jpsa.2025012","url":null,"abstract":"<p><p>The present study aimed to determine the inheritance and effect of dwarfism, which occurs naturally in the Nicobari chicken breed, on various growth and production traits. The dwarf character did not affect body weight for up to 4 weeks; but had a negative impact from 8 weeks onward, with body weight declining by 5.5%-9.0% in males and 9.0%-16% in females. Shank length was 22% and 27% shorter in male and female dwarf birds, respectively, than in full-size birds. The average age at first egg was 3.08% higher in dwarf hens than in their normal counterparts, and was accompanied by a non-significant decline (5.63%) in 40 weeks egg production. Egg weights were 2.23% and 2.64% lower at 32 and 40 weeks, respectively, in dwarf hens. Instead, the shape index and shell thickness were better in dwarf hens. The eggs of dwarf hens were darker and red, with less hue than those of normal hens; whereas internal egg quality was the same. Fertility and hatchability were lower in dwarf dams mated with dwarf sires than in crosses or reciprocal crosses between normal and dwarf birds. Breeding experiments and sequencing of transmembrane protein 263 ruled out the sex-linked (dw) and autosomal dwarfism (adw), as the genetic causes of dwarfism in the Nicobari breed, which instead appears to follow a novel pattern and has a unique effect on growth traits.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025012"},"PeriodicalIF":1.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of betaine on growth performance, methionine metabolism, and methyl transfer in broilers aged 1 to 21 days and fed a low-methionine diet.","authors":"Heng Wang, Lin Liu, Xi He, Guozhi Bian","doi":"10.2141/jpsa.2025010","DOIUrl":"10.2141/jpsa.2025010","url":null,"abstract":"<p><p>Betaine has been proposed as a low-cost source of methyl groups in poultry feed, replacing methionine and choline. The present study aimed to investigate the effect of betaine on growth performance, methionine metabolism, and methyl transfer in broilers aged 1 to 21 days fed a low-methionine diet. A total of 960 one-day-old male broilers were randomly divided into four groups: positive control (0.62% methionine in the diet), negative control (0.37% methionine in the diet), and two treatment groups (0.37% methionine in the diet plus either 1500 or 3000 mg betaine/kg diet). Chicks fed the 1500 mg betaine/kg diet had the highest feed-to-gain ratio (<i>P</i> < 0.05), but no significant difference in final body weight, average daily gain, average daily feed intake, or mortality. Serum S-adenosyl-L-methionine and total homocysteine were higher at 1500 mg betaine/kg diet; whereas serum S-adenosylhomocysteine exhibited the opposite trend. Except for DNA methyltransferase 1, key enzymes and metabolites involved in the hepatic single-carbon pathway showed the highest levels at 1500 mg betaine/kg diet and declined thereafter. Furthermore, betaine promoted dose-dependent mRNA and protein expression of enzymes involved in the hepatic single-carbon metabolic cycle and methyl transferase pathways in chicks fed methionine-deficient diets. In conclusion, while the addition of betaine did not significantly improve the growth performance of chicks aged 1-21 days, inclusion of 1500 mg betaine/kg diet effectively stabilized methionine metabolism and methyl transfer in methionine-deficient diets.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025010"},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks.","authors":"Yuhui Zhang, Kaoruko Murata, Junya Takegaki, Takaoki Saneyasu, Kazuhisa Honda","doi":"10.2141/jpsa.2025011","DOIUrl":"10.2141/jpsa.2025011","url":null,"abstract":"<p><p>Freedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood. In humans, increased blood osmolality is probably the strongest signal for drinking. Angiotensin II, a hyperosmotic signal, induces water intake in chickens; this effect is attenuated by an opioid receptor antagonist. Vasotocin and mesotocin appear to have osmoregulatory functions in chicken. Dehydration activates brain corticotrophin-releasing factor (CRF) neurons in rats, and the central administration of CRF induces water intake in rabbits. This study aimed to clarify the effects of neuropeptides such as opioid peptides, vasotocin, mesotocin, and CRF on water intake to identify thirst-inducing neuropeptides in chicks. Eight-day-old male chicks were intracerebroventricularly injected with saline or the peptides. Water intake was measured 120 min after the injection under feed-deprived conditions. Intracerebroventricular administration of Met-enkephalin (a δ-opioid receptor agonist), β-endorphin (a δ-opioid receptor agonist), and nociception (a κ-opioid receptor and opioid receptor-like protein agonist) significantly suppressed water intake in chicks, whereas dynorphin B (a κ-opioid receptor agonist) and endomorphin-1 and 2 (μ-opioid receptor agonists) did not affect water intake. Intracerebroventricular administration of vasotocin, mesotocin, and CRF significantly suppressed water intake in chicks. Our findings suggest that none of the neuropeptides used in this study function as thirst-inducing peptides in the central nervous system of chicks.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025011"},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Intestinal Health in Broiler Chickens Following <i>Salmonella</i> Typhimurium and Coccidiosis Vaccination and Challenge with <i>Salmonella</i> Typhimurium.","authors":"Andrea Pietruska, Kenneth S Macklin, Xu Wang, James T Krehling, Teresa Dormitorio, Rüdiger Hauck","doi":"10.2141/jpsa.2025009","DOIUrl":"10.2141/jpsa.2025009","url":null,"abstract":"<p><p><i>Salmonella enterica</i> and coccidia (<i>Eimeria</i> spp.) are important intestinal pathogens in broiler production. <i>Salmonella</i> has high zoonotic potential, and coccidia are responsible for large economic losses. Live vaccines reduce shedding of <i>Salmonella</i> and minimize the impact of coccidial infections on broiler performance. This study investigated the interaction between both vaccines on the intestinal health of broilers. The 2 × 2 experimental design included vaccination against <i>Salmonella</i> Typhimurium (ST) (no vaccination or vaccination on day 14) and vaccination against coccidiosis (no vaccination or vaccination on day 1). On day 28, all groups were challenged with a ST marker strain resistant to nalidixic acid. Re-isolation of ST from the liver and ceca on day 42 indicated higher susceptibility to systemic infection with ST in birds vaccinated against coccidiosis than that in unvaccinated birds. On day 42, cecal immunoglobulin A (IgA) levels against ST decreased in the group vaccinated against ST and coccidia compared to those in all other groups. IgG antibodies in the cecal contents significantly decreased in the group vaccinated against coccidiosis compared to that of the group vaccinated against ST. There was no difference in systemic IgG levels among groups. Analysis of the cecal microbiota revealed a significant difference in beta diversity on days 28 and 42 between the groups vaccinated against coccidiosis and unvaccinated groups. Functional pathway profiling showed increased activity of pathways associated with carbohydrate and arachidonic acid metabolism in the group vaccinated against ST compared to that in other groups. Gene expression of claudin 1, claudin 4, E-cadherin, β-catenin, and zonula occludens 2 in the cecal wall differed between the groups on days 28 and 42. These findings indicated the significant influence of ST and coccidiosis vaccines on the intestinal health of broilers; however, further studies are required to clarify the implications for health and performance.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025009"},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wet Feeding Promotes Growth without Affecting Hypothalamic Peptide Gene Expression in Growing Broiler Chicks.","authors":"Tomoya Matsunami, Yuhui Zhang, Yuji Taniguchi, Sei-Ichi Hinomoto, Takaoki Saneyasu, Hiroshi Kamisoyama, Kazuhisa Honda","doi":"10.2141/jpsa.2025008","DOIUrl":"10.2141/jpsa.2025008","url":null,"abstract":"<p><p>From the perspective of animal welfare, freedom from hunger and thirst is an undeniable requirement for the poultry industry. Regulatory mechanisms underlying drinking behavior have not yet been identified in chickens; however, the regulation of osmolality and water intake appears to be closely related. This study clarified whether wet feeding affects appetite, osmolality, and stress-related gene expression in the hypothalami of chicks. In Experiment 1, the effects of different wet feed percentages on the growth of broiler chicks were examined. Wet feeds were prepared by mixing either 0.25 g (20% wet feed), 0.667 g (40% wet feed), or 1.5 g (60% wet feed) of distilled water per g of commercial feed. Then, the wet feeds were offered to 4-day-old broiler chicks until 42 d of age. Forty percent wet feed significantly increased body, breast, and leg weights. In Experiment 2, 7-day-old broiler chicks were given either commercial starter feed or 40% wet feed until 21 d of age. Again, weights of the body, breasts, and legs were significantly increased by wet feeding. The total amount of water loss in the individual waterers was significantly decreased by wet feeding. No significant changes were observed in mRNA levels of the genes encoding appetite-regulatory peptides (neuropeptide Y and α melanocyte-stimulating hormone), osmoregulatory peptides (vasotocin and mesotocin), or stress-related peptides (corticotrophin-releasing factor) in the chicken hypothalamus. Overall, 40% wet feed improved growth without inducing thirst or hunger in broiler chicks. These findings suggest that wet feeding contributes to both meat yield and animal welfare during broiler production.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025008"},"PeriodicalIF":1.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bird's-Eye Overview of Leptin and Female Reproduction -with Mammalian Comparisons.","authors":"Sadequllah Ahmadi, Takeshi Ohkubo","doi":"10.2141/jpsa.2025007","DOIUrl":"10.2141/jpsa.2025007","url":null,"abstract":"<p><p>Leptin, a key regulator of reproductive physiology, influences various processes in vertebrates, including oocyte proliferation, embryogenesis, the onset of puberty, ovarian function, and follicle development. In mammals, leptin affects steroidogenesis, folliculogenesis, and hormonal regulation through the hypothalamic-pituitary-gonadal axis. Instead, in avian species, leptin-controlled mechanisms are poorly understood, because birds do not produce leptin in adipocytes. In birds, leptin is expressed in the brain, pituitary glands, and gonads, where it enhances ovarian function and egg-laying performance, particularly during feed deprivation. In this review, we discuss and summarize the recently discovered role of leptin in regulating ovarian function during different life stages in birds and compare it with its function in mammals.</p>","PeriodicalId":16883,"journal":{"name":"Journal of Poultry Science","volume":"62 ","pages":"2025007"},"PeriodicalIF":1.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}