Journal of Plastic Surgery and Hand Surgery最新文献

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Evaluation of an assessment scale for aesthetic outcome in breast reconstructions based on digital photos in both 2D and 3D format. 基于2D和3D格式数码照片的乳房重建美学效果评估量表的评价。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2152820
Linda Tallroth, Nathalie Mobargha, Patrik Velander, Stina Klasson, Magnus Becker
{"title":"Evaluation of an assessment scale for aesthetic outcome in breast reconstructions based on digital photos in both 2D and 3D format.","authors":"Linda Tallroth,&nbsp;Nathalie Mobargha,&nbsp;Patrik Velander,&nbsp;Stina Klasson,&nbsp;Magnus Becker","doi":"10.1080/2000656X.2022.2152820","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2152820","url":null,"abstract":"<p><p>The aesthetic outcome is crucial in a breast reconstruction. Our aim was to evaluate the intra- and interrater reliability of an aesthetic outcome assessment scale with digital photos of breast reconstructions in two-dimensional (2D) and three-dimensional (3D) format. Thirty-three women with delayed breast reconstructions, consecutively participating in a five-year follow-up between November 2019 and June 2021, were included in the study. Of these, 14 were reconstructed with an expander prosthesis (EP) and 19 with a deep inferior epigastric perforator (DIEP) flap. Photos of the breasts were assessed in 2D and 3D format by expert, layman and patient panels. Data were analysed with the weighted kappa (wk) statistics. The intrarater agreements were moderate to substantial, with wk between 0.66 and 0.73 for the panels. Within the panels, the interrater agreements were 0.46-0.62. Moderate agreements were found between the matched 2D and 3D format photos (wk 0.62-0.66). The patient panel graded scar appearance worse in 3D compared with 2D format. In all panels, there was a tendency towards DIEP flap reconstructions receiving higher aesthetic outcome grades compared with EP. Thus, the aesthetic outcome assessment scale demonstrated acceptable agreements between the individual panellists and within the panels. Scars captured in 3D format may provide a greater resemblance to the reality compared with 2D. Implications for clinics remain to be further studied.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"427-433"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10794415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single versus dual venous anastomosis in radial forearm free flaps in head and neck reconstruction. 前臂桡骨游离皮瓣在头颈部重建中的单静脉与双静脉吻合。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2152821
Hanjin Ruan, Zhengxue Han
{"title":"Single versus dual venous anastomosis in radial forearm free flaps in head and neck reconstruction.","authors":"Hanjin Ruan,&nbsp;Zhengxue Han","doi":"10.1080/2000656X.2022.2152821","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2152821","url":null,"abstract":"<p><p>A retrospective cohort study of 253 radial forearm free flap (RFFF) procedures in head and neck reconstruction performed in our department between 2005 and 2018 was reviewed. In order to explore the effects between single and dual anastomoses, we applied Fisher's exact test for statistical analysis. Although no flap failure was identified, more venous compromises were observed in single anastomosis group (5/80 vs. 1/173). We conclude that dual venous anastomoses can reduce venous compromise resulted from unexpected causes in RFFF transfer. Therefore, we especially recommend dual venous anastomoses for those who cannot withstand a second surgery.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"434-437"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pain, hand function, activity performance and apprehensiveness, in patients with surgically treated distal radius fractures. 手术治疗桡骨远端骨折患者的疼痛、手功能、活动表现和忧虑。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2060992
J Blomstrand, G Kjellby Wendt, J Karlsson, J Wangdell, M Fagevik Olsén
{"title":"Pain, hand function, activity performance and apprehensiveness, in patients with surgically treated distal radius fractures.","authors":"J Blomstrand,&nbsp;G Kjellby Wendt,&nbsp;J Karlsson,&nbsp;J Wangdell,&nbsp;M Fagevik Olsén","doi":"10.1080/2000656X.2022.2060992","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2060992","url":null,"abstract":"<p><p>Distal radius fracture (DRF) is a common injury, affecting both function and activity performance. Postoperative rehabilitation is an essential part of the treatment of a surgically treated DRF. The study aims were to assess pain, hand function, activity performance and apprehensiveness and their association, during the first three months after a surgically treated DRF. Eighty-eight patients with a DRF were assessed for pain, hand function, activity performance and apprehensiveness three days and two, six and 12 weeks after surgery. The results indicated that pain, range of motion (ROM), grip strength, apprehensiveness, and activity performance (PRWE) improved significantly between follow-ups (<i>p</i> < .001-.01). Apprehensiveness correlated moderately with activity performance on all visits (0.40-0.47, <i>p</i> < .01), which implies a correlation between the variables, but the regression model showed that the differences in the PRWE at twelve weeks cannot be explained by the differences in apprehensiveness or range of motion at cast removal. At 12 weeks, the study participants had regained almost 70% of their grip strength and 74-96% of the ROM of the uninjured hand.The study shows that, during the study period, the participants improved in both pain, hand function and activity performance, and indicates that a simple question on apprehensiveness in terms of using the injured hand in daily life could be an important factor in distal radius fracture rehabilitation.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"247-252"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9343897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corset trunkoplasty is able to preserve postoperative abdominal skin sensation in massive weight loss patients. 胸衣躯干成形术能够保留大量减肥患者术后腹部皮肤感觉。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2152822
Kathrin Bachleitner, Maximilian Mahrhofer, Friedrich Knam, Thomas Schoeller, Laurenz Weitgasser
{"title":"Corset trunkoplasty is able to preserve postoperative abdominal skin sensation in massive weight loss patients.","authors":"Kathrin Bachleitner,&nbsp;Maximilian Mahrhofer,&nbsp;Friedrich Knam,&nbsp;Thomas Schoeller,&nbsp;Laurenz Weitgasser","doi":"10.1080/2000656X.2022.2152822","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2152822","url":null,"abstract":"<p><p>Conventional abdominoplasty techniques commonly cause postoperative peri- and infraumbilical skin hypesthesia due to abdominal skin flap undermining. The aim of this study was to evaluate abdominal skin sensation after corset trunkoplasty in massive weight loss patients. Forty-nine massive weight loss patients suffering from excess skin underwent corset trunkoplasty between April 2017 and July 2021. Patient demographics and perioperative complications were recorded. Sensibility of the abdominal skin was measured in three qualities postoperatively using a Semmes-Weinstein monofilament, Tip-Therm<sup>®</sup> device for thermal sensation and a cotton wooden stick for sharp/blunt discrimination. Results were compared with a control group of healthy individuals to create a baseline. Revision surgery for major complications was necessary in five cases (10%) including hematoma and major wound healing disturbances. Minor complications that did not require surgical intervention were observed in eight cases (16%). Postoperative abdominal sensibility did not show any significant difference between the patient and the control group in all 16 measured areas. Sharp/blunt and thermal discrimination was positive in all patients for the whole abdominal surface area. The corset trunkoplasty technique is able to address both horizontal and vertical soft tissue excess in massive weight loss patients and at the same time limits loss of sensibility of the abdominal skin. Compared to conventional abdominoplasty techniques the abdominal sensation can mainly be preserved due to absence of undermining abdominal skin flaps.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"438-444"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9345403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between trauma and paediatric trigger thumb deformity; experience from a single tertiary referral hospital. 创伤与儿童触发拇指畸形之间的关系来自单一三级转诊医院的经验。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2032104
Nadia L Salloum, Pauline McGee, Wee L Lam
{"title":"The association between trauma and paediatric trigger thumb deformity; experience from a single tertiary referral hospital.","authors":"Nadia L Salloum,&nbsp;Pauline McGee,&nbsp;Wee L Lam","doi":"10.1080/2000656X.2022.2032104","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2032104","url":null,"abstract":"<p><p>Whilst the natural history and management of trigger thumb have been thoroughly investigated, the aetiology of the condition remains poorly understood. There are suggestions that this could be a congenital or acquired condition, but evidence remains limited. A history of trauma has repeatedly been noted in a proportion of patients presenting with trigger thumb. This retrospective study reviewed the presentations of 75 cases of trigger thumb in 65 consecutive children who underwent surgery for trigger thumb. We found that 28% of affected digits presented with a traumatic history to the thumb, of those 90% presented immediately post-injury with a flexion deformity. Those who presented with a traumatic history were typically younger at presentation (median age 27.0 months compared to 37.5 months for traumatic and atraumatic presentations respectively) but also tended to present earlier than the atraumatic group (one day compared to 12.17 months respectively). We conclude that a single traumatic event is unlikely to be the causative factor in the development of trigger thumb in children but it may expediate the development of individuals who are predisposed.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"181-185"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10795790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An external validation of a novel predictive algorithm for male nipple areolar positioning: an improvement to current practice through a multicenter endeavor. 一种新的男性乳头乳晕定位预测算法的外部验证:通过多中心努力对当前实践的改进。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2021.1994982
Floyd W Timmermans, Laure Ruyssinck, Sterre E Mokken, Marlon Buncamper, Kevin M Veen, Margriet G Mullender, Karel E Y Claes, Mark-Bram Bouman, Stanislas Monstrey, Timotheus C van de Grift
{"title":"An external validation of a novel predictive algorithm for male nipple areolar positioning: an improvement to current practice through a multicenter endeavor.","authors":"Floyd W Timmermans,&nbsp;Laure Ruyssinck,&nbsp;Sterre E Mokken,&nbsp;Marlon Buncamper,&nbsp;Kevin M Veen,&nbsp;Margriet G Mullender,&nbsp;Karel E Y Claes,&nbsp;Mark-Bram Bouman,&nbsp;Stanislas Monstrey,&nbsp;Timotheus C van de Grift","doi":"10.1080/2000656X.2021.1994982","DOIUrl":"https://doi.org/10.1080/2000656X.2021.1994982","url":null,"abstract":"<p><p>The correct positioning of nipple-areolar complexes (NAC) during gender-affirming mastectomies remains a particular challenge. Recently, a Dutch two-step algorithm was proposed predicting the most ideal NAC-position derived from a large cisgender male cohort. We aimed to externally validate this algorithm in a Belgian cohort. The Belgian validation cohort consisted of cisgender men. Based on patient-specific anthropometry, the algorithm predicts nipple-nipple distance (NN) and sternal-notch-to-nipple distance (SNN). Predictions were externally validated using the performance measures: <i>R</i><sup>2</sup>-value, means squared error (MSE) and mean absolute percentage error (MAPE). Additionally, data were collected from a Belgian and Dutch cohort of transgender men having undergone mastectomy with free nipple grafts. The observed and predicted NN and SNN were compared and the inter-center variability was assessed. A total of 51 Belgian cisgender and 25 transgender men were included, as well as 150 Dutch cisgender and 96 transgender men. Respectively, the performance measures (<i>R</i><sup>2</sup>-value, MSE and MAPE) for NN were 0.315, 2.35 (95%CI:0-6.9), 4.9% (95%CI:3.8-6.1) and 0.423, 1.51 (95%CI:0-4.02), 4.73%(95%CI:3.7-5.7) for SNN. When applying the algorithm to both transgender cohorts, the predicted SNN was larger in both Dutch (17.1<sub>measured</sub>(<b>±</b>1.7) vs. 18.7<sub>predicted</sub>(<b>±</b>1.4), p= <0.001) and Belgian (16.2<sub>measured</sub>(<b>±</b>1.8) vs. 18.4<sub>predicted</sub>(<b>±</b>1.5), <i>p</i>= <0.001) cohorts, whereas NN was too long in the Belgian (22.0<sub>measured</sub>(<b>±</b>2.6) vs. 21.2<sub>predicted</sub>(<b>±</b>1.6), <i>p</i> = 0.025) and too short in the Dutch cohort (19.8<sub>measured</sub>(<b>±</b>1.8) vs. 20.7<sub>predicted</sub>(<b>±</b>1.9), <i>p</i> = 0.001). Both models performed well in external validation. This indicates that this two-step algorithm provides a reproducible and accurate clinical tool in determining the most ideal patient-tailored NAC-position in transgender men seeking gender-affirming chest surgery.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"103-108"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10784424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Survival after lymphadenectomy of nodal metastases from melanoma of unknown primary site. 原发部位未知的黑色素瘤淋巴结转移淋巴结切除术后的生存率。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2021.2010739
Hans Petter Gullestad, Truls Ryder, Mariusz Goscinski
{"title":"Survival after lymphadenectomy of nodal metastases from melanoma of unknown primary site.","authors":"Hans Petter Gullestad,&nbsp;Truls Ryder,&nbsp;Mariusz Goscinski","doi":"10.1080/2000656X.2021.2010739","DOIUrl":"https://doi.org/10.1080/2000656X.2021.2010739","url":null,"abstract":"<p><p>Although the vast majority of melanomas have a primary site, 3%-4% of all melanomas in distant sites display no known primary site (MUP). This phenomenon is not fully understood and various hypotheses have been introduced. The prognostic significance of MUP has been unclear, with some studies showing no survival benefit while others find improved survival compared to stage-matched patients with melanoma of known primary site (MKP). Between 1997 and 2014, 864 patients underwent an en bloc resection of clinical nodal metastases at a referral centre for metastatic melanoma in Norway. The MUP (<i>n</i> = 113) and MKP (<i>n</i> = 751) patients were graded with stage III or IV. The overall survival (OS) was calculated with the Kaplan-Meier method, and multivariate analysis identified factors of significance for the two groups. A significant five-year OS emerged for stage III, MUP = 58% and 42% for MKP, but not for stage IV. The five-year relapse-free survival (RFS) was 41% and 31% for MUP and MKP respectively (<i>p</i> = 0.049). The statistically significant inter-group differences (MUP/MKP) were observed in the univariate and multivariate analyses of age, gender, number of affected nodes, tumour size and perinodal growth within stage III and tumour size within stage IV. After regional lymphadenectomy, MUP patients with clinical nodal metastases had a better outcome than MKP patients. This finding supports the theory that an endogenously mediated immune response may promote the regression of a cutaneous melanoma.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"109-114"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9343859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Reverse homodigital dorsal wraparound flap for reconstruction of distal thumb. 反向同指背环绕皮瓣重建拇指远端。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2088542
Hui Wang, Xiaoxi Yang, Yongxin Huo, Ruizheng Hao, Bin Wang, Wei Wang
{"title":"Reverse homodigital dorsal wraparound flap for reconstruction of distal thumb.","authors":"Hui Wang,&nbsp;Xiaoxi Yang,&nbsp;Yongxin Huo,&nbsp;Ruizheng Hao,&nbsp;Bin Wang,&nbsp;Wei Wang","doi":"10.1080/2000656X.2022.2088542","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2088542","url":null,"abstract":"<p><p>Reconstruction of degloving injury or amputation of distal thumb with no indication of replantation has always been a challenging problem for hand surgeons. In this study, a reverse homodigital dorsal wraparound flap innervated by the dorsal digital nerve was devised to repair degloving injury or amputation of distal thumb in 20 consecutive cases. In nine cases of thumb amputation, we skeletonized the phalanxes of the amputated part as a free cortical bone with Kirschner wires. All flaps survived uneventfully. The radiographs showed bone healing in all the patients of thumb amputation within 6 weeks postoperatively. At final follow-up, the appearance of the reconstructed thumb was acceptable and flap sensation and range of joint motion were satisfactory. This flap is a simple and reliable alternative method for degloving injury or amputation of distal thumb when replantation is impossible and patients refuse to donate tissues from toes. Type of study/level of evidence Therapeutic IV.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"336-342"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9360138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway. ADAM17通过介导EGFR/ERK信号通路调控瘢痕疙瘩成纤维细胞的增殖和细胞外基质。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2021.2017944
Xin Le, You-Fen Fan
{"title":"ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway.","authors":"Xin Le,&nbsp;You-Fen Fan","doi":"10.1080/2000656X.2021.2017944","DOIUrl":"https://doi.org/10.1080/2000656X.2021.2017944","url":null,"abstract":"<p><p>To investigate the role of a disintegrin and metalloprotease protein 17 (ADAM17) in regulating the proliferation and extracellular matrix (ECM) expression of keloid fibroblasts (KFs) via the epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase (ERK) pathway. ADAM17 expression in keloid tissues was detected by western blotting. KFs were isolated, cultured and divided into the control, shNC (negative control), shADAM17, transforming growth factor-β1 (TGF-β1), TGF-β1 + shNC and TGF-β1 + shADAM17 groups. The expression of ECM was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Western blotting was performed to detect the expression of proteins. Cell proliferation was detected by a 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, while cell invasion and migration were examined by Transwell and wound healing assays. The expression of ADAM17 was increased in keloid tissues and KFs. Compared with the control group, the expression of p-EGFR and p-ERK/1/2/ERK1/2, as well as the expression of collagen I, collagen III, connective tissue growth factor (CTGF) and α-smooth muscle actin (α-SMA), were decreased in KFs from the shADAM17 group, with decreased cell proliferation, invasion and migration. In contrast, the TGF-β1 group presented the opposite trend in these aspects. In addition, compared with the TGF-β1 group, KFs from the TGF-β1 + shADAM17 group had decreased ECM expression, proliferation, invasion and migration. ADAM17 expression was upregulated in keloid tissues. Silencing ADAM17 may inhibit the activity of the EGFR/ERK pathway to limit the deposition of ECM in KFs with reduced proliferation, invasion and migration.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"129-136"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9359613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Remodelling of the superficial vascular network of skin flaps in rats, following a vasodilatory cream application, before elevation. 大鼠皮瓣浅表血管网络的重塑,在血管扩张霜应用后,抬高前。
IF 1.2 4区 医学
Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI: 10.1080/2000656X.2022.2039679
Glykeria Pantazi, Iraklis Evangelopoulos, Christos Evangelopoulos, Sofia Tilaveridou, Ioannis Iakovou, Athanassios Kyrgidis, Ioannis Tilaveridis
{"title":"Remodelling of the superficial vascular network of skin flaps in rats, following a vasodilatory cream application, before elevation.","authors":"Glykeria Pantazi,&nbsp;Iraklis Evangelopoulos,&nbsp;Christos Evangelopoulos,&nbsp;Sofia Tilaveridou,&nbsp;Ioannis Iakovou,&nbsp;Athanassios Kyrgidis,&nbsp;Ioannis Tilaveridis","doi":"10.1080/2000656X.2022.2039679","DOIUrl":"https://doi.org/10.1080/2000656X.2022.2039679","url":null,"abstract":"<p><p>Flap necrosis on random pattern skin flaps continues to be a challenge. In this study, we evaluated whether topical application of a vasodilator substance (the prostaglandin PGI<sub>2</sub> analogue, Iloprost<sup>®</sup>, in cream form) as pre-treatment, would increase blood flow and improve flap viability. Wistar rats randomly allocated into four groups with 7 rats per group and two flaps 4cm × 2cm in the same rat i.e. 56 flaps were developed. Flaps on the wright side received pre-treatment with Cream in different drug concentrations, 2.5μgr/gr, 5 μgr/gr, and 10μgr/gr and 20 μgr/gr containing the active factor Iloprost<sup>®®</sup> ZK 36,374(M. W 360.5) prepared with white petrolatum as a base. Flaps on the left side received placebo cream (white petrolatum). After 10 days of flap pre-treatment, evaluation of blood flow by laser Doppler flowmetry (LDF) were recorded, then flap elevation and re suturing back were performed. After 7 days we estimated flap viability on digital imaging and the percentages of flap survival estimated. Means and standard deviations were used to describe blood flow measurements and survival percentages. The significance was set at 0.05 in all cases and the analysis were carried out with the use of the SPSS v23.0. Furthermore, we performed dynamic analyses of circulation using the radioisotope 99mTc which confirmed hyperaemia of the treated areas relative to that observed in control areas. These findings demonstrated that pretreatment of skin flaps with Iloprost<sup>®</sup> cream for 10 days prior to elevation increased blood flow in the flap and improved their overall survival rate.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":"57 1-6","pages":"206-215"},"PeriodicalIF":1.2,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9359631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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