Could hyperbaric oxygen be an effective therapy option for pathological scars? A systematic review and meta-analysis.

IF 1 4区医学 Q3 ORTHOPEDICS

Journal of Plastic Surgery and Hand Surgery Pub Date : 2023-02-01 DOI:10.1080/2000656X.2022.2075371

Ruxin Xie, Ai Zhong, Junliang Wu, Ying Cen, Junjie Chen

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引用次数: 0

Abstract

Background: Hyperbaric oxygen (HBO) therapy involves breathing pure oxygen or a high oxygen concentration above atmospheric (ATM) pressure in an enclosed chamber. Studies on pathological scars have demonstrated that HBO can inhibit the formation of pathological scars.

Objective: To evaluate the efficacy of HBO in the treatment of pathological scars via meta-analysis.

Methods: Searches were run on various databases, including the Cochrane, Embase, PubMed, Web of Science, and CNKI databases. A comparative study was conducted on patients with pathological scars treated with or without HBO. We used RevMan 5.4 software to determine the recurrence rate, treatment satisfaction, and Vancouver Scar Scale(VSS) score in the pathological scar.

Results: A total of 543 publications were identified; after screening, four were selected for review, including one randomized controlled trial (RCT), one controlled clinical trial (CCT), and two retrospective cohort studies. Meta-analysis results showed that HBO treatment reduced the pathological scar recurrence rate after surgery and radiotherapy (OR = 0.26, 95% CI: 0.13-0.52, p = 0.0001). Patients had higher satisfaction after HBO therapy (OR = 4.45, 95% CI: 1.49-13.30, p = 0.007). The Vancouver scar scale (VSS) score of patients with pathological scars was significantly improved in the HBO group (SMD: -3.82, 95% CI: -6.07to -0.49, p = 0.02).

Conclusions: HBO treatment decreased the recurrence rate of pathological scars after surgery and radiotherapy, increased patient satisfaction, and reduced the VSS score, thus providing a new way to treat pathological scar hyperplasia. However, evaluation of the longer-term effects of HBO treatment requires further comprehensive studies, including more RCTs.

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高压氧是治疗病理性疤痕的有效方法吗?系统回顾和荟萃分析。

背景:高压氧(HBO)治疗包括在封闭的室内呼吸纯氧或高于大气压(ATM)的高浓度氧气。病理性疤痕的研究表明，HBO可以抑制病理性疤痕的形成。目的:通过meta分析，评价高压氧治疗病理性瘢痕的疗效。方法:在Cochrane、Embase、PubMed、Web of Science和CNKI等数据库上进行检索。我们对病理性瘢痕患者进行了HBO治疗和不HBO治疗的对比研究。采用RevMan 5.4软件测定病理性瘢痕的复发率、治疗满意度及温哥华疤痕量表(Vancouver Scar Scale, VSS)评分。结果:共检索到543篇文献;筛选后，选择4项纳入综述，包括1项随机对照试验(RCT)、1项对照临床试验(CCT)和2项回顾性队列研究。meta分析结果显示，HBO治疗降低了手术和放疗后病理性瘢痕复发率(OR = 0.26, 95% CI: 0.13-0.52, p = 0.0001)。高压氧治疗后患者满意度较高(OR = 4.45, 95% CI: 1.49 ~ 13.30, p = 0.007)。HBO组病理性瘢痕患者温哥华疤痕量表(VSS)评分明显改善(SMD: -3.82, 95% CI: -6.07 ~ -0.49, p = 0.02)。结论:HBO治疗可降低病理性瘢痕术后放疗复发率，提高患者满意度，降低VSS评分，为治疗病理性瘢痕增生提供了新的途径。然而，评估高压氧治疗的长期效果需要进一步的综合研究，包括更多的随机对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Plastic Surgery and Hand Surgery ORTHOPEDICS-SURGERY

CiteScore

2.10

自引率

0.00%

发文量

108

审稿时长

6-12 weeks

期刊介绍： The purpose of the Journal of Plastic Surgery and Hand Surgery is to serve as an international forum for plastic surgery, hand surgery and related research. Interest is focused on original articles on basic research and clinical evaluation. The scope of the journal comprises: • Articles concerning operative methods and follow-up studies • Research articles on subjects related to plastic and hand surgery • Articles on cranio-maxillofacial surgery, including cleft lip and palate surgery. Extended issues are published occasionally, dealing with special topics such as microvascular surgery, craniofacial surgery, or burns. Supplements, usually doctoral theses, may also be published. The journal is published for the Acta Chirurgica Scandinavica society and sponsored by the Key Foundation, Sweden. The journal was previously published as Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery.