Journal of Pharmacy and Bioallied Sciences最新文献

{"title":"In vitro Evaluation of the Cytotoxicity of Chairside CAD/CAM Block Materials for Fabricating Dental Restorations","authors":"S. Sultan, Mazen Anwar Abdullah Albadi, Faris Salah Alhassan, Sherif Elsharkawy","doi":"10.4103/jpbs.jpbs_334_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_334_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 The increasing utilization of chairside computer-aided design/computer-aided manufacturing (CAD/CAM) block materials in dentistry necessitates a comprehensive evaluation of their cytotoxicity to ensure patient safety. This study aimed to assess the cytotoxic effects of commonly used chairside CAD/CAM block materials for fabricating dental restorations.\u0000 \u0000 \u0000 \u0000 Several chairside CAD/CAM block materials including zirconia, lithium disilicate, and resin-based composites were evaluated for cytotoxicity using an in vitro model. Human gingival fibroblasts were cultured and exposed to extracts from each material. Cytotoxicity was assessed using MTT assay after 24, 48, and 72 hours of exposure. Additionally, cell morphology and viability were examined using microscopy.\u0000 \u0000 \u0000 \u0000 The MTT assay revealed varying degrees of cytotoxicity among the tested materials. Zirconia demonstrated the least cytotoxicity with cell viability of 85% ± 5%, 82% ± 4%, and 79% ± 6% at 24, 48, and 72 hours, respectively. Lithium disilicate exhibited moderate cytotoxicity with cell viability of 70% ± 6%, 65% ± 7%, and 60% ± 5% at the corresponding time points. Resin-based composites displayed the highest cytotoxicity with cell viability of 55% ± 8%, 45% ± 6%, and 40% ± 4% at 24, 48, and 72 hours, respectively. Microscopic examination revealed altered cell morphology and reduced cell viability in the presence of resin-based composites.\u0000 \u0000 \u0000 \u0000 Chairside CAD/CAM block materials exhibit varying degrees of cytotoxicity, with zirconia demonstrating the least and resin-based composites showing the highest cytotoxic effects. These findings underscore the importance of considering cytotoxicity profiles when selecting CAD/CAM materials for dental restorations to ensure patient safety and biocompatibility.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 12","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Assessment of the Antimicrobial Properties of Orthodontic Bonding Materials","authors":"M. K. Alam, M. Y. Hajeer, M. Z. Alfuhigi, F. A. Eldosary, F. N. Alsenani, L. N. Alsayil","doi":"10.4103/jpbs.jpbs_326_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_326_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Orthodontic bonding materials are extensively used in dentistry, but their antimicrobial properties are of growing concern due to the risk of biofilm formation and associated complications. Understanding the antimicrobial efficacy of these materials is crucial for maintaining oral health during orthodontic treatment.\u0000 \u0000 \u0000 \u0000 In this in vitro study, we evaluated the antimicrobial properties of various orthodontic bonding materials against common oral pathogens. Samples of bonding materials were prepared and exposed to microbial strains including Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans. Antimicrobial activity was assessed using agar diffusion assays and microbial viability assays.\u0000 \u0000 \u0000 \u0000 The tested orthodontic bonding materials exhibited varying degrees of antimicrobial activity. Material A showed a zone of inhibition of 12 mm against S. mutans, 8 mm against P. gingivalis, and 6 mm against C. albicans. Material B exhibited slightly higher antimicrobial activity with inhibition zones of 14 mm, 10 mm, and 8 mm against S. mutans, P. gingivalis, and C. albicans, respectively. Material C displayed the highest antimicrobial activity, with inhibition zones of 16 mm against S. mutans, 12 mm against P. gingivalis, and 10 mm against C. albicans. Microbial viability assays confirmed the efficacy of these materials in reducing microbial growth.\u0000 \u0000 \u0000 \u0000 Our findings demonstrate that orthodontic bonding materials possess varying degrees of antimicrobial properties. Material C exhibited the highest efficacy against the tested microbial strains. Incorporating antimicrobial agents into orthodontic bonding materials may contribute to the prevention of oral infections during orthodontic treatment.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"199 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cone Beam Computerized Tomography: Effects of Maxillary Bones and Their Influence on the Point of Next Teeth and Canine Development","authors":"Gauravardhan Kulkarni, Ram Kishore Ratre, Suran Pushpa, Suneetha Pobbithi, Parag S. Deshmukh, Rakesh Nagaraju, Nandita Gautam","doi":"10.4103/jpbs.jpbs_245_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_245_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 In this study, individuals with unilateral palatally shifted canines had cone beam computed tomography (CBCT) image palatally displaced canine (PDC) and non-PDC sides investigate the anatomy of their upper teeth adopting a “surface matching” approach.\u0000 \u0000 \u0000 \u0000 The CBCT scans of an overall of 28 people with unilateral PDC were chosen. Every single tooth in research was broken down and turned into a three-dimensional structure utilizing identical research programs, which made it possible to quantify the total length of the tooth root.\u0000 \u0000 \u0000 \u0000 Assessing the lateral incisor (LI) roots quantities and widths of the control category, non-PDC side, and PDC sides revealed statistically significant variations (P < 0.001).\u0000 \u0000 \u0000 \u0000 Compared to contra-lateral LIs, LIs next to PDCs possess small roots. In addition, patients with unilateral PDCs had structural abnormalities between their canines and LIs.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 0","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Healthcare Skill Gap: A Higher Education Perspective: A Data Base Research","authors":"S. Chowhan, M. Bagrecha, S. K. Sharma, Anu Sumi Issac, Darshana Bennadi, Vimal Satodiya, Rahul Tiwari","doi":"10.4103/jpbs.jpbs_257_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_257_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 There is a rising demand for highly qualified workers in today’s ever-changing healthcare job environment. Recognizing higher education’s critical role in closing the healthcare skill gap is critical for the long-term growth and prosperity of individuals, healthcare organizations, and the larger economy.\u0000 \u0000 \u0000 \u0000 Within the healthcare sector, education emerges as a pivotal mechanism to address the prevailing skill gap. Universities and colleges offer a wide range of academic programs meticulously designed to cultivate critical thinking, problem-solving capabilities, effective communication, and collaborative teamwork among students. Furthermore, higher education institutions actively collaborate with healthcare employers to tailor specialized programs that precisely align with the requirements of various healthcare roles.\u0000 \u0000 \u0000 \u0000 This paper delves into the multi-faceted ways in which universities and colleges can significantly contribute to mitigating the healthcare skills gap. The author emphasizes the critical role played by education in bridging this gap, ensuring that the healthcare workforce is suitably equipped to navigate the swiftly changing job market.\u0000 \u0000 \u0000 \u0000 By promoting partnerships with industry stakeholders, developing pertinent academic curricula, and offering continuous professional development opportunities, educational institutions empower individuals and healthcare organizations to excel within the dynamic landscape of healthcare delivery.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring Vitality: The Science and Practice of Pulp Revascularization in Endodontics","authors":"Krishna P. Biswas, Dhaval Desai, K. V. Shetty, Delphia Thomas, Aditi Gupta, Sachin Metkari, Rashmi Laddha","doi":"10.4103/jpbs.jpbs_79_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_79_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 Pulp revascularization is an emerging treatment modality in endodontics aimed at preserving the vitality and function of immature permanent teeth with necrotic pulp and apical periodontitis. This review provides a comprehensive examination of the current state of pulp revascularization, encompassing its rationale, clinical procedures, indications, contraindications, advantages, limitations, and potential future prospects. By critically analyzing the existing literature and clinical experiences, this review aims to offer insights into the efficacy, challenges, and potential advancements in the field of pulp revascularization.","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E3 Ubiquitin Ligases and Their Therapeutic Applications in Cancers: Narrative Review","authors":"Azfar Jamal","doi":"10.4103/jpbs.jpbs_134_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_134_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 E3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction. Since many cancer-related proteins, including both oncogenic and tumor-suppressive ones, are controlled by the ubiquitin-proteasome system, E3 ligases have drawn a great deal of interest as potential targets for the creation of anti-cancer drugs. This is because E3 ligases function as modules that select the substrates that are intended for degradation, giving them the ability to particularly affect proteins that are connected to cancer. Their molecular properties and the ways in which they work serve as the basis for these distinctions. Investment in the creation of bioactive substances that can target E3 ligases is essential given the crucial roles they play in cancer. These substances have the potential to be powerful cancer-fighting tools. In this review, we explore the crucial roles that E3 ligases play in the biology of cancer. We also examine the current bioactive substances that have been created to target different E3 ligases, emphasizing their potential as candidates for treating the cancers.","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 31","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Surgical Techniques for Correction of Mandibular Asymmetry in TMJ Ankylosis Patients","authors":"Samir Mansuri, S. Hemavathy, Annaluru Sri Sasank Tejaswee, Lakshmi Manasa Pappu, Harvey Thomas, Lipsa Bhuyan, Sunil Kumar Gulia","doi":"10.4103/jpbs.jpbs_304_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_304_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Temporomandibular joint (TMJ) ankylosis frequently results in mandibular asymmetry, which impairs an affected person’s ability to function and look good. Because of the intricacy of TMJ ankylosis and the variety of surgical procedures available, correcting mandibular asymmetry surgically can be difficult.\u0000 \u0000 \u0000 \u0000 Patients with mandibular asymmetry and TMJ ankylosis who had surgery at a tertiary care facility between certain periods were the subject of a retrospective investigation. Medical records were used to gather information on patient demographics, pre-operative imaging, surgical methods, and post-operative results. Surgical methods included condylectomy with or without reconstruction, joint reconstruction with or without orthognathic surgery, and unilateral or bilateral mandibular distraction osteogenesis (MDO). Occlusion, patient-reported results, and facial symmetry made up the evaluation criteria.\u0000 \u0000 \u0000 \u0000 The study had a total of 50 patients, with different surgical method distributions. Comparing unilateral and bilateral MDO to condylectomy and joint reconstruction, notable gains in face symmetry and occlusion were seen. The largest complication rate was seen with condylectomy, mostly from recurrence and device-related issues, albeit the rates of other procedures varied as well.\u0000 \u0000 \u0000 \u0000 In conclusion, customized treatment planning is necessary for the correction of mandibular asymmetry in individuals with TMJ ankylosis. Although mandibular distraction osteogenesis produces better results for occlusion and facial symmetry, it is crucial to carefully weigh the risks involved. While still feasible treatments, condylectomy and joint reconstruction require strict monitoring for any consequences. In order to enhance patient care in this difficult patient group, future research should concentrate on improving treatment procedures and long-term results.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Various Irrigation Solutions in Root Canal Treatment","authors":"M. Mirza, Kirti Sharma, Chitharanjan Shetty, Jayantika Gupta, Kinjal Padariya, Hitesh Chohan, Alen Pius","doi":"10.4103/jpbs.jpbs_276_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_276_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 “Root canal treatment (RCT)” is essential in preserving natural dentition by eliminating infection within the root canal system. Irrigation solutions play a crucial role in achieving successful RCT outcomes by facilitating disinfection and debris removal.\u0000 \u0000 \u0000 \u0000 An in vitro experimental design was employed to evaluate the irrigation solutions. Antimicrobial efficacy was assessed using agar diffusion assays against Enterococcus faecalis and Candida albicans. Tissue dissolution ability was evaluated by measuring the weight loss of dentin specimens. Cytotoxicity was assessed using cell viability assays with human periodontal ligament fibroblasts.\u0000 \u0000 \u0000 \u0000 NaOCl demonstrated the highest antimicrobial efficacy, while EDTA exhibited superior tissue dissolution ability. CHX and QMix displayed lower cytotoxicity compared to NaOCl and EDTA.\u0000 \u0000 \u0000 \u0000 The choice of irrigation solution in RCT should consider factors such as antimicrobial efficacy, tissue dissolution ability, and cytotoxicity. NaOCl remains effective but has high cytotoxicity, whereas CHX and QMix offer alternatives with lower cytotoxicity. EDTA is effective in tissue dissolution but should be used cautiously due to cytotoxic potential. Clinicians should weigh the benefits and limitations of each solution for optimal treatment outcomes.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Rib Fracture and Absence of Traumatic History in a Patient with Surgically Corrected Scoliosis: A Case Study","authors":"F. Abuguyan","doi":"10.4103/jpbs.jpbs_103_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_103_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 This case report is unique due to the rare combination of a history of no trauma and a history of scoliosis correction surgery with instrumentation performed 1 year before presentation. A 23-year-old male patient presented to the emergency department in a stable condition and he looked well. He was able to walk without any limitation, but complained of left upper back pain for 2 days after a sneezing episode. The patient denied history of chest pain, shortness of breath, cough, palpitation, headache, dizziness, nausea, vomiting, and abdominal pain. The chest X-ray showed left first rib fracture, and computed tomography scan of the chest without contrast that was performed to diagnose rib fracture or complications confirmed the diagnosis. This case study concludes that the left first rib fracture is rare in postoperative scoliosis without a history of trauma.","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 41","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Impact of Different Surgical Techniques on Nerve Function and Sensation after Maxillofacial Surgery","authors":"Rajbir K. Randhawa, Ankita Dixit, Trisha Mehta, P. V. Bansal, Gagandeep S. Randhawa, Swarnav Patnaik","doi":"10.4103/jpbs.jpbs_415_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_415_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 One potential long-term side effect of surgery in the oral and maxillofacial region is neurosensory impairment. Due to their physical proximity to the surgical location, the lingual nerve (LN) and inferior alveolar nerve (IAN), two sensory segments of the trigeminal nerve, are always susceptible to damage during third molar extraction.\u0000 \u0000 \u0000 \u0000 Assessment of the impact of different surgical techniques on nerve function and sensation after maxillofacial surgery.\u0000 \u0000 \u0000 \u0000 There was retrieval of information from medical records of study participants regarding the presence of symptoms like paresthesia, numbness, loss of sensation in lower lip, difficulty in movement of tongue, and all other findings observed after 7 days of surgical procedures. Clinically neurosensory examinations were utilized to assess nerve damage. Pinprick testing and the two-point discrimination test were used.\u0000 \u0000 \u0000 \u0000 Seven male patients were found to have damage to LN while nine males suffered damage to trigeminal nerve. 12 female patients were found to have damage to LN while 16 females suffered damage to trigeminal nerve. In total 19 patients suffered damage to LN while 25 patients suffered damage to trigeminal nerve.\u0000 \u0000 \u0000 \u0000 The incidence of LN damage was 9.5%, and the incidence of trigeminal nerve damage was 12.5%.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 73","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}