Journal of Pharmacy and Bioallied Sciences最新文献

{"title":"Comparative Analysis of the Color Stability of Machined Denture Base Materials: An In-Vitro Approach","authors":"S. Sultan, M. Salloum","doi":"10.4103/jpbs.jpbs_332_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_332_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Color stability is a crucial aspect in the selection of denture base materials as it directly impacts the esthetic appeal and longevity of dental prostheses. This study aimed to compare the color stability of different denture base materials through an in vitro approach.\u0000 \u0000 \u0000 \u0000 Three machined denture base materials including polymethyl methacrylate (PMMA), Acetal (AC), and polyether ether ketone (PEEK) were subjected to artificial aging using a xenon-arc lamp. Color measurements were taken before and after aging using a spectrophotometer. Statistical analysis was performed to determine any significant differences among the materials.\u0000 \u0000 \u0000 \u0000 The color stability of the denture base materials was quantitatively assessed using parameters such as ΔE values. PEEK exhibited the least color change (ΔE = 2.1 ± 0.3), followed by AC (ΔE = 3.5 ± 0.4), while PMMA showed the highest color change (ΔE = 5.9 ± 0.7).\u0000 \u0000 \u0000 \u0000 In this in vitro study, PEEK demonstrated superior color stability compared to AC and PMMA denture base materials under artificial aging conditions. These findings emphasize the importance of material selection in achieving long-term esthetic outcomes in dental prostheses.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Giant Cell Granuloma – A Case Report of a 9-Year-Old Male Child","authors":"Moitrayee Sharma, M. Sarma, Devajit Choudhury, Sindhu S Rao, BS Santosh, Asim Debnath, Muktanjalee Deka","doi":"10.4103/jpbs.jpbs_88_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_88_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 “Giant cell epulis” nowadays known as “peripheral giant cell granuloma” (PGCG) is a soft tissue benign overgrowth seen in the oral cavity. It is a type of reactive exophytic lesion of gingiva whose etiology is still not specific. Peripheral giant cell lesion may not be a life-threatening condition but when the size of the lesion exceeds a certain limit it hampers day-to-day activity of the oral cavity. It may also have a psychological effect on the person. We report a case of a 9-year-old boy with a large peripheral giant cell lesion, which interfered with his chewing habits. The purpose of reporting this case is to create awareness about peripheral giant cell lesions and its treatment modality.\u0000 \u0000 \u0000 \u0000 Under general anesthesia, the soft tissue growth was excised using an electrocautery that was approximately 5.3 cm in length and 2 cm in width.\u0000 \u0000 \u0000 \u0000 The patient was reviewed on the 7th day (postoperative), followed by 10, 20, and 30 days. After this, the patient was reviewed monthly for 6 months. Healing was successful without any events.\u0000 \u0000 \u0000 \u0000 Proper history taking is mandatory before coming to a final diagnosis. Various diagnostic aids help in coming to a confirmatory diagnosis. Complete surgical excision and elimination of any irritant factor along with clearing of the base of the lesion is mandatory to avoid recurrence rate and have a complete uneventful healing.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment for Trigeminal Neuralgia Revisited for Longer Remission: A Series of 56 Cases","authors":"G. Brar, S. P. Sodhi","doi":"10.4103/jpbs.jpbs_191_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_191_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 The primary challenge associated with peripheral neurectomy is the occurrence of spontaneous nerve regeneration. This study focused on addressing this issue by employing a novel approach involving the use of sticky (steaky) bone to obliterate the foramina post-peripheral neurectomy. The study involved 56 patients diagnosed with trigeminal neuralgia, divided into two groups. In group I, the proximal nerve stump in the foramina was chemically cauterized after peripheral neurectomy, while in group II, sticky bone was used to obliterate the foramina. After a 2-year follow-up period, group II exhibited a significant improvement in the mean Visual Analogue Scale scores. Additionally, cone-beam computed tomography analysis revealed a noteworthy reduction in the size of the foramina in group II at 2 years post-operatively.","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 24","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of the Frictional Resistance of Various Archwire-Ligature Combinations in Orthodontics","authors":"M. K. Alam, M. Z. Alfuhigi, M. Y. Hajeer, F. N. Alsenani, F. A. Eldosary, L. N. Alsayil","doi":"10.4103/jpbs.jpbs_324_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_324_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Frictional resistance is a critical factor influencing the efficacy of orthodontic treatment. Archwire-ligature combinations play a significant role in determining frictional forces within the orthodontic system. This study aimed to conduct a comparative analysis of the frictional resistance exhibited by various archwire-ligature combinations commonly used in orthodontics.\u0000 \u0000 \u0000 \u0000 A total of five archwire-ligature combinations were evaluated in this study: stainless steel archwire with elastic ligatures, stainless steel archwire with metal ligatures, nickel-titanium archwire with elastic ligatures, nickel-titanium archwire with metal ligatures, and beta-titanium archwire with metal ligatures. Frictional resistance was measured using a universal testing machine under standardized conditions, with a constant load applied to simulate clinical conditions.\u0000 \u0000 \u0000 \u0000 The frictional resistance varied significantly among the different archwire-ligature combinations. The mean frictional resistance values (in arbitrary units) recorded were as follows: stainless steel archwire with elastic ligatures (X), stainless steel archwire with metal ligatures (Y), nickel-titanium archwire with elastic ligatures (Z), nickel-titanium archwire with metal ligatures (A), and beta-titanium archwire with metal ligatures (B). Statistical analysis revealed that combination A exhibited the lowest frictional resistance, followed by combination B, combination Z, combination X, and combination Y.\u0000 \u0000 \u0000 \u0000 The choice of archwire-ligature combination significantly affects the frictional resistance within the orthodontic system. Nickel-titanium archwires combined with metal ligatures demonstrated lower frictional resistance compared with stainless steel archwires, regardless of the ligature type. Among the combinations tested, nickel-titanium archwire with metal ligatures exhibited the lowest frictional resistance, suggesting its potential for reducing friction and improving treatment efficiency in orthodontic practice.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 23","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Biocompatibility of Orthodontic Brackets and Wires: An In-Vitro Study","authors":"M. K. Alam, M. Z. Alfuhigi, M. Y. Hajeer, Mohammed Abdullah Alrubaysh, Moath Ahmad Alslai, Abdulmajeed Fehaid Alsabilah","doi":"10.4103/jpbs.jpbs_325_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_325_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Orthodontic treatment involves the use of various materials, including brackets and wires, which come into direct contact with oral tissues. Biocompatibility of these materials is crucial to ensure patient safety and treatment success. This study aims to evaluate the biocompatibility of orthodontic brackets and wires through an in-vitro investigation.\u0000 \u0000 \u0000 \u0000 Orthodontic brackets and wires commonly used in clinical practice were selected for this study. A series of in-vitro tests were conducted to assess the biocompatibility of these materials. Cell culture assays were performed to evaluate cytotoxicity, cell proliferation, and inflammatory response. In addition, scanning electron microscopy (SEM) was used to examine the surface characteristics of the materials.\u0000 \u0000 \u0000 \u0000 The cytotoxicity assays revealed minimal adverse effects on cell viability, with cell viability percentages ranging from 90% to 95% for all materials tested. Cell proliferation assays demonstrated similar rates of cell growth on the surfaces of both brackets and wires. SEM analysis indicated smooth surfaces with minimal irregularities, suggesting favorable biocompatibility.\u0000 \u0000 \u0000 \u0000 The findings of this in-vitro study suggest that the orthodontic brackets and wires examined exhibit satisfactory biocompatibility characteristics. Minimal cytotoxicity and favorable cell proliferation indicate that these materials are well suited for use in orthodontic treatment. Further clinical studies are warranted to validate these findings and ensure the safety and efficacy of orthodontic appliances in patient care.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 28","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Surface Roughness of Different Denture Teeth Materials: A Quantitative In-Vitro Study","authors":"S. Sultan, M. Salloum","doi":"10.4103/jpbs.jpbs_333_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_333_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 The surface roughness of denture teeth materials significantly influences their clinical performance and patient satisfaction. Understanding the variations in surface roughness among different materials is crucial for optimizing denture fabrication processes.\u0000 \u0000 \u0000 \u0000 In this quantitative in-vitro study, three commonly used denture teeth materials, namely acrylic resin, composite resin, and porcelain, were evaluated for surface roughness. Twenty samples of each material were prepared and subjected to profilometric analysis. The surface roughness parameters Ra and Rz were measured using a contact profilometer. Statistical analysis was performed to compare the surface roughness among the different materials.\u0000 \u0000 \u0000 \u0000 The mean surface roughness (Ra) values were found to be 0.32 μm for acrylic resin, 0.25 μm for composite resin, and 0.18 μm for porcelain. Similarly, the mean Rz values were 2.45 μm for acrylic resin, 1.98 μm for composite resin, and 1.62 μm for porcelain. Statistical analysis revealed significant differences in surface roughness among the three materials (P < 0.05).\u0000 \u0000 \u0000 \u0000 Porcelain denture teeth exhibited the smoothest surface, followed by composite resin and acrylic resin. These findings suggest that material selection plays a crucial role in determining the surface roughness of denture teeth. Porcelain may offer superior aesthetics and reduced plaque accumulation compared with acrylic and composite resin materials. Clinicians should consider these differences when choosing denture materials to achieve optimal clinical outcomes and patient satisfaction.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 21","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Assessment of the Fracture Resistance of Different Prosthodontic Materials for Fixed Dental Prostheses","authors":"S. Sultan, N. H. S. Almuhyi, Khalid Maziad Alzabni, Rayan Hamad Qubayl Alruwaili","doi":"10.4103/jpbs.jpbs_331_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_331_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Fixed dental prostheses (FDPs) are commonly used in prosthodontics to restore missing teeth and improve oral function and esthetics. The selection of prosthodontic materials significantly impacts the fracture resistance of FDPs, thus influencing their clinical success. This study aimed to assess the fracture resistance of different prosthodontic materials commonly used in FDPs through in vitro testing.\u0000 \u0000 \u0000 \u0000 Thirty standardized FDP specimens were fabricated using three different materials: Monolithic zirconia, heat press lithium disilicate, and metal ceramic. Each group consisted of ten specimens. The specimens were subjected to standardized loading using a universal testing machine until fracture occurred. Fracture resistance values were recorded in Newtons (N) and statistically analyzed using one-way analysis of variance (ANOVA) followed by post-hoc Tukey tests.\u0000 \u0000 \u0000 \u0000 The mean fracture resistance values for the three materials were as follows: zirconia, 1450 N; lithium disilicate, 1200 N; and metal ceramic, 950 N. Statistical analysis revealed a significant difference among the groups (P < 0.05). Post hoc Tukey tests indicated that zirconia exhibited significantly higher fracture resistance compared to lithium disilicate and metal ceramic (P < 0.05). However, there was no significant difference in fracture resistance between lithium disilicate and metal-ceramic groups (P > 0.05).\u0000 \u0000 \u0000 \u0000 Within the limitations of this in vitro study, zirconia demonstrated the highest fracture resistance among the tested materials for FDPs, followed by lithium disilicate and metal ceramic. The findings highlight the importance of material selection in achieving optimal clinical outcomes and longevity of fixed dental prostheses.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Cellular Response to Different Dental Implant Surfaces: An In vitro Study","authors":"M. Sghaireen, M. Alrwuili, Nasser Attallah Alenzi, Mohammed Ahmed Aljabab, Rakhi Issrani, M. K. Alam","doi":"10.4103/jpbs.jpbs_329_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_329_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Dental implant surfaces play a crucial role in determining the success of osseointegration and long-term stability. Understanding the cellular response to various implant surfaces is essential for optimizing implant design and clinical outcomes.\u0000 \u0000 \u0000 \u0000 In this in vitro study, we investigated the cellular response to different dental implant surfaces. Titanium implants with three distinct surface treatments (polished, acid-etched, and sandblasted) were prepared. Human osteoblast-like cells were cultured on these surfaces, and cellular behaviors including adhesion, proliferation, and morphology were evaluated using standard assays and imaging techniques.\u0000 \u0000 \u0000 \u0000 Our results revealed significant differences in cellular responses among the different implant surfaces. Cells exhibited higher adhesion and proliferation rates on the acid-etched and sandblasted surfaces compared to the polished surface. Furthermore, cells displayed a more spread-out morphology with well-defined filopodia and lamellipodia on the acid-etched and sandblasted surfaces, indicating enhanced cellular interaction and spreading.\u0000 \u0000 \u0000 \u0000 The cellular response to dental implant surfaces varies depending on surface characteristics. Acid-etched and sandblasted surfaces promote better cellular adhesion, proliferation, and spreading compared to polished surfaces. These findings underscore the importance of surface modifications in enhancing osseointegration and ultimately improving the success rates of dental implant procedures.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 39","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141370268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Marginal Fit of Virgilite Based Lithium Disilicate Ceramic Crowns: An In-Vitro Comparative Study","authors":"S. Sultan, Khaled Ahmad Saud Alsabilah, Bader Mahali Alharbi, Addulrhman Fahad Alnaser","doi":"10.4103/jpbs.jpbs_330_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_330_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Achieving optimal marginal fit is essential for the success of Virgilite Based Lithium Disilicate Ceramic crowns.\u0000 \u0000 \u0000 \u0000 In this in-vitro study, we compared the marginal fit of Virgilite Based Lithium Disilicate Ceramic crowns using two different CAD/CAM scanners, powder free (System A, Omnicam) and powder based (System B, Blue cam).\u0000 \u0000 \u0000 \u0000 The mean marginal gap for System A was found to be 63.5 μm (standard deviation ± 10.2 μm), while for System B, it was 57.8 μm (standard deviation ± 9.8 μm). System B demonstrated a slightly superior marginal fit compared to System A, with a difference of 5.7 μm.\u0000 \u0000 \u0000 \u0000 Within the limitations of this study, it can be concluded that both Omnicam and Blue cam produced clinically acceptable marginal fit of Virgilite Based Lithium Disilicate Ceramic crowns. However, Blue cam exhibited a slightly better marginal fit compared to Omnicam. Further clinical studies are warranted to validate these findings.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 45","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141370685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Vitro Study of Osseointegration: Evaluating the Influence of Surface Modifications on Dental Implant Stability","authors":"M. Sghaireen, M. K. Alam, Ahmed Azhari Salih Mohamedeissa, J. Kazma","doi":"10.4103/jpbs.jpbs_328_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_328_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Osseointegration is critical for the success of dental implants. Surface modifications of dental implants play a crucial role in enhancing osseointegration and implant stability. This in-vitro study aims to evaluate the influence of various surface modifications on dental implant stability.\u0000 \u0000 \u0000 \u0000 Dental implants with different surface modifications were prepared and subjected to in-vitro testing. Surface modifications included sandblasting, acid etching, and plasma spraying. Implant stability was assessed using resonance frequency analysis (RFA) and pull-out tests. Statistical analysis was performed to compare the stability of implants with different surface modifications.\u0000 \u0000 \u0000 \u0000 The results showed that implants with sandblasted and acid-etched surfaces exhibited significantly higher stability compared with those with only a machined surface. The mean RFA values for sandblasted and acid-etched implants were 75 ± 5 and 80 ± 6, respectively, whereas machined implants recorded a mean RFA value of 60 ± 4. Similarly, pull-out tests demonstrated higher maximum tensile strengths for sandblasted and acid-etched implants compared with machined implants.\u0000 \u0000 \u0000 \u0000 Surface modifications, such as sandblasting and acid etching, significantly enhance dental implant stability in vitro. These modifications promote better osseointegration, which is crucial for the long-term success of dental implants in clinical practice.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":" 40","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141370418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}