Journal of Pharmacy and Bioallied Sciences最新文献

{"title":"Exploring the Therapeutic Potential of Omega-3 Fatty Acid Supplementation in Dry Eye Syndrome: An In vitro Investigation","authors":"Abdulmajeed Alharbi","doi":"10.4103/jpbs.jpbs_367_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_367_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Dry eye syndrome (DES) is a prevalent ocular condition characterized by insufficient tear production or excessive tear evaporation, leading to discomfort and visual disturbances. Omega-3 fatty acids have been proposed as a potential therapeutic intervention for DES due to their anti-inflammatory and lipid modulation properties.\u0000 \u0000 \u0000 \u0000 Cultured human corneal epithelial cells were exposed to various concentrations of omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for 72 h. Cell viability was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, while inflammatory cytokine levels (interleukin-6 (IL-6), interleukin-8 (IL-8)) and lipid profile (measured by lipid staining) were evaluated using enzyme-linked immunosorbent assay. Untreated cells served as controls for comparison.\u0000 \u0000 \u0000 \u0000 Omega-3 fatty acid supplementation demonstrated a dose-dependent increase in cell viability compared to untreated cells. At optimal concentrations, EPA and DHA significantly enhanced cell viability by 30% and 35%, respectively (P < 0.05). Moreover, omega-3 fatty acid supplementation led to a significant reduction in inflammatory cytokine levels, with a 50% decrease in IL-6 and IL-8 secretion compared to untreated cells (P < 0.01). Additionally, lipid staining revealed improved lipid profile and organization in corneal epithelial cells following omega-3 fatty acid supplementation, indicative of enhanced tear film stability.\u0000 \u0000 \u0000 \u0000 \u0000 In vitro findings suggest that omega-3 fatty acid supplementation exerts beneficial effects on cellular markers associated with DES.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141652709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schoolchildren’s Musculoskeletal Pain and Backpack Weight Impact on Posture: A Short-Term Study","authors":"Nishath A Ahmed, M. M. Ahmed, Nida A Ahmed, Afreen Shahid, Gaurav Mittal","doi":"10.4103/jpbs.jpbs_339_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_339_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Research indicates heavy backpacks can cause students to adjust their posture, potentially harming their spine and shoulders. This study focuses on musculoskeletal pain in schoolchildren in Bangalore, attributed to backpack weight, and examines postural impacts in both urban and rural settings.\u0000 \u0000 \u0000 \u0000 With consent, 500 students from various schools underwent physical measurements, including backpack weight, and provided data through questionnaires. Postural angles were assessed without backpacks to determine the impact of weight.\u0000 \u0000 \u0000 \u0000 On average, students carried backpacks weighing 6.53 kg, about 13.53% of their body weight. Pain was reported by 50.9% of boys and 63.9% of girls, with a higher incidence among girls from private schools (88.2%) compared to boys from government schools (51.6%).\u0000 \u0000 \u0000 \u0000 A significant link was found between heavier backpacks and decreased craniovertebral angle, head on neck (HON), and head and neck on trunk (HNOT) angles, aligning with increased pain prevalence. This underscores the health risks of heavy school backpacks and the need for weight management.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"63 19","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141654390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of C-Reactive Proteins Levels in Peri-Implantitis Patients","authors":"Megha Sharma, A. P. Singh, Barun Kumar, Puneet Girdhar, Arundeep S Brar, Pooja Mittal","doi":"10.4103/jpbs.jpbs_428_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_428_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 To evaluate C-reactive protein (CRP) levels in peri-implantitis patients.\u0000 \u0000 \u0000 \u0000 This study comprised a total of 100 participants. Fifty participants with a confirmed clinical and radiological diagnosis of peri-implantitis formed one group. Another group of 50 volunteers who came in for a normal health checkup served as healthy controls. All the patients were recalled in the morning. Fasting venous blood samples were collected. CRP concentrations in the laboratory were determined using an auto-analyzer.\u0000 \u0000 \u0000 \u0000 In this study, there were 40 females and 60 males. Mean CRP levels among subjects of the peri-implantitis group and the control group were 0.615 and 0.201 mg/dL, respectively.\u0000 \u0000 \u0000 \u0000 It was observed that mean CRP levels were higher among subjects having peri-implantitis as compared to the controls.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"50 19","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141654653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Knowledge of Infection Control Practice of Healthcare Workers","authors":"G. R. Rahman, Amiya Bhaumik","doi":"10.4103/jpbs.jpbs_344_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_344_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Healthcare-associated infections (HAIs), also known as nosocomial infections, are a significant risk in hospitals, leading to increased morbidity and mortality among patients due to poor hygiene practices.\u0000 \u0000 \u0000 \u0000 This descriptive study involved 350 participants from Wuhan’s private hospitals. Respondents answered a questionnaire distributed in person or via email, and data were analyzed using SPSS version 25.0.\u0000 \u0000 \u0000 \u0000 Analysis revealed a knowledge gap among healthcare workers in infection control, affecting their ability to maintain hospital cleanliness. Education levels were assessed, showing that 60% of participants held diplomas or higher qualifications.\u0000 \u0000 \u0000 \u0000 The study highlights the urgent need for enhanced training and information dissemination on infection control practices among healthcare staff. Identifying this knowledge and practice gap is crucial for improving hospital hygiene and reducing HAI incidence.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"47 18","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141654844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Warm and Cold Gutta-Percha Techniques for Root Canal Filling: An In Vitro Study","authors":"B. Swathika, S. Basheer, S. Sriram, Sujith Rajmohan, Sabari Murugesan, S. Subramani","doi":"10.4103/jpbs.jpbs_404_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_404_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Gutta-percha is commonly used in endodontic therapy for obturating root canals after cleaning and shaping procedures. Warm and cold gutta-percha techniques are two common methods employed for obturation, each with its own advantages and limitations.\u0000 \u0000 \u0000 \u0000 Twenty extracted human teeth with single-rooted canals were selected and divided into two groups: warm gutta-percha obturation and cold gutta-percha obturation. In the warm gutta-percha group, gutta-percha was heated to a predetermined temperature using a warm gutta-percha heating device and injected into the root canal using a heated carrier. In the cold gutta-percha group, gutta-percha was applied directly to the root canal without prior heating. Root canal obturation quality was assessed using radiographic imaging to evaluate the presence of voids, completeness of obturation, and adaptation to the canal walls. Micro-computed tomography (micro-CT) analysis was also performed to quantify the volume of obturating material and assess the three-dimensional distribution of gutta-percha within the root canal space.\u0000 \u0000 \u0000 \u0000 Both warm and cold gutta-percha techniques demonstrated effective obturation of root canals, with comparable outcomes in terms of void formation, completeness of obturation, and adaptation to canal walls. However, micro-CT analysis revealed differences in the volume and distribution of gutta-percha within the root canal space. Warm gutta-percha obturation exhibited more uniform distribution of gutta-percha material and higher volumetric filling compared to cold gutta-percha obturation. Additionally, the warm gutta-percha technique demonstrated superior flowability and adaptation to irregularities within the root canal system.\u0000 \u0000 \u0000 \u0000 In this in vitro study, warm gutta-percha obturation demonstrated advantages over cold gutta-percha obturation in terms of volumetric filling, distribution within the root canal space, and adaptation to canal irregularities.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"21 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141654944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Surgical Techniques for Pterygium Management: An In Vitro Study","authors":"Abdulmajeed Alharbi","doi":"10.4103/jpbs.jpbs_361_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_361_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Pterygium is a common ocular surface disorder characterized by the growth of fibrovascular tissue onto the cornea, leading to discomfort and visual impairment. Various surgical techniques, including conjunctival autografting, amniotic membrane transplantation, and bare sclera excision, are employed in the management of pterygium.\u0000 \u0000 \u0000 \u0000 Cultured human conjunctival epithelial cells were subjected to simulated pterygium conditions, mimicking the fibrovascular proliferation observed in vivo. Subsequently, different surgical techniques, including conjunctival autografting, amniotic membrane transplantation, and bare sclera excision, were simulated in vitro. Cell viability, proliferation, migration, and inflammatory cytokine expression were assessed using various assays, including MTT assay, scratch assay, and enzyme-linked immunosorbent assay (ELISA). Untreated cells served as controls for comparison.\u0000 \u0000 \u0000 \u0000 Conjunctival autografting demonstrated superior outcomes in terms of cell viability and proliferation compared to amniotic membrane transplantation and bare sclera excision. Autografted cells exhibited a significantly higher percentage of viable cells and enhanced proliferative capacity compared to cells subjected to other surgical techniques (P < 0.05). Additionally, conjunctival autografting promoted faster cell migration into the defect area, resulting in more rapid wound closure compared to other techniques. Furthermore, reduced expression of inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), was observed in cells treated with conjunctival autografts compared to other groups.\u0000 \u0000 \u0000 \u0000 \u0000 In vitro findings suggest that conjunctival autografting may offer superior outcomes in the management of pterygium compared to amniotic membrane transplantation and bare sclera excision.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"23 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141653908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Tele-Orthodontics in Enhancing Patient Compliance and Treatment Monitoring","authors":"S. Almoammar","doi":"10.4103/jpbs.jpbs_368_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_368_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Tele-orthodontics, the application of telecommunications technology in orthodontic care, has emerged as a promising tool to enhance patient compliance and facilitate treatment monitoring. In traditional orthodontic practice, patient compliance and monitoring are pivotal but often challenging aspects. Tele-orthodontics offers a solution by providing remote communication and monitoring capabilities, potentially improving patient engagement and treatment outcomes.\u0000 \u0000 \u0000 \u0000 This study conducted a retrospective analysis of orthodontic patients who utilized tele-orthodontics as part of their treatment plan. A total of 100 patients were included in the study, with ages ranging from 12 to 40 years old. Patients were provided with mobile applications or web-based platforms enabling them to communicate with their orthodontists, submit progress images, and receive feedback remotely. Treatment compliance was assessed based on adherence to scheduled appointments, wearing of orthodontic appliances, and completion of prescribed exercises.\u0000 \u0000 \u0000 \u0000 The analysis revealed a significant improvement in patient compliance with the implementation of tele-orthodontics. Adherence to scheduled appointments increased by 30%, with patients attending 95% of their appointments compared to 65% before the introduction of tele-orthodontics. Moreover, compliance with wearing orthodontic appliances showed a remarkable rise, with patients consistently wearing their appliances for an average of 22 h per day, up from 14 h per day previously. Additionally, the completion rate of prescribed exercises saw a notable enhancement, with 80% of patients completing their exercises as instructed, compared to 50% previously.\u0000 \u0000 \u0000 \u0000 Tele-orthodontics plays a significant role in enhancing patient compliance and treatment monitoring in orthodontic care. The remote communication and monitoring capabilities provided by tele-orthodontic platforms empower patients to actively participate in their treatment process, leading to improved adherence to appointments, better compliance with wearing orthodontic appliances, and increased completion of prescribed exercises. These findings underscore the importance of integrating tele-orthodontics into orthodontic practice to optimize patient outcomes and satisfaction.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"39 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141652310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Zirconia Crowns Versus Metal Crowns in Anterior Teeth: In vitro Study","authors":"N. Alharethi","doi":"10.4103/jpbs.jpbs_369_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_369_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 The selection between Zirconia crowns and metal crowns for anterior teeth restorations is pivotal in prosthodontics due to their distinct properties. However, a comprehensive investigation into their effectiveness in anterior tooth restorations is warranted.\u0000 \u0000 \u0000 \u0000 This in vitro study aimed to compare the effectiveness of Zirconia crowns and metal crowns in anterior teeth restorations. A total of thirty extracted human maxillary central incisors were prepared to receive crowns and randomly allocated into two groups: group A, zirconia crowns; and group B, metal crowns. The crowns were fabricated following standardized protocols and cemented onto the prepared teeth. Various tests, including fracture resistance, marginal adaptation, and color-matching assessment, were conducted on the samples.\u0000 \u0000 \u0000 \u0000 The mean fracture resistance of Zirconia crowns (Group A) was determined to be 320 N (SD ± 25), whereas it was 280 N (SD ± 30) for metal crowns (Group B). Marginal adaptation assessment revealed a mean gap width of 50 microns (SD ± 10) for Zirconia crowns and 70 microns (SD ± 15) for metal crowns. Evaluation of color matching showed a higher percentage of acceptable matches for Zirconia crowns compared to metal crowns.\u0000 \u0000 \u0000 \u0000 Zirconia crowns exhibited superior fracture resistance, marginal adaptation, and color matching in comparison to metal crowns for anterior teeth restorations. These findings advocate for Zirconia crowns as a more effective choice for restoring anterior teeth, offering both strength and esthetic appeal.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"40 15","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Different Behavioral Management Techniques in Treating Anxious Pediatric Dental Patients","authors":"Z. Alkahtani","doi":"10.4103/jpbs.jpbs_362_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_362_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Pediatric dental anxiety poses a significant challenge in the delivery of dental care, often resulting in compromised treatment outcomes and negative experiences for both patients and dental professionals.\u0000 \u0000 \u0000 \u0000 A randomized controlled trial (RCT) was conducted involving 120 pediatric dental patients aged 4 to 10 years old, presenting with varying degrees of dental anxiety. Patients were randomly assigned to three groups: Group A received tell-show-do (TSD) technique, Group B received audiovisual distraction (AVD), and Group C received non-pharmacological behavior guidance (NPBG). Anxiety levels were assessed using a standardized anxiety scale before and after the dental procedure. Patient cooperation during treatment, as well as dentist and parent satisfaction, was also evaluated.\u0000 \u0000 \u0000 \u0000 The study revealed significant reductions in anxiety levels across all groups post-treatment. However, Group B (AVD) demonstrated the most substantial reduction in anxiety scores, with a mean decrease of 60% from baseline. Group A (TSD) and Group C (NPBG) showed comparable reductions in anxiety levels, with mean decreases of 45% and 50%, respectively. Patient cooperation during treatment was highest in Group B, followed by Groups C and A. Dentist and parent satisfaction scores were significantly higher in Group B compared to the other groups.\u0000 \u0000 \u0000 \u0000 AVD emerged as the most effective behavioral management technique for treating anxious pediatric dental patients, resulting in significant reductions in anxiety levels and higher levels of patient cooperation during treatment compared to TSD and NPBG techniques.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"42 8","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Precision in Endodontic Procedures: An In vitro Investigation of Magnification and Enhanced Visualization","authors":"S. Ganesan, S. Basheer, Ohm Nijandhan Kumar, Hitesh Chohan, Sabari Murugesan, S. Subramani","doi":"10.4103/jpbs.jpbs_405_24","DOIUrl":"https://doi.org/10.4103/jpbs.jpbs_405_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 Endodontic procedures require precise manipulation and visualization to achieve optimal treatment outcomes. Magnification and enhanced visualization tools, such as dental loupes and dental operating microscopes (DOMs), have been introduced to enhance precision in endodontic practice.\u0000 \u0000 \u0000 \u0000 Extracted human teeth with single-rooted canals were divided into two groups: a control group without magnification and an experimental group with magnification and enhanced visualization. Endodontic procedures, including access cavity preparation, cleaning, shaping, and obturation, were performed on both groups. The experimental group utilized either dental loupes or a DOM for enhanced visualization. Treatment outcomes were assessed based on predefined criteria, including the quality of access cavity preparation, canal cleanliness, shaping, and obturation. Scores were assigned to each criterion to quantify treatment precision.\u0000 \u0000 \u0000 \u0000 The use of magnification and enhanced visualization significantly improved precision in endodontic procedures compared to the control group. Access cavity preparation in the experimental group resulted in more conservative tooth structure removal and improved visualization of canal orifices. Canal cleanliness, shaping, and obturation were markedly superior in the experimental group, with higher scores indicating better precision. The experimental group also exhibited a reduced incidence of procedural errors and complications compared to the control group.\u0000 \u0000 \u0000 \u0000 Magnification and enhanced visualization tools, such as dental loupes and DOMs, enhance precision in endodontic procedures.\u0000","PeriodicalId":16824,"journal":{"name":"Journal of Pharmacy and Bioallied Sciences","volume":"21 7","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141653509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}