Journal of pharmacy practice最新文献_第9页

Managing Resistant Hypertension in Rural Veterans: A Pharmacist-Led Telehealth Approach. 管理顽固性高血压在农村退伍军人：药剂师主导的远程医疗方法。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-06-26 DOI: 10.1177/08971900251356009

Jordan Burnette, Taylor Maynard

{"title":"Managing Resistant Hypertension in Rural Veterans: A Pharmacist-Led Telehealth Approach.","authors":"Jordan Burnette, Taylor Maynard","doi":"10.1177/08971900251356009","DOIUrl":"10.1177/08971900251356009","url":null,"abstract":"This case study explores the role that pharmacists can have managing resistant hypertension (RH) in rural Appalachian veterans, where health care access is limited. RH, defined as blood pressure above target despite adherence to multiple antihypertensive medications, presents challenges in chronic disease management. The Department of Veterans Affairs (VA) has integrated CPPs to improve medication adherence, reduce hospitalizations, and enhance blood pressure control, particularly in underserved areas. The patient, a 65-year-old male veteran with hypertension, obstructive sleep apnea, depression, and PTSD, had struggled with poorly controlled hypertension for years, experiencing adverse reactions to multiple antihypertensive medications. Living more than 60 minutes from the nearest VA facility, he had not seen his primary care provider since early 2021, exacerbating his condition. Despite initial reluctance to restart medications, the CPP implemented a stepwise management approach, utilizing telehealth for remote blood pressure monitoring and regular follow-ups. Over several months, pharmacologic therapy combined with lifestyle modifications led to significant blood pressure improvement. This case highlights the crucial role of CPPs in rural health care, offering accessible, continuous care and personalized management of complex conditions. Telehealth and remote monitoring further facilitated care, overcoming geographic barriers and enhancing patient engagement. The collaboration between pharmacists and specialists ensured comprehensive care and optimized treatment. This case demonstrates the potential for expanding CPP roles in rural areas to improve chronic disease management, reduce health care disparities, and enhance patient outcomes through telehealth and team-based care.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"235-238"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Change in Medication Regimen Complexity-ICU (MRC-ICU) Score Following Implementation of a Virtual Intensive Care Model in a Multisite, Rural Health-System. 在多站点农村卫生系统中实施虚拟重症监护模式后药物治疗方案复杂性- icu （MRC-ICU）评分变化的评估

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-09-06 DOI: 10.1177/08971900251370888

David Mastro, Karen Williams, Joshua Campbell

{"title":"Evaluation of Change in Medication Regimen Complexity-ICU (MRC-ICU) Score Following Implementation of a Virtual Intensive Care Model in a Multisite, Rural Health-System.","authors":"David Mastro, Karen Williams, Joshua Campbell","doi":"10.1177/08971900251370888","DOIUrl":"10.1177/08971900251370888","url":null,"abstract":"Background: Telehealth in the ICU (Tele-ICU) may improve patient outcomes and optimize utilization of high acuity intensive care unit (ICU) beds. However, the relationship between tele-ICU and medication regimen complexity-ICU (MRC-ICU) score is unexplored. Objective: To assess the effect of tele-ICU on MRC-ICU score and describe pharmacists' work. Methods: Adult ICU encounters lasting at least 24 h were retrospectively compared pre- and post- implementation of tele-ICU services in a rural, five-hospital system. The primary outcome was MRC-ICU score 24 h after ICU admission. Prospectively, pharmacist interventions during ICU encounters were captured. Encounters were categorized on exposure to clinical pharmacist review. Results: The difference in mean MRC-ICU score between pre- and post-intervention encounters was -0.2032 (95% CI,-0.8253, 0.4188, P = 0.5217). Post-intervention encounters had a higher rate of thromboembolism prophylaxis (64.5% vs 54.9%, P = 0.001), higher adherence to stress-ulcer prophylaxis (74.1% vs 60.9%, P < 0.001), and a lower presence of glycemic control agent(s) (39.8% vs 46.2%, P = 0.017) 24 h after ICU admission. Tele-ICU services did not significantly change ICU LOS (3.261 vs 3.166 days, P = 0.536), nor ICU mortality (11.1% vs 12.7%, P = 0.377). In the prospective period (n = 196 encounters), 189 interventions were recorded on 80 encounters. There was no difference in median MRC-ICU score at 24 h in encounters with clinical pharmacist review and intervention vs without scheduled clinical pharmacist review (9 vs 8, P = 0.0596). Conclusion: Implementation of Tele-ICU did not change the MRC-ICU score at 24 h, although some ICU bundled care metrics improved. Many encounters lack opportunity for meaningful pharmacy interventions.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"184-192"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greater HIV Viral Load Suppression in Patients Using an Integrated Health System Specialty Pharmacy. 使用综合卫生系统专业药房的患者更大的HIV病毒载量抑制。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-09-04 DOI: 10.1177/08971900251376796

Karen Salomon-Escoto, Martha Stutsky, George Reed, Monica Y Hinestroza Jordan, Jonathan Kay, Mireya Wessolossky

{"title":"Greater HIV Viral Load Suppression in Patients Using an Integrated Health System Specialty Pharmacy.","authors":"Karen Salomon-Escoto, Martha Stutsky, George Reed, Monica Y Hinestroza Jordan, Jonathan Kay, Mireya Wessolossky","doi":"10.1177/08971900251376796","DOIUrl":"10.1177/08971900251376796","url":null,"abstract":"PurposeThis study assessed the impact of an integrated health system specialty pharmacy (HSSP) on viral load (VL) suppression in HIV patients, compared to patients utilizing non-health system specialty pharmacies (non-HSSPs).MethodsThis was a single-center, retrospective observational cohort study of patients ≥18 years with a HIV diagnosis and an encounter in the outpatient HIV clinic at an academic medical center associated with a HSSP, at least one order for an antiretroviral (ARV) medication, and at least one HIV-1 RNA VL result between January 2018 and May 2022. Outcomes included average rate of VL suppression and socio-demographic factors associated with VL suppression. Comparison of VL suppression between groups was tested using a generalized estimating equation logistic regression.ResultsFrom January 2018 to May 2022, 889 patients met the inclusion criteria; 326 provided VL results while filling at the HSSP and 681 had results while filling through a non-HSSP (118 patients provided results in both groups). Of the 5295 VL results, 90.6% reflected VL suppression, with the average rate of 91.0% in the HSSP group vs 86.0% in the non-HSSP group (adjusted OR = 1.89 95% CI: [1.40, 2.56]). Sex, ethnicity, and race were not associated with VL suppression. However, VL suppression decreased significantly with Charleson Comorbidity Index 1-3; increased with age; and increased over time from VL index date.ConclusionsHIV patients filling ARV therapy through a HSSP had a higher rate of VL suppression than those filling through non-HSSPs, highlighting the potential clinical benefit of this specialty pharmacy model.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"204-210"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key Articles and Guidelines in the Management of Chronic Coronary Disease. 慢性冠状动脉疾病管理的关键文章和指南。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-10-29 DOI: 10.1177/08971900251394069

Dave L Dixon, Tomasz Jurga, Michael Kelly, Dejan Landup, Yun Lu, Tracy Macaulay, Mark Munger, Nicholas Norgard, Kelly C Rogers, Toby Trujillo

引用次数: 0

Supporting Pharmacists with Legislative Changes: Pharmacist Knowledge and Comfort with Contraception Prescribing. 支持药剂师与立法变化：药剂师的知识和舒适的避孕处方。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-07-17 DOI: 10.1177/08971900251356350

Emily J Zielinski, Todd A Walroth, Kala L Sanders, Christopher J Wickesberg, Todd Bailey Cox, Rajarpreet Sandhu, Charity Cicak, Ashley H Meredith

{"title":"Supporting Pharmacists with Legislative Changes: Pharmacist Knowledge and Comfort with Contraception Prescribing.","authors":"Emily J Zielinski, Todd A Walroth, Kala L Sanders, Christopher J Wickesberg, Todd Bailey Cox, Rajarpreet Sandhu, Charity Cicak, Ashley H Meredith","doi":"10.1177/08971900251356350","DOIUrl":"10.1177/08971900251356350","url":null,"abstract":"BackgroundDue to contraceptive access scarcity and other variables, the U.S. exhibits high rates of unintended pregnancy, and Healthy People 2030 has a goal to address this through increased use of birth control. In 2023, Indiana passed legislation allowing pharmacists to prescribe self-administered contraception. Uptake of pharmacist contraceptive prescribing has been limited, and many states are not utilizing this opportunity to advance reproductive equity. We aimed to address significant gaps in literature assessing pharmacists' comfortability and knowledge regarding the implementation and utilization of this protocol.ObjectivesThe purpose of this study was to evaluate pharmacists' comfort and knowledge level before and after a formal education program on conducting contraceptive care via a pharmacist-driven protocol.MethodsThis was a retrospective, cohort study conducted at a safety-net, academic medical center in Indianapolis, Indiana. A formal education program with associated pharmacist surveys took place over two training sessions in November and December 2023.ResultsA total of 30 paired pre- and post-pharmacist surveys were included in analysis (63% response rate). The median [IQR] composite score (knowledge and comfort level) increased pre- vs post-survey from 38 [34,57] to 86 [81,91] (P < .001). Overall correct median [IQR] knowledge scores increased from 40% [40,50] to 70% [60,80] (P < .001). Overall median [IQR] comfort level scores increased from 36% [27,68] to 95% [86 100] (P < .001).ConclusionFollowing completion of a formal education program, pharmacists demonstrated an increase in knowledge and comfort level with prescribing contraception. Intentional training opportunities should be provided to pharmacists prior to implementation. Other health-systems could benefit from offering a similar program.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"165-171"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Bedside: Utilization of an On-Call Pharmacist to Bridge Gaps in Clinical Coverage for Select Critically ill Populations. 超越床边：利用一个随叫随到的药剂师，以弥合差距，在临床覆盖的选择重症人群。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-09-04 DOI: 10.1177/08971900251376800

Alyssa S Meester, Erica Caffarini, Mariela Cardona Gonzalez, Michael Young, Jordan DeWitt

{"title":"Beyond the Bedside: Utilization of an On-Call Pharmacist to Bridge Gaps in Clinical Coverage for Select Critically ill Populations.","authors":"Alyssa S Meester, Erica Caffarini, Mariela Cardona Gonzalez, Michael Young, Jordan DeWitt","doi":"10.1177/08971900251376800","DOIUrl":"10.1177/08971900251376800","url":null,"abstract":"PurposeTo describe the utilization of an on-call critical care pharmacist to bridge gaps in clinical coverage for subspecialized critically ill populations.MethodsIn October 2022, a 24/7 on-call team of medical and cardiac ICU pharmacists was established to field questions regarding patients with mechanical circulatory support and pulmonary hypertension. On-call pharmacists were available via centralized telephone number Monday through Friday from 4:00 p.m. to 8:00 a.m., and at all hours on weekends. Information characterizing calls received was collected in an electronic database. A review of all database entries through March 2025 was conducted and descriptive statistics were used to quantify calls received, time spent, multidisciplinary team member engagement, and types of interventions.ResultsOn-call pharmacists received 207 calls and documented 218 interventions. Calls were most often received between the hours of 4:00 p.m. and 8:00 a.m., and the median time spent per call was 10 minutes (IQR 5-20 minutes). On-call critical care pharmacists received the most calls for ECMO patients (38.2%), followed by pulmonary hypertension (26.1%) and Impella® patients (20.8%). The majority of inquiries were from pharmacists (35.7%), followed by advanced practice providers (33.3%) and physicians (21.3%). Anticoagulation and hemostasis was the most commonly cited intervention category (56.4%).ConclusionIn the absence of an onsite critical care pharmacist, a 24/7 on-call critical care pharmacist was utilized by members of the multidisciplinary team to bridge gaps in clinical coverage. Further research is needed to determine the pharmacoeconomic and clinical impacts of on-call critical care pharmacists when onsite resources are unavailable.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"211-218"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic Subcutaneous Semaglutide Overdose: A Case Report and Literature Review. 无症状皮下注射西马鲁肽过量1例报告及文献复习。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-04-15 DOI: 10.1177/08971900251335111

Courtney B Diec, Elizabeth A Cook, Nguyet T Nguyen

{"title":"Asymptomatic Subcutaneous Semaglutide Overdose: A Case Report and Literature Review.","authors":"Courtney B Diec, Elizabeth A Cook, Nguyet T Nguyen","doi":"10.1177/08971900251335111","DOIUrl":"10.1177/08971900251335111","url":null,"abstract":"Semaglutide is a glucagon-like-peptide-1 receptor agonist (GLP-1 RA) that is approved for the treatment of type 2 diabetes mellitus (T2DM) and obesity. Common adverse drug reactions (ADR) of semaglutide include nausea, vomiting, abdominal pain, constipation, and diarrhea, which are often dose-dependent in nature. Select ADRs that are less common, but may result in more significant concerns, include development of acute pancreatitis, gallbladder and biliary tract diseases, acute kidney injury, and ileus. Limited clinical literature exists at present regarding management of GLP-1 RA overdose, particularly for subcutaneous semaglutide. This report describes an 80-year-old male with T2DM and mild cognitive impairment who self-administered subcutaneous semaglutide 1 mg daily over the span of 7 days. The patient denied any ADRs, including those related to gastrointestinal upset or hypoglycemia. Blood glucose readings from the patient's glucometer ranged from 100 - 180 mg/dL. The patient declined to present for medical evaluation until 5 weeks after the overdose incident. No clinically significant changes were noted in his renal function, hepatic function, nor his pancreatic enzymes upon laboratory follow-up. Published reports concerning GLP-1 RA overdoses describe mixed presentation of patients following such events. Treatments detailed in the case reports included primarily supportive care measures. Based on the mechanism of action of GLP-1 RAs, and those case reports detailed, we recommend close monitoring and supportive care in the form of providing antiemetics, correcting fluid and electrolyte imbalances from gastrointestinal losses, and monitoring for hypoglycemia in the event of an overdose.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"219-224"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varying Lamotrigine Concentrations in Patients Following One Anastomosis Gastric Bypass Surgery: A Case Series. 一次吻合胃旁路手术后患者拉莫三嗪浓度的变化：一个病例系列。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-05-26 DOI: 10.1177/08971900251345898

Carmil Azran, Hasan Kais, Daniel Porat, Arik Dahan

引用次数: 0

Chronic Hepatitis C Treatment Failure With Crushed Sofosbuvir/Velpatasvir in a Patient With Total Parenteral Nutrition-dependent Short Bowel Syndrome. 索非布韦/维帕他韦粉碎治疗全肠外营养依赖性短肠综合征患者慢性丙型肝炎失败

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-06-17 DOI: 10.1177/08971900251352671

Noelle E Nelson

引用次数: 0

Interventions for Improved Time to Antibiotic Administration in Pediatric Patients With Febrile Neutropenia. 改善小儿发热性中性粒细胞减少症患者抗生素使用时间的干预措施。

IF 1.1

Journal of pharmacy practice Pub Date : 2026-06-01 Epub Date: 2025-08-08 DOI: 10.1177/08971900251364058

Kathleen M Villarama, Jessica Lise, Martha Hugger, Marvella Cephas, Richard Drachtman, Minh-Tu Do, Nadia I Awad

{"title":"Interventions for Improved Time to Antibiotic Administration in Pediatric Patients With Febrile Neutropenia.","authors":"Kathleen M Villarama, Jessica Lise, Martha Hugger, Marvella Cephas, Richard Drachtman, Minh-Tu Do, Nadia I Awad","doi":"10.1177/08971900251364058","DOIUrl":"10.1177/08971900251364058","url":null,"abstract":"Background: For pediatric patients with suspected neutropenic fever in the emergency department, the gold standard antibiotic administration time is 60 min upon presentation. Unfortunately, this is difficult to achieve given operational delays and the lack of multidisciplinary collaboration. Objective: To implement quality improvement strategies to improve the time to antibiotic administration for pediatric patients with suspected neutropenic fever. Methods: Eligible participants included children with suspected febrile neutropenia. A chart review was conducted to determine if intravenous antibiotics were administered within 60 min from triage. Various process-driven and educational interventions were then implemented. The primary outcome was mean time to antibiotic administration from triage. Results: From January 2023 to September 2023, 72 patients were evaluated for the pre-interventions group. From October 2023 to April 2024, 93 patients were assessed for the post-interventions group. The mean time to antibiotic decreased from 92 to 39 min (95% confidence interval [CI], 31.42 to 64.11; P < .001), and the percentage of patients receiving antibiotics within 60 min increased from 35 to 88% (95% CI 0.57 to 0.72; P < .001). Prior to interventions, the major source of delay was the time between nurse triaging and physician ordering of the antibiotic. After interventions, the mean time from triaging to ordering decreased from 34 to 16 min (95% CI, 4.34-31.88; P = .0103). Conclusion: In pediatric patients with suspected neutropenic fever in the emergency department, a multidisciplinary approach and identification of delays in antibiotic delivery can be instrumental in reducing the time to antibiotics administration.","PeriodicalId":16818,"journal":{"name":"Journal of pharmacy practice","volume":" ","pages":"172-178"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0