打破艰难梭菌反复感染的循环：探索当前和新型治疗策略的叙述性综述。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-12-01 Epub Date: 2024-05-13 DOI:10.1177/08971900241248883

Shelbye R Herbin, Hannah Crum, Krista Gens

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引用次数: 0

摘要

艰难梭状芽孢杆菌是一种产毒细菌，是导致抗生素相关性腹泻的主要原因。难辨梭状芽孢杆菌感染（CDI）与胃肠道（GI）微生物群紊乱有关，CDI靶向抗生素治疗会进一步加剧胃肠道微生物群紊乱，从而导致难辨梭状芽孢杆菌感染复发（rCDI），加重患者和医疗系统的负担。复发性 CDI 的治疗包括抗生素治疗，如果不能获得持续的临床反应，还可以搭配使用预防性疗法，如贝洛单抗或粪便微生物群移植（FMT）。新近批准的预防性疗法有助于恢复消化道系统的平衡，从而达到预防反复感染的目的。

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Breaking the Cycle of Recurrent Clostridioides difficile Infections: A Narrative Review Exploring Current and Novel Therapeutic Strategies.

Clostridioides difficile is a toxin-producing bacteria that is a main cause of antibiotic-associated diarrhea. Clostridioides difficile infections (CDI) are associated with disruptions within the gastrointestinal (GI) microbiota which can be further exacerbated by CDI-targeted antibiotic treatment thereby causing recurrent CDI (rCDI) and compounding the burden placed on patients and the healthcare system. Treatment of rCDI consists of antibiotics which can be paired with preventative therapeutics, such as bezlotoxumab or fecal microbiota transplants (FMTs), if sustained clinical response is not obtained. Newer preventative strategies have been recently approved to assist in restoring balance within the GI system with the goal of preventing recurrent infections.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.