Jeremy Szmerling BPharm (Hons), GradCertPharmPrac, ANZCAP-Reg (PainMgmt, Steward), Sam Maleki BPharm, MPharmPrac, FANZCAP (OncHaem, Research), Gordon Mar BA, MB, Mmed, FANZCA, Anne Goulopoulos BPharm(Hons), GradCertPharmPrac, MClinPharm, AdvPracPharm, FANZCAP (Lead&Mgmt)
{"title":"Cultivating optimal analgesic prescribing practices in a metropolitan hospital network: evaluating an analgesic stewardship program","authors":"Jeremy Szmerling BPharm (Hons), GradCertPharmPrac, ANZCAP-Reg (PainMgmt, Steward), Sam Maleki BPharm, MPharmPrac, FANZCAP (OncHaem, Research), Gordon Mar BA, MB, Mmed, FANZCA, Anne Goulopoulos BPharm(Hons), GradCertPharmPrac, MClinPharm, AdvPracPharm, FANZCAP (Lead&Mgmt)","doi":"10.1002/jppr.1914","DOIUrl":"10.1002/jppr.1914","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The increasing incidence of opioid-related harm associated with inappropriate opioid prescription underscores the need for effective interventions directed at enhancing analgesic prescribing practices. Analgesic stewardship (AGS) programs have emerged to facilitate appropriate analgesic use, reducing analgesic-related harm and optimising patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to assess the impact of an AGS program on the appropriateness of opioid analgesia prescribing for adult inpatients within a metropolitan health network during the initial two months following program implementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This retrospective audit examined de-identified aggregate data of 100 adult inpatients of a major Australian metropolitan hospital network between August–September 2022. The multidisciplinary AGS program involving pharmacy, nursing, and medical staff provided clinical interventions and recommendations for patients, supported by organisational interventions, including education and guideline reinforcement. Data collection included patient demographics, clinical data, and AGS program recommendations documented in patient medical records. Ethical approval was granted by the Eastern Health Office of Research and Ethics (Reference no: QA23-015-91886) and the study confirms to the <i>Australian Statement on Ethical Conduct in Human Research</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>It was found that 51% of opioid-naïve patients were prescribed modified-release opioids for acute non-cancer pain, contrary to local guidelines. The AGS program recommendations resulted in an 89.7% cessation of these prescriptions. For non-opioid-naïve patients, there was a statistically significant reduction in mean Oral Morphine Equivalent Daily Dose of 19.85 mg (95% confidence interval [CI] 10.3–29.4 mg, p < 0.05). AGS recommendations were predominantly adhered to, with 82% showing full or partial compliance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the positive impact of an AGS program on the appropriateness of opioid analgesic prescribing for adult inpatients. These findings support the implementation of AGS programs into healthcare systems to mitigate opioid-related harm and improve patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reasonable adjustments to application of the Medication Safety Standard for adult patients living with intellectual disability in Australian hospital settings","authors":"Robyn Anne Wallace BSc(Hons), DipEd, MSc, MBBS, FRACP, CF, PhD, FAFRM, GDipNeurosci, ClinDipPallCare, MDisPrac, GChPom, GCertHealthMment","doi":"10.1002/jppr.1889","DOIUrl":"10.1002/jppr.1889","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose of review</h3>\u0000 \u0000 <p>Adults living with intellectual disability experience higher rates of preventable adverse medication events across the medicine pathway compared to their peers without disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Source of information</h3>\u0000 \u0000 <p>The Medication Safety Standard, developed by the Australian Commission on Safety and Quality in Health Care, describes systems and strategies to ensure that clinicians and health organisations safely prescribe, dispense, administer appropriate medications to informed patients, and monitor their use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key findings</h3>\u0000 \u0000 <p>Optimal application of the Medication Safety Standard for this population requires the development of reasonable adjustments to its action which take into account the barriers to safe medication management experienced by them in hospital settings. Design of such reasonable adjustments is influenced by consideration of the experiences of medicine management within with people living with intellectual disability, with intellectual disability, the roles of disability supports, and the disability-health sector interface in relation to medication management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review describes the formulation of a range of practice point reasonable adjustments to the usual clinical processes, content, knowledge, and organisation required in application of the Medication Safety Standard for adult patients living with intellectual disability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jppr.1889","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chih Yuan Wang BPharm, MClinPharm, Alexandra Clavarino BA(Hons), BSocWk, PhD, Karen Luetsch BPharm, GradCertClinEd, PhD
{"title":"Opportunities and achievements — experiences of pharmacists as Foundation Residency Program residents — a qualitative study","authors":"Chih Yuan Wang BPharm, MClinPharm, Alexandra Clavarino BA(Hons), BSocWk, PhD, Karen Luetsch BPharm, GradCertClinEd, PhD","doi":"10.1002/jppr.1903","DOIUrl":"10.1002/jppr.1903","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Australian Foundation Residency Program prepares new-to-hospital and early career pharmacists for extended roles and advanced pharmacy practice. An understanding of the outcomes residents perceive they achieve through completion of a residency and what supports them in their achievements is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To explore pharmacists' experiences during their residency and what they perceive as its outcomes and their achievements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Focus groups and interviews were conducted and recorded with 12 early career or new-to-hospital pharmacists who recently completed a residency program in an Australian hospital. Recordings were transcribed and analysed using inductive thematic analysis. Ethical approval was granted by the University of Queensland Human Research Ethics Committee (Reference no: 2021/HE001225) and the study conforms to the <i>Australian Statement on Ethical Conduct in Human Research</i>. Informed consent was obtained from all participants via the distribution of project information sheets and completion of written consent forms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five distinct themes were generated from participants' discussions of their experiences and achievements throughout their residency. The outcomes and achievements they described included gaining the confidence to take on new and challenging roles as well as advancing their career by developing a deeper understanding of their role and potential in the healthcare system. Skill development was accelerated by the structure and assessment requirements of the residency program and by support from mentors, which positively influenced their attitudes towards feedback and competency assessments. Participants reflected on the differences between postgraduate university-based learning and workplace-based learning and saw benefits in both.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The residency was reported to offer a structured and supportive training pathway for pharmacists in the early stages of their hospital pharmacy career. Completion of residency facilitates pharmacists' skill development and a deeper understanding of their roles. Dedicated and qualified mentorship and routine networking events between peers and past residents enhance these experiences and outcomes for residents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jppr.1903","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140251457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ross Wagner PharmD, BCPS, Ruchira Mahashabde MS, Jacob Painter PharmD, MBA, PhD, Kaci Boehmer PharmD, BCACP
{"title":"Factors associated with an increased risk of vitamin B12 deficiency in patients with type 2 diabetes mellitus on metformin","authors":"Ross Wagner PharmD, BCPS, Ruchira Mahashabde MS, Jacob Painter PharmD, MBA, PhD, Kaci Boehmer PharmD, BCACP","doi":"10.1002/jppr.1913","DOIUrl":"10.1002/jppr.1913","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Metformin is used to treat type 2 diabetes mellitus, but prolonged use has been associated with vitamin B<sub>12</sub> deficiency. Many other factors have also been associated with vitamin B<sub>12</sub> deficiency. Studies on the possible additive effect of risk factors for developing a vitamin B<sub>12</sub> deficiency are lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The objective of this study was to assess the correlation between other known risk factors for vitamin B<sub>12</sub> deficiency among patients with type 2 diabetes mellitus prescribed metformin who had a vitamin B<sub>12</sub> deficiency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>For inclusion in this single-centre, retrospective cohort study, patients needed to be at least 18 years old, diagnosed with type 2 diabetes, taking metformin for at least 2 years and actively taking metformin during the study period. The primary outcome was the rate of low B<sub>12</sub> levels with metformin. Secondary outcomes were risk factors associated with B<sub>12</sub> deficiency. The patient and clinical characteristics were compared between the two study groups using Student's t-test for continuous variables and chi-squared tests for categorical variables. This project was exempt due to the local policy requirements that constitute research by the University of Arkansas for Medical Sciences Institutional Review Board (IRB) (IRB Program Manager, 11 August 2021). The justification for this ethics exemption was as follows: the project was determined to be of minimal risk to privacy of subjects because the research team had mechanisms to protect the personal health identifiers from improper use or disclosure; to destroy the identifiers at the earliest opportunity consistent with the conduct of research, and provided assurance that the identifiers will not be re-used or disclosed to any other person or entity, except as required by law, for authorised oversight of the research project, or for other research as permitted by the HIPAA regulations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 387 patients were included in this study, from which 364 patients had a vitamin B<sub>12</sub> deficiency. The cohort was an average 69-years-old and predominantly female (66%). No risk factors were associated with a higher incidence of B<sub>12</sub> deficiency. Patient age (p = 0.0063) and time on metformin (p = 0.0144) were significantly and negatively correlated with B12 deficiency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Younger age and shorter ","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shania Liu, Thuy Bui, Kenny Kwon Ho Lee, Wei Sheng Arthur Lim, Daniel Lim, Christine Onishko, J. Penm, Chi Tran, Penelope Tuffin, Yee Mellor
{"title":"Standard of practice in pain management for pharmacy services","authors":"Shania Liu, Thuy Bui, Kenny Kwon Ho Lee, Wei Sheng Arthur Lim, Daniel Lim, Christine Onishko, J. Penm, Chi Tran, Penelope Tuffin, Yee Mellor","doi":"10.1002/jppr.1910","DOIUrl":"https://doi.org/10.1002/jppr.1910","url":null,"abstract":"In Australia, everyone shares a fundamental right to basic healthcare. All healthcare systems in 20 Australia must abide by the Australian Charter of Healthcare Rights (3) as it is essential to ensure 21 that the care provided to patients is of high quality and safe. The Charter summarises the basic rights 22 that patients and consumers are entitled to receive when accessing healthcare services including 23 access, safety, respect, communication, participation, privacy and comment. Internationally the 24 Declaration of Montreal is a declaration that access to pain management is a fundamental human 25 right (4). The provision of pharmacy services must encompass the Charter and Declaration to deliver 26 effective, efficient, timely, equitable and patient-centred pain management. 27","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Norkasihan Ibrahim PhD, Muhammad Firdaus Afandi BPharm, Karmila Abu Bakar MD, Caroline Eng MD, Shamala Balan PhD, Mohd Shahezwan Abd Wahab PhD, Janattul-Ain Jamal PhD
{"title":"Willingness and understanding of the safety and effectiveness of COVID-19 vaccines in young children: a cross-sectional study among parents in Malaysia","authors":"Norkasihan Ibrahim PhD, Muhammad Firdaus Afandi BPharm, Karmila Abu Bakar MD, Caroline Eng MD, Shamala Balan PhD, Mohd Shahezwan Abd Wahab PhD, Janattul-Ain Jamal PhD","doi":"10.1002/jppr.1901","DOIUrl":"10.1002/jppr.1901","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The safety and efficacy of COVID-19 vaccinations are crucial factors that parents consider when deciding whether to vaccinate their children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate parents' understanding of COVID-19 vaccines and its association with the degree of willingness to vaccinate their young children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A cross-sectional survey was conducted among the public with children younger than 12 years old. Information on parents' demography, understanding of COVID-19 vaccines and their willingness to get their children vaccinated were collected. The association between the level of understanding and willingness was tested using the One-way analysis of variance (ANOVA) test. Predictors of good understanding and high willingness were investigated using multiple linear regression. Ethics approval was granted by the Research Ethics Committee of Universiti Teknologi MARA (Reference no: REC [PH]/012/2022) and the study conforms with the Declaration of Helsinki. Informed consent was obtained from all participants. A web-based survey link was distributed through social media platforms. The initial section of the survey included a project information sheet including the purpose of the study, length of questionnaire, identity of researchers and measures taken to ensure data confidentiality and anonymity of participants. Participants provided their consent electronically prior to being granted access to the questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 386 respondents, 53.4% had a good understanding, and 74.6% had a high willingness. Only 42.5% agreed that the vaccines are effective in protecting children from getting COVID-19, 79.5% and 73.3% misunderstood the severity and tendency to experience the side effects, respectively. A better understanding was associated with a higher willingness to vaccinate ([<i>F</i>(4381) = 54.417, p = 0.000). A higher understanding was significantly associated with higher educational status (postgraduate [<i>β</i> = 0.297, p = 0.028] and bachelor [<i>β</i> = 0.275, p = 0.034], work in a health-related field [<i>β</i> = 0.300, p < 0.001]) and have received a COVID-19 booster (<i>β</i> = 0.347, p < 0.001). A high willingness was prevalent among parents working in a health-related field, had received a COVID-19 booster and had medical condition. Low willingness was observed among parents aged above 30 years old and those who have used herbal medicines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 ","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139778686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Norkasihan Ibrahim, Muhammad Firdaus Afandi, Karmila Abu Bakar, Caroline Eng, S. Balan, Mohd Shahezwan Abd Wahab, J. Jamal
{"title":"Willingness and understanding of the safety and effectiveness of COVID‐19 vaccines in young children: a cross‐sectional study among parents in Malaysia","authors":"Norkasihan Ibrahim, Muhammad Firdaus Afandi, Karmila Abu Bakar, Caroline Eng, S. Balan, Mohd Shahezwan Abd Wahab, J. Jamal","doi":"10.1002/jppr.1901","DOIUrl":"https://doi.org/10.1002/jppr.1901","url":null,"abstract":"The safety and efficacy of COVID−19 vaccinations are crucial factors that parents consider when deciding whether to vaccinate their children.This study aimed to investigate parents' understanding of COVID−19 vaccines and its association with the degree of willingness to vaccinate their young children.A cross‐sectional survey was conducted among the public with children younger than 12 years old. Information on parents' demography, understanding of COVID−19 vaccines and their willingness to get their children vaccinated were collected. The association between the level of understanding and willingness was tested using the One‐way analysis of variance (ANOVA) test. Predictors of good understanding and high willingness were investigated using multiple linear regression. Ethics approval was granted by the Research Ethics Committee of Universiti Teknologi MARA (Reference no: REC [PH]/012/2022) and the study conforms with the Declaration of Helsinki. Informed consent was obtained from all participants. A web‐based survey link was distributed through social media platforms. The initial section of the survey included a project information sheet including the purpose of the study, length of questionnaire, identity of researchers and measures taken to ensure data confidentiality and anonymity of participants. Participants provided their consent electronically prior to being granted access to the questionnaire.Of the 386 respondents, 53.4% had a good understanding, and 74.6% had a high willingness. Only 42.5% agreed that the vaccines are effective in protecting children from getting COVID−19, 79.5% and 73.3% misunderstood the severity and tendency to experience the side effects, respectively. A better understanding was associated with a higher willingness to vaccinate ([F(4381) = 54.417, p = 0.000). A higher understanding was significantly associated with higher educational status (postgraduate [β = 0.297, p = 0.028] and bachelor [β = 0.275, p = 0.034], work in a health‐related field [β = 0.300, p < 0.001]) and have received a COVID−19 booster (β = 0.347, p < 0.001). A high willingness was prevalent among parents working in a health‐related field, had received a COVID−19 booster and had medical condition. Low willingness was observed among parents aged above 30 years old and those who have used herbal medicines.It is of utmost importance to comprehend parents’ understanding of this topic to minimise hesitancy toward COVID−19 vaccination in children.","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139838560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of pharmaceutical care for improving medication-related quality of life and adherence to treatment among people living with schizophrenia: a randomised controlled trial","authors":"Tatta Sriboonruang PhD, Wasanan Phonphairin MSc (Pharm), Siripan Phattanarudee PhD, Sirichai Chusiri PharmD, BCP","doi":"10.1002/jppr.1909","DOIUrl":"10.1002/jppr.1909","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>People living with schizophrenia frequently exhibit poor medication adherence because of adverse drug reactions (ADRs) or lack of disease awareness. This prospective randomised controlled trial investigated the benefits of pharmaceutical care delivered by hospital pharmacists for improving pharmacotherapy-related quality of life and medication adherence among this patient group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The purpose of this study was to evaluate the effectiveness of pharmaceutical care interventions in enhancing medication adherence and improving the quality of life of people living with schizophrenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Data were collected during inpatient and subsequent outpatient treatment from 6 January–8 June 2021. Participants were divided into two groups via block randomisation: a control group receiving standard treatment; and an intervention group receiving pharmaceutical care combined with standard treatment. The pharmaceutical care comprised medication review, monitoring of drug-related problems (including ADRs), adjustment of the dose of antipsychotic medicines in collaboration with psychiatrists, and counselling of participants and caregivers about disease management before discharge. Pharmacotherapy-related quality of life was assessed using the short version of the Patient-Reported Outcomes Measure of Pharmaceutical Therapy for Quality of Life (PROMPT-QoL), whereas medication adherence was evaluated using the Medication Taking Behaviour in Thai Patients (MTB-Thai). The primary outcomes were the average change in the PROMPT-QoL score from inpatient to outpatient care and the average outpatient MTB-Thai score. Ethical approval was granted by the Srithanya Hospital Office of the Ethics Commission for Human Research (Reference no: STY.COA008/2564) and the study conforms to the Declaration of Helsinki. Informed consent was obtained from all patient and caregiver participants via a project information sheet and the completion of a written consent form.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the end of the study, compared with the control group, the intervention group exhibited a significantly lower ADR prevalence (57.90% vs 79.70%, p < 0.05) and a greater change in the mean PROMPT-QoL scores pertaining to ‘obtaining information of medicines and diseases’, ‘impact of medicine side effects’, ‘ease of use of medicines’, and ‘therapeutic relationship’. In addition, the intervention group achieved a significantly higher mean of medicine adherence score than the control group (22.81 ± 1.61 vs 16.85 ± 3.00, p < 0.001).</p>\u0000 ","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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