Journal of physiology and biochemistry最新文献

{"title":"Crosstalk between MST1-Hippo and Wnt/β-Catenin, Notch, and PI3K/Akt pathways in cardiac physiology and pathology.","authors":"Jin Wang, Kai Jing, Vadim Mitrokhin, Stanislav Schileyko, Anastasija Rodina, Alexandra Zolotareva, Valentin Zolotarev, Natalia Bocharnikova, Dmitry Kaminer, Emilija Antova, Radoslav Stojchevski, Nikola Hadzi-Petrushev, Dimiter Avtanski, Andre Kamkin, Mitko Mladenov","doi":"10.1007/s13105-025-01099-2","DOIUrl":"10.1007/s13105-025-01099-2","url":null,"abstract":"","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":"557-571"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pancreatitis experimental models, advantages and disadvantages.","authors":"Genaro J Rosales-Muñoz, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U Miranda-Labra, Luis E Gomez-Quiroz, María Concepción Gutiérrez-Ruiz","doi":"10.1007/s13105-025-01091-w","DOIUrl":"10.1007/s13105-025-01091-w","url":null,"abstract":"<p><p>Acute pancreatitis represents a severe health problem, not only because of the number of people affected but also because of the severity of its clinical presentation that can eventually lead to the death of patients. The study of the disease is complex, and we lack optimized models that can approach the clinical presentation in patients, in addition to the significant vulnerability of the organ itself. In the present work, we undertook the task of reviewing and analyzing the experimental methods most currently used for the induction of acute pancreatitis, emphasizing the advantages and disadvantages of each model and their delimitation based on experimental objectives. We aimed to provide an actual and quick-access guide for researchers interested in experimental acute pancreatitis.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":"539-556"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway.","authors":"Huayu Shang, Ranggui Ma, Shengju Chen, Hao Deng, Mengyu Li, Shiqiao Zheng, He Zhang, Duo Zhang, Tianai Yang, Ying Yang, Zhi Xia","doi":"10.1007/s13105-025-01093-8","DOIUrl":"10.1007/s13105-025-01093-8","url":null,"abstract":"<p><p>Eccentric exercise is known to induce more pronounced muscle damage associated with delayed-onset muscle soreness than concentric exercise. This study aimed to investigate whether AMP-activated protein kinase (AMPK) pathway participates in control of mitophagy in rat skeletal muscle in response to downhill running. Eighty-eight male Sprague-Dawley rats were exercised on a treadmill tilted at 16° decline at 16 m·min^- 1 for 90 min, with the soleus muscle sampled at 0 h, 12 h, 24 h, 48 h and 72 h after exercise. The AMPK inhibitor compound C or AMPK activator AICAR or saline was injected intraperitoneally 20 min before exercise. After downhill treadmill running, the skeletal muscle mitochondrial structure appeared to be abnormal and contained mitophagosomes; the expression levels of AMPK phosphorylation, cyclophilin D (CypD), cytochrome C (CytC), mitochondrial FK506-binding protein 8 (FKBP8), microtubule-associated protein 1 light chain 3 (LC3), and the co-localization of FKBP8 with LC3 and mitochondria with dynamin-related protein 1 (Drp1), lysosomal-associated membrane protein 2 (LAMP2) were significantly higher; the expression levels of mechanistic target of rapamycin (mTOR Ser2448) phosphorylation and heat shock protein 60 (HSP60), mitochondrial respiratory complex I (NDUFB8) and complex III (UQCRC2), and adenosine triphosphate (ATP) content were significantly lower than those in the C group. Further study showed that the effect of downhill treadmill running was partly blocked by compound C and strengthened by AICAR. A session of downhill treadmill running activated the AMPK pathway and promoted LC3 co-localizations with mitochondria and FKBP8, and induced mitophagy and mitochondrial damage within rat skeletal muscle.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":"673-685"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cell junctions in atherosclerosis: implications for inflammation, endothelial dysfunction, and plaque stability.","authors":"Siarhei A Dabravolski, Vasily V Kashtalap, Ulyana V Rozhkova, Anastasia O Maksaeva, Vasily N Sukhorukov, Alexander N Orekhov","doi":"10.1007/s13105-025-01106-6","DOIUrl":"10.1007/s13105-025-01106-6","url":null,"abstract":"<p><p>Atherosclerosis, a chronic inflammatory disease, involves a complex interplay between endothelial cells, smooth muscle cells, and inflammatory mediators. Cell-to-cell junctions, including adherens junctions (AJs), tight junctions (TJs), and gap junctions (GJs), play a critical role in maintaining vascular integrity and regulating cellular interactions in the vascular wall. This review summarises the molecular mechanisms by which these junctions contribute to atherosclerosis, focusing on key proteins like VE-cadherin (AJs), ZO-1, occludin, and claudins (TJs), and connexins (GJs). Dysregulation of these junctions, driven by factors such as oxidative stress, pro-inflammatory cytokines, atheroprone shear stress (aSS), and lipid-mediated signalling pathways, leads to endothelial dysfunction, increased permeability, monocyte infiltration, and plaque instability. Furthermore, the role of signalling pathways, including NFκB, PI3K/AKT, and Wnt/β-catenin, in the regulation of junctional proteins is explored. Emerging factors, including oxygenated cholesterol, radiation, and various drugs, provide new insights into junctional modulation in atherosclerosis. The potential of targeting junctional proteins and their associated pathways for therapeutic interventions is also discussed. Future studies focusing on the detailed mechanisms of junctional dysregulation in vivo and the clinical translation of these findings are necessary to develop novel therapeutic strategies for atherosclerosis. Clinical trial number Not applicable.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":"573-587"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training on metabolic impairments in liver tissue of rats with type 2 diabetes: a metabolomics-based approach.","authors":"Kayvan Khoramipour, Mohammad Amin Rajizadeh, Mohammad Khaksari, Mansour Aminzadeh, Paula Crespo-Escobar, Alejandro Santos-Lozano, Mohammad Arjmand","doi":"10.1007/s13105-025-01085-8","DOIUrl":"10.1007/s13105-025-01085-8","url":null,"abstract":"<p><p>Our aim was to study the metabolic effects of eight weeks of high-intensity interval training (HIIT) on the liver of rats with type 2 diabetes (T2D) using untargeted metabolomics. Twenty male Wistar rats, were divided into four groups (n = 5 per group): control (CTL), type 2 diabetes (DB), HIIT (EX), and type 2 diabetes + HIIT (DTX). A two months of a high-fat diet followed by a single dose of streptozotocin (35 mg/kg body weight) was used to induce T2D. Animals in the EX and DTX groups were trained for eight weeks (5 times per week, 4-10 running intervals at 80-100% of their maximum velocity). Metabolomic data were collected using proton nuclear magnetic resonance (¹H-NMR) to assess metabolic changes in the liver after training. Data were then pre-processed using ProMetab (MATLAB) for baseline correction, normalisation and binning. Fasting blood glucose (FBG) levels were analysed using a repeated-measures mixed ANOVA [i.e., time as the within-subject factor (Baseline - Month 0, Post-induction - Month 2, and Post-intervention - Month 4) and gruop (CTL, DB, HIIT, DTX) as the between-subject factor]. A one-way ANOVA with Tukey's post hoc test (p < 0.05) was applied to assess differences in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Multivariate analysis - using sparse partial least squares discriminant analysis (sPLS-DA) - was performed to identify key metabolites, followed by pathway analysis (MetaboAnalyst) to determine significantly affected metabolic pathways. DB group showed higher HOMA-IR than CTL and DTX groups (p < 0.05). Furthermore, distinct clustering patterns was shown for metabolites by multivariate analysis. Key altered metabolic pathways included valine, leucine, and isoleucine biosynthesis; glutathione metabolism; pantothenate and coenzyme A biosynthesis; fructose and mannose metabolism; glycine, serine, and threonine metabolism; cysteine and methionine metabolism; arginine biosynthesis; tyrosine metabolism; histidine metabolism; beta-alanine metabolism; propanoate metabolism; glycolysis/gluconeogenesis; phenylalanine, tyrosine, and tryptophan biosynthesis; arginine and proline metabolism; and thiamine metabolism. These results suggest that eight weeks of HIIT may reverse metabolic changes induced by T2D in the rat liver, potentially contributing to reduced FBG and HOMA-IR levels. Clinical trial number: Not applicable.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":"611-624"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purinergic receptors in atherosclerosis: implications for pathophysiology and therapeutic strategies.","authors":"Siarhei A Dabravolski, Vasily V Kashtalap, Aleksandra S Utkina, Gulalek A Babayeva, Anastasia O Maksaeva, Vasily N Sukhorukov, Alexander N Orekhov","doi":"10.1007/s13105-025-01108-4","DOIUrl":"https://doi.org/10.1007/s13105-025-01108-4","url":null,"abstract":"<p><p>Atherosclerosis is a complex cardiovascular disease characterised by the accumulation of lipids, inflammatory cells, and fibrous elements within arterial walls, leading to plaque formation and increased risk of cardiovascular events. Recent evidence highlights the pivotal roles of purinergic receptors in mediating the inflammatory and cellular processes associated with atherosclerosis. This review examines the roles of purinergic receptors in the pathophysiology of atherosclerosis, with a particular focus on the P1 subtype (A2A and A3 receptors), the P2X subtype (P2X4 and P2X7 receptors), and the P2Y subtype (P2Y2, P2Y11, and P2Y12 receptors). The A2A and A3 receptors are involved in modulating vascular inflammation, endothelial cell function, and vascular smooth muscle cell calcification. P2X4 has been implicated in the production of pro-inflammatory cytokines and the promotion of plaque inflammation, whereas P2X7 contributes to vascular inflammation, plaque progression, and rupture. The P2Y2 receptor plays critical roles in regulating vascular inflammation and calcification, smooth muscle cell migration, and plaque growth. Furthermore, the P2Y11 receptor has been shown to modulate endothelial cell inflammation, while P2Y12 is associated with lipid accumulation, foam cell formation, vascular smooth muscle cell migration, and plaque development. By synthesising current knowledge on the involvement of purinergic signalling in atherosclerosis, this review discusses potential therapeutic targets for intervention. Specifically, P2Y receptor antagonists present promising avenues for reducing inflammation and improving vascular function in atherosclerotic patients. However, despite the advancements in understanding purinergic receptor functions, challenges remain in translating this knowledge into clinical practice. Further research is essential to unravel the intricate signalling pathways of these receptors and to develop effective biomarker strategies and therapeutic interventions aimed at combatting atherosclerosis and its associated complications.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-184 in hepatocellular carcinoma: a promising therapeutic target.","authors":"Leila Hosseinzadeh, Fereshteh Jalilian, Mohammad Reza Kalhori, Reza Alibakhshi, Amir Ali Kalhori, Mohsen Karami","doi":"10.1007/s13105-025-01104-8","DOIUrl":"https://doi.org/10.1007/s13105-025-01104-8","url":null,"abstract":"<p><p>Hepatocellular carcinoma is the most prevalent form of liver cancer worldwide and has high mortality rates. miRNAs, particularly miR-184, have been implicated in cancer biology, where they regulate gene expression and influence tumorigenesis. This study explored the role of miR-184 in HCC, revealing its dual function as both an oncogene and a tumor suppressor, depending on the target genes. We highlight the regulatory effects of miR-184 on critical genes such as INPPL1, FOXO3a, MTSS, OSGIN1, and SOX7 and its impact on key signaling pathways, including the Wnt/β-catenin and JAK2/STAT3/AKT pathways. Dysregulation of miR-184 expression in HCC tissues compared with normal liver tissue was linked to increased proliferation, reduced apoptosis, and autophagy inhibition. Furthermore, miR-184 shows promise as a diagnostic and prognostic biomarker in HCC because of its altered expression in cancerous tissues and blood. Its regulation through circRNAs and lncRNAs such as lncRNA UCA1, circ_0004913, circ-0001141, circ-102,166, LINC00205, and SNHG11 adds a layer of complexity, challenging us to delve deeper into the intricate mechanisms of miR-184, positioning it as a crucial target for potential therapeutic intervention.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health.","authors":"Silvia Lorente-Cebrián, André G V Costa, J Andrés Castillo-Rivas, Marta Castro, José Miguel Arbonés-Mainar, Saioa Goñi, Sara Remón, Paula Aranaz, Víctor López, Inmaculada Martín-Burriel, Fermín I Milagro","doi":"10.1007/s13105-025-01105-7","DOIUrl":"https://doi.org/10.1007/s13105-025-01105-7","url":null,"abstract":"<p><p>Phenolic compounds are a large class of phytochemicals with relevant physiological effects that are naturally found in plant-origin foods and derived products. Beneficial effects associated with polyphenol consumption are related to their ability to prevent and/or counteract disease features: they exert anti-inflammatory, antioxidant and anticancer effects, as well as protective actions against metabolic diseases. Phenolic compounds and their metabolites can modulate cell function by regulating gene expression. These effects are partially mediated through specific changes in epigenetic mechanisms such as DNA methylation, histone modifications and microRNA (miRNA) expression. Some polyphenols affect DNA methylation and are effective in counteracting deleterious actions induced by inflammatory/pro-oxidant factors, both in in vitro and in vivo settings. Specific mechanisms include modulation of methyl-transferases, whose levels are inhibited upon polyphenols treatment. Some polyphenols are histone deacetylase inhibitors, which prevent transcriptional repression and suppress tumor and inflammation genes by affecting selective regulation of miRNA expression. Their mostly recognized actions as anti-inflammatory and antioxidants seem to be partially mediated through regulation of individual miRNAs. Due to these actions, polyphenols and polyphenol-derived metabolites are under study in clinical and interventional trials for their benefits on inflammation and/or metabolic disorders. In conclusion, phenolic compounds might be an interesting approach to contribute to human homeostasis given their capacity to dynamically regulate epigenetic factors at cellular and systemic level. The present review aims to study available evidence regarding regulatory effects of polyphenols on gene expression, specifically mediated through epigenetic mechanisms.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-steatotic effect of Opuntia ficus-indica extracts rich in betalains and phenolics from fruit peel and pulp of different varieties in in vitro models.","authors":"Irene Besné-Eseverri, Jenifer Trepiana, Itziar Eseberri, Andrea Gómez-Maqueo, M Pilar Cano, Joao Tomé-Carneiro, Alberto Dávalos, María P Portillo","doi":"10.1007/s13105-025-01097-4","DOIUrl":"10.1007/s13105-025-01097-4","url":null,"abstract":"<p><p>Opuntia ficus-indica exhibits antioxidant, anti-inflammatory and anti-hyperglycemic properties, making it a promising candidate for the prevention and treatment of metabolic dysfunction-associated fatty liver disease. However, its effects on triglyceride accumulation remain largely unexplored. The aim of the present study is to evaluate the anti-steatotic effect of peel and pulp extracts from different varieties of Opuntia ficus-indica fruits (Pelota, Colorada and Sanguinos) in hepatic murine in vitro models, using both AML12 hepatocytes and hepatic organoids. The pulp extracts of Pelota and Colorada varieties, as well as both peel and pulp extracts of Sanguinos, were effective in reducing palmitic acid-induced triglyceride accumulation in AML12 hepatocytes. The doses that caused the greatest triglyceride reduction were 50 µg/mL of the pulp of Pelota and 100 µg/mL for the other extracts. The potential mechanisms underlying these effects seem to be associated, at least in part, with the inhibition of fatty acid uptake and triglyceride assembly. The pulp extract of the Colorada variety was able to prevent triglyceride accumulation also in hepatic organoids, likely due to downregulation of fatty acid transporters. These findings underscore the value of employing diverse in vitro models (e.g., 2D, 3D) to investigate the potential effects of these extracts, and suggest that the pulp extract of the Colorada variety may be effective in preventing steatosis.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dietary camelina oil intake on skeletal muscle metabolism and sarcopenia in older mice.","authors":"Jean-Paul Rigaudière, Christophe Montaurier, Philippe Denis, Olivier Le Bacquer, Mathieu Rambeau, Chrystèle Jouve, Julia Soullier, Justine Bertrand-Michel, David M Mutch, Frederic Capel","doi":"10.1007/s13105-025-01089-4","DOIUrl":"10.1007/s13105-025-01089-4","url":null,"abstract":"<p><p>The age-related decrease in skeletal muscle mass and function, mostly known as sarcopenia, increases the risk of mobility impairments, chronic disease and early mortality. Physical activity and targeted dietary approaches are the most effective intervention to prevent or limit sarcopenia. Omega-3 polyunsaturated fatty acids (PUFA) could alleviate some aspects of age-related diseases. We investigated the effect of a chronic intake of a diet containing a high content of omega-3 PUFA in old mice exposed to a normocaloric or an obesogenic diet. Female C57BL/6J mice received a low-fat or a high-fat diet containing 5 or 6%, respectively, of camelina oil (comprising 27% omega-3 PUFA) for 18 weeks and were compared to animals receiving the similar diets containing high-oleic sunflower oil instead. Circulating parameters, calorimetry and physical performances were evaluated as well as muscle lipid content and molecular adaptations. Consumption of camelina oil increased omega-3 PUFA content in biological membranes, as well as circulating levels of anti-inflammatory oxylipin mediators. High-fat diets induced changes in body composition but these effects were not affected by the intake of camelina oil. However, camelina oil consumption increased motor coordination in the low-fat condition. Some lipidomic adaptations were observed in relation to oil intake. Variations in plasma levels of glycerol, free fatty acids and muscle gene expression suggested improved lipid homeostasis in groups receiving camelina oil. In conclusion, the consumption of an energy-balanced diet with a high content of omega-3 PUFA provided by camelina oil could provide benefits on muscle health. CLINICAL TRIAL REGISTRATION: Not applicable.</p>","PeriodicalId":16779,"journal":{"name":"Journal of physiology and biochemistry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}