Journal of Pediatric Urology最新文献

{"title":"Semen quality in healthy adolescents related to available norms.","authors":"Marcel Drlík, Zuzana Krátká, Tomáš Fürst, Petra Nováková, Radim Kočvara","doi":"10.1016/j.jpurol.2026.106236","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106236","url":null,"abstract":"<p><strong>Introduction: </strong>Andrological assessment during adolescence is crucial for evaluating and preventing future fertility issues, however, current semen analysis relies on adult reference ranges from the WHO Manual, lacking specific standards for adolescents. This study aimed to evaluate sperm quality in healthy adolescent boys and compare the findings with established adult norms.</p><p><strong>Methods: </strong>Forty-four healthy adolescents aged 15-17 years, all in Tanner stage 5 of puberty, were prospectively enrolled. Exclusion criteria included genitourinary diseases or relevant medical conditions affecting future fertility. Two semen samples were collected 4 weeks apart from each participant after 3-4 days of abstinence and analyzed according to the WHO Manual (volume, sperm count, concentration, morphology, and progressive motility). Additionally, functional sperm parameters such as percentage of vital (non-apoptotic) sperm, sperm with permeable acrosome, and DNA fragmentation were assessed using flow cytometry. Abnormal findings were considered if present in both samples. We determined the frequency of pathological findings for each parameter and their frequency in the study group. We also calculated the intraindividual variability of the parameters, established a reference range of the 25th-75th percentiles for each parameter and compared the results with existing reference values for adult males.</p><p><strong>Results: </strong>At least one repeatedly detected abnormal standard sperm parameter was found in 16 (36.3 %) boys, while 35 (79%) showed at least one repeatedly detected abnormal functional sperm parameter. The most common pathological finding in standard semen analysis was low progressive motility in 10 (22.7 %) cases. Functional abnormalities included a low proportion of non-apoptotic sperm in 15 (34 %) and high acrosome permeability in 24 (55 %) boys. Notably, all adolescents had a normal proportion of sperm with fragmented DNA. Descriptive parameters such as sperm count, concentration, and morphology were largely normal or superior to adult reference values. Although Spearman's coefficients showed moderate parameter stability (0.53-0.60), the mean relative difference between the two analyses was high, reaching 62% for total count and 74% for concentration.</p><p><strong>Conclusion: </strong>This is the first study encompassing both descriptive and functional semen parameters in healthy adolescent boys. Our findings demonstrate that, even in healthy adolescents, a single semen analysis is insufficient to accurately evaluate semen quality. A significant proportion of these healthy boys exhibited abnormal functional semen parameters, even when their descriptive parameters were within or better than adult norms. This highlights the inadequacy of adult WHO reference ranges for this age group and the need for age-specific standards to guide clinical decisions.</p>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106236"},"PeriodicalIF":2.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor re: \"Perioperative analgesic efficacy of ultrasound-guided erector spinae plane block and posterior transversus abdominis plane block in paediatric patients undergoing open pyeloplasty: A prospective randomised trial\".","authors":"Anudeep Jafra, Seema Naib, Venkata Varadayya Naidu Bongarala, Yash Panwar","doi":"10.1016/j.jpurol.2026.106229","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106229","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106229"},"PeriodicalIF":2.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re: \"Perioperative analgesic efficacy of ultrasound-guided erector spinae plane block and posterior transversus abdominis plane block in paediatric patients undergoing open pyeloplasty: A prospective randomised trial\".","authors":"Xin Xie, Juan Qiao","doi":"10.1016/j.jpurol.2026.106228","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106228","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106228"},"PeriodicalIF":2.2,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-surgical assessment of lower urinary tract dysfunction in ureterocele patients.","authors":"Tyler Overholt Daniel, Kevin T Hobbs, Esther K Liu, Brett A Teplitz, Katelyn N Carty, Murali Kovvur, Glenn M Cannon, Francis X Schneck, Omar M Ayyash, Rajeev Chaudhry","doi":"10.1016/j.jpurol.2026.106208","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106208","url":null,"abstract":"<p><strong>Introduction: </strong>The primary aim of this analysis was to assess LUTD in ureterocele patients using validated questionnaire data.</p><p><strong>Methods: </strong>The authors queried the electronic medical records (EMR) at a tertiary center for ureterocele patients (01/01/2002-12/31/2021). Families were prospectively contacted to complete the Dysfunctional Voiding Symptom Score (DVSS), a 10-question survey validated to assess LUTD. The primary outcome was LUTD rate. Secondary outcomes included demographics, ureterocele characteristics, surgical history, and individual DVSS items.</p><p><strong>Results: </strong>Of 123 eligible, 70 (57%) completed the DVSS. Median age at survey completion was 10.5 years (IQR 7-16). Most were female gender (67.1%). There were 27 respondents (38.6%) with DVSS scores consistent with significant LUTD. Individual items with the highest scores were holding urine and pushing to defecate. Most respondents (87.1%) underwent transurethral incision of ureterocele for initial management at median age 3 months (0-9.5). Thirty respondents (42.9%) had subsequent major reconstructive surgery at median age 17 months (13-32). Respondents who underwent reconstructive surgery involving the bladder had higher median DVSS scores compared to respondents who underwent endoscopic incision alone (p = 0.02). There were no differences in DVSS scores between genders, ureterocele location, UTI status, VUR status, or number of surgeries performed (p > 0.05).</p><p><strong>Conclusions: </strong>The rate of LUTD identified in ureterocele patients was high, affecting 38.6% of respondents over a 20-year period. Most common dysfunction areas included holding urine and straining to defecate. Patients of all ages and genders were affected, but higher voiding dysfunction rates may be seen in those who undergo reconstructive surgery.</p>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106208"},"PeriodicalIF":2.2,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re: \"Implementation of a simulation curriculum for operating room nursing staff utilizing a high-fidelity physical simulator model for training pediatric urethral catheter insertion\".","authors":"S Hariharan, A Arungeethan, J Vasanthapriya, J Anitha","doi":"10.1016/j.jpurol.2026.106210","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106210","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106210"},"PeriodicalIF":2.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary to \"The effectiveness of music-based sensory activation solutions (SAS) method in patients with treatment-resistant nocturnal enuresis\".","authors":"Amanda K Berry","doi":"10.1016/j.jpurol.2026.106213","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106213","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106213"},"PeriodicalIF":2.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re: \"Myh11 haploinsufficiency recapitulates megacystis and voiding dysfunction in a mouse model of MMIHS\".","authors":"Glenda M Beaman, Karolina Baker, William G Newman, Adrian S Woolf","doi":"10.1016/j.jpurol.2026.106211","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106211","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106211"},"PeriodicalIF":2.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re: \"Clinical and endocrine correlates of genetic etiologies in severe hypospadias: Study from 34 patients\".","authors":"Qinhui Jin, Danjie Zhang, Xiaqi Lv, Yinfeng Ma","doi":"10.1016/j.jpurol.2026.106212","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106212","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106212"},"PeriodicalIF":2.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re: \"Comparison of cohen procedure and modified intravesical detrusorrhaphy technique in the treatment of obstructive or refluxive megaureters: A prospective comparative study\".","authors":"Jiali Huang, Xinyu Zhai, Xuyang Zheng","doi":"10.1016/j.jpurol.2026.106209","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106209","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106209"},"PeriodicalIF":2.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical antibiotic prophylaxis in pediatric urology: Are we following the AUA guidelines? A multi-center evaluation of compliance and impact on morbidity.","authors":"Sri Saran Manivasagam, Jennifer A Kane, Paul Smith, Thomas M FitzGibbon","doi":"10.1016/j.jpurol.2026.106203","DOIUrl":"https://doi.org/10.1016/j.jpurol.2026.106203","url":null,"abstract":"<p><strong>Introduction: </strong>The American Urological Association (AUA) provides guidance on surgical antibiotic prophylaxis (SAP) for urologic procedures. In the absence of pediatric-specific recommendations, these guidelines are often extrapolated to children. We evaluated national compliance with SAP components (administration, antibiotic choice, timing, and re-dosing) across pediatric urologic procedures and examined associations with postoperative outcomes.</p><p><strong>Methods: </strong>Using the ACS NSQIP-Pediatrics database (2021-2023), we analyzed five procedure categories: hypospadias/urethroplasty, endourologic stone procedures, renal/bladder surgery, cystoscopy, and inguinal/scrotal cases. Compliance was defined per best practice statement on urologic procedures and antimicrobial prophylaxis (2019). Outcomes included infectious complications, readmissions, and reoperations. Multivariable logistic regression adjusted for demographic, clinical, and procedural covariates.</p><p><strong>Results: </strong>Among 25,058 procedures in which SAP is indicated, complete compliance was 75.8% for hypospadias/urethroplasty, 79.6% for endourologic stone procedures, and 76.4% for renal/bladder surgery. Non-compliance was associated with increased wound dehiscence (2.1% vs 1.4%, p = 0.046) and urinary tract infections (1.3% vs 0.7%, p = 0.036) after hypospadias repair, higher superficial infections (1.2% vs 0.7%, p = 0.009) and readmissions (5.7% vs 4.9%, p = 0.047) after renal/bladder surgery, and lower readmissions (3.3% vs 2.6%, p = 0.011) and reoperations (0.9% vs 0.7%, p = 0.003) with SAP during cystoscopy. On multivariate logistic regression analysis, SAP use was not associated with reduced post-operative morbidity.</p><p><strong>Conclusions: </strong>National compliance with SAP is generally high but variable across components and procedures. Given inconsistent associations with outcomes and recognized risks of unnecessary antibiotic exposure, pediatric-specific, evidence-based SAP recommendations and stewardship frameworks are warranted.</p>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":"106203"},"PeriodicalIF":2.2,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}