Journal of Pediatric Urology最新文献

{"title":"Commentary on: “Onabotulinum toxin A injections: A novel option for management of refractory nocturnal enuresis” by Tyler Overholt, Davis Temple, Adam Cohen, Anthony Atala, Marc Colaco, Steve Hodges","authors":"Valeska Bidault-Jourdainne","doi":"10.1016/j.jpurol.2024.09.038","DOIUrl":"10.1016/j.jpurol.2024.09.038","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 53-54"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratification of Wilms tumor patients using physicochemical properties of the adaptive immune receptor polypeptides, IGL and TRG","authors":"David P. Adams ,&nbsp;Etienne C. Gozlan ,&nbsp;Nikhila Medikonda ,&nbsp;Joanna J. Song ,&nbsp;Arpan Sahoo ,&nbsp;Michelle Yeagley ,&nbsp;George Blanck","doi":"10.1016/j.jpurol.2024.10.012","DOIUrl":"10.1016/j.jpurol.2024.10.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Wilms tumor (WT) is the most common pediatric renal malignancy. Current guidelines that stratify WT risk and determine treatment courses are inadequate, as over 60 % of WT survivors develop treatment-related complications. Recently, numerous advances in establishing patient sub-groups with different clinical features have been realized by evaluating the adaptive immune receptor (IR) complementarity determining region-3 (CDR3) amino acid (AA) sequences, a reasonable series of successes, given the prominent role of the CDR3 in antigen binding, including tumor antigen binding. However, the possibility that adaptive IR chemical variability correlates with distinct survival outcomes for WT has not yet been explored.</div></div><div><h3>Objective</h3><div>The goal of this study was to isolate the T-cell receptor and B-cell receptor recombination, sequencing reads from WT RNAseq files, representing the actual tumor tissue, translate the sequences to AAs, identify the adaptive IR CDR3 domains, and determine whether the physicochemical properties of those CDR3 AA sequences correlated with survival probability distinctions.</div></div><div><h3>Study design</h3><div>WT RNA-seq files were mined to obtain the CDR3 AAs for various adaptive IRs. The physicochemical properties of these CDR3s were examined for trends in how those properties correlated with survival probabilities for WT patients, using a Kaplan–Meier analyses, verified via several approaches.</div></div><div><h3>Results</h3><div>The above processes indicated the association of the (a) IGL CDR3s′ instability index and the (b) TRG CDR3s’ fraction disorder promoting features with better outcomes. Additionally, the IGL CDR3 data were assessed using the Predictor of Natural Disordered Regions web tool, which strengthened the evidence for the association with the IGL CDR3 instability index with a better outcome.</div></div><div><h3>Discussion</h3><div>The approaches described here indicate that greater adaptive IR CDR3 instability and flexibility may serve as prognostic indicators; and may indicate the flexibility of CDR3 domains provides for greater opportunity to bind tumor antigens.</div></div><div><h3>Conclusion</h3><div>Further exploration and development of these approaches and findings may lead to new guidelines for more precise treatment regimens, or even watchful waiting periods, that could thereby decrease the lifetime occurrence of adverse events.<span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (196KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span><span><span><p><span>Summary figure</span>. </p></span></span></figure></span></div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 130-135"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic balloon dilatation of primary obstructive megaureter: An effective first line management in children","authors":"Olugbenga Awolaran ,&nbsp;Ijeoma Nwachukwu ,&nbsp;Anu Paul ,&nbsp;Massimo Garriboli ,&nbsp;Arash Taghizadeh ,&nbsp;Sara Lobo ,&nbsp;Karim Awad ,&nbsp;Kate Burns ,&nbsp;Mohamed Shalaby ,&nbsp;Mark Woodward ,&nbsp;Pankaj Mishra","doi":"10.1016/j.jpurol.2024.09.007","DOIUrl":"10.1016/j.jpurol.2024.09.007","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;This study evaluates outcomes of endoscopic balloon dilatation (EBD) in the management of primary obstructive megaureter (POM) in children.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Retrospective data between 2013 and 2023 from two tertiary paediatric surgical centres in the UK were reviewed. Pre and post-operative clinical and imaging parameters of children managed with EBD were assessed. Failure of procedure was defined as requiring further intervention due to persistent/recurrent symptoms, upper tract dilatation and/or obstruction on MAG3 over the follow up period.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;55 children with 61 renal units were evaluated. Median age at treatment was 18 months with a median follow up of 24 months. There was significant reduction in upper tract ultrasound measurements following balloon dilatation but there was no significant difference between the pre and post-operative renal function on MAG3. No significance difference was demonstrated when the outcomes of cutting and non-cutting balloons were compared. No significant difference was shown when outcomes after EBD were compared between infants vs older children as well as ureteric dilatation less than or over 25 mm (p = 0.841). 87% were successfully treated with a single dilatation and this increased to 95% after second dilatation. The remaining 5% had ureteric re-implantation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;Although a retrospective study, the patient population is relatively large. 87% success rate shown after EBD is comparable to similar studies. It has been suggested that children less than 12months and those with severe ureteric dilatation (&gt;25 mm) may not be suitable for EBD. No significant difference was demonstrated when the outcomes of these categories of children were compared to other children with POM. All of the patients that had repeat balloon dilatation required no further intervention, a finding that has so far not been well evaluated in available literature.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;This study demonstrates 87% success rate after single EBD in children with POM and this outcome increased to 95% following a second dilatation. EBD is shown to be an effective definitive surgical management option of POM. It can be safely offered as first line management in all patient groups and repeated if no initial response.&lt;span&gt;&lt;div&gt;&lt;span&gt;&lt;span&gt;&lt;p&gt;&lt;span&gt;Summary table&lt;/span&gt;. &lt;/p&gt;&lt;/span&gt;&lt;/span&gt;&lt;div&gt;&lt;table&gt;&lt;thead&gt;&lt;tr&gt;&lt;td&gt;&lt;span&gt;Empty Cell&lt;/span&gt;&lt;/td&gt;&lt;th&gt;P-value&lt;/th&gt;&lt;/tr&gt;&lt;/thead&gt;&lt;tbody&gt;&lt;tr&gt;&lt;th&gt;Outcomes based on age (median post-op APD)&lt;/th&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;&lt;/span&gt;&lt;span&gt;&lt;div&gt;- &lt;12months&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/td&gt;&lt;td&gt;20 units (13 mm)&lt;/td&gt;&lt;td&gt;0.433&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;&lt;/span&gt;&lt;span&gt;&lt;div&gt;- &gt;/ = 12mo&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/td&gt;&lt;td&gt;41 units (13 mm)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;th&gt;Outcomes based on severity of DUD diameter (median post-op DUD)&lt;/th&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;&lt;/span&gt;&lt;span&gt;&lt;div&gt;- &lt;25 mm&lt;/div&gt;&lt;/span&gt;&lt;/li&gt;&lt;/ul","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 124-129"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and preferences of women with CAH and parents about disclosure of childhood surgery","authors":"Ashley W. Johnston ,&nbsp;Mimi S. Kim ,&nbsp;Paul Kokorowski ,&nbsp;Devon J. Hensel ,&nbsp;Patrice M. Yasuda ,&nbsp;Richard C. Rink ,&nbsp;Konrad M. Szymanski ,&nbsp;Life with Congenital Adrenal Hyperplasia","doi":"10.1016/j.jpurol.2024.09.030","DOIUrl":"10.1016/j.jpurol.2024.09.030","url":null,"abstract":"<div><h3>Introduction</h3><div>Complete disclosure of childhood genital surgery to patients with congenital adrenal hyperplasia (CAH) is a critical part of CAH care. There are no guidelines or uniform recommendations on the timing and content of surgical disclosure discussions.</div></div><div><h3>Objective</h3><div>Our objective was to describe the experiences and preferences of females with CAH and parents of females with CAH who underwent childhood genital surgery regarding surgical disclosure.</div></div><div><h3>Methods</h3><div>We conducted an anonymous cross-sectional online survey of females with CAH (46XX, ≥16 years [y] old) and parents of females with CAH who underwent genital surgery before age 4y in North America. Participants reported experiences, preferences, and advice about initial (“first time you were told”) and complete disclosure (“told all details”). Non-parametric statistics and qualitative analysis were used.</div></div><div><h3>Results</h3><div>Participants included 59 females with CAH (median age: 37y, 92% White, 93% non-Hispanic) and 41 parents (median: 36y, 85% White, 93% non-Hispanic, daughter median: 26y). The 76% of females who received complete disclosure were younger (median age: 33y) and underwent surgery more recently (median decade: 1980s) than the 14% who received only initial disclosure (median: 47y, 1970s) and the 10% who did not receive any disclosure (median: 60y, 1960s, p = 0.0003, <strong>Summary Figure</strong>). Females reported median ages of initial and complete disclosure as 7-10y and 11-13y, respectively. Disclosure was preferred by 98% of females with initial disclosure by age 14y and complete disclosure by 18y. Parents reported similar findings. Most disclosures were by mothers (initial: 82%, complete: 64%). Doctors were more involved in complete vs. initial disclosures (complete: 47%, initial: 13%, p &lt; 0.001). Qualitative analysis of advice about surgical disclosure revealed 8 themes.</div></div><div><h3>Conclusions</h3><div>Disclosure of childhood genital surgery to women with CAH has increased over time. Although timing of disclosure varied, women preferred disclosure, and that it be initiated before age 14y and completed by age 18y.<span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (269KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span><span><span><p><span>Summary figure</span>. <!-->Surgical disclosure of females with CAH</p></span></span></figure></span></div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 78-86"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on hypospadias and appeal to tradition fallacy","authors":"Hüseyin Özbey","doi":"10.1016/j.jpurol.2024.09.034","DOIUrl":"10.1016/j.jpurol.2024.09.034","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 55-56"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of dorsal inlay graft urethroplasty","authors":"Ramazan Karabulut,&nbsp;Zafer Turkyilmaz,&nbsp;Ali Atan,&nbsp;Cem Kaya,&nbsp;Kaan Sonmez","doi":"10.1016/j.jpurol.2024.09.037","DOIUrl":"10.1016/j.jpurol.2024.09.037","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Page 243"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor re surgical and functional outcomes of dorsal inlay graft urethroplasty in revision vs primary hypospadias repair in the pediatric age","authors":"Michele Gnech,&nbsp;Carolina Bebi,&nbsp;Alfredo Berrettini,&nbsp;Dario Guido Minoli,&nbsp;Erika Adalgisa De Marco,&nbsp;Gianantonio Manzoni","doi":"10.1016/j.jpurol.2024.10.022","DOIUrl":"10.1016/j.jpurol.2024.10.022","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 241-242"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic analysis of gonadal tissue in patients with Turner syndrome and Y chromosome material","authors":"Julia Bhuiyan,&nbsp;Raghuveer Kavarthapu,&nbsp;Mary Soliman,&nbsp;G Thomas Brown,&nbsp;Jacqueline C. Yano,&nbsp;Tazim Dowlut-McElroy,&nbsp;Veronica Gomez-Lobo","doi":"10.1016/j.jpurol.2024.08.007","DOIUrl":"10.1016/j.jpurol.2024.08.007","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 222-223"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study of the effectiveness of warm ischemia and cold ischemia during testis-sparing surgery in rats","authors":"Emine Doğan ,&nbsp;Ayşe Karaman ,&nbsp;Habibe Meltem Özgüner ,&nbsp;Cengiz Karakaya","doi":"10.1016/j.jpurol.2024.08.015","DOIUrl":"10.1016/j.jpurol.2024.08.015","url":null,"abstract":"<div><h3>Introduction</h3><div>The postpubertal effects of testis-sparing surgery on prepubertal testicular tumors are not fully understood.</div></div><div><h3>Objective</h3><div>In this study, we aimed to evaluate the effect of different durations of warm and cold ischemia during a rat prepubertal testis-sparing surgery model on the ischemic and contralateral normal testes in the postpubertal period.</div></div><div><h3>Study design</h3><div>The study encompassed a group of 54 male rats in the prepubertal stage who were then arranged to be put into nine groups: sham (Sh), control-cold (Cc), control-biopsy (Cb), 30, 60 or 90min warm ischemia (WIb³⁰,WIb⁶⁰,WIb⁹⁰) and cold ischemia (CIb³⁰,CIb⁶⁰,CIb⁹⁰). In the ischemia groups, a microvascular clamp was applied to the right spermatic cord, then testicular biopsy was taken. In the cold ischemia groups, the testicles were preserved in sterile ice mud. After the experiment, the rats were observed for 4 weeks to pinpoint any changes during their progression into the post-pubertal period. Bilateral orchiectomy materials were examined histopathologically, and Johnsen scores were used to evaluate postpubertal fertility potential.</div></div><div><h3>Results</h3><div>In our investigation, rats in all groups exhibited similar weight gains. The postpubertal size of the right testis in the testicular biopsy groups was found to be smaller compared to the remaining groups. In the warm ischemia group, testicular atrophy occurred after ischemic duration exceeding 30 min. Conversely, no testicular atrophy was observed in the cold ischemia groups. The dimensions of the rats' left testicles were similar. On histopathology, right testicular Johnsen scores were significantly lower in the warm ischemic groups than in the cold ischemic groups.</div></div><div><h3>Discussion</h3><div>Our study is the first to investigate the postpubertal effects of varying durations of warm and cold ischemia in a prepubertal testis-sparing surgery model. In our study, the Johnsen scores of testes subjected to 30, 60, and 90 min of ischemia were found to be higher in the cold ischemia groups compared to the warm ischemia groups. As the ischemia duration prolonged, a discernible progression of testicular atrophy was observed in the warm ischemia groups, contrasting with the sustained stability of testicular sizes in the cold ischemia groups.</div></div><div><h3>Conclusions</h3><div>Warm ischemia applied to the testis causes damage to the testicle within the first 30 min and leads to atrophy after 30 min. In the cases of warm ischemia, both the Johnsen scores, which serve as indicators of post-pubertal fertility, and the testicular size decline in parallel with the duration of ischemia.</div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Pages 11-19"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study of the effectiveness of warm ischemia and cold ischemia during testis-sparing surgery in rats","authors":"Raimund Stein","doi":"10.1016/j.jpurol.2024.09.018","DOIUrl":"10.1016/j.jpurol.2024.09.018","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 1","pages":"Page 20"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}