Umay Kavgacı, Bora Gulhan, Eda Didem Kurt-Sukur, Ali Düzova, Hasan Serkan Dogan, Serdar Tekgul, Rezan Topaloglu, Fatih Ozaltin
{"title":"Comprehensive analysis of pediatric urolithiasis in a tertiary care center and insights into demographics, risk factors, and management outcomes.","authors":"Umay Kavgacı, Bora Gulhan, Eda Didem Kurt-Sukur, Ali Düzova, Hasan Serkan Dogan, Serdar Tekgul, Rezan Topaloglu, Fatih Ozaltin","doi":"10.1016/j.jpurol.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.03.006","url":null,"abstract":"<p><strong>Background: </strong>Pediatric urolithiasis is a growing global health concern, with increasing incidence and potential risks for chronic kidney disease if untreated. Contributing factors include metabolic disorders, genetic predisposition, dietary influences, and regional variations. Despite advancements in diagnosis and treatment, management remains challenging, particularly in high-risk infants.</p><p><strong>Objective: </strong>This study investigates the clinical characteristics, metabolic risk factors, and treatment outcomes of pediatric urolithiasis in a tertiary care center in Türkiye. Special attention is given to infants, assessing their distinct metabolic and clinical features, treatment responses, and the effectiveness of conservative management. Additionally, factors influencing stone burden and recurrence are evaluated to support individualized, risk-based management.</p><p><strong>Methods: </strong>We retrospectively analyzed 308 children (0-18 years) diagnosed with urinary stones. Demographic data, clinical presentation, laboratory and imaging findings, treatment strategies, and outcomes were reviewed. Metabolic evaluations included urinary levels of citrate, oxalate, and calcium. Treatment approaches varied based on stone size, location, and symptoms, ranging from conservative management to medical therapy and surgical interventions.</p><p><strong>Results: </strong>The median age at diagnosis was 12.5 months (range: 0-214), with a high prevalence of infant-onset cases. A family history of urolithiasis was present in 59.9 %, and parental consanguinity in 31.2 %. At the first visit, hypocitraturia (46.5 %), hyperoxaluria (36 %), and hypercalciuria (11.3 %) were common. Infants had higher rates of bilateral and multiple stones, while older children had larger stones (>5 mm, p < 0.001). Among infants with bilateral, multiple stones, hypocitraturia and hyperoxaluria were detected in 68.7 % and 66.1 %, respectively at follow-up, emphasizing the need for serial metabolic assessments. Nearly 70 % of patients received medical therapy, primarily Shohl's solution, while 28.2 % were managed conservatively. Among those with stones ≤5 mm, one-third were observed without intervention, with no significant difference in stone-free rates. Surgical interventions included extracorporeal shock wave lithotripsy (21.8 %), percutaneous nephrolithotomy (8.8 %), ureterorenoscopy (12.3 %), and open surgery (2.3 %).</p><p><strong>Discussion: </strong>Comparable stone-free rates between treated and untreated small stones (≤5 mm) support the role of conservative management in selected cases without metabolic risk factors. However, the high rate of surgical interventions highlights the need for individualized treatment. Early-onset urolithiasis is frequently bilateral and multiple, reinforcing the importance of serial urine testing for accurate diagnosis.</p><p><strong>Conclusion: </strong>Pediatric urolithiasis generally has a favorable prognosis w","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial commentary on JPUROL-D-24-00626R comparing clinical and radiological success in open versus endoscopic surgery of primary vesicoureteral reflux.","authors":"Yuval Bar-Yosef","doi":"10.1016/j.jpurol.2025.02.046","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.02.046","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Highlights from the International Children's Continence Society annual meeting in Salvador, Brazil","authors":"","doi":"10.1016/j.jpurol.2025.02.010","DOIUrl":"10.1016/j.jpurol.2025.02.010","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 2","pages":"Page 259"},"PeriodicalIF":2.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fall 2024 edition of Dialogues in Pediatric Urology – Pediatric urology and radiology: A powerful synergy between fields","authors":"Emily Blum, Jason Van Batavia","doi":"10.1016/j.jpurol.2025.02.013","DOIUrl":"10.1016/j.jpurol.2025.02.013","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 2","pages":"Page 257"},"PeriodicalIF":2.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supul Hennayake, Mahmoud Marei Marei, Adrian Bianchi
{"title":"A commentary on the STAC technique: Preservation of the bulbospongiosus muscle and a broader perspective.","authors":"Supul Hennayake, Mahmoud Marei Marei, Adrian Bianchi","doi":"10.1016/j.jpurol.2025.02.045","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.02.045","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadja Riehle, Marc Sütterlin, Samantha Wakerlin, Thomas Kohl
{"title":"Intermediate outcomes of children (4-10 years) with postnatally preserved renal function after vesico-amniotic shunt insertion for lower urinary tract obstruction (LUTO).","authors":"Nadja Riehle, Marc Sütterlin, Samantha Wakerlin, Thomas Kohl","doi":"10.1016/j.jpurol.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.03.004","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this retrospective study was to examine the intermediate outcomes and renal development of children (four to ten years) who had undergone prenatal vesico-amniotic shunt insertion (VAS) for lower urinary tract obstruction (LUTO), and later demonstrated preserved kidney function as neonates.</p><p><strong>Patients & methods: </strong>Of 63 fetuses that underwent VAS for LUTO, 47 survived both the pregnancy and the neonatal period. Twenty-four of them were born with preserved renal function as defined by normal laboratory values for creatine, urea, and/or GFR. Twenty of them (83.3 %) were available for our study. We analyzed their pediatric general, surgical, urological, and radiological medical records with a particular emphasize on renal function.</p><p><strong>Results: </strong>All children of the cohort are still alive. None of the pediatric study subjects have required renal replacement therapy after four to ten years of follow-up. In 90 % of the cases, renal function as defined by laboratory values for creatine, urea, and/or GFR remained preserved. Only two children (10 %) demonstrated impaired renal function.</p><p><strong>Conclusion: </strong>The findings of our retrospective study suggest that when normal laboratory values for creatine, urea, and/or GFR are observed in the neonatal period following prenatal VAS for LUTO, these parameters will likely remain normal in most patients for the first four to ten years of their life. Confirming our previously published novel management strategy, the highest preservation rates can be achieved when after early detection of LUTO, VAS can be performed prior to the completion of 16 weeks of gestation.</p>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James T Rague, Ilina Rosoklija, David I Chu, Earl Y Cheng, Emilie K Johnson
{"title":"Practice patterns in the care of proximal hypospadias among pediatric urologists.","authors":"James T Rague, Ilina Rosoklija, David I Chu, Earl Y Cheng, Emilie K Johnson","doi":"10.1016/j.jpurol.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.03.002","url":null,"abstract":"<p><strong>Introduction: </strong>About 25 % of patients with hypospadias have a proximal form, often associated with an underlying genetic cause or difference of sex development (DSD). Surgical complication/re-operation rates are high, surgical practice patterns are variable, and consensus recommendations to guide medical and surgical management are not yet available. One presumed barrier to consensus is understanding variability in management for this condition.</p><p><strong>Objective: </strong>To assess medical and surgical practice patterns of pediatric urologists regarding care of proximal hypospadias.</p><p><strong>Study design: </strong>An anonymous, web-based survey was sent to members of the Societies for Pediatric Urology to capture medical and surgical management practices for patients with proximal hypospadias. Respondent demographics were obtained. Median estimated patients cared for per year was determined. Comparisons between those ≤50th percentile for volume and >50th percentile were made using chi squared and Fisher's exact tests.</p><p><strong>Results: </strong>137 completed surveys were returned (137/311 (44 %) opened emails), and 125 responses met inclusion criteria. Respondents were predominantly male (70 %), and practice in an urban (85 %), academic (72 %) setting. The median (IQR) estimated number of patients cared for per year was 7 (5.0, 10.0). Half (50 %) never receive referrals from other pediatric urologists for surgical care. Most never refer patients to other surgeons within (55 %) or outside (72 %) of their practice. Frequent independent ordering of a karyotype was reported, with less frequent ordering of hormonal and advanced genetic testing (Table). Performing systematic, post-operative data collection was reported infrequently (37 %). Those >50th percentile in volume compared to those ≤50th percentile reported receiving more referrals from other urologists for surgical care (any referrals received, 66 % vs 36 %, p = 0.001) and more commonly perform surgery independently (63 % vs 32 %, p = 0.003). There were no differences between groups regarding lab testing, medical specialty referrals, or surgical management.</p><p><strong>Discussion: </strong>Proximal hypospadias surgery is uncommonly performed by most pediatric urologists and patterns of independent lab evaluation and referral to medical subspecialities are variable. Few differences in practice were seen based on surgeon volume, especially around lab testing and medical specialty referrals. Though an optimal approach to medical evaluation is not yet defined, opportunities for greater uniformity in the management of proximal hypospadias exist. Clinical practice guidelines to help surgeons determine the best approach to medical evaluation and surgical management could improve quality of care in proximal hypospadias.</p><p><strong>Conclusions: </strong>The approach to pre-operative medical care of patients with proximal hypospadias varies among pediatric urolog","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Authors' reply to comment on \"Comparing clinical and radiological success in open versus endoscopic surgery of primary vesicoureteral reflux\".","authors":"Pejman Shadpour, Nasrollah Abian","doi":"10.1016/j.jpurol.2025.02.043","DOIUrl":"https://doi.org/10.1016/j.jpurol.2025.02.043","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}