Journal of Pediatric Urology最新文献

{"title":"What the editors are reading - August 2025","authors":"John S. Wiener","doi":"10.1016/j.jpurol.2025.05.016","DOIUrl":"10.1016/j.jpurol.2025.05.016","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 1025-1026"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"March 2025 edition of Dialogues in Pediatric Urology - Society for Fetal Urology spring 2024 case reports","authors":"Douglas W. Storm","doi":"10.1016/j.jpurol.2025.05.018","DOIUrl":"10.1016/j.jpurol.2025.05.018","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Page 829"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision aid development for shared surgical decision-making in differences of sex development: A review of existing aids","authors":"Aalaa S. Abdallah ,&nbsp;Adam Davies ,&nbsp;Emma Trasatti ,&nbsp;Emilie K. Johnson ,&nbsp;Jax Whitehead","doi":"10.1016/j.jpurol.2025.04.005","DOIUrl":"10.1016/j.jpurol.2025.04.005","url":null,"abstract":"<div><h3>Background</h3><div>For some children with differences of sex development (DSD), surgical intervention is a potential treatment option to address risk of neoplasia or potential for difficulties with urination. The shared decision-making (SDM) process can be challenging for patients, families, and clinicians; decision aids (DAs) can assist in this process.</div></div><div><h3>Objective</h3><div>To conduct a narrative review of literature relevant to the use of DAs in surgical SDM for children with DSD, and to provide a framework for providers to create and implement DAs alongside key stakeholders.</div></div><div><h3>Methods</h3><div>Primary and secondary literature searches were conducted using PubMed to generate a narrative literature review, which informed a framework incorporating aspects of community-based participatory research.</div></div><div><h3>Results</h3><div>Six publications were included in the narrative review. Effective DAs were noted to include the following core components: (1) an overview of the process and the family's goals and values, (2) a review of nomenclature, (3) a list of topics and desired depth of discussion for each, (4) a list of questions for the medical team, and (5) management options including non-surgical management. A framework of key components and steps for future DA development was constructed based on the findings of the reviewed publications.</div></div><div><h3>Conclusion</h3><div>Our framework for a community-based participatory research approach to the development of DAs for surgical SDM for children with DSD provides a critical tool for clinicians to ensure patients and their caregivers are well-informed about their diagnoses and treatment options. Future research should further assess implementation and effectiveness of DAs.</div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 894-902"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to editor for Intraoperative urinary ACR as a prognostic biomarker in unilateral pelviureteric junction obstruction in paediatric population - An observational study","authors":"Keerthana Bachala,&nbsp;Amit Kumar Sinha,&nbsp;Bindey Kumar,&nbsp;Mala Mahto,&nbsp;Amit Kumar,&nbsp;Rashi Rashi","doi":"10.1016/j.jpurol.2025.04.025","DOIUrl":"10.1016/j.jpurol.2025.04.025","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 934-935"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Commentary on “Robotically procured living donor kidneys transplanted into pediatric recipients”","authors":"Enric Lledo Graell,&nbsp;Marina M. Tabbara,&nbsp;Mahmoud Morsi,&nbsp;Angel Alvarez,&nbsp;Jayanthi Chandar,&nbsp;Rodrigo Vianna,&nbsp;Gaetano Ciancio","doi":"10.1016/j.jpurol.2025.03.028","DOIUrl":"10.1016/j.jpurol.2025.03.028","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 983-984"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re: “The impact of artifact levels on intra- and interobserver agreement in pediatric urodynamic traces”","authors":"Peter F.W.M. Rosier","doi":"10.1016/j.jpurol.2025.04.037","DOIUrl":"10.1016/j.jpurol.2025.04.037","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 1033-1034"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of chronic kidney disease in children with anorectal malformations","authors":"Esra Karabag Yilmaz ,&nbsp;Ali Ekber Hakalmaz ,&nbsp;Seha Saygılı ,&nbsp;Ayse Agbas ,&nbsp;Kubra Karatas ,&nbsp;Memnune Nur Cebi ,&nbsp;Rahsan Ozcan ,&nbsp;Sebuh Kurugoglu ,&nbsp;Mehmet Elicevik ,&nbsp;Haluk Emir ,&nbsp;Nur Canpolat","doi":"10.1016/j.jpurol.2025.03.015","DOIUrl":"10.1016/j.jpurol.2025.03.015","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Anorectal malformations&lt;span&gt; (ARM) are often accompanied by urological anomalies, which can contribute to the development of chronic kidney disease (CKD).&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aimed to investigate the prevalence of kidney and urinary tract anomalies&lt;span&gt;, as well as bladder dysfunction, and their potential impact on the development of CKD in children with ARM.&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Study design&lt;/h3&gt;&lt;div&gt;This single-center, retrospective study included 175 children with ARM, after excluding 75 children with missing data. Clinical and radiological findings&lt;span&gt; and serum creatinine levels were obtained from medical records&lt;span&gt;. Anorectal malformations were classified as “high” and “low” type based on the Wingspread classification, and also further classified by fistula type and sex distribution according to the Krickenbeck International Classification. CKD was defined and staged according to the KDIGO (Kidney Disease Improving Global Outcomes) guidelines.&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;&lt;span&gt;&lt;span&gt;The median age of the patients was 9.7 years, with a male-to-female ratio of 1.13:1. Among the 175 patients, 97 (55 %) had intermediate or low-type ARM, and 78 (45 %) had high-type ARM. Kidney and/or urinary tract anomalies were identified in 85 patients (48.5 %), with 63 having kidney anomalies and 71 having urinary tract anomalies. The most common urinary tract anomaly was &lt;/span&gt;vesicoureteral reflux (&lt;/span&gt;&lt;em&gt;n&lt;/em&gt; = 58). Bladder dysfunction was observed in 56 patients (32 %). CKD was diagnosed in 30 patients (17 %); six of them were in CKD stage 5, and the remaining 24 were in stages 2–4. The development of CKD was more common in both females and males with kidney anomalies (&lt;em&gt;p&lt;/em&gt; &lt; 0.001), urinary tract anomalies (&lt;em&gt;p&lt;/em&gt; &lt; 0.001 and &lt;em&gt;p&lt;/em&gt; = 0.002, respectively), bladder dysfunction (&lt;em&gt;p&lt;/em&gt; &lt; 0.001), urinary tract infection (&lt;em&gt;p&lt;/em&gt;&lt;span&gt; &lt; 0.001), in addition females with persistent cloaca (&lt;/span&gt;&lt;em&gt;p&lt;/em&gt; = 0.023) and spinal anomalies (&lt;em&gt;p&lt;/em&gt; = 0.013). Kidney anomalies and bladder dysfunction were independently associated with the development of CKD (&lt;em&gt;p&lt;/em&gt; &lt; 0.001 and &lt;em&gt;p&lt;/em&gt; = 0.046, respectively).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;This study highlights that approximately half of the children with ARM had kidney and urinary tract anomalies, and one-third had bladder dysfunction. Additionally, almost one-fifth of the patients developed CKD, mostly in the early stages. Our findings also suggest that both kidney anomalies and bladder dysfunction are significant risk factors for CKD development in children with ARM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study emphasizes the presence of kidney anomalies, along with bladder dysfunction as risk factors for CKD. Physicians should take care to monitor and manage these risks to minimize the long-term impacts on kidney health in children with ARM.&lt;/d","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 908-914"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p66shc exacerbates the progression of obstructive nephropathy through apoptosis, mitochondrial damage, and EMT","authors":"Xilin Gao ,&nbsp;Xu Fan ,&nbsp;Xiaohan Yu ,&nbsp;Rui Wang ,&nbsp;Buzhou Zhang ,&nbsp;Yanqiu Li ,&nbsp;Xin Liu ,&nbsp;Yi Yang","doi":"10.1016/j.jpurol.2025.03.017","DOIUrl":"10.1016/j.jpurol.2025.03.017","url":null,"abstract":"<div><h3>Background</h3><div><span>Many factors contribute to hydronephrosis<span>, ultimately resulting in renal fibrosis and even deterioration of </span></span>renal function<span>. This study investigated the pathogenic role of p66shc, a redox-regulatory protein, in hydronephrosis-induced renal injury.</span></div></div><div><h3>Objective</h3><div><span>This study focused on the mechanism of p66shc in renal fibrosis associated with obstructive </span>nephropathy.</div></div><div><h3>Methods</h3><div><span><span><span><span>The expression of p66shc was found in kidney samples from pediatric </span>hydronephrosis patients. A complete unilateral </span>ureteral obstruction (CUUO) model was established in neonatal mice to recapitulate hydronephrotic progression. </span>Cell proliferation, </span>apoptosis<span><span>, reactive oxygen species (ROS), mitochondrial damage, and degree of epithelial-mesenchymal transition (EMT) in renal tubular epithelial cells were studied following p66shc silencing and overexpression. We also investigated the therapeutic effects of silencing p66shc in vivo and carried out </span>RNA sequencing after overexpressing p66shc in cells.</span></div></div><div><h3>Results</h3><div>p66shc inhibited renal tubular epithelial cell growth, exacerbated cell oxidative and mitochondrial damage, and promoted cell apoptosis and EMT. Silencing its expression in vivo could efficiently reduce renal fibrosis. Combined with RNA sequencing, we analyzed the potential molecular mechanisms of p66shc downstream.</div></div><div><h3>Conclusion</h3><div>p66shc enhances cell damage and the EMT process in obstructive nephropathy. Suppressing the expression of p66shc is one potential strategy for mitigating renal fibrotic progression.</div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 834-843"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bulking agent treatment of incontinent catheterizable channels in pediatric patients and young adults","authors":"Pyry Jaakkola ,&nbsp;Niklas Pakkasjärvi ,&nbsp;Eija Mäkelä ,&nbsp;Seppo Taskinen","doi":"10.1016/j.jpurol.2025.03.014","DOIUrl":"10.1016/j.jpurol.2025.03.014","url":null,"abstract":"<div><h3>Background</h3><div>Catheterizable continent channels (CCC) provide means for urinary continence when urethral catheterization is not feasible. However, some patients present with stomal incontinence warranting further interventions. The purpose of this study is to evaluate the effectiveness of endoscopic injection (EI) of bulking agent (Deflux©) as a minimally invasive treatment for CCC incontinence and to explore patient-specific variables influencing outcomes in a pediatric cohort.</div></div><div><h3>Methods</h3><div>Hospital's pediatric urology procedure registry was retrospectively reviewed to identify all patients with a CCC and at least one EI of bulking agent for the leakage of the stoma at our institution between 2001 and 2021. The postoperative outcomes were assessed three months after the procedure and annually thereafter.</div></div><div><h3>Results</h3><div>A total of 21 children and young adults were included with CCC indications including neurogenic bladder (n = 13), bladder or cloacal exstrophy (n = 5) and other conditions (n = 3). The most common channel type was appendicovesicostomy (n = 7) followed by Monti tube (n = 5), spiral Monti (n = 3), ureter (n = 3), and other types (n = 3). The median age at first EI was 9.7 years (IQR 8.2–15.1) with a median follow-up time of 4.0 years (IQR 1.2–6.7). At follow-up, 11 patients (52 %) achieved continence. Surgical correction was ultimately required in nine patients (43 %) due to incontinence and in three patients for other reasons. No patient (0 %) experienced long term benefit from &gt;1 injections.</div></div><div><h3>Conclusion</h3><div>Endoscopic injections offer a minimally invasive option and can be considered a first-line approach for treating CCC incontinence. However, surgical correction remains necessary for some patients. In our material, re-injections were ineffective.</div></div>","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 919-924"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Recurrent ventral curvature; hitherto unappreciated roles of spongiosum and bulbospongiosus muscle”","authors":"Supul Hennayake,&nbsp;Sanjaya Abeygunasekara,&nbsp;Adrian Bianchi","doi":"10.1016/j.jpurol.2025.03.027","DOIUrl":"10.1016/j.jpurol.2025.03.027","url":null,"abstract":"","PeriodicalId":16747,"journal":{"name":"Journal of Pediatric Urology","volume":"21 4","pages":"Pages 1039-1040"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}