Journal of Pharmaceutical and Allied Sciences最新文献_第10页

The effects of advertising on sales in the pharmaceutical industry in Nigeria - A survey 广告对尼日利亚制药业销售的影响——一项调查

Journal of Pharmaceutical and Allied Sciences Pub Date : 2009-12-01 DOI: 10.4314/JOPHAS.V5I1.48468

G. Adepoju, O. Laiyemo

引用次数: 0

Effect of ciprofloxacin on single dose chloroquine salivary and urinary excretion in healthy volunteers: a pharmacokinetic consideration 环丙沙星对健康志愿者单剂量氯喹唾液和尿液排泄的影响:药代动力学研究

Journal of Pharmaceutical and Allied Sciences Pub Date : 2009-12-01 DOI: 10.4314/JOPHAS.V4I1.48454

Jm Okonto, C. Ukwe, W. Obonga, P. Udeogaranya

引用次数: 0

The aqueous solubility of ofloxacin in the presence of metallic cations 氧氟沙星在金属阳离子存在下的水溶性

Journal of Pharmaceutical and Allied Sciences Pub Date : 2009-12-01 DOI: 10.4314/JOPHAS.V3I2.48423

C. Eboka, H. Okeri

{"title":"The aqueous solubility of ofloxacin in the presence of metallic cations","authors":"C. Eboka, H. Okeri","doi":"10.4314/JOPHAS.V3I2.48423","DOIUrl":"https://doi.org/10.4314/JOPHAS.V3I2.48423","url":null,"abstract":"Ofloxacin belongs to the class of fluoroquinolones which has found widespread use in the treatment of microbial infections resistant to other antibiotics. However, metallic cations and anti-acids have been found to adversely affect the bioavailability and antibacterial activity of ofloxacin. Many reasons have been suggested to explain the observed effects. In order to gain further understanding of how ofloxacin-metallic cation interaction affects ofloxacin availability and activity, the aqueous solubility of ofloxacin was investigated in the presence of some metallic cations spectrophometrically in this study. All the cations investigated increased the aqueous solubility of ofloxacin to varying extents. Ferrous sulphate produced the greatest increase in the solubility of ofloxacin. It was followed by ferric ammonium citrate, magnesium sulphate, aluminium hydroxide and calcium carbonate. Potassium chloride and sodium bicarbonate produced very slight increases. In all the cases, the solubility of ofloxacin increased as the amount of each metallic cation increased. The observed results can be attributed to formation of soluble ionic ofloxacin carboxylate salts and complexes of the metallic cations. The implication of such increase of the aqueous solubility of ofloxacin in the presence of metallic cations on the bioavailability and antibacterial activity of ofloxacin is discussed.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78410078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo and Invitro antioxidant properties of methanol extract of streblus asper lour 毛豆甲醇提取物体内外抗氧化性能研究

Journal of Pharmaceutical and Allied Sciences Pub Date : 2009-12-01 DOI: 10.4314/JOPHAS.V5I2.48472

B. Kakoti

{"title":"In vivo and Invitro antioxidant properties of methanol extract of streblus asper lour","authors":"B. Kakoti","doi":"10.4314/JOPHAS.V5I2.48472","DOIUrl":"https://doi.org/10.4314/JOPHAS.V5I2.48472","url":null,"abstract":"The in vivo and in vitro antioxidant properties of methanol extract of Streblus asper Lour (Family: Moraceae) (MESA) was evaluated. The in vitro antioxidant potential was determined by performing various assays such as DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, lipid peroxidation inhibition assay, hydroxyl radical scavenging assay, nitric oxide scavenging assay and reducing ability. 3, 5-Di-tert-butyl-4-hydroxytoluene (BHT) was used as a standard. The IC50 values of MESA and BHT in DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, lipid peroxidation inhibition, hydroxyl radical scavenging, and nitric oxide scavenging assays were 116.05, 110.07, 130.49, 143.99 ig/ml & 78.87, 89.97, 71.03, 103.77 ig/ml respectively. In the reducing ability assay, the Fe3+ to Fe2+ transformation was established as reducing capacity and the ability increased with increasing concentration. The phenolic content of the sample, determined using Folin-Ciocalteu reagent and was found to be 55.28±5.24 mg gallic acid equivalents (GA)/g dry weight. The total flavonoid concentrations, detected using 2% aluminum chloride, was 20.57±3.82 mg quercetin equivalents (QE)/g dry weight. In the in vivo antioxidant study, MESA (250 and 500 mg/kg) was administered four days prior to single dose of carbon tetrachloride (CCl4) and on the 7th day, the antioxidant status was measured in the liver. The level of reduced glutathione (GSH) and catalase (CAT) significantly reduced in CC14 control animal, when compared to normal animal liver. MESA treatment significantly increased the GSH and CAT levels. The thiobarbituric acid reactive substances (TBARS) level significantly reduced in the extract - treated groups, when compared to CCl4 control group. Serum biochemical parameters such as transaminases, phosphataes and total bilirubin level were significantly increased in toxin control groups and it restored to normal by supplementation of MESA and BHT. The obtained in vitro and in vivo results suggest that MESA possesses a significant antioxidant and hepatoprotective property.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90496376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Quality and influence of tropical storage conditions on amoxicillin formulations marketed in ethiopia 热带储存条件对在埃塞俄比亚销售的阿莫西林制剂的质量和影响

Journal of Pharmaceutical and Allied Sciences Pub Date : 2009-12-01 DOI: 10.4314/JOPHAS.V3I2.48428

W. Mikre, N. Mekonnen

{"title":"Quality and influence of tropical storage conditions on amoxicillin formulations marketed in ethiopia","authors":"W. Mikre, N. Mekonnen","doi":"10.4314/JOPHAS.V3I2.48428","DOIUrl":"https://doi.org/10.4314/JOPHAS.V3I2.48428","url":null,"abstract":"The quality of drugs in some less developed countries is inadequate. The quality of drugs in countries having a tropical climate may be adversely affected if their formulations have not been optimized for stability under these conditions. Amoxicillin is a broad-spectrum penicillin, active against certain Gram negative and Gram-positive organisms, and is a widely used. There are currently several formulations of it in Ethiopia. The aim of the present study was to investigate the physicochemical equivalence of eight brands of amoxicillin capsules and five brands of amoxicillin for oral suspensions sourced from different retail Pharmacy outlets in Addis Ababa, Ethiopia market and to study the effect of tropical storage conditions on the their quality with respect to the USP and BP requirements using the WHO guidelines. The assessment included the evaluation of uniformity of weight, identification, moisture content, dissolution profiles and the pH values of the reconstituted oral suspensions in addition to the quantitative determination of the amoxicillin content for the studied formulations. Almost all of the amoxicillin formulations examined met Pharmacopoeial requirements at zero time, three-months and six months after storage under tropical condition.","PeriodicalId":16719,"journal":{"name":"Journal of Pharmaceutical and Allied Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90577912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effectiveness of genomic DNA extraction protocol from three species of African Mistletoe(Lorantheceae) 三种非洲槲寄生基因组DNA提取方案的有效性

Journal of Pharmaceutical and Allied Sciences Pub Date : 2009-01-01 DOI: 10.4314/JOPHAS.V6I3.48530

V. Aina, H. Inuwa, S. Ibrahim, D. Ameh, Aj Noka, I. Aimola, P. Wuyep

引用次数: 0

Isolation and characterization of microcrystalline cellulose obtained from palm nut ( Elaeis guineensis ) fibres 棕榈仁纤维微晶纤维素的分离与特性研究

Journal of Pharmaceutical and Allied Sciences Pub Date : 2006-04-21 DOI: 10.4314/JOPHAS.V3I1.34987

F. Ohwoavworhua, I. Uya, O. Kunle

引用次数: 2

Flavones from Marchantia convoluta : isolation of apigenin7O- ß-D-glucuronide AND 5-hydroxyl-7-methoxyl-2-methylchromone 卷地苋黄酮:芹菜素70 - ß- d -葡糖苷和5-羟基-7-甲氧基-2-甲基色素的分离

Journal of Pharmaceutical and Allied Sciences Pub Date : 2006-04-21 DOI: 10.4314/JOPHAS.V3I1.34996

J. Xiao, F. Ren, M. Xu

引用次数: 7

Pesticidal and insecticidal effect of Campsis grandiflora (Thumb.) 桔梗的杀虫杀虫作用

Journal of Pharmaceutical and Allied Sciences Pub Date : 2006-04-21 DOI: 10.4314/JOPHAS.V3I1.34990

K. Pandey

引用次数: 2

Pharmacodynamic effects of cimetidine and metronidazole on the blood glucose lowering effect of glyburide in rats 西咪替丁与甲硝唑对大鼠格列本脲降血糖作用的药效学影响

Journal of Pharmaceutical and Allied Sciences Pub Date : 2006-04-21 DOI: 10.4314/JOPHAS.V3I1.34992

J. Okonta, P. Udeogaranya, C. Ezeagu

引用次数: 1