Effect of ciprofloxacin on single dose chloroquine salivary and urinary excretion in healthy volunteers: a pharmacokinetic consideration

The effects of ciprofloxacin on the salivary and urinary concentrations of chloroquine (CQ) were investigated in six healthy volunteers, 20 to 30 years of age. Ciprofloxacin reduced the absorption, excretion rate and t1/2 of chloroquine in urine, Cmax and AUC in saliva but increased the Tmax in saliva. Thus, concurrent administration of chloroquine, especially as chemoprophylactic agent, and ciprofloxacin, may lead to therapeutic failure hence may not be advisable.